JP2004526124A - タンパク質凝集の迅速且つ高感度の検出 - Google Patents

タンパク質凝集の迅速且つ高感度の検出 Download PDF

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JP2004526124A
JP2004526124A JP2002506112A JP2002506112A JP2004526124A JP 2004526124 A JP2004526124 A JP 2004526124A JP 2002506112 A JP2002506112 A JP 2002506112A JP 2002506112 A JP2002506112 A JP 2002506112A JP 2004526124 A JP2004526124 A JP 2004526124A
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JP2004526124A5 (enExample
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バムダッド,シンシア・シー
バムダッド,アール・ショシャナ
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ミナーヴァ・バイオテクノロジーズ・コーポレーション
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
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  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Psychology (AREA)
  • Pathology (AREA)
  • Nanotechnology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
JP2002506112A 2000-06-23 2001-06-25 タンパク質凝集の迅速且つ高感度の検出 Pending JP2004526124A (ja)

Applications Claiming Priority (3)

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US60268900A 2000-06-23 2000-06-23
US63181800A 2000-08-03 2000-08-03
PCT/US2001/020232 WO2002001230A2 (en) 2000-06-23 2001-06-25 Rapid and sensitive detection of protein aggregation

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JP2013160587A Division JP2014013242A (ja) 2000-06-23 2013-08-01 タンパク質凝集の迅速且つ高感度の検出

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JP2004526124A5 JP2004526124A5 (enExample) 2008-08-14

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JP2002506112A Pending JP2004526124A (ja) 2000-06-23 2001-06-25 タンパク質凝集の迅速且つ高感度の検出
JP2013160587A Pending JP2014013242A (ja) 2000-06-23 2013-08-01 タンパク質凝集の迅速且つ高感度の検出
JP2014240068A Withdrawn JP2015096855A (ja) 2000-06-23 2014-11-27 タンパク質凝集の迅速且つ高感度の検出
JP2017018410A Expired - Lifetime JP6662797B2 (ja) 2000-06-23 2017-02-03 タンパク質凝集の迅速且つ高感度の検出

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JP2013160587A Pending JP2014013242A (ja) 2000-06-23 2013-08-01 タンパク質凝集の迅速且つ高感度の検出
JP2014240068A Withdrawn JP2015096855A (ja) 2000-06-23 2014-11-27 タンパク質凝集の迅速且つ高感度の検出
JP2017018410A Expired - Lifetime JP6662797B2 (ja) 2000-06-23 2017-02-03 タンパク質凝集の迅速且つ高感度の検出

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JP (4) JP2004526124A (enExample)
AU (1) AU2001270157A1 (enExample)
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WO (1) WO2002001230A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008032554A (ja) * 2006-07-28 2008-02-14 Japan Science & Technology Agency βアミロイドオリゴマーを用いたバイオチップおよびアミロイドセンサーならびに生体試料中に存在するβアミロイドの検出方法
JP2008157730A (ja) * 2006-12-22 2008-07-10 Rohm Co Ltd 生体分子または生体関連物質の測定方法
JP2010164513A (ja) * 2009-01-19 2010-07-29 Fujifilm Corp 抗体固定基板、並びに該抗体固定基板の製造方法及び利用
JP2013508720A (ja) * 2009-10-23 2013-03-07 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 巨大分子多量体の測定方法
JP2014013242A (ja) * 2000-06-23 2014-01-23 Minerva Biotechnologies Corp タンパク質凝集の迅速且つ高感度の検出
WO2015159534A1 (ja) * 2014-04-16 2015-10-22 富士フイルム株式会社 検出液及びそれを用いたバイオセンシング方法

