HK1054571A1 - 新的蛋白酶 - Google Patents

新的蛋白酶

Info

Publication number
HK1054571A1
HK1054571A1 HK03106801.3A HK03106801A HK1054571A1 HK 1054571 A1 HK1054571 A1 HK 1054571A1 HK 03106801 A HK03106801 A HK 03106801A HK 1054571 A1 HK1054571 A1 HK 1054571A1
Authority
HK
Hong Kong
Prior art keywords
novel proteases
proteases
novel
Prior art date
Application number
HK03106801.3A
Other languages
English (en)
Inventor
D Plowman Gregory
Whyte David
Sudarsanam Sucha
Manning Gerard
Caenepeel Sean
Payne Villa
Original Assignee
Sugen Inc
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc, Upjohn Co filed Critical Sugen Inc
Publication of HK1054571A1 publication Critical patent/HK1054571A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Analytical Chemistry (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
HK03106801.3A 2000-05-04 2003-09-22 新的蛋白酶 HK1054571A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20187900P 2000-05-04 2000-05-04
PCT/US2001/014431 WO2001083782A2 (en) 2000-05-04 2001-05-04 Novel proteases

Publications (1)

Publication Number Publication Date
HK1054571A1 true HK1054571A1 (zh) 2003-12-05

Family

ID=22747660

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03106801.3A HK1054571A1 (zh) 2000-05-04 2003-09-22 新的蛋白酶

Country Status (6)

