JP2004504812A - 新規プロテアーゼ - Google Patents

新規プロテアーゼ Download PDF

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Publication number
JP2004504812A
JP2004504812A JP2001580389A JP2001580389A JP2004504812A JP 2004504812 A JP2004504812 A JP 2004504812A JP 2001580389 A JP2001580389 A JP 2001580389A JP 2001580389 A JP2001580389 A JP 2001580389A JP 2004504812 A JP2004504812 A JP 2004504812A
Authority
JP
Japan
Prior art keywords
seq
protease
sequence
polypeptide
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001580389A
Other languages
English (en)
Japanese (ja)
Inventor
プラウマン,グレゴリー・ディー
ホワイト,デイビッド
シュダーサナム,スーチャ
マニング,ジェラルド
ケーネピール,ショーン
ペイン,ヴィリア,アン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sugen LLC
Pharmacia LLC
Original Assignee
Sugen LLC
Pharmacia LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen LLC, Pharmacia LLC filed Critical Sugen LLC
Publication of JP2004504812A publication Critical patent/JP2004504812A/ja
Withdrawn legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433Serine endopeptidases (3.4.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Wood Science & Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
JP2001580389A 2000-05-04 2001-05-04 新規プロテアーゼ Withdrawn JP2004504812A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20187900P 2000-05-04 2000-05-04
PCT/US2001/014431 WO2001083782A2 (en) 2000-05-04 2001-05-04 Novel proteases

Publications (1)

Publication Number Publication Date
JP2004504812A true JP2004504812A (ja) 2004-02-19

Family

ID=22747660

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001580389A Withdrawn JP2004504812A (ja) 2000-05-04 2001-05-04 新規プロテアーゼ

Country Status (6)

Country Link
EP (1) EP1294901A2 (zh)
JP (1) JP2004504812A (zh)
AU (1) AU2001259473A1 (zh)
CA (1) CA2408105A1 (zh)
HK (1) HK1054571A1 (zh)
WO (1) WO2001083782A2 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011137685A (ja) * 2009-12-28 2011-07-14 Kyushu Univ 乳癌の検出方法

