JP2004526154A5 - - Google Patents
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- JP2004526154A5 JP2004526154A5 JP2002572414A JP2002572414A JP2004526154A5 JP 2004526154 A5 JP2004526154 A5 JP 2004526154A5 JP 2002572414 A JP2002572414 A JP 2002572414A JP 2002572414 A JP2002572414 A JP 2002572414A JP 2004526154 A5 JP2004526154 A5 JP 2004526154A5
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27463801P | 2001-03-12 | 2001-03-12 | |
| PCT/GB2002/001125 WO2002073204A2 (en) | 2001-03-12 | 2002-03-12 | Cell-based detection and differentiation of disease states |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004526154A JP2004526154A (ja) | 2004-08-26 |
| JP2004526154A5 true JP2004526154A5 (enExample) | 2005-12-22 |
Family
ID=23049031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002572414A Pending JP2004526154A (ja) | 2001-03-12 | 2002-03-12 | 細胞ベースの検出および病態の判別 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20030199685A1 (enExample) |
| EP (1) | EP1373896A2 (enExample) |
| JP (1) | JP2004526154A (enExample) |
| KR (1) | KR20030094281A (enExample) |
| CN (1) | CN1554025A (enExample) |
| CA (1) | CA2440753A1 (enExample) |
| IL (1) | IL157872A0 (enExample) |
| NZ (1) | NZ528205A (enExample) |
| WO (1) | WO2002073204A2 (enExample) |
| ZA (1) | ZA200307121B (enExample) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2350692A1 (en) * | 1998-10-29 | 2000-05-11 | Cell Works Inc. | Multiple marker characterization of single cells |
| US20030190602A1 (en) * | 2001-03-12 | 2003-10-09 | Monogen, Inc. | Cell-based detection and differentiation of disease states |
| US7043500B2 (en) * | 2001-04-25 | 2006-05-09 | Board Of Regents, The University Of Texas Syxtem | Subtractive clustering for use in analysis of data |
| US7298877B1 (en) * | 2001-11-20 | 2007-11-20 | Icad, Inc. | Information fusion with Bayes networks in computer-aided detection systems |
| EP2261368A1 (en) * | 2002-03-13 | 2010-12-15 | Genomic Health, Inc. | Gene expression profiling in biopsied tumor tissues |
| US7274809B2 (en) * | 2002-08-29 | 2007-09-25 | Perceptronix Medical, Inc. And British Columbia Cancer Agency | Computerized methods and systems related to the detection of malignancy-associated changes (MAC) to detect cancer |
| EP2359689B1 (en) | 2002-09-27 | 2015-08-26 | The General Hospital Corporation | Microfluidic device for cell separation and use thereof |
| EP1422526A1 (en) * | 2002-10-28 | 2004-05-26 | MTM Laboratories AG | Method for improved diagnosis of dysplasias |
| CA2506066A1 (en) * | 2002-11-15 | 2004-06-03 | Genomic Health, Inc. | Gene expression profiling of egfr positive cancer |
| US20040122705A1 (en) * | 2002-12-18 | 2004-06-24 | Sabol John M. | Multilevel integrated medical knowledge base system and method |
| US20040122704A1 (en) * | 2002-12-18 | 2004-06-24 | Sabol John M. | Integrated medical knowledge base interface system and method |
| US20040122707A1 (en) * | 2002-12-18 | 2004-06-24 | Sabol John M. | Patient-driven medical data processing system and method |
| US20040122708A1 (en) * | 2002-12-18 | 2004-06-24 | Avinash Gopal B. | Medical data analysis method and apparatus incorporating in vitro test data |
| US20040122706A1 (en) * | 2002-12-18 | 2004-06-24 | Walker Matthew J. | Patient data acquisition system and method |
| US20040122709A1 (en) * | 2002-12-18 | 2004-06-24 | Avinash Gopal B. | Medical procedure prioritization system and method utilizing integrated knowledge base |
| US20040122702A1 (en) * | 2002-12-18 | 2004-06-24 | Sabol John M. | Medical data processing system and method |
| US20040122787A1 (en) * | 2002-12-18 | 2004-06-24 | Avinash Gopal B. | Enhanced computer-assisted medical data processing system and method |
| US7490085B2 (en) * | 2002-12-18 | 2009-02-10 | Ge Medical Systems Global Technology Company, Llc | Computer-assisted data processing system and method incorporating automated learning |
