JP2004504347A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004504347A5 JP2004504347A5 JP2002513458A JP2002513458A JP2004504347A5 JP 2004504347 A5 JP2004504347 A5 JP 2004504347A5 JP 2002513458 A JP2002513458 A JP 2002513458A JP 2002513458 A JP2002513458 A JP 2002513458A JP 2004504347 A5 JP2004504347 A5 JP 2004504347A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- cancer
- histone
- histone deacetylase
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 102000003964 Histone deacetylase Human genes 0.000 claims 12
- 108090000353 Histone deacetylase Proteins 0.000 claims 12
- 238000000034 method Methods 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 108010033040 Histones Proteins 0.000 claims 4
- NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims 4
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 claims 4
- 229960000604 valproic acid Drugs 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- OBETXYAYXDNJHR-SSDOTTSWSA-M (2r)-2-ethylhexanoate Chemical compound CCCC[C@@H](CC)C([O-])=O OBETXYAYXDNJHR-SSDOTTSWSA-M 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000006947 Histones Human genes 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000006197 histone deacetylation Effects 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 230000001624 sedative effect Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000017701 Endocrine disease Diseases 0.000 claims 1
- 102100039996 Histone deacetylase 1 Human genes 0.000 claims 1
- 102100038715 Histone deacetylase 8 Human genes 0.000 claims 1
- 101001035024 Homo sapiens Histone deacetylase 1 Proteins 0.000 claims 1
- 101001032118 Homo sapiens Histone deacetylase 8 Proteins 0.000 claims 1
- 108010044467 Isoenzymes Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000021736 acetylation Effects 0.000 claims 1
- 238000006640 acetylation reaction Methods 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 208000030172 endocrine system disease Diseases 0.000 claims 1
- 102000015694 estrogen receptors Human genes 0.000 claims 1
- 108010038795 estrogen receptors Proteins 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 230000037426 transcriptional repression Effects 0.000 claims 1
- 230000011199 transformed cell apoptotic process Effects 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00114088A EP1170008A1 (en) | 2000-07-07 | 2000-07-07 | Valproic acid and derivatives thereof as histone deacetylase inhibitors |
| PCT/EP2001/007704 WO2002007722A2 (en) | 2000-07-07 | 2001-07-05 | Valproic acid and derivatives thereof as histone deacetylase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004504347A JP2004504347A (ja) | 2004-02-12 |
| JP2004504347A5 true JP2004504347A5 (enExample) | 2005-02-03 |
Family
ID=8169134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002513458A Ceased JP2004504347A (ja) | 2000-07-07 | 2001-07-05 | ヒストン脱アセチル化酵素阻害剤としてのバルプロ酸およびその誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7265154B2 (enExample) |
| EP (2) | EP1170008A1 (enExample) |
| JP (1) | JP2004504347A (enExample) |
| AT (1) | ATE295725T1 (enExample) |
| AU (2) | AU2001283925B2 (enExample) |
| CA (1) | CA2414967C (enExample) |
| DE (1) | DE60110912T2 (enExample) |
| ES (1) | ES2239677T3 (enExample) |
| PT (1) | PT1301184E (enExample) |
| WO (1) | WO2002007722A2 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1170008A1 (en) | 2000-07-07 | 2002-01-09 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Valproic acid and derivatives thereof as histone deacetylase inhibitors |
| GB0024362D0 (en) * | 2000-10-05 | 2000-11-22 | Glaxo Group Ltd | Medicaments |
| WO2003018767A2 (en) * | 2001-08-27 | 2003-03-06 | Advanced Cell Technology, Inc. | Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
| EP1293205A1 (en) * | 2001-09-18 | 2003-03-19 | G2M Cancer Drugs AG | Valproic acid and derivatives thereof for the combination therapy of human cancers, for the treatment of tumour metastasis and minimal residual disease |
| US6706686B2 (en) | 2001-09-27 | 2004-03-16 | The Regents Of The University Of Colorado | Inhibition of histone deacetylase as a treatment for cardiac hypertrophy |
| EP2269609A3 (en) * | 2001-10-16 | 2012-07-11 | Sloan-Kettering Institute for Cancer Research | Treatment of neurodegenerative diseases and cancer of the brain with SAHA |
| ATE458047T1 (de) | 2002-03-07 | 2010-03-15 | Univ Delaware | Verfahren zur verstärkung der oligonucleotid- vermittelten nucleinsäuresequenzänderung unter verwendung von zusammensetzungen mit einem hydroxyharnstoff |
