JP2004525962A5 - - Google Patents

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Publication number
JP2004525962A5
JP2004525962A5 JP2002580951A JP2002580951A JP2004525962A5 JP 2004525962 A5 JP2004525962 A5 JP 2004525962A5 JP 2002580951 A JP2002580951 A JP 2002580951A JP 2002580951 A JP2002580951 A JP 2002580951A JP 2004525962 A5 JP2004525962 A5 JP 2004525962A5
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JP
Japan
Prior art keywords
acid
bile
radical
general formula
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002580951A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004525962A (ja
JP4324706B2 (ja
Filing date
Publication date
Priority claimed from IL142650A external-priority patent/IL142650A/en
Application filed filed Critical
Publication of JP2004525962A publication Critical patent/JP2004525962A/ja
Publication of JP2004525962A5 publication Critical patent/JP2004525962A5/ja
Application granted granted Critical
Publication of JP4324706B2 publication Critical patent/JP4324706B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2002580951A 2001-04-17 2002-04-15 胆汁酸または胆汁酸塩脂肪酸結合体の使用 Expired - Lifetime JP4324706B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL142650A IL142650A (en) 1998-04-08 2001-04-17 Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes
PCT/IL2002/000303 WO2002083147A1 (en) 2001-04-17 2002-04-15 Use of bile acid or bile salt fatty acid conjugates

Publications (3)

Publication Number Publication Date
JP2004525962A JP2004525962A (ja) 2004-08-26
JP2004525962A5 true JP2004525962A5 (enExample) 2005-12-22
JP4324706B2 JP4324706B2 (ja) 2009-09-02

Family

ID=11075322

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002580951A Expired - Lifetime JP4324706B2 (ja) 2001-04-17 2002-04-15 胆汁酸または胆汁酸塩脂肪酸結合体の使用

Country Status (24)

Country Link
US (2) US7501403B2 (enExample)
EP (2) EP1790346B1 (enExample)
JP (1) JP4324706B2 (enExample)
KR (1) KR100883080B1 (enExample)
CN (1) CN1259918C (enExample)
AT (2) ATE432705T1 (enExample)
AU (2) AU2002307771B2 (enExample)
BR (1) BR0208924A (enExample)
CA (2) CA2703688C (enExample)
CY (1) CY1106853T1 (enExample)
CZ (2) CZ309042B6 (enExample)
DE (2) DE60220775T2 (enExample)
DK (2) DK1379254T3 (enExample)
EA (1) EA007565B1 (enExample)
ES (2) ES2289137T3 (enExample)
HU (1) HU230548B1 (enExample)
IL (1) IL142650A (enExample)
MX (1) MXPA03009553A (enExample)
NO (2) NO333910B1 (enExample)
NZ (1) NZ528868A (enExample)
PL (2) PL205057B1 (enExample)
PT (2) PT1790346E (enExample)
UA (1) UA78699C2 (enExample)
WO (1) WO2002083147A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL142650A (en) * 1998-04-08 2007-06-03 Galmed Int Ltd Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes
US8975246B2 (en) 2001-04-17 2015-03-10 Galmed Research And Development Ltd. Bile acid or bile salt fatty acid conjugates
TR201901012T4 (tr) * 2007-07-25 2019-02-21 Univ Graz Medizinische Arteriosklerozun tedavisinde nor-safra asitlerinin kullanımı.
US8470885B2 (en) * 2009-01-12 2013-06-25 Biokier, Inc. Composition and method for treatment of diabetes
US9314444B2 (en) 2009-01-12 2016-04-19 Biokier, Inc. Composition and method for treatment of NASH
US9006288B2 (en) 2009-01-12 2015-04-14 Biokier, Inc. Composition and method for treatment of diabetes
WO2010086864A1 (en) 2009-02-02 2010-08-05 Galmed International Ltd. Methods and compositions for treating alzheimer's disease
US20120202890A1 (en) 2011-02-08 2012-08-09 Nian Wu Polymer-carbohydrate-lipid conjugates
WO2013166176A1 (en) * 2012-05-01 2013-11-07 Catabasis Pharmaceuticals, Inc. Fatty acid conjugates of statin and fxr agonists; compositions and method of uses
CN103571617A (zh) * 2012-07-26 2014-02-12 丰益(上海)生物技术研发中心有限公司 改进的动物油脂加工工艺
ES2701077T3 (es) 2012-11-29 2019-02-20 St Pharm Co Ltd Conjugado de oligómero de ácido biliar para un nuevo transporte vesicular y uso del mismo
IL227890A0 (en) * 2013-08-08 2014-01-30 Galderm Therapeutics Ltd Antiaging compounds containing bile acid and fatty acid conjugates
WO2016199137A1 (en) * 2015-06-10 2016-12-15 Galmed Research And Development Ltd. Low dose compositions of aramchol salts
HUE045209T2 (hu) * 2013-12-04 2019-12-30 Galmed Res & Development Ltd Aramchol-sók
US11571431B2 (en) 2013-12-04 2023-02-07 Galmed Research And Development Ltd Aramchol salts
EP3148549A4 (en) * 2014-06-01 2017-11-15 Galmed Research and Development Ltd. Fatty acid bile acid conjugates for treatment of lipodystrophy
IL243707A0 (en) 2016-01-20 2016-05-01 Galmed Res And Dev Ltd Treatment to regulate the microbiota in the intestine
US11197870B2 (en) 2016-11-10 2021-12-14 Galmed Research And Development Ltd Treatment for hepatic fibrosis
CN116687850A (zh) 2022-02-24 2023-09-05 甘莱制药有限公司 包含环状膦酸酯化合物的药物组合物及其制备方法与用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3859437A (en) * 1972-06-02 1975-01-07 Intellectual Property Dev Corp Reducing cholesterol levels
US3856953A (en) * 1973-05-15 1974-12-24 Intellectual Property Dev Corp Method of treating fatty liver
IT1167479B (it) * 1981-07-24 1987-05-13 Carlo Scolastico Derivati dell'acido chenodesossicolico
IT1167478B (it) * 1981-07-24 1987-05-13 Carlo Scolastico Derivati dell'acido ursodesossicolico
JPS6164701A (ja) * 1984-09-06 1986-04-03 Meito Sangyo Kk カチオン化デキストラン誘導体とポリウロン酸の高分子電解質錯体及びその利用
DE3930696A1 (de) * 1989-09-14 1991-03-28 Hoechst Ag Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
US5278320A (en) * 1992-09-11 1994-01-11 Merck & Co., Inc. Cholesterol lowering compounds produced by directed biosynthesis
DE4432708A1 (de) * 1994-09-14 1996-03-21 Hoechst Ag Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
KR20010031501A (ko) * 1997-10-31 2001-04-16 추후제출 5-알파 환원효소 활성을 조절하는 방법 및 조성물
US20030153541A1 (en) * 1997-10-31 2003-08-14 Robert Dudley Novel anticholesterol compositions and method for using same
IL142650A (en) * 1998-04-08 2007-06-03 Galmed Int Ltd Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes
IL123998A (en) * 1998-04-08 2004-09-27 Galmed Int Ltd Conjugates of bile salts and pharmaceutical preparations containing them
US6620821B2 (en) * 2000-06-15 2003-09-16 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
JP2006306800A (ja) * 2005-04-28 2006-11-09 Kirin Brewery Co Ltd ファルネソイドｘ受容体活性化剤

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