| US20040122703A1 (en) * | 2002-12-19 | 2004-06-24 | Walker Matthew J. | Medical data operating model development system and method |
| US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
| WO2004071572A2 (en) * | 2003-02-06 | 2004-08-26 | Genomic Health, Inc. | Gene expression markers for response to egfr inhibitor drugs |
| CA2516553C (en) * | 2003-02-20 | 2013-04-16 | Genomic Health, Inc. | Use of intronic rna to measure gene expression |
| US7668801B1 (en) * | 2003-04-21 | 2010-02-23 | At&T Corp. | Method and apparatus for optimizing queries under parametric aggregation constraints |
| EP1631689A2 (en) * | 2003-05-28 | 2006-03-08 | Genomic Health, Inc. | Gene expression markers for predicting response to chemotherapy |
| CA2527321A1 (en) * | 2003-05-30 | 2004-12-23 | Genomic Health, Inc. | Gene expression markers for response to egfr inhibitor drugs |
| WO2005039382A2 (en) * | 2003-06-24 | 2005-05-06 | Genomic Health | Prediction of likelihood of cancer recurrence |
| EP1644858B1 (en) * | 2003-07-10 | 2017-12-06 | Genomic Health, Inc. | Expression profile algorithm and test for cancer prognosis |
| US20100246837A1 (en) * | 2009-03-29 | 2010-09-30 | Krause Lee S | Systems and Methods for Tuning Automatic Speech Recognition Systems |
| AU2004284434A1 (en) * | 2003-10-16 | 2005-05-06 | Genomic Health, Inc. | qRT-PCR assay system for gene expression profiling |
| US7552035B2 (en) * | 2003-11-12 | 2009-06-23 | Siemens Corporate Research, Inc. | Method to use a receiver operator characteristics curve for model comparison in machine condition monitoring |
| WO2005047451A2 (en) * | 2003-11-12 | 2005-05-26 | Trustees Of Boston University | Isolation of nucleic acid from mouth epithelial cells |
| EP1681988B1 (en) | 2003-11-12 | 2015-04-08 | The Children's Hospital Medical Center | Method for diagnosis and treatment of pulmonary disorders |
| JP5192632B2 (ja) * | 2003-12-12 | 2013-05-08 | 愛知県 | 肺癌組織中の遺伝子発現強度を識別する方法 |
| JP4718490B2 (ja) | 2003-12-23 | 2011-07-06 | ジェノミック ヘルス, インコーポレイテッド | フラグメント化rnaの全般的増幅 |
| DE102004009934A1 (de) * | 2004-02-26 | 2005-09-22 | Niendorf, Axel, Prof.Dr.med. | Verfahren zur Untersuchung einer Gewebeprobe |
| CA2848463A1 (en) | 2004-04-09 | 2005-10-27 | Genomic Health, Inc. | Gene expression markers for predicting response to chemotherapy |
| US7991557B2 (en) * | 2004-06-19 | 2011-08-02 | Genenews Corporation | Computer system and methods for constructing biological classifiers and uses thereof |
| CA2571180A1 (en) * | 2004-06-19 | 2006-01-05 | Chondrogene, Inc. | Computer systems and methods for constructing biological classifiers and uses thereof |
| CN101115848A (zh) * | 2004-11-03 | 2008-01-30 | 阿尔马科诊断有限公司 | 转录组微阵列技术及应用该技术的方法 |
| JP4939425B2 (ja) | 2004-11-05 | 2012-05-23 | ジェノミック ヘルス, インコーポレイテッド | 乳癌の治療反応の予後および予測の分子指標 |
| CA3061785A1 (en) * | 2004-11-05 | 2006-05-18 | Genomic Health, Inc. | Predicting response to chemotherapy using gene expression markers |
| US20060136259A1 (en) * | 2004-12-17 | 2006-06-22 | General Electric Company | Multi-dimensional analysis of medical data |
| US20060136417A1 (en) * | 2004-12-17 | 2006-06-22 | General Electric Company | Method and system for search, analysis and display of structured data |
| AU2006228990B8 (en) * | 2005-04-01 | 2013-02-07 | Medvet Science Pty. Ltd. | A method of diagnosis and treatment and agents useful for same |
| EP1874920A4 (en) * | 2005-04-05 | 2009-11-04 | Cellpoint Diagnostics | DEVICES AND METHOD FOR ENRICHING AND CHANGING CIRCULATING TUMOR CELLS AND OTHER PARTICLES |
| US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
| EP1874962A2 (en) | 2005-04-14 | 2008-01-09 | The Trustees Of Boston University | Diagnostic for lung disorders using class prediction |
| US8351665B2 (en) * | 2005-04-28 | 2013-01-08 | The General Hospital Corporation | Systems, processes and software arrangements for evaluating information associated with an anatomical structure by an optical coherence ranging technique |