| IL149404A0 (en) * | 2002-04-29 | 2002-11-10 | Yissum Res Dev Co | METHODS AND COMPOSITIONS FOR MODULATING β-CATENIN PHOSPHORYLATION |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| GB0226855D0 (en) | 2002-11-18 | 2002-12-24 | Queen Mary & Westfield College | Histone deacetylase inhibitors |
| AU2003288433B2 (en) * | 2002-12-05 | 2009-06-25 | Imperial College Innovations Limited | Control of apoptosis using a complex of an oligonucleotide and a regulatory peptide |
| US7244751B2 (en) | 2003-02-14 | 2007-07-17 | Shenzhen Chipscreen Biosciences Ltd. | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity |
| US7381825B2 (en) * | 2003-03-17 | 2008-06-03 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| EP1491188A1 (en) * | 2003-06-25 | 2004-12-29 | G2M Cancer Drugs AG | Topical use of valproic acid for the prevention or treatment of skin disorders |
| US20050159470A1 (en) * | 2003-12-19 | 2005-07-21 | Syrrx, Inc. | Histone deacetylase inhibitors |
| US20050137234A1 (en) * | 2003-12-19 | 2005-06-23 | Syrrx, Inc. | Histone deacetylase inhibitors |
| DE602004014723D1 (de) * | 2004-04-30 | 2008-08-14 | Desitin Arzneimittel Gmbh | Histondeacetylase-Inhibitor enthaltende Formulierung zur zweiphasigen Freisetzung |
| KR100659779B1 (ko) | 2004-09-04 | 2006-12-19 | 주식회사 바이넥스 | 히스톤 디아세틸라제 억제제를 함유하는 중간엽줄기세포의 골분화유도용 조성물 및 이를 이용한 골분화증가방법 |
| WO2006066133A2 (en) * | 2004-12-16 | 2006-06-22 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| EP1896436A2 (en) | 2005-05-11 | 2008-03-12 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| ZA200800901B (en) * | 2005-07-14 | 2010-05-26 | Takeda San Diego Inc | Histone deacetylase inhibitors |
| EP1976835A2 (en) * | 2006-01-13 | 2008-10-08 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US8338482B2 (en) * | 2006-07-20 | 2012-12-25 | Wisconsin Alumni Research Foundation | Modulating notch1 signaling pathway for treating neuroendocrine tumors |
| CA2661024A1 (en) * | 2006-08-28 | 2008-03-06 | The Regents Of The University Of California | Small molecule potentiator of hormonal therapy for breast cancer |
| GB0620823D0 (en) | 2006-10-19 | 2006-11-29 | Univ London | Histone deacetylase inhibitors |
| CN101626763A (zh) * | 2006-12-06 | 2010-01-13 | 北海道公立大学法人札幌医科大学 | 使用组蛋白脱乙酰酶（hdac）抑制物的细胞免疫增强 |
| US20090023186A1 (en) * | 2007-07-22 | 2009-01-22 | Excellgene Sa | Use of valproic acid for enhancing production of recombinant proteins in mammalian cells |
| EP2231596A4 (en) * | 2007-12-14 | 2012-06-06 | Univ Georgetown | INHIBITORS OF HISTONATE ACETYLASE |
| US8623853B2 (en) | 2008-07-23 | 2014-01-07 | The Brigham And Women's Hospital, Inc. | Treatment of cancers characterized by chromosomal rearrangement of the NUT gene |
| US7994357B2 (en) | 2009-04-03 | 2011-08-09 | Naturewise Biotech & Medicals Corporation | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase |
| EP2236503B1 (en) | 2009-04-03 | 2014-02-26 | NatureWise Biotech & Medicals Corporation | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase |
| EP2277387B1 (en) | 2009-07-22 | 2016-10-19 | NatureWise Biotech & Medicals Corporation | New use of histone deacetylase inhibitors in changing mrjp3 protein in royal jelly |
| US20120165384A1 (en) * | 2009-09-07 | 2012-06-28 | Jawaharlal Nehru Centre For Advanced Scientific Research | Inhibition of histone acetyltransferases by ctk7a and methods thereof |
| US8921533B2 (en) | 2011-07-25 | 2014-12-30 | Chromatin Technologies | Glycosylated valproic acid analogs and uses thereof |
| EP3052662B1 (en) | 2013-10-01 | 2019-05-15 | The J. David Gladstone Institutes | Compositions, systems and methods for gene expression noise drug screening and uses thereof |
| JP2017514909A (ja) * | 2014-05-02 | 2017-06-08 | オンコエシックス ゲーエムベーハー | チエノトリアゾロジアゼピン化合物を用いる急性骨髄性白血病及び／又は急性リンパ芽球性白血病の治療方法 |
| CN105622712B (zh) * | 2014-10-27 | 2019-08-27 | 天津金耀集团有限公司 | 一种甾体3-酮-4-烯物合成工艺 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| US20210386787A1 (en) * | 2018-10-12 | 2021-12-16 | Life Technologies Corporation | Hematopoietic Stem and Progenitor Cell Expansion System |
| CN111358777A (zh) * | 2020-02-24 | 2020-07-03 | 军事科学院军事医学研究院环境医学与作业医学研究所 | 一种提高外周血单个核细胞线粒体功能的方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6300373B1 (en) * | 1993-09-10 | 2001-10-09 | American Biogenetic Sciences, Inc. | Antiproliferative and neurotrophic molecules |
