JP2004524172A - マイクロ突起物アレイおよびマイクロ突起物の製造方法 - Google Patents
マイクロ突起物アレイおよびマイクロ突起物の製造方法 Download PDFInfo
- Publication number
- JP2004524172A JP2004524172A JP2002562213A JP2002562213A JP2004524172A JP 2004524172 A JP2004524172 A JP 2004524172A JP 2002562213 A JP2002562213 A JP 2002562213A JP 2002562213 A JP2002562213 A JP 2002562213A JP 2004524172 A JP2004524172 A JP 2004524172A
- Authority
- JP
- Japan
- Prior art keywords
- forming
- layer
- etching
- substrate
- microprojections
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150274—Manufacture or production processes or steps for blood sampling devices
- A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150977—Arrays of piercing elements for simultaneous piercing
- A61B5/150984—Microneedles or microblades
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
- B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
- B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
- B81C1/00111—Tips, pillars, i.e. raised structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B2201/00—Specific applications of microelectromechanical systems
- B81B2201/05—Microfluidics
- B81B2201/055—Microneedles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C2201/00—Manufacture or treatment of microstructural devices or systems
- B81C2201/01—Manufacture or treatment of microstructural devices or systems in or on a substrate
- B81C2201/0101—Shaping material; Structuring the bulk substrate or layers on the substrate; Film patterning
- B81C2201/0128—Processes for removing material
- B81C2201/013—Etching
- B81C2201/0133—Wet etching
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Manufacturing & Machinery (AREA)
- Chemical & Material Sciences (AREA)
- Optics & Photonics (AREA)
- Analytical Chemistry (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Micromachines (AREA)
- Particle Formation And Scattering Control In Inkjet Printers (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26643101P | 2001-02-05 | 2001-02-05 | |
PCT/US2002/003206 WO2002062202A2 (fr) | 2001-02-05 | 2002-02-05 | Reseau de microprotuberances et procedes de formation d'une microprotuberance |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2004524172A true JP2004524172A (ja) | 2004-08-12 |
JP2004524172A5 JP2004524172A5 (fr) | 2005-12-22 |
Family
ID=23014567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002562213A Pending JP2004524172A (ja) | 2001-02-05 | 2002-02-05 | マイクロ突起物アレイおよびマイクロ突起物の製造方法 |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1364396A4 (fr) |
JP (1) | JP2004524172A (fr) |
AU (1) | AU2002250011A1 (fr) |
WO (1) | WO2002062202A2 (fr) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004526581A (ja) * | 2001-03-14 | 2004-09-02 | ザ プロクター アンド ギャンブル カンパニー | ソフトリソグラフィ及びフォトリソグラフィを使用して微小針(microneedles)構造を製造する方法 |
WO2006075716A1 (fr) * | 2005-01-14 | 2006-07-20 | Fujikura Ltd. | Instrument d'administration de medicament et son procede de fabrication |
JP2010059529A (ja) * | 2008-08-06 | 2010-03-18 | Sumitomo Precision Prod Co Ltd | シリコン基板のエッチング方法 |
JP2013048908A (ja) * | 2004-12-28 | 2013-03-14 | Nabtesco Corp | 皮膚用針、皮膚用針製造装置、および皮膚用針製造方法 |
JP2013094224A (ja) * | 2011-10-28 | 2013-05-20 | Toppan Printing Co Ltd | マイクロニードルデバイスおよびその製造方法 |
JP2017217132A (ja) * | 2016-06-06 | 2017-12-14 | 三島光産株式会社 | マイクロニードルアレイ |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0308319B1 (pt) | 2002-03-11 | 2015-06-09 | Beaver Visitec Int Us Inc | Método para fabricar um dispositivo de corte de material cristalino e método para fabricar uma lâmina cirúrgica de material cristalino |
US7578954B2 (en) * | 2003-02-24 | 2009-08-25 | Corium International, Inc. | Method for manufacturing microstructures having multiple microelements with through-holes |
JP2007514457A (ja) | 2003-09-17 | 2007-06-07 | ベクトン・ディキンソン・アンド・カンパニー | シリコンおよびその他の結晶質材料にルータを用いて直線状および非直線状の溝を作成するシステムおよび方法 |