| US7766231B2 (en) * | 2005-06-24 | 2010-08-03 | Schneider Electric USA, Inc. | Devices and methods for determining the amount of individual usage of a shared commodity |
| US20070099239A1 (en) * | 2005-06-24 | 2007-05-03 | Raymond Tabibiazar | Methods and compositions for diagnosis and monitoring of atherosclerotic cardiovascular disease |
| US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| JP2009508493A (ja) | 2005-09-19 | 2009-03-05 | ベリデックス・エルエルシー | すい臓がんを診断するための方法 |
| US20070078873A1 (en) * | 2005-09-30 | 2007-04-05 | Avinash Gopal B | Computer assisted domain specific entity mapping method and system |
| US9347945B2 (en) | 2005-12-22 | 2016-05-24 | Abbott Molecular Inc. | Methods and marker combinations for screening for predisposition to lung cancer |
| EP1806587A1 (en) * | 2006-01-07 | 2007-07-11 | Université de Liège | An in-vitro method for screening accessible biological markers in pathologic tissues |
| EP2605018A1 (en) * | 2006-03-09 | 2013-06-19 | The Trustees of the Boston University | Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells |
| WO2007109580A1 (en) * | 2006-03-17 | 2007-09-27 | Mayo Foundation For Medical Education And Research | Assessing lung nodules |
| US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
| US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
| EP2029779A4 (en) | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS |
| US7502767B1 (en) * | 2006-07-21 | 2009-03-10 | Hewlett-Packard Development Company, L.P. | Computing a count of cases in a class |
| EP2084535B9 (en) * | 2006-09-08 | 2016-09-07 | Richard Porwancher | Bioinformatic approach to disease diagnosis |
| US7599898B2 (en) * | 2006-10-17 | 2009-10-06 | International Business Machines Corporation | Method and apparatus for improved regression modeling |
| EP2104744B1 (en) * | 2007-01-16 | 2012-05-16 | MUSC Foundation For Research Development | Compositions and methods for diagnosing, treating, and preventing prostate conditions |
| US7892770B2 (en) * | 2007-08-24 | 2011-02-22 | Van Andel Research Institute | Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods |
| US8541183B2 (en) | 2007-09-11 | 2013-09-24 | Cancer Prevention And Cure, Ltd. | Methods of identification, assessment, prevention and therapy of lung diseases and kits thereof |
| CN101990577A (zh) | 2007-09-19 | 2011-03-23 | 波士顿大学理事会 | 鉴定肺病药物开发的新途径 |
| WO2009049228A2 (en) * | 2007-10-10 | 2009-04-16 | The Regents Of The University Of Michigan | Compositions and methods for assessing disorders |
| WO2009121070A1 (en) * | 2008-03-28 | 2009-10-01 | The Trustees Of Boston University | Multifactorial methods for detecting lung disorders |
| WO2010021843A1 (en) * | 2008-08-20 | 2010-02-25 | Eli Lilly And Company | Use of antifolates in patients with detectable levels of tff-1 for the cancer treatment |
| US10359425B2 (en) | 2008-09-09 | 2019-07-23 | Somalogic, Inc. | Lung cancer biomarkers and uses thereof |
| CA3011730C (en) * | 2008-09-09 | 2022-05-17 | Somalogic, Inc. | Lung cancer biomarkers and uses thereof |
| HUE031848T2 (en) | 2008-09-20 | 2017-08-28 | Univ Leland Stanford Junior | Non-invasive diagnosis of fetal aneuploidy by sequencing |
| US9495515B1 (en) | 2009-12-09 | 2016-11-15 | Veracyte, Inc. | Algorithms for disease diagnostics |
| US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
| GB2512153B (en) * | 2008-11-17 | 2014-11-12 | Veracyte Inc | Methods and compositions of molecular profiling for disease diagnostics |
| US20100185568A1 (en) * | 2009-01-19 | 2010-07-22 | Kibboko, Inc. | Method and System for Document Classification |
| US9074258B2 (en) | 2009-03-04 | 2015-07-07 | Genomedx Biosciences Inc. | Compositions and methods for classifying thyroid nodule disease |
| EP3444359A1 (en) * | 2009-03-12 | 2019-02-20 | Cancer Prevention And Cure, Ltd. | Methods of identification of non-small cell lung cancer |
