JP2004518677A - 抗菌性キノロン誘導体および細菌感染を治療するためのその使用 - Google Patents
抗菌性キノロン誘導体および細菌感染を治療するためのその使用 Download PDFInfo
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- JP2004518677A JP2004518677A JP2002559418A JP2002559418A JP2004518677A JP 2004518677 A JP2004518677 A JP 2004518677A JP 2002559418 A JP2002559418 A JP 2002559418A JP 2002559418 A JP2002559418 A JP 2002559418A JP 2004518677 A JP2004518677 A JP 2004518677A
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- 150000007660 quinolones Chemical class 0.000 title abstract description 21
- 230000000844 anti-bacterial effect Effects 0.000 title abstract description 8
- 208000035143 Bacterial infection Diseases 0.000 title abstract description 6
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- 238000000034 method Methods 0.000 claims abstract description 37
- JGRCHNVLXORPNM-UHFFFAOYSA-N 1,2-oxazol-4-one Chemical compound O=C1CON=C1 JGRCHNVLXORPNM-UHFFFAOYSA-N 0.000 claims abstract description 16
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 9
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- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims description 3
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- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 18
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 16
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 13
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- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
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- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 1
- KHORERZDMJTBMR-UHFFFAOYSA-N tert-butyl 4-(4-formylphenyl)piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCN1C1=CC=C(C=O)C=C1 KHORERZDMJTBMR-UHFFFAOYSA-N 0.000 description 1
- AGYHJAIRNLHSFF-SAPNQHFASA-N tert-butyl 4-[4-[(e)-3-ethoxy-1-hydroxy-3-oxoprop-1-en-2-yl]phenyl]piperazine-1-carboxylate Chemical compound C1=CC(/C(=C\O)C(=O)OCC)=CC=C1N1CCN(C(=O)OC(C)(C)C)CC1 AGYHJAIRNLHSFF-SAPNQHFASA-N 0.000 description 1
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- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25790400P | 2000-12-21 | 2000-12-21 | |
| PCT/US2001/044731 WO2002059116A2 (en) | 2000-12-21 | 2001-11-29 | Antimicrobial quinolone derivatives and use of the same to treat bacterial infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004518677A true JP2004518677A (ja) | 2004-06-24 |
| JP2004518677A5 JP2004518677A5 (OSRAM) | 2005-12-22 |
Family
ID=22978270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002559418A Pending JP2004518677A (ja) | 2000-12-21 | 2001-11-29 | 抗菌性キノロン誘導体および細菌感染を治療するためのその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6689769B2 (OSRAM) |
| EP (1) | EP1349853B1 (OSRAM) |
| JP (1) | JP2004518677A (OSRAM) |
| AT (1) | ATE319710T1 (OSRAM) |
| CA (1) | CA2424402A1 (OSRAM) |
| DE (1) | DE60117861T2 (OSRAM) |
| ES (1) | ES2256331T3 (OSRAM) |
| PE (1) | PE20030137A1 (OSRAM) |
| WO (1) | WO2002059116A2 (OSRAM) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006515862A (ja) * | 2002-12-04 | 2006-06-08 | グラクソ グループ リミテッド | キノリン類およびそれらの窒素化誘導体ならびにそれらの抗菌剤としての使用 |
| JP2010509314A (ja) * | 2006-11-10 | 2010-03-25 | アクテリオン ファーマシューティカルズ リミテッド | ５−ヒドロキシメチル−オキサゾリジン−２−オン誘導体 |
| US7820823B2 (en) | 2001-10-04 | 2010-10-26 | Morphochem Aktiengesellschaft Fur Kominatorische Chemi | Dual action antibiotics |