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AU2002216614A1 (en) 2000-10-03 2002-04-15 Minerva Biotechnologies Corporation Electronic detection of interaction based on the interruption of flow
EP1336104B1 (en) * 2000-11-01 2009-03-25 Minerva Biotechnologies Corporation Proteomics based drug comparison methods
JP4568840B2 (ja) * 2004-12-28 2010-10-27 国立大学法人金沢大学 アルツハイマー病の検査方法
JP5164971B2 (ja) * 2006-04-21 2013-03-21 ピープルバイオ,アイ エヌ シー 三次元的相互作用を用いてマルチマー形成ポリペプチドのモノマーからマルチマーを分別検出する方法
AU2009246397B2 (en) 2008-05-13 2013-01-17 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
CA2753586A1 (en) * 2009-02-24 2010-09-02 Winton G. Gibbons Detection of complexes of tau and amyloid
WO2013081946A1 (en) 2011-12-02 2013-06-06 Plaxgen, Inc. Plaque array method and compositions for forming and detecting plaques
WO2013181461A2 (en) 2012-06-01 2013-12-05 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
KR101448353B1 (ko) 2012-09-24 2014-10-10 한양대학교 산학협력단 단백질분해효소 활성 분석 방법 및 그 응용
KR101451797B1 (ko) * 2012-11-07 2014-10-16 가천대학교 산학협력단 멀티머-형성 폴리펩타이드의 멀티머 정량분석을 위한 표준 단백질 복합체
DE102015003404B4 (de) * 2015-03-18 2021-10-07 Forschungszentrum Jülich GmbH Verfahren zur Herstellung eines Standards für den Nachweis von Proteinaggregaten einer Proteinfehlfaltungserkrankung sowie Standard und dessen Verwendung
EP3362785A4 (en) * 2015-10-14 2019-06-12 University Health Network (UHN) ELECTROCHEMICAL TEST FOR A PROTEIN ANALYTE
CN111848470A (zh) * 2016-08-05 2020-10-30 深圳深见医药科技有限公司 一种含金团簇的物质及其制备方法与应用
US12352746B2 (en) 2018-01-23 2025-07-08 Oxford University Innovation Limited Peptide-comprising electrode
CA3136356A1 (en) 2019-04-12 2020-10-15 Ecolab Usa Inc. Antimicrobial multi-purpose cleaner and methods of making and using the same
WO2021075879A2 (ko) * 2019-10-15 2021-04-22 고려대학교 산학협력단 단백질 응집체 검출용 형광 프로브 화합물 및 이를 포함하는 단백질 응집체 검출용 형광 센서
CN115867807B (zh) 2020-06-24 2025-10-31 旭化成生命科学股份有限公司 含蛋白质的溶液的评价方法
CA3183682A1 (en) 2020-06-26 2021-12-30 Minerva Biotechnologies Corporation Anti-nme antibody and method of treating cancer or cancer metastasis
WO2022221683A1 (en) * 2021-04-16 2022-10-20 Regents Of The University Of Minnesota Methods and materials for detecting misfolded polypeptides
CA3248038A1 (en) 2022-04-12 2023-10-19 Minerva Biotechnologies Corporation ANTI-MUC1* VARIABLE ANTIBODIES AND RELATED USES
JP2024142624A (ja) 2023-03-30 2024-10-11 セイコーエプソン株式会社 生体物質抽出用磁性ビーズ

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JPS63271162A (ja) * 1987-01-21 1988-11-09 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ ベノートスハップ 表面プラズモン共鳴を用いる測定方法
JPH01272968A (ja) * 1988-04-26 1989-10-31 Nippon Telegr & Teleph Corp <Ntt> レーザ磁気免疫測定方法を実施するための検体調整方法
JPH06116602A (ja) * 1990-12-05 1994-04-26 Akzo Nv リガンド金結合
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
JPH09184841A (ja) * 1992-07-02 1997-07-15 Becton Dickinson & Co 異なった検出可能な物質を含む微粒子を用いた免疫検定における信号の強化方法
WO1998037421A1 (en) * 1997-02-19 1998-08-27 Regents Of The University Of Minnesota Aβ DEPOSITION INHIBITOR SCREEN USING SYNTHETIC AMYLOID
JPH1132764A (ja) * 1997-07-14 1999-02-09 Yakult Honsha Co Ltd ビフィドバクテリウム・ブレーベ用モノクローナル抗体