| WO2010111656A2 (en) * | 2009-03-27 | 2010-09-30 | Life Technologies Corporation | Systems and methods for assessing images |
| JP6078339B2 (ja) | 2009-05-07 | 2017-02-08 | ベラサイト インコーポレイテッド | 甲状腺状態の診断のための方法および組成物 |
| US20130143747A1 (en) * | 2011-12-05 | 2013-06-06 | Myriad Genetics, Incorporated | Methods of detecting cancer |
| US8811535B2 (en) * | 2009-07-17 | 2014-08-19 | Mitre Corporation | Time-frequency space constructions of families of signals |
| CA2717477A1 (en) * | 2009-09-24 | 2011-03-24 | Heidi E. Wagner | Computer based standardized method and apparatus for guiding decision support for surgical anatomic pathology operations |
| US10446272B2 (en) | 2009-12-09 | 2019-10-15 | Veracyte, Inc. | Methods and compositions for classification of samples |
| JP6114035B2 (ja) * | 2010-02-10 | 2017-04-12 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 肺癌検出用唾液バイオマーカー |
| JP5931874B2 (ja) | 2010-08-13 | 2016-06-08 | ソマロジック・インコーポレーテッド | 膵癌バイオマーカーおよびその使用 |
| GB2498283A (en) * | 2010-09-08 | 2013-07-10 | Nodality Inc | Benchmarks for normal cell identification |
| US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
| WO2012070970A1 (ru) * | 2010-11-22 | 2012-05-31 | Farber Boris Slavinovich | Диагностический способ для прогноза развития и контроля эффективности лечения онкологических заболеваний |
| WO2012070969A1 (ru) * | 2010-11-22 | 2012-05-31 | Farber Boris Slavinovich | Диагностический способ для прогноза развития и контроля эффективности лечения сердечно-сосудистых заболеваний |
| WO2012129325A1 (en) * | 2011-03-22 | 2012-09-27 | The General Hospital Corporation | Molecular analysis of tumor samples |
| WO2013045500A1 (en) * | 2011-09-26 | 2013-04-04 | Universite Pierre Et Marie Curie (Paris 6) | Method for determining a predictive function for discriminating patients according to their disease activity status |
| CA2876405C (en) * | 2012-06-14 | 2020-01-07 | Erasmus University Medical Center Rotterdam | Methods, reagents and kits for detecting minimal residual disease |
| US10158898B2 (en) | 2012-07-26 | 2018-12-18 | Comcast Cable Communications, Llc | Customized options for consumption of content |
| US10526655B2 (en) | 2013-03-14 | 2020-01-07 | Veracyte, Inc. | Methods for evaluating COPD status |
| US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| GB201316524D0 (en) * | 2013-09-17 | 2013-10-30 | Medical Res Council | Biomarkers |
| DK3108256T3 (da) | 2014-02-17 | 2020-09-21 | Sienna Cancer Diagnostics Ltd | Fremgangsmåde til detektering af cancer |
| US12297505B2 (en) | 2014-07-14 | 2025-05-13 | Veracyte, Inc. | Algorithms for disease diagnostics |
| EP3770274A1 (en) | 2014-11-05 | 2021-01-27 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
| JP6903672B2 (ja) * | 2016-03-08 | 2021-07-14 | マグアレイ,インコーポレイテッド | 肺癌の診断および治療のための蛋白質と自己抗体バイオマーカー |
| US10927417B2 (en) | 2016-07-08 | 2021-02-23 | Trustees Of Boston University | Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions |
| EP4115891A1 (en) * | 2016-08-05 | 2023-01-11 | The Research Foundation for The State University of New York | Keratin 17 as a biomarker for bladder cancer |
| WO2018187496A2 (en) | 2017-04-04 | 2018-10-11 | Lung Cancer Proteomics, Llc | Plasma based protein profiling for early stage lung cancer prognosis |
| US11217329B1 (en) | 2017-06-23 | 2022-01-04 | Veracyte, Inc. | Methods and systems for determining biological sample integrity |
| WO2019157214A2 (en) * | 2018-02-07 | 2019-08-15 | Ai Technologies Inc. | Deep learning-based diagnosis and referral of diseases and disorders |
| EP3935581A4 (en) | 2019-03-04 | 2022-11-30 | Iocurrents, Inc. | DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING |
| CN110970131B (zh) * | 2019-10-24 | 2024-01-26 | 中国医科大学附属盛京医院 | 一种基于免疫球蛋白定量检测的肾小球疾病分类分型模型及其应用 |
| CN110807426B (zh) * | 2019-11-05 | 2023-11-21 | 苏州华文海智能科技有限公司 | 一种基于深度学习的寄生虫检测系统及方法 |
