JP2004503214A - 細胞結合核酸分子(アプタマー) - Google Patents

細胞結合核酸分子(アプタマー) Download PDF

Info

Publication number
JP2004503214A
JP2004503214A JP2001577520A JP2001577520A JP2004503214A JP 2004503214 A JP2004503214 A JP 2004503214A JP 2001577520 A JP2001577520 A JP 2001577520A JP 2001577520 A JP2001577520 A JP 2001577520A JP 2004503214 A JP2004503214 A JP 2004503214A
Authority
JP
Japan
Prior art keywords
nucleic acid
acid molecule
seq
aptamer
detecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001577520A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004503214A5 (https=
Inventor
シュリュセナー,ヘルマン
ブランク,ミヒャエル
Original Assignee
エーバーハルト−カルルス−ウニヴェルズィテート テュービンゲン ウニヴェルズィテートクリーニクム
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エーバーハルト−カルルス−ウニヴェルズィテート テュービンゲン ウニヴェルズィテートクリーニクム filed Critical エーバーハルト−カルルス−ウニヴェルズィテート テュービンゲン ウニヴェルズィテートクリーニクム
Publication of JP2004503214A publication Critical patent/JP2004503214A/ja
Publication of JP2004503214A5 publication Critical patent/JP2004503214A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2001577520A 2000-04-18 2001-04-17 細胞結合核酸分子(アプタマー) Pending JP2004503214A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10019154A DE10019154A1 (de) 2000-04-18 2000-04-18 Zellbindende Nukleinsäuremoleküle (Aptamere)
PCT/EP2001/004340 WO2001079538A2 (de) 2000-04-18 2001-04-17 Zellbindende nukleinsäuremoleküle (aptamere)

Publications (2)

Publication Number Publication Date
JP2004503214A true JP2004503214A (ja) 2004-02-05
JP2004503214A5 JP2004503214A5 (https=) 2005-08-18

Family

ID=7639154

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001577520A Pending JP2004503214A (ja) 2000-04-18 2001-04-17 細胞結合核酸分子(アプタマー)

Country Status (5)

Country Link
EP (1) EP1294938B1 (https=)
JP (1) JP2004503214A (https=)
AT (1) ATE382098T1 (https=)
DE (2) DE10019154A1 (https=)
WO (1) WO2001079538A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012528587A (ja) * 2009-06-01 2012-11-15 ソンギュングヮン ユニバーシティ ファウンデーション フォー コーポレート コラボレーション 膵臓癌細胞または組織に特異的に結合できる核酸アプタマー及びその用途
JP2016168062A (ja) * 2009-04-08 2016-09-23 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Dna−細胞コンジュゲート

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10258924A1 (de) * 2002-12-17 2004-07-08 Eberhard-Karls-Universität Tübingen Universitätsklinikum Mit die Adhäsion von biologischem Material vermittelnden Substanzen beschichtete Vorrichtung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127119A (en) * 1990-06-11 2000-10-03 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands of tissue target
US6013443A (en) * 1995-05-03 2000-01-11 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue SELEX
DE69633227T2 (de) * 1995-05-03 2005-09-15 Gilead Sciences, Inc., Foster City Systematische evoultion von liganden durch exponentielle anreicherung: gewebe-selex

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016168062A (ja) * 2009-04-08 2016-09-23 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Dna−細胞コンジュゲート
JP2012528587A (ja) * 2009-06-01 2012-11-15 ソンギュングヮン ユニバーシティ ファウンデーション フォー コーポレート コラボレーション 膵臓癌細胞または組織に特異的に結合できる核酸アプタマー及びその用途

Also Published As

Publication number Publication date
DE10019154A1 (de) 2001-10-31
WO2001079538A3 (de) 2003-01-16
ATE382098T1 (de) 2008-01-15
DE50113417D1 (de) 2008-02-07
EP1294938B1 (de) 2007-12-26
EP1294938A2 (de) 2003-03-26
WO2001079538A2 (de) 2001-10-25

Similar Documents

Publication Publication Date Title
JP2002520074A (ja) シス作用性核酸エレメントおよび使用法
CN104593372B (zh) 一种检测胰腺导管癌的核酸适配体、试剂盒及方法
EP3369820B1 (en) Dna aptamer capable of bonding to vwf
JP2022061987A (ja) 癌細胞に結合するdnaアプタマー
WO2015184224A1 (en) Aptamer targeting mage-a3 peptide and uses thereof
WO2019149115A1 (zh) 核酸适配体在识别并结合碱性磷酸酶异源二聚体或肿瘤检测中的应用
CN119752914A (zh) 一种结合cd117蛋白的核酸适体及其应用
CN101148666A (zh) 一组与人乳腺癌组织高特异性和高亲和力的核酸适配子及其制备方法与应用
CN107868786B (zh) 多药耐药结肠癌细胞的单链dna适配体
EP3827082B1 (en) Icam-1 aptamers, diagnostic and therapeutic uses thereof
US9422563B2 (en) CD7 receptor aptamers
JP2004503214A (ja) 細胞結合核酸分子(アプタマー)
CN112779261A (zh) 结合人b7-h4蛋白的适配体及其应用和应用其的检测方法
JP2003527398A (ja) 内皮特異性ターゲティング
JP2024046855A (ja) インテグリンα7β1受容体に対する結合能を有するDNAアプタマー
US20140369934A1 (en) dsRNA/DNA Hybrid Genome Replication Intermediate Of Metakaryotic Stem Cells
US20120195829A1 (en) Methods for identifying targeting domains and method and compositions comprising the same
WO2023211299A1 (en) Dna aptamer having affinity for pd-l1 protein and its use, functional covalent complex and its use
CN108239646A (zh) 结合肝癌细胞的核酸适配体及其应用和应用其的检测方法
WO2003066639A2 (en) Methods for identifying targeting domains and methods and compositions comprising the same
US20180119149A1 (en) In vitro selection of formaldehyde cross-linking aptamers
KR101421792B1 (ko) Pap의 세포외 도메인에 선택적으로 결합하는 rna 앱타머
Requena Aptamers as Reversible Sorting Ligands in Dual FACS and MACS: Antisense and Nuclease-Mediated Approaches
CA3003576C (en) Dna aptamer that binds to vwf
CN119955791A (zh) 一种结合cd86蛋白的核酸适配体及其应用