JP2004502696A5 - - Google Patents
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- Publication number
- JP2004502696A5 JP2004502696A5 JP2002507824A JP2002507824A JP2004502696A5 JP 2004502696 A5 JP2004502696 A5 JP 2004502696A5 JP 2002507824 A JP2002507824 A JP 2002507824A JP 2002507824 A JP2002507824 A JP 2002507824A JP 2004502696 A5 JP2004502696 A5 JP 2004502696A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- compound according
- ring
- alkaryl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 54
- 125000003118 aryl group Chemical group 0.000 description 24
- 125000002877 alkyl aryl group Chemical group 0.000 description 20
- 125000000217 alkyl group Chemical group 0.000 description 18
- 125000001475 halogen functional group Chemical group 0.000 description 14
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 9
- -1 ruthenium (II) compound Chemical class 0.000 description 8
- 125000000623 heterocyclic group Chemical group 0.000 description 7
- 125000002947 alkylene group Chemical group 0.000 description 6
- 229910052799 carbon Inorganic materials 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 125000002837 carbocyclic group Chemical group 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 150000003857 carboxamides Chemical class 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 229940124530 sulfonamide Drugs 0.000 description 4
- 150000003456 sulfonamides Chemical class 0.000 description 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 4
- SPIPKVJLGXVNNN-UHFFFAOYSA-N 1,4,9,10-tetrahydroanthracene Chemical compound C1C2=CC=CC=C2CC2=C1CC=CC2 SPIPKVJLGXVNNN-UHFFFAOYSA-N 0.000 description 3
- FTDLXZYXJAJLIP-UHFFFAOYSA-N 1,4-dihydroanthracene Chemical compound C1=CC=C2C=C3CC=CCC3=CC2=C1 FTDLXZYXJAJLIP-UHFFFAOYSA-N 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 150000001454 anthracenes Chemical class 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 0 Cc(c(*)c1*)c(*)c(*)c1O Chemical compound Cc(c(*)c1*)c(*)c(*)c1O 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0016052.3 | 2000-06-30 | ||
| GBGB0016052.3A GB0016052D0 (en) | 2000-06-30 | 2000-06-30 | Ruthenium (II) compounds |
| PCT/GB2001/002824 WO2002002572A1 (en) | 2000-06-30 | 2001-06-26 | Ruthenium (ii) compounds for use in the therapy of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004502696A JP2004502696A (ja) | 2004-01-29 |
| JP2004502696A5 true JP2004502696A5 (https=) | 2008-07-24 |
Family
ID=9894730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002507824A Pending JP2004502696A (ja) | 2000-06-30 | 2001-06-26 | 癌治療用のルテニウム（ｉｉ）化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6936634B2 (https=) |
| EP (1) | EP1294732B1 (https=) |
| JP (1) | JP2004502696A (https=) |
| AT (1) | ATE273985T1 (https=) |
| AU (1) | AU2001267687A1 (https=) |
| BR (1) | BR0112122A (https=) |
| CA (1) | CA2414446A1 (https=) |
| DE (1) | DE60105028T2 (https=) |
| DK (1) | DK1294732T3 (https=) |
| ES (1) | ES2227225T3 (https=) |
| GB (1) | GB0016052D0 (https=) |
| MX (1) | MXPA02012911A (https=) |
| PT (1) | PT1294732E (https=) |
| WO (1) | WO2002002572A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003512471A (ja) * | 1999-10-27 | 2003-04-02 | ユニバーシティ コート， エディンバラ大学 | 窒素および配位子を含む癌治療用の半サンドイッチ状ルテニウム（ｉｉ）化合物 |
| AU2002346686A1 (en) * | 2001-12-07 | 2003-06-23 | Intermune, Inc. | Compositions and method for treating hepatitis virus infection |
| GB0215526D0 (en) * | 2002-07-05 | 2002-08-14 | Univ Edinburgh | Anticancer compounds |
| US7241913B2 (en) * | 2003-04-30 | 2007-07-10 | The University Court Of The University Of Edinburgh | Ruthenium compounds |
| GB0418643D0 (en) * | 2004-08-20 | 2004-09-22 | Univ Edinburgh | Ruthenium (II) compounds |
| GB0604602D0 (en) * | 2006-03-07 | 2006-04-19 | Univ Edinburgh | Ruthenium (II) compounds |
| GB0610062D0 (en) * | 2006-05-19 | 2006-06-28 | Univ Edinburgh | Ruthenium (ll) compounds |
| CN101851256B (zh) * | 2010-04-30 | 2013-01-09 | 广东药学院 | 一种以柔性碳链联接的钌(ⅱ)卟啉配合物及其制备方法和应用 |
| CN101863925B (zh) * | 2010-05-21 | 2012-08-29 | 广东药学院 | 一种芳基钌(ⅱ)配合物及其制备方法和应用 |
| US9751081B2 (en) | 2014-12-01 | 2017-09-05 | Clemson University | Self-regenerating antioxidant catalysts and methods of using the same |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980472A (en) * | 1983-06-23 | 1990-12-25 | American Cyanamid Company | Method of making (3-amino-1H-pyrazol-4-yl) (aryl)methanones |
| EP0191096B1 (de) * | 1984-07-24 | 1989-09-13 | ASTA Pharma AG | Tumorhemmend wirkende rutheniumverbindungen |
| WO1986000804A1 (fr) | 1984-07-24 | 1986-02-13 | Byk Gulden Lomberg Chemische Fabrik Gesellschaft M | Compositions de ruthenium a effet inhibiteur de tumeurs |
| US4980473A (en) * | 1985-01-18 | 1990-12-25 | The Trustees Of Columbia University In The City Of New York | Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents |
| US4699978A (en) * | 1985-01-18 | 1987-10-13 | The Trustees Of Columbia University In The City Of New York | Site-specific chiral ruthenium (II) and cobalt (III) antitumor agents |
| US5225556A (en) * | 1985-01-18 | 1993-07-06 | The Trustees Of Columbia University In The City Of New York | Chemical probes for left-handed DNA and for A-DNA; chiral metal complexes as Z-specific antitumor agents and as double strand cleavers |
| AU4017695A (en) | 1994-10-28 | 1996-05-23 | Procept, Inc. | Ruthenium complexes and their use as immunosuppressive agents |
| JPH11209314A (ja) | 1997-09-30 | 1999-08-03 | Takasago Internatl Corp | シクロオクタジエン類の製造方法 |
| JP3488103B2 (ja) * | 1998-11-12 | 2004-01-19 | 高砂香料工業株式会社 | ４−メチル−５−ヘキセン−１−アールを含有する香料組成物 |
| GB0028025D0 (en) | 2000-11-17 | 2001-01-03 | Univ York | Compounds |
-
2000
- 2000-06-30 GB GBGB0016052.3A patent/GB0016052D0/en not_active Ceased
-
2001
- 2001-06-26 US US10/312,940 patent/US6936634B2/en not_active Expired - Fee Related
- 2001-06