| CN113049344B (zh) * | 2021-04-20 | 2022-02-01 | 深圳天烁生物科技有限公司 | 细胞染色的质控品制备方法 |
| WO2023278468A1 (en) * | 2021-06-29 | 2023-01-05 | The Regents Of The University Of Michigan | Methods of determining risk of and treating cancer recurrence |
| KR102830294B1 (ko) * | 2021-07-30 | 2025-07-08 | 한국 한의학 연구원 | 유사 이미지 분류를 위한 딥 러닝 성능 향상 방법 및 장치 |
| CN116178496A (zh) * | 2022-12-08 | 2023-05-30 | 西安交通大学医学院第一附属医院 | 一种靶向识别神经内分泌肿瘤标志物insm1的短肽及其产品和应用 |
| CN119199125A (zh) * | 2024-10-31 | 2024-12-27 | 武汉大学 | 一种原位检测活循环恶性细胞中多重肺癌相关标志物及肿瘤异质化的方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4579827A (en) * | 1983-03-11 | 1986-04-01 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies |
| WO1987006620A1 (en) | 1986-04-29 | 1987-11-05 | Murex Corporation | Diagnostic kit for sexually transmitted diseases |
| US4853770A (en) | 1988-03-01 | 1989-08-01 | Joe Schneller | Video system for viewing microscopic specimens |
| US5784162A (en) * | 1993-08-18 | 1998-07-21 | Applied Spectral Imaging Ltd. | Spectral bio-imaging methods for biological research, medical diagnostics and therapy |
| US5543291A (en) | 1993-01-29 | 1996-08-06 | Dana Farber Cancer Institute | Method of detecting carcinoma |
| SK153594A3 (en) | 1993-04-14 | 1995-07-11 | Int Murex Tech Corp | Determination method of antibodies to two or bigger number of different patogens in tested sample |
| EP0656070A4 (en) * | 1993-05-24 | 1996-03-20 | Amoco Corp | NUCLEIC ACID SAMPLES FOR LEGIONELLA GENERATIONS. |
| IT1270951B (it) * | 1993-06-07 | 1997-05-26 | Boehringer Mannheim Italia | Metodo e dispositivo per il rilevamento simultano di neisseria gonorrhoeae, chlamydia trachomatis e mycoplasma |
| EP0727664A3 (en) | 1995-02-15 | 1996-11-20 | Bayer Ag | Tumor markers to detect the recurrence of breast cancer |
| US6218529B1 (en) | 1995-07-31 | 2001-04-17 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer |
| US5895748A (en) | 1996-11-27 | 1999-04-20 | Johnson; Keith R. | Panel of antibodies for detecting cadherins and catenins in tissues and method of using the panel of antibodies |
| NO308755B1 (no) * | 1996-12-20 | 2000-10-23 | Iystein Fodstad | FremgangsmÕte til karakterisering av unormale celler, anvendelse og sett for utførelse av fremgangsmÕten |
| DE69837529T2 (de) * | 1997-02-12 | 2007-07-26 | Electrophoretics Ltd., Cobham | Proteinmarker für lungenkrebs und deren verwendung |
| CN1282422A (zh) | 1997-10-21 | 2001-01-31 | 癌症研究行动技术有限公司 | 对细胞生长异常的测定 |
| US6335170B1 (en) * | 1999-02-22 | 2002-01-01 | Torben F. Orntoft | Gene expression in bladder tumors |
| AU3395900A (en) * | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | Human lung cancer associated gene sequences and polypeptides |
| GB9926805D0 (en) | 1999-11-13 | 2000-01-12 | Zeneca Ltd | Diagnostic methods |
| GB0018140D0 (en) * | 2000-07-24 | 2000-09-13 | Medical Res Council | Screening for abnormalities |
| US7219016B2 (en) * | 2001-04-20 | 2007-05-15 | Yale University | Systems and methods for automated analysis of cells and tissues |
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- 2002-03-12 EP EP02708460A patent/EP1373896A2/en not_active Withdrawn
- 2002-03-12 WO PCT/GB2002/001125 patent/WO2002073204A2/en not_active Ceased
- 2002-03-12 US US10/095,298 patent/US20030199685A1/en not_active Abandoned
- 2002-03-12 CN CNA028097599A patent/CN1554025A/zh active Pending
- 2002-03-12 NZ NZ528205A patent/NZ528205A/en unknown
- 2002-03-12 KR KR10-2003-7011975A patent/KR20030094281A/ko not_active Ceased
- 2002-03-12 US US10/095,297 patent/US6939670B2/en not_active Expired - Fee Related
- 2002-03-12 JP JP2002572414A patent/JP2004526154A/ja active Pending
- 2002-03-12 CA CA002440753A patent/CA2440753A1/en not_active Abandoned
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2003
- 2003-09-11 ZA ZA200307121A patent/ZA200307121B/en unknown
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