JP2004522695A - ヌクレオシド，ヌクレオシド誘導体および非ヌクレオシド誘導体を合成する方法 - Google Patents

ヌクレオシド，ヌクレオシド誘導体および非ヌクレオシド誘導体を合成する方法 Download PDF

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JP2004522695A
JP2004522695A JP2002523919A JP2002523919A JP2004522695A JP 2004522695 A JP2004522695 A JP 2004522695A JP 2002523919 A JP2002523919 A JP 2002523919A JP 2002523919 A JP2002523919 A JP 2002523919A JP 2004522695 A JP2004522695 A JP 2004522695A
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formula
compound
alkyl
component
product
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Japanese (ja)
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ベイジェルマン，レオニド
カーペイスキー，アレキサンダー
セレブリヤニー，ウラディミール
ハエベルリ，ピーター
スウィードラー，デイヴィッド
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Sirna Therapeutics Inc
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Sirna Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
JP2002523919A 2000-09-01 2001-08-31 ヌクレオシド，ヌクレオシド誘導体および非ヌクレオシド誘導体を合成する方法 Pending JP2004522695A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23005700P 2000-09-01 2000-09-01
US28657101P 2001-04-25 2001-04-25
PCT/US2001/027116 WO2002018405A2 (en) 2000-09-01 2001-08-31 Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives

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JP2004522695A true JP2004522695A (ja) 2004-07-29

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JP2002523919A Pending JP2004522695A (ja) 2000-09-01 2001-08-31 ヌクレオシド，ヌクレオシド誘導体および非ヌクレオシド誘導体を合成する方法

Country Status (8)

Country Link
US (1) US6686463B2 (https=)
EP (1) EP1313752B1 (https=)
JP (1) JP2004522695A (https=)
AT (1) ATE506372T1 (https=)
AU (2) AU8695901A (https=)
CA (1) CA2421040C (https=)
DE (1) DE60144479D1 (https=)
WO (1) WO2002018405A2 (https=)

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* Cited by examiner, † Cited by third party
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013520395A (ja) * 2009-02-22 2013-06-06 ケムジーンズ コーポレーション 治療、診断、ｇ‐テトラド形成オリゴヌクレオシド及びアプタマーといった生物学的応用のための新規修飾を取り入れたアラ‐２’‐ｏ‐メチル‐ヌクレオシド、当該ホスホラミダイト及びオリゴヌクレオチドの合成

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AU8695901A (en) 2002-03-13
CA2421040C (en) 2010-01-12
US6686463B2 (en) 2004-02-03
US20020120129A1 (en) 2002-08-29
DE60144479D1 (https=) 2011-06-01
WO2002018405A2 (en) 2002-03-07
AU2001286959B2 (en) 2007-09-06
ATE506372T1 (de) 2011-05-15
EP1313752B1 (en) 2011-04-20
EP1313752A2 (en) 2003-05-28
WO2002018405A3 (en) 2003-01-03
CA2421040A1 (en) 2002-03-07

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