JP2004520343A5 - - Google Patents
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- Publication number
- JP2004520343A5 JP2004520343A5 JP2002555821A JP2002555821A JP2004520343A5 JP 2004520343 A5 JP2004520343 A5 JP 2004520343A5 JP 2002555821 A JP2002555821 A JP 2002555821A JP 2002555821 A JP2002555821 A JP 2002555821A JP 2004520343 A5 JP2004520343 A5 JP 2004520343A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- use according
- medicament
- triterpene
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 21
- 150000003648 triterpenes Chemical class 0.000 claims 21
- 239000003814 drug Substances 0.000 claims 15
- 238000004519 manufacturing process Methods 0.000 claims 12
- 241000124008 Mammalia Species 0.000 claims 11
- 238000000034 method Methods 0.000 claims 7
- 125000003158 alcohol group Chemical group 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 206010020751 Hypersensitivity Diseases 0.000 claims 4
- 241001135917 Vitellaria paradoxa Species 0.000 claims 4
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 4
- UBLNLUPLUKPSPP-UHFFFAOYSA-N 3-beta-form-3-Lupanol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(C)C)C5C4CCC3C21C UBLNLUPLUKPSPP-UHFFFAOYSA-N 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 240000001548 Camellia japonica Species 0.000 claims 3
- 235000006467 Camellia japonica Nutrition 0.000 claims 3
- 240000006833 Camellia sasanqua Species 0.000 claims 3
- 235000002537 Camellia sasanqua Nutrition 0.000 claims 3
- 244000269722 Thea sinensis Species 0.000 claims 3
- 235000006468 Thea sinensis Nutrition 0.000 claims 3
- 208000036142 Viral infection Diseases 0.000 claims 3
- 208000026935 allergic disease Diseases 0.000 claims 3
- 208000037976 chronic inflammation Diseases 0.000 claims 3
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 3
- -1 cinnamic acid ester Chemical class 0.000 claims 3
- 230000009610 hypersensitivity Effects 0.000 claims 3
- 230000009385 viral infection Effects 0.000 claims 3
- XHMHQMBOUUDXGO-FXCPCPCLSA-N (3S,5R,8S,10S,13R,14S,17R)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,5,6,7,8,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol Chemical compound CC1(C)[C@@H](O)CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@]4(C)[C@@H]3CC[C@H]21 XHMHQMBOUUDXGO-FXCPCPCLSA-N 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 201000005569 Gout Diseases 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 239000002537 cosmetic Substances 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 235000015872 dietary supplement Nutrition 0.000 claims 2
- 150000002168 ethanoic acid esters Chemical class 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 238000005984 hydrogenation reaction Methods 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 238000007911 parenteral administration Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 208000017520 skin disease Diseases 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- DICCPNLDOZNSML-XGKJEQFASA-N (3S,5R,9R,10R,13S,14S,17S)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol Chemical compound C[C@H](CCC=C(C)C)[C@@H]1CC[C@]2(C)C3=CC[C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]12C DICCPNLDOZNSML-XGKJEQFASA-N 0.000 claims 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims 1
- 206010002198 Anaphylactic reaction Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- CIUWDTKQGZYEEE-UHFFFAOYSA-N Butyrospermol Natural products C12CCC3(C)C(C(CCC=C(C)C)C)CCC3(C)C2=CCC2C1CCC(O)C2(C)C CIUWDTKQGZYEEE-UHFFFAOYSA-N 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- DICCPNLDOZNSML-UHFFFAOYSA-N Delta7-tirucallol Natural products CC1(C)C(O)CCC2(C)C(CCC3(C(C(CCC=C(C)C)C)CCC33C)C)C3=CCC21 DICCPNLDOZNSML-UHFFFAOYSA-N 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 230000036783 anaphylactic response Effects 0.000 claims 1
- 208000003455 anaphylaxis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229930016911 cinnamic acid Natural products 0.000 claims 1
- 235000013985 cinnamic acid Nutrition 0.000 claims 1
- 208000010247 contact dermatitis Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 230000028709 inflammatory response Effects 0.000 claims 1
- MQYXUWHLBZFQQO-QGTGJCAVSA-N lupeol Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C MQYXUWHLBZFQQO-QGTGJCAVSA-N 0.000 claims 1
- PKGKOZOYXQMJNG-UHFFFAOYSA-N lupeol Natural products CC(=C)C1CC2C(C)(CCC3C4(C)CCC5C(C)(C)C(O)CCC5(C)C4CCC23C)C1 PKGKOZOYXQMJNG-UHFFFAOYSA-N 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 201000007094 prostatitis Diseases 0.000 claims 1
- 208000008742 seborrheic dermatitis Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100049 | 2001-01-12 | ||