| JP2011519914A (ja) * | 2008-05-09 | 2011-07-14 | アクテリオン ファーマシューティカルズ リミテッド | 細菌性腸管疾患の治療のための５−ヒドロキシメチル−オキサゾリジン−２−オン誘導体 |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| WO2003031441A1 (en) * | 2001-10-04 | 2003-04-17 | Morphochen Aktiengesellschaft Für Kombinatorische Chemie | Multiple action compounds |
| US6875784B2 (en) * | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| WO2004069244A1 (en) * | 2003-02-07 | 2004-08-19 | Warner-Lambert Company Llc | Oxazolidinone derivatives n-substituted by a bicyclic ring, for use as antibacterial agents |
| EP1594865A2 (en) * | 2003-02-07 | 2005-11-16 | Warner-Lambert Company LLC | Antibacterial agents |
| EP1620098B1 (en) * | 2003-04-30 | 2008-06-11 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
| JP4607107B2 (ja) | 2003-07-02 | 2011-01-05 | メルク・シャープ・エンド・ドーム・コーポレイション | シクロプロピル基置換されたオキサゾリジノン抗生物質およびこれらの誘導体 |
| EP1654259A1 (en) * | 2003-07-02 | 2006-05-10 | Merck & Co., Inc. | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof |
| DE10340485B4 (de) | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
| US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| CN106957316A (zh) * | 2003-12-18 | 2017-07-18 | 莫弗凯姆联合化学股份公司 | 噁唑烷酮‑喹诺酮杂化物抗生素 |
| US8158797B2 (en) | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| EP1557416A1 (en) * | 2004-01-23 | 2005-07-27 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
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- 2001-11-29 AT AT01994117T patent/ATE319710T1/de not_active IP Right Cessation
- 2001-11-29 DE DE60117861T patent/DE60117861T2/de not_active Expired - Fee Related
- 2001-11-29 US US09/996,927 patent/US6689769B2/en not_active Expired - Fee Related
- 2001-11-29 ES ES01994117T patent/ES2256331T3/es not_active Expired - Lifetime
- 2001-11-29 JP JP2002559418A patent/JP2004518677A/ja active Pending
- 2001-11-29 CA CA002424402A patent/CA2424402A1/en not_active Abandoned
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7820823B2 (en) | 2001-10-04 | 2010-10-26 | Morphochem Aktiengesellschaft Fur Kominatorische Chemi | Dual action antibiotics |
| US8329908B2 (en) | 2001-10-04 | 2012-12-11 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Dual action antibiotics |
| JP2006515862A (ja) * | 2002-12-04 | 2006-06-08 | グラクソ グループ リミテッド | キノリン類およびそれらの窒素化誘導体ならびにそれらの抗菌剤としての使用 |
| JP2010509314A (ja) * | 2006-11-10 | 2010-03-25 | アクテリオン ファーマシューティカルズ リミテッド | ５−ヒドロキシメチル−オキサゾリジン−２−オン誘導体 |
| JP2010132677A (ja) * | 2006-11-10 | 2010-06-17 | Actelion Pharmaceuticals Ltd | ５−ヒドロキシメチル−オキサゾリジン−２−オン誘導体 |
| JP2011519914A (ja) * | 2008-05-09 | 2011-07-14 | アクテリオン ファーマシューティカルズ リミテッド | 細菌性腸管疾患の治療のための５−ヒドロキシメチル−オキサゾリジン−２−オン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002059116A2 (en) | 2002-08-01 |
| DE60117861D1 (de) | 2006-05-04 |
| EP1349853A2 (en) | 2003-10-08 |
| DE60117861T2 (de) | 2006-11-02 |
| PE20030137A1 (es) | 2003-03-08 |
| ATE319710T1 (de) | 2006-03-15 |
| CA2424402A1 (en) | 2002-08-01 |
| US6869965B2 (en) | 2005-03-22 |
| WO2002059116A3 (en) | 2002-12-05 |
| US20040215017A1 (en) | 2004-10-28 |
| US20030013737A1 (en) | 2003-01-16 |
| US6689769B2 (en) | 2004-02-10 |
| ES2256331T3 (es) | 2006-07-16 |
| EP1349853B1 (en) | 2006-03-08 |
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