| US5672746A (en) * | 1994-08-30 | 1997-09-30 | American Biogenetic Sciences, Inc. | Antiproliferative and neurotrophic molecules |
| WO1995011699A1 (en) * | 1993-10-29 | 1995-05-04 | The Trustees Of Boston University | Physiologically stable compositions of butyric acid, and butyric acid salts and derivatives as anti-neoplastic agents |
| WO1997011366A1 (en) * | 1995-09-20 | 1997-03-27 | Merck & Co., Inc. | Histone deacetylase as target for antiprotozoal agents |
| US6777217B1 (en) * | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| WO1997047307A1 (en) * | 1996-06-14 | 1997-12-18 | The Uab Research Foundation | Use of histone deacetylase inhibitors to activate transgene expression |
| WO1998029114A1 (en) * | 1996-12-30 | 1998-07-09 | Bar-Ilan University | Tricarboxylic acid-containing oxyalkyl esters and uses thereof |
| US6387673B1 (en) * | 1997-05-01 | 2002-05-14 | The Salk Institute For Biological Studies | Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds |
| WO1999023885A1 (en) * | 1997-11-10 | 1999-05-20 | The Salk Institute For Biological Studies | Methods for the use of inhibitors of co-repressors for the treatment of neoplastic diseases |
| US6262116B1 (en) * | 1998-01-23 | 2001-07-17 | Sloan-Kettering Institute For Cancer Research | Transcription therapy for cancers |
| EP1170008A1 (en) | 2000-07-07 | 2002-01-09 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Valproic acid and derivatives thereof as histone deacetylase inhibitors |
-
2000
- 2000-07-07 EP EP00114088A patent/EP1170008A1/en not_active Withdrawn
-
2001
- 2001-07-05 DE DE60110912T patent/DE60110912T2/de not_active Expired - Lifetime
- 2001-07-05 EP EP01962831A patent/EP1301184B1/en not_active Expired - Lifetime
- 2001-07-05 AU AU2001283925A patent/AU2001283925B2/en not_active Ceased
- 2001-07-05 CA CA002414967A patent/CA2414967C/en not_active Expired - Fee Related
- 2001-07-05 AT AT01962831T patent/ATE295725T1/de active
- 2001-07-05 AU AU8392501A patent/AU8392501A/xx active Pending
- 2001-07-05 ES ES01962831T patent/ES2239677T3/es not_active Expired - Lifetime
- 2001-07-05 JP JP2002513458A patent/JP2004504347A/ja not_active Ceased
- 2001-07-05 WO PCT/EP2001/007704 patent/WO2002007722A2/en not_active Ceased
- 2001-07-05 PT PT01962831T patent/PT1301184E/pt unknown
- 2001-07-05 US US10/332,353 patent/US7265154B2/en not_active Expired - Fee Related
-
2007
- 2007-01-17 US US11/653,855 patent/US20070232696A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004504347A5 (enExample) | ||
| Niu et al. | Epigenetic modifications in tumor-associated macrophages: a new perspective for an old foe | |
| Li et al. | Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity | |
| ES2259379T3 (es) | Inhibidores hidrazino carbociclicos de la amina oxidasas que contienen cobre. | |
| US11691959B2 (en) | Anti-inflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes compounds | |
| JP2005512961A5 (enExample) | ||
| JP2007527362A (ja) | 強力な分化および抗増殖活性をもつ新規ベンズアミド誘導体のヒストン脱アセチル化酵素阻害剤 | |
| ATE295725T1 (de) | Valproinsäure und deren derivate als histondeacetylaseinhibitoren | |
| Dalvai et al. | The role of histone modifications and variants in regulating gene expression in breast cancer | |
| JP2017538104A5 (enExample) | ||
| Wang et al. | Synthesis and biological evaluation of selective histone deacetylase 6 inhibitors as multifunctional agents against Alzheimer's disease | |
| CN115397820A (zh) | 用于治疗骨髓增生性肿瘤的赖氨酸特异性组蛋白脱甲基化酶抑制剂 | |
| US11266617B2 (en) | Beta-hydroxybutyrate encapsulated PLGA nanoparticle compositions | |
| CN1337851A (zh) | 将非cox－2选择性抑制剂的cox抑制化合物转化成为cox－2选择性抑制剂的衍生物的方法 | |
| Hou et al. | Lactylation in cancer biology: Unlocking new avenues for research and therapy | |
| EP4431156A2 (en) | Antitumor tet2 modulating compounds | |
| Zhou et al. | Discovery of a tetrahydroisoquinoline-based HDAC inhibitor with improved plasma stability | |
| Pollock et al. | Epigenetic approaches to cancer therapy | |
| JP7244511B2 (ja) | Ｌｙ６Ｋを阻害する化合物およびそれらを使用する方法 | |
| JP2024508754A (ja) | 癌および前癌性パピローマウイルス病変を処置するための２－ｓリマンタジンおよび２－ｒリマンタジン | |
| JP2024518712A (ja) | Ｋｄｍ４阻害剤による癌の処置 | |
| US20150065486A1 (en) | Methods for treating polycystic kidney disease | |
| CN109982700A (zh) | 具有外显子14跳跃突变或外显子14跳跃表型的癌症的治疗 | |
| CN115819349B (zh) | 一种吡唑类化合物及其制备方法和应用 | |
| JP2022509257A (ja) | ２，３－ジヒドロ－イソインドール－１－オン化合物を用いた組合せ療法及び様々な変異を有する患者を治療するための方法 |