US7753888B2 (en) * | 2003-11-21 | 2010-07-13 | The Regents Of The University Of California | Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles |
US7183215B2 (en) * | 2004-07-21 | 2007-02-27 | Hewlett-Packard Development Company, L.P. | Etching with electrostatically attracted ions |
US8277409B2 (en) * | 2005-12-05 | 2012-10-02 | Becton, Dickinson And Company | Cutting element for a retracting needle syringe |
DE102006028781A1 (de) | 2006-06-23 | 2007-12-27 | Robert Bosch Gmbh | Verfahren zur Herstellung von porösen Mikronadeln und ihre Verwendung |
DE102006040642A1 (de) | 2006-08-30 | 2008-03-13 | Robert Bosch Gmbh | Mikronadeln zur Platzierung in der Haut zwecks transdermaler Applikation von Pharmazeutika |
EP2146689B1 (fr) | 2007-04-16 | 2020-08-12 | Corium, Inc. | Réseaux de micro-aiguilles coulées dans un solvant contenant un actif |
US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
EP2566501B1 (fr) | 2010-05-04 | 2019-03-13 | Corium International, Inc. | Méthode et dispositif permettant l'administration transdermique d'hormone parathyroïdienne au moyen d'un réseau de microprojections |
CA2896188C (fr) | 2012-12-21 | 2021-02-23 | Corium International, Inc. | Micro-reseau pour la distribution d'un agent therapeutique et ses procedes d'utilisation |
ES2921481T3 (es) | 2013-03-12 | 2022-08-26 | Corium Inc | Aplicadores para microproyecciones |
CN105228522B (zh) | 2013-03-14 | 2018-06-26 | 萨诺智能公司 | 用于生物监测的人体上的微传感器 |
US10820860B2 (en) | 2013-03-14 | 2020-11-03 | One Drop Biosensor Technologies, Llc | On-body microsensor for biomonitoring |
EP2968751B1 (fr) | 2013-03-15 | 2022-11-30 | Corium, Inc. | Applicateurs de microprojection d'impacts multiples |
AU2014237279B2 (en) | 2013-03-15 | 2018-11-22 | Corium Pharma Solutions, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
WO2014144973A1 (fr) | 2013-03-15 | 2014-09-18 | Corium International, Inc. | Micro-réseau pour administrer un agent thérapeutique, procédés d'utilisation et procédés de fabrication |
AU2014233695A1 (en) | 2013-03-15 | 2015-10-01 | Corium International, Inc. | Microarray for delivery of therapeutic agent and methods of use |
US10595754B2 (en) | 2014-03-13 | 2020-03-24 | Sano Intelligence, Inc. | System for monitoring body chemistry |
EP3116397A4 (fr) | 2014-03-13 | 2017-11-01 | Sano Intelligence, Inc. | Système de surveillance de chimie du corps |
WO2016036866A1 (fr) | 2014-09-04 | 2016-03-10 | Corium International, Inc. | Matrice de microstructures, procédé de production et procédés d'utilisation |
JP5967595B2 (ja) * | 2014-09-08 | 2016-08-10 | 株式会社かいわ | 穿刺器具 |
US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
CN110076528A (zh) * | 2019-05-13 | 2019-08-02 | 大连理工大学 | 一种平面金属微针阵列及其制备方法 |
CN111675190A (zh) * | 2020-06-18 | 2020-09-18 | 苏州恒之清生物科技有限公司 | 一种微型实心硅针的制备方法 |
USD988882S1 (en) | 2021-04-21 | 2023-06-13 | Informed Data Systems Inc. | Sensor assembly |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5753130A (en) * | 1992-05-15 | 1998-05-19 | Micron Technology, Inc. | Method for forming a substantially uniform array of sharp tips |
US5536988A (en) * | 1993-06-01 | 1996-07-16 | Cornell Research Foundation, Inc. | Compound stage MEM actuator suspended for multidimensional motion |
US5779514A (en) * | 1996-02-13 | 1998-07-14 | National Science Council | Technique to fabricate chimney-shaped emitters for field-emission devices |
FR2764441B1 (fr) * | 1997-06-05 | 2001-05-18 | Suisse Electronique Microtech | Procede de fabrication d'un organe palpeur pour capteur micromecanique, notamment pour microscope a force atomique |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
CA2330207C (fr) * | 1998-06-10 | 2005-08-30 | Georgia Tech Research Corporation | Dispositifs a microaiguilles et procedes de fabrication et d'utilisation correspondants |