| US26116801P | 2001-01-16 | 2001-01-16 | |
| PCT/IB2002/000081 WO2002055087A1 (en) | 2001-01-12 | 2002-01-14 | Dihydro-triterpenes in the treatment of viral infections, cardiovascular disease, inflammation, hypersensitivity or pain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004520343A JP2004520343A (ja) | 2004-07-08 |
| JP2004520343A5 true JP2004520343A5 (enExample) | 2005-12-22 |
Family
ID=26068943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002555821A Pending JP2004520343A (ja) | 2001-01-12 | 2002-01-14 | ウイルス感染、心血管疾患、炎症、過敏症、または痛みの処置におけるジヒドロトリテルペン |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1349553B1 (enExample) |
| JP (1) | JP2004520343A (enExample) |
| CN (1) | CN1520300B (enExample) |
| AT (1) | ATE338556T1 (enExample) |
| AU (1) | AU2002225259B2 (enExample) |
| CA (1) | CA2434670C (enExample) |
| CY (1) | CY1106270T1 (enExample) |
| DE (1) | DE60214509T2 (enExample) |
| DK (1) | DK1349553T3 (enExample) |
| ES (1) | ES2272689T3 (enExample) |
| NZ (1) | NZ526969A (enExample) |
| WO (1) | WO2002055087A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7070815B2 (en) | 2002-11-27 | 2006-07-04 | Loders Croklaan Usa Llc | Anti diarrhoea compositions |
| EP1424073A1 (en) * | 2002-11-27 | 2004-06-02 | Loders Croklaan B.V. | Anti diarrhoea compositions |
| US20060003948A1 (en) * | 2004-02-06 | 2006-01-05 | Krasutsky Pavel A | Compositions that include a triterpene and a carrier |
| JP4810642B2 (ja) * | 2004-11-30 | 2011-11-09 | 秋田県 | 癌転移抑制用トリテルペン誘導体及び該トリテルペン誘導体を用いた癌転移抑制用組成物 |
| JPWO2007108042A1 (ja) * | 2006-03-15 | 2009-07-30 | 株式会社トロピカルテクノセンター | 抗炎症剤 |
| JP5428000B2 (ja) * | 2007-06-27 | 2014-02-26 | 株式会社スカイライト・バイオテック | ルペオール含有医薬組成物、食品及び飼料 |
| CN102499925B (zh) * | 2011-10-21 | 2015-11-11 | 上海中医药大学 | 一种中性粒细胞弹性蛋白酶抑制剂 |
| CN104107179B (zh) * | 2014-06-27 | 2016-08-24 | 王英 | 闭花木酮Cleistanone的二乙胺衍生物在制备抗急性痛风药物中的应用 |
| KR101672431B1 (ko) * | 2015-01-06 | 2016-11-04 | 목포대학교산학협력단 | 동백나무 추출물을 유효성분으로 포함하는 심혈관계 질환의 예방 또는 치료용 조성물 |
| CN106265684A (zh) * | 2016-08-11 | 2017-01-04 | 江苏康缘药业股份有限公司 | 乙酰羽扇豆醇酯的应用 |
| IT201600093764A1 (it) * | 2016-09-19 | 2018-03-19 | Codex V Srl | Insaponificabili di lipidi naturali per l’uso nel trattamento di patologie reumatiche |
| WO2018082034A1 (en) * | 2016-11-04 | 2018-05-11 | Trineo Biotechnology Co., Ltd | Uses of triterpenoid mixture for treating multiple sclerosis |
| CN113993533A (zh) * | 2019-05-22 | 2022-01-28 | 人类科学有限公司 | 包含山茶树提取物作为有效成分的用于预防及治疗病毒感染的药物组合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB932662A (en) * | 1960-04-13 | 1963-07-31 | Laroche Navarron Lab | Therapeutic compositions comprising butyrospermol |
| CA1265785A (en) * | 1984-06-04 | 1990-02-13 | Kumi Yoshida | Triterpenyl esters of organic acids, process for their production, and hypolipidemic agents composed of them |
| JP2912489B2 (ja) * | 1992-01-10 | 1999-06-28 | サンスター株式会社 | 皮膚化粧料 |
| CA2193396A1 (en) * | 1994-06-20 | 1995-12-28 | Kurt Berg | A pharmaceutical composition for the prevention and/or treatment of viral infections and optionally inflammations as well as a method for the treatment thereof |
| WO1998032443A1 (de) * | 1997-01-24 | 1998-07-30 | Marigen S.A. | Ultramikroemulsionen aus spontan dispergierbaren konzentraten enthaltend antitumoral, antiviral und antiparasitär wirksame ester von pentacyclischen triterpenen |
| FR2770400B1 (fr) * | 1997-10-30 | 1999-12-03 | Sederma Sa | Compositions a usage cosmetique ou dermopharmaceutique contenant un extrait vegetal obtenu a partir de la fleur de l'arbre a karite ou butyrospermum parkii kotschy |
| JP2003504340A (ja) * | 1999-07-09 | 2003-02-04 | ベーエスペー ファルマ アクティーゼルスカブ | ブチロスペルマムパルキイの抽出物を含有する組成物および薬剤または栄養補助食品としての使用 |
-
2002
- 2002-01-14 JP JP2002555821A patent/JP2004520343A/ja active Pending
- 2002-01-14 NZ NZ526969A patent/NZ526969A/en not_active IP Right Cessation
- 2002-01-14 CA CA2434670A patent/CA2434670C/en not_active Expired - Fee Related
- 2002-01-14 DE DE60214509T patent/DE60214509T2/de not_active Expired - Lifetime
- 2002-01-14 AT AT02715601T patent/ATE338556T1/de active
- 2002-01-14 AU AU2002225259A patent/AU2002225259B2/en not_active Ceased
- 2002-01-14 WO PCT/IB2002/000081 patent/WO2002055087A1/en not_active Ceased
- 2002-01-14 ES ES02715601T patent/ES2272689T3/es not_active Expired - Lifetime
- 2002-01-14 DK DK02715601T patent/DK1349553T3/da active
- 2002-01-14 EP EP02715601A patent/EP1349553B1/en not_active Expired - Lifetime
- 2002-01-14 CN CN028036794A patent/CN1520300B/zh not_active Expired - Fee Related
-
2006
- 2006-11-28 CY CY20061101714T patent/CY1106270T1/el unknown
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