JP2004521894A - 胆汁酸金属イオン封鎖剤およびステロール吸収阻害剤の併用および血管適応症の治療 - Google Patents

胆汁酸金属イオン封鎖剤およびステロール吸収阻害剤の併用および血管適応症の治療 Download PDF

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Publication number
JP2004521894A
JP2004521894A JP2002559067A JP2002559067A JP2004521894A JP 2004521894 A JP2004521894 A JP 2004521894A JP 2002559067 A JP2002559067 A JP 2002559067A JP 2002559067 A JP2002559067 A JP 2002559067A JP 2004521894 A JP2004521894 A JP 2004521894A
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alkyl
group
aryl
substituted
independently
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JP2004521894A5 (US07560449-20090714-C00011.png
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,ハリー アール. デイビス
テディー コソグロー,
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Merck Sharp and Dohme Corp
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Schering Corp
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/655Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
JP2002559067A 2001-01-26 2002-01-25 胆汁酸金属イオン封鎖剤およびステロール吸収阻害剤の併用および血管適応症の治療 Pending JP2004521894A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26460001P 2001-01-26 2001-01-26
US32384201P 2001-09-21 2001-09-21
PCT/US2002/002010 WO2002058733A2 (en) 2001-01-26 2002-01-25 Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications

Publications (2)

Publication Number Publication Date
JP2004521894A true JP2004521894A (ja) 2004-07-22
JP2004521894A5 JP2004521894A5 (US07560449-20090714-C00011.png) 2006-01-19

Family

ID=26950649

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002559067A Pending JP2004521894A (ja) 2001-01-26 2002-01-25 胆汁酸金属イオン封鎖剤およびステロール吸収阻害剤の併用および血管適応症の治療

Country Status (16)

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US (2) US20030053981A1 (US07560449-20090714-C00011.png)
EP (2) EP1785144A3 (US07560449-20090714-C00011.png)
JP (1) JP2004521894A (US07560449-20090714-C00011.png)
AR (1) AR035739A1 (US07560449-20090714-C00011.png)
AT (1) ATE369851T1 (US07560449-20090714-C00011.png)
AU (1) AU2002241956A1 (US07560449-20090714-C00011.png)
CA (1) CA2434033A1 (US07560449-20090714-C00011.png)
CY (1) CY1106915T1 (US07560449-20090714-C00011.png)
DE (1) DE60221798T2 (US07560449-20090714-C00011.png)
DK (1) DK1363668T3 (US07560449-20090714-C00011.png)
ES (1) ES2287250T3 (US07560449-20090714-C00011.png)
MX (1) MXPA03006631A (US07560449-20090714-C00011.png)
PT (1) PT1363668E (US07560449-20090714-C00011.png)
SI (1) SI1363668T1 (US07560449-20090714-C00011.png)
TW (1) TW200744638A (US07560449-20090714-C00011.png)
WO (1) WO2002058733A2 (US07560449-20090714-C00011.png)

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CY1106915T1 (el) 2012-09-26
WO2002058733A9 (en) 2003-03-06
MXPA03006631A (es) 2004-03-18
ATE369851T1 (de) 2007-09-15
EP1785144A3 (en) 2007-05-23
CA2434033A1 (en) 2002-08-01
EP1363668A2 (en) 2003-11-26
ES2287250T3 (es) 2007-12-16
PT1363668E (pt) 2007-11-07
EP1363668B1 (en) 2007-08-15
DK1363668T3 (da) 2007-11-05
US20080261942A1 (en) 2008-10-23
US20030053981A1 (en) 2003-03-20
TW200744638A (en) 2007-12-16
WO2002058733A3 (en) 2003-06-26
AU2002241956A1 (en) 2002-08-06
SI1363668T1 (sl) 2007-12-31
EP1785144A2 (en) 2007-05-16
WO2002058733A2 (en) 2002-08-01

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