JP2004503214A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004503214A5 JP2004503214A5 JP2001577520A JP2001577520A JP2004503214A5 JP 2004503214 A5 JP2004503214 A5 JP 2004503214A5 JP 2001577520 A JP2001577520 A JP 2001577520A JP 2001577520 A JP2001577520 A JP 2001577520A JP 2004503214 A5 JP2004503214 A5 JP 2004503214A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- seq
- detecting
- sequence listing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020004707 nucleic acids Proteins 0.000 claims 18
- 102000039446 nucleic acids Human genes 0.000 claims 18
- 150000007523 nucleic acids Chemical class 0.000 claims 18
- 238000000034 method Methods 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 238000001514 detection method Methods 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 239000012620 biological material Substances 0.000 claims 4
- 241000283690 Bos taurus Species 0.000 claims 3
- 241001529936 Murinae Species 0.000 claims 3
- 239000000032 diagnostic agent Substances 0.000 claims 3
- 229940039227 diagnostic agent Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 210000002889 endothelial cell Anatomy 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 239000000439 tumor marker Substances 0.000 claims 2
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 claims 1
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 claims 1
- 230000009843 endothelial lesion Effects 0.000 claims 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 claims 1
- 238000010562 histological examination Methods 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10019154A DE10019154A1 (de) | 2000-04-18 | 2000-04-18 | Zellbindende Nukleinsäuremoleküle (Aptamere) |
| PCT/EP2001/004340 WO2001079538A2 (de) | 2000-04-18 | 2001-04-17 | Zellbindende nukleinsäuremoleküle (aptamere) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004503214A JP2004503214A (ja) | 2004-02-05 |
| JP2004503214A5 true JP2004503214A5 (https=) | 2005-08-18 |
Family
ID=7639154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001577520A Pending JP2004503214A (ja) | 2000-04-18 | 2001-04-17 | 細胞結合核酸分子（アプタマー） |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1294938B1 (https=) |
| JP (1) | JP2004503214A (https=) |
| AT (1) | ATE382098T1 (https=) |
| DE (2) | DE10019154A1 (https=) |
| WO (1) | WO2001079538A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10258924A1 (de) * | 2002-12-17 | 2004-07-08 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Mit die Adhäsion von biologischem Material vermittelnden Substanzen beschichtete Vorrichtung |
| ES2924287T3 (es) * | 2009-04-08 | 2022-10-05 | Univ California | Conjugados de ADN-células |
| US8563711B2 (en) * | 2009-06-01 | 2013-10-22 | Sungkyunkwan University Foundation For Corporate Collaboration | Nucleic acid aptamer capable of binding specifically to pancreatic cancer cells or tissues and use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6127119A (en) * | 1990-06-11 | 2000-10-03 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands of tissue target |
| US6013443A (en) * | 1995-05-03 | 2000-01-11 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: tissue SELEX |
| DE69633227T2 (de) * | 1995-05-03 | 2005-09-15 | Gilead Sciences, Inc., Foster City | Systematische evoultion von liganden durch exponentielle anreicherung: gewebe-selex |
-
2000
- 2000-04-18 DE DE10019154A patent/DE10019154A1/de not_active Ceased
-
2001
- 2001-04-17 JP JP2001577520A patent/JP2004503214A/ja active Pending
- 2001-04-17 DE DE50113417T patent/DE50113417D1/de not_active Expired - Fee Related
- 2001-04-17 EP EP01929568A patent/EP1294938B1/de not_active Expired - Lifetime
- 2001-04-17 WO PCT/EP2001/004340 patent/WO2001079538A2/de not_active Ceased
- 2001-04-17 AT AT01929568T patent/ATE382098T1/de not_active IP Right Cessation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5723594A (en) | High affinity PDGF nucleic acid ligands | |
| ES2316693T3 (es) | Metodo de diagnostico de la enfermedad de alzheimer sobre la base de un patron de transcripcion genico. | |
| DE69831222T2 (de) | Verbindungen zur immundiagnose von prostatakrebs und deren verwendung | |
| de la Torre et al. | Synthesis and binding properties of oligonucleotides carrying nuclear localization sequences | |
| JP2004532817A5 (https=) | ||
| KR930701597A (ko) | 재조합 bpi 단백질, bpi 단백질의 용도 및 그의 제조방법 | |
| WO2003049684A3 (en) | Pseudo-antibody constructs | |
| JP2002335982A (ja) | 線維芽細胞成長因子−１０ | |
| JP2003505111A5 (https=) | ||
| SE9500023D0 (sv) | Method of detecting cancer | |
| JPWO2005014625A1 (ja) | 脳移行活性を有するポリペプチド、およびその利用 | |
| ES2223814T3 (es) | Dispositivo de analisis y/o de tratamiento con un vastago flexible. | |
| CA2441327A1 (en) | Human arginine-rich protein-related compositions | |
| JP2005506047A5 (https=) | ||
| JP3472587B2 (ja) | 骨関連カルボキシペプチダーゼ様タンパク質およびその製造法 | |
| JP2004503214A5 (https=) | ||
| US6743627B1 (en) | Using polyamide nucleic acid oligomers to engender a biological response | |
| US20030100519A1 (en) | Using polyamide nucleic acid oligomers to engender a biological response | |
| JP2003510074A (ja) | ２６個のヒト分泌タンパク質 | |
| WO2002088375A3 (en) | Compositions and methods relating to breast specific genes and proteins | |
| CN118931908B (zh) | 一种结合蛋白磷酸酶1调节亚基26蛋白的核酸适配体、筛选方法及其应用 | |
| JP5371306B2 (ja) | 負の超らせんｄｎａ結合ドメイン | |
| FR2791357B1 (fr) | Diagnostic de la maladie de whipple | |
| KR20000071011A (ko) | 콜라겐 유전자의 발현을 억제하는 올리고머 | |
| CA2306731A1 (en) | Using polyamide nucleic acid oligomers to engender a biological response |