Country Link
EP (1) EP1294901A2 (zh)
JP (1) JP2004504812A (zh)
AU (1) AU2001259473A1 (zh)
CA (1) CA2408105A1 (zh)
HK (1) HK1054571A1 (zh)
WO (1) WO2001083782A2 (zh)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030096391A1 (en) * 2000-12-22 2003-05-22 Millennium Pharmaceuticals, Inc. 17903, a novel human aminopeptidase and uses therefor
US6683165B1 (en) 1999-04-13 2004-01-27 Genome Therapeutics Corporation Human gene relating to respiratory diseases and obesity
DE60040089D1 (de) 1999-11-19 2008-10-09 Solvay Pharm Bv Menschliches homolog aus der familie der metalloproteasen
EP1134286A3 (en) * 2000-03-14 2003-05-02 Pfizer Products Inc. Adamts polypeptides, nucleic acids encoding them, and uses thereof
AU2001253512A1 (en) * 2000-04-13 2001-10-30 Genome Therapeutics Corporation Novel human gene relating to respiratory diseases, obesity, and inflammatory bowel disease
DE10031932A1 (de) * 2000-06-30 2002-01-10 Basf Ag Calpain-Protease 12
JP2004507234A (ja) * 2000-07-28 2004-03-11 イミュネックス・コーポレーション メタロプロテイナーゼ−ディスインテグリンポリペプチドとその製造及び使用の方法
GB0020345D0 (en) * 2000-08-17 2000-10-04 Glaxo Group Ltd Protein
JP2004531201A (ja) * 2000-08-22 2004-10-14 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトプロテアーゼ及び該プロテアーゼをコードするポリヌクレオチド
WO2002020805A2 (en) * 2000-09-11 2002-03-14 Bayer Aktiengesellschaft Regulation of human carboxypeptidase-like enzyme
AU2001289886A1 (en) * 2000-09-20 2002-04-02 Bayer Aktiengesellschaft Regulation of human adam-ts 1 precursor-like protein
WO2002026948A2 (en) * 2000-09-25 2002-04-04 Millennium Pharmaceuticals, Inc. 55054, a human metalloprotease and uses therefor
AU2002215312A1 (en) * 2000-09-29 2002-04-08 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
AU2001294684A1 (en) * 2000-09-29 2002-04-08 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
EP1328623A2 (en) * 2000-10-04 2003-07-23 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
WO2002033087A2 (en) * 2000-10-17 2002-04-25 Curagen Corporation Proteins and nucleic acids encoding same
US6689599B1 (en) * 2000-10-20 2004-02-10 Genetics Institute, Llc Aggrecanase molecules
CA2426588A1 (en) * 2000-10-26 2002-07-18 Curagen Corporation Novel human proteins, polynucleotides encoding them and methods of using the same
WO2002051995A1 (en) * 2000-12-22 2002-07-04 Millennium Pharmaceuticals, Inc. A human metallo protease member of the adamts family, and uses thereof
DE60126659T2 (de) * 2000-12-25 2007-10-31 Astellas Pharma Inc. Neue protease
US6903201B2 (en) 2001-01-05 2005-06-07 Curagen Corporation Proteins and nucleic acids encoding same
WO2002057461A2 (en) * 2001-01-18 2002-07-25 Bayer Aktiengesellschaft Regulation of human adam-ts-like zinc metalloprotease
WO2002088303A2 (en) * 2001-04-03 2002-11-07 Bristol-Myers Squibb Company Polynucleotide encoding a novel cysteine protease of the calpain superfamily, can-12, and variants thereof
US7034134B2 (en) * 2001-04-26 2006-04-25 Bristol-Myers Squibb Company Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29
CA2447935A1 (en) * 2001-06-04 2002-12-12 Curagen Corporation Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use
JP2004533848A (ja) 2001-07-10 2004-11-11 バイエル・ヘルスケア・アクチェンゲゼルシャフト ヒトアミノペプチダーゼｎの調節
WO2003012038A2 (en) 2001-07-27 2003-02-13 Wyeth Aggrecanase molecules
WO2003018764A2 (en) * 2001-08-22 2003-03-06 Lexicon Genetics Incorporated Novel human proteases and polynucleotides encoding the same
WO2003027282A1 (fr) * 2001-09-24 2003-04-03 Daiichi Fine Chemical Co., Ltd. Adamts-15, -16, -17, -18 et -19
WO2003042379A2 (en) * 2001-11-13 2003-05-22 Universite De Liege A new disintegrin and metalloproteinase with thrombospondin type i repeats polynucleotide and its encoded polypeptide
US20030228676A1 (en) * 2001-12-31 2003-12-11 Agostino Michael J. Aggrecanase molecules
JP2005515779A (ja) * 2002-01-31 2005-06-02 ワイス アグレカナーゼ分子
AU2003227428A1 (en) * 2002-04-19 2003-11-03 K. K. Dnaform Novel proteins and dnas encoding the same
WO2004001047A1 (ja) * 2002-06-20 2003-12-31 Yamanouchi Pharmaceutical Co., Ltd. 新規プロモーター
NL1022371C2 (nl) * 2003-01-13 2003-11-18 Hoffmann La Roche Nieuwe metallo-proteasen met trombospondine domeinen en daarvoor coderende nucle´nezuur samenstellingen.
WO2004073657A2 (en) * 2003-02-19 2004-09-02 Protein Design Labs, Inc. Methods of diagnosis of cancer and other diseases, composition and methods of screening for modulators of cancer and other diseases
EP1671127A2 (en) * 2003-09-27 2006-06-21 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with arginyl aminopeptidase rnpep (rnpep)
US20080248462A1 (en) * 2003-10-21 2008-10-09 Baayer Healhcare Ag Diagnostics and Therapeutics for Diseases Associated with Arginyl Aminopeptidase (Aminopeptidase B)-Like 1 (Rnpepl1)
US7892750B1 (en) * 2004-12-23 2011-02-22 University Of Notre Dame Du Lac Cathepsin E as a marker of colon cancer
JP5532216B2 (ja) * 2009-12-28 2014-06-25 国立大学法人埼玉大学 乳癌の検出方法
CN114075544A (zh) * 2020-08-21 2022-02-22 复旦大学附属华山医院 基于超滤离心制备去泛素红细胞制品的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO841276L (no) * 1983-03-31 1984-10-01 Codon Genetic Eng Lab Rekombinant dna-koding for et polypeptid som utviser melkesammenloepende aktivitet
US6046031A (en) * 1997-01-21 2000-04-04 Human Genome Sciences, Inc. Metalloproteinases
AU3622600A (en) * 1999-03-08 2000-09-28 Neurocrine Biosciences, Inc. Metalloproteinases and methods of use therefor
US6383780B1 (en) * 1999-11-19 2002-05-07 Millennium Pharmaceuticals, Inc. 2786, a novel human aminopeptidase
CA2411971A1 (en) * 2000-06-16 2001-12-27 Incyte Genomics, Inc. Proteases

Also Published As

Publication number Publication date
JP2004504812A (ja) 2004-02-19
AU2001259473A1 (en) 2001-11-12
WO2001083782A3 (en) 2003-01-23
CA2408105A1 (en) 2001-11-08
WO2001083782A2 (en) 2001-11-08
EP1294901A2 (en) 2003-03-26

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