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JPH09511492A (ja) * 1994-02-03 1997-11-18 ザ ピコワー インスティテュート フォア メディカル リサーチ アミロイドーシスの前進性グリコシル化終末産物仲介モジュレーション用組成物及び方法
US6306584B1 (en) * 1997-01-21 2001-10-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
DE19715483A1 (de) * 1997-04-14 1998-10-15 Boehringer Mannheim Gmbh Methode zur gleichzeitigen Bestimmung von biomolekularen Wechselwirkungen mittels Plasmonenresonanz undFluoreszenzdetektion
JP2001515044A (ja) * 1997-08-14 2001-09-18 ザ・レジェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア 蛍光アミロイドAβペプチドとその使用
WO2000024941A1 (en) * 1998-10-27 2000-05-04 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
JP5122705B2 (ja) * 1999-01-25 2013-01-16 ミナーヴァ・バイオテクノロジーズ・コーポレーション 神経変性疾患における異常型タンパク質凝集の迅速かつ高感度の検出
CA2413884A1 (en) * 2000-06-23 2002-01-03 Minerva Biotechnologies Corporation Rapid and sensitive detection of protein aggregation

Patent Citations (7)

* Cited by examiner, † Cited by third party
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JPS63271162A (ja) * 1987-01-21 1988-11-09 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ ベノートスハップ 表面プラズモン共鳴を用いる測定方法
JPH01272968A (ja) * 1988-04-26 1989-10-31 Nippon Telegr & Teleph Corp <Ntt> レーザ磁気免疫測定方法を実施するための検体調整方法
JPH06116602A (ja) * 1990-12-05 1994-04-26 Akzo Nv リガンド金結合
JPH09184841A (ja) * 1992-07-02 1997-07-15 Becton Dickinson & Co 異なった検出可能な物質を含む微粒子を用いた免疫検定における信号の強化方法
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
WO1998037421A1 (en) * 1997-02-19 1998-08-27 Regents Of The University Of Minnesota Aβ DEPOSITION INHIBITOR SCREEN USING SYNTHETIC AMYLOID
JPH1132764A (ja) * 1997-07-14 1999-02-09 Yakult Honsha Co Ltd ビフィドバクテリウム・ブレーベ用モノクローナル抗体

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014013242A (ja) * 2000-06-23 2014-01-23 Minerva Biotechnologies Corp タンパク質凝集の迅速且つ高感度の検出
JP2008032554A (ja) * 2006-07-28 2008-02-14 Japan Science & Technology Agency βアミロイドオリゴマーを用いたバイオチップおよびアミロイドセンサーならびに生体試料中に存在するβアミロイドの検出方法
JP2008157730A (ja) * 2006-12-22 2008-07-10 Rohm Co Ltd 生体分子または生体関連物質の測定方法
JP2010164513A (ja) * 2009-01-19 2010-07-29 Fujifilm Corp 抗体固定基板、並びに該抗体固定基板の製造方法及び利用
JP2013508720A (ja) * 2009-10-23 2013-03-07 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 巨大分子多量体の測定方法
WO2015159534A1 (ja) * 2014-04-16 2015-10-22 富士フイルム株式会社 検出液及びそれを用いたバイオセンシング方法
JPWO2015159534A1 (ja) * 2014-04-16 2017-04-13 富士フイルム株式会社 検出液及びそれを用いたバイオセンシング方法

Also Published As

Publication number Publication date
WO2002001230A2 (en) 2002-01-03
AU2001270157A1 (en) 2002-01-08
JP2014013242A (ja) 2014-01-23
JP2017122728A (ja) 2017-07-13
EP1356296B1 (en) 2016-04-20
WO2002001230A3 (en) 2003-08-14
EP1356296A2 (en) 2003-10-29
CA2413884A1 (en) 2002-01-03
JP6662797B2 (ja) 2020-03-11
JP2015096855A (ja) 2015-05-21

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