US6406638B1 (en) * | 2000-01-06 | 2002-06-18 | The Regents Of The University Of California | Method of forming vertical, hollow needles within a semiconductor substrate, and needles formed thereby |
-
2002
- 2002-02-05 WO PCT/US2002/003206 patent/WO2002062202A2/fr active Application Filing
- 2002-02-05 AU AU2002250011A patent/AU2002250011A1/en not_active Abandoned
- 2002-02-05 EP EP02718901A patent/EP1364396A4/fr not_active Ceased
- 2002-02-05 JP JP2002562213A patent/JP2004524172A/ja active Pending
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004526581A (ja) * | 2001-03-14 | 2004-09-02 | ザ プロクター アンド ギャンブル カンパニー | ソフトリソグラフィ及びフォトリソグラフィを使用して微小針(microneedles)構造を製造する方法 |
JP4778669B2 (ja) * | 2001-03-14 | 2011-09-21 | コリウム インターナショナル, インコーポレイテッド | ソフトリソグラフィ及びフォトリソグラフィを使用して微小針(microneedles)構造を製造する方法 |
JP2013048908A (ja) * | 2004-12-28 | 2013-03-14 | Nabtesco Corp | 皮膚用針、皮膚用針製造装置、および皮膚用針製造方法 |
JP2015157147A (ja) * | 2004-12-28 | 2015-09-03 | ナブテスコ株式会社 | 皮膚用針製造装置および皮膚用針製造方法 |
JP2015157148A (ja) * | 2004-12-28 | 2015-09-03 | ナブテスコ株式会社 | 皮膚用針製造装置および皮膚用針製造方法 |
JP5882556B2 (ja) * | 2004-12-28 | 2016-03-09 | ナブテスコ株式会社 | 皮膚用針、皮膚用針製造装置および皮膚用針製造方法 |
WO2006075716A1 (fr) * | 2005-01-14 | 2006-07-20 | Fujikura Ltd. | Instrument d'administration de medicament et son procede de fabrication |
JP2010059529A (ja) * | 2008-08-06 | 2010-03-18 | Sumitomo Precision Prod Co Ltd | シリコン基板のエッチング方法 |
JP2013094224A (ja) * | 2011-10-28 | 2013-05-20 | Toppan Printing Co Ltd | マイクロニードルデバイスおよびその製造方法 |
JP2017217132A (ja) * | 2016-06-06 | 2017-12-14 | 三島光産株式会社 | マイクロニードルアレイ |
Also Published As
Publication number | Publication date |
---|---|
AU2002250011A1 (en) | 2002-08-19 |
WO2002062202A3 (fr) | 2002-10-10 |
EP1364396A2 (fr) | 2003-11-26 |
WO2002062202A2 (fr) | 2002-08-15 |
EP1364396A4 (fr) | 2005-08-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2004524172A (ja) | マイクロ突起物アレイおよびマイクロ突起物の製造方法 | |
US20040060902A1 (en) | Microprotrusion array and methods of making a microprotrusion | |
JP5542811B2 (ja) | マイクロニードル、マイクロニードルアレイ、およびそれらの作製方法 | |
ES2278926T3 (es) | Microagujas para el suministro de farmacos minimamente invasivo. | |
JP5347378B2 (ja) | マイクロニードルの製造方法 | |
JP4750347B2 (ja) | マイクロニードル構造及びその製造方法 | |
US7201846B2 (en) | Micro-fluidic anti-microbial filter | |
CA2424520C (fr) | Reseau de microaiguilles et procede de fabrication | |
JP5028872B2 (ja) | 針状体の製造方法 | |
US20080245764A1 (en) | Method for producing a device including an array of microneedles on a support, and device producible according to this method | |
CN101862503B (zh) | 一种用于透皮给药的离面空心微针阵列的制备方法 | |
US9919916B2 (en) | Manufacture of microneedles | |
JP2008035874A (ja) | 針状体の製造方法 | |
JP5889232B2 (ja) | 凹凸構造体の製造方法 | |
Park et al. | High-aspect-ratio tapered structures using an integrated lens technique | |
JP5568234B2 (ja) | 針状体および針状体製造方法 | |
WO2005059650A2 (fr) | Dispositif et procede d'impression par microcontact | |
JP2006334225A (ja) | 微細針の成形鋳型の製造方法 | |
Shikida et al. | Non-photolithographic pattern transfer for fabricating arrayed 3D microstructures by chemical anisotropic etching | |
Shikida et al. | Fabrication of pen-shaped microneedle structure by using non-photolithographic pattern transfer | |
TW202408430A (zh) | 高縱橫比微針及工具之製造方法 | |
Swaminathan | Fabrication of Nano-Injection Needles for Neural Pathway Study in Mice | |
Diehl et al. | Wet etched pyramidal microneedles with fluid-delivery microchannels | |
SE531049C2 (sv) | Metoder för tillverkning av mikronålar |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050204 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20050204 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20071228 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20080328 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20080404 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20080627 |