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030096391A1 (en) * 2000-12-22 2003-05-22 Millennium Pharmaceuticals, Inc. 17903, a novel human aminopeptidase and uses therefor
US6683165B1 (en) 1999-04-13 2004-01-27 Genome Therapeutics Corporation Human gene relating to respiratory diseases and obesity
CA2392076A1 (en) 1999-11-19 2001-05-25 Solvay Pharmaceuticals B.V. Human enzymes of the metalloprotease family
EP1134286A3 (en) * 2000-03-14 2003-05-02 Pfizer Products Inc. Adamts polypeptides, nucleic acids encoding them, and uses thereof
AU2001253512A1 (en) * 2000-04-13 2001-10-30 Genome Therapeutics Corporation Novel human gene relating to respiratory diseases, obesity, and inflammatory bowel disease
DE10031932A1 (de) * 2000-06-30 2002-01-10 Basf Ag Calpain-Protease 12
AU2001279060A1 (en) * 2000-07-28 2002-02-13 Immunex Corporation Metalloproteinase-disintegrin polypeptides and methods of making and use thereof
GB0020345D0 (en) * 2000-08-17 2000-10-04 Glaxo Group Ltd Protein
JP2004531201A (ja) * 2000-08-22 2004-10-14 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトプロテアーゼ及び該プロテアーゼをコードするポリヌクレオチド
AU2002218160A1 (en) * 2000-09-11 2002-03-22 Bayer Aktiengesellschaft Regulation of human carboxypeptidase-like enzyme
WO2002024927A2 (en) * 2000-09-20 2002-03-28 Bayer Aktiengesellschaft Regulation of human adam-ts 1 precursor-like protein
WO2002026948A2 (en) * 2000-09-25 2002-04-04 Millennium Pharmaceuticals, Inc. 55054, a human metalloprotease and uses therefor
WO2002026955A2 (en) * 2000-09-29 2002-04-04 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
WO2002026949A2 (en) * 2000-09-29 2002-04-04 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
CA2424953A1 (en) * 2000-10-04 2002-04-11 Lexicon Genetics Incorporated Novel human proteases and polynucleotides encoding the same
WO2002033087A2 (en) * 2000-10-17 2002-04-25 Curagen Corporation Proteins and nucleic acids encoding same
US6689599B1 (en) * 2000-10-20 2004-02-10 Genetics Institute, Llc Aggrecanase molecules
WO2002055702A2 (en) * 2000-10-26 2002-07-18 Curagen Corp Human proteins, polynucleotides encoding them and methods of using the same
US20020119555A1 (en) * 2000-12-22 2002-08-29 Rajasehkar Bandaru 53014, a human metalloprotease family member and uses therefor
DE60126659T2 (de) * 2000-12-25 2007-10-31 Astellas Pharma Inc. Neue protease
US6903201B2 (en) 2001-01-05 2005-06-07 Curagen Corporation Proteins and nucleic acids encoding same
WO2002057461A2 (en) * 2001-01-18 2002-07-25 Bayer Aktiengesellschaft Regulation of human adam-ts-like zinc metalloprotease
WO2002088303A2 (en) * 2001-04-03 2002-11-07 Bristol-Myers Squibb Company Polynucleotide encoding a novel cysteine protease of the calpain superfamily, can-12, and variants thereof
US7034134B2 (en) * 2001-04-26 2006-04-25 Bristol-Myers Squibb Company Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29
JP2005506833A (ja) * 2001-06-04 2005-03-10 キュラジェン コーポレイション 抗原性ポリペプチドに結合する新規抗体、抗原をコード化する核酸、および使用方法
JP2004533848A (ja) 2001-07-10 2004-11-11 バイエル・ヘルスケア・アクチェンゲゼルシャフト ヒトアミノペプチダーゼnの調節
WO2003012038A2 (en) 2001-07-27 2003-02-13 Wyeth Aggrecanase molecules
CA2457915A1 (en) * 2001-08-22 2003-03-06 Lexicon Genetics Incorporated Novel human proteases and polynucleotides encoding the same
WO2003027282A1 (fr) * 2001-09-24 2003-04-03 Daiichi Fine Chemical Co., Ltd. Adamts-15, -16, -17, -18 et -19
WO2003042379A2 (en) * 2001-11-13 2003-05-22 Universite De Liege A new disintegrin and metalloproteinase with thrombospondin type i repeats polynucleotide and its encoded polypeptide
AU2002360832A1 (en) * 2001-12-31 2003-07-24 Wyeth Aggrecanase molecules
SG158739A1 (en) * 2002-01-31 2010-02-26 Wyeth Corp Aggrecanase molecules
WO2003089644A1 (fr) * 2002-04-19 2003-10-30 Riken Nouvelles proteines et adn codant pour elles
CA2480892A1 (en) * 2002-06-20 2003-12-31 Yamanouchi Pharmaceutical Co., Ltd. Novel promoter
NL1022371C2 (nl) * 2003-01-13 2003-11-18 Hoffmann La Roche Nieuwe metallo-proteasen met trombospondine domeinen en daarvoor coderende nucle´nezuur samenstellingen.
WO2004073657A2 (en) * 2003-02-19 2004-09-02 Protein Design Labs, Inc. Methods of diagnosis of cancer and other diseases, composition and methods of screening for modulators of cancer and other diseases
WO2005031359A2 (en) * 2003-09-27 2005-04-07 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with arginyl aminopeptidase rnpep (rnpep)
EP1678320A2 (en) * 2003-10-21 2006-07-12 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with arginyl aminopeptidase (aminopeptidase b)-like 1 (rnpepl1)
US7892750B1 (en) * 2004-12-23 2011-02-22 University Of Notre Dame Du Lac Cathepsin E as a marker of colon cancer
CN114075544A (zh) * 2020-08-21 2022-02-22 复旦大学附属华山医院 基于超滤离心制备去泛素红细胞制品的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO841276L (no) * 1983-03-31 1984-10-01 Codon Genetic Eng Lab Rekombinant dna-koding for et polypeptid som utviser melkesammenloepende aktivitet
AU6241698A (en) * 1997-01-21 1998-08-07 Human Genome Sciences, Inc. Tace-like and matrilysin-like polypeptides
AU3622600A (en) * 1999-03-08 2000-09-28 Neurocrine Biosciences, Inc. Metalloproteinases and methods of use therefor
US6383780B1 (en) * 1999-11-19 2002-05-07 Millennium Pharmaceuticals, Inc. 2786, a novel human aminopeptidase
EP1292684A2 (en) * 2000-06-16 2003-03-19 Incyte Genomics, Inc. Proteases

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011137685A (ja) * 2009-12-28 2011-07-14 Kyushu Univ 乳癌の検出方法

Also Published As

Publication number Publication date
EP1294901A2 (en) 2003-03-26
CA2408105A1 (en) 2001-11-08
WO2001083782A2 (en) 2001-11-08
HK1054571A1 (zh) 2003-12-05
WO2001083782A3 (en) 2003-01-23
AU2001259473A1 (en) 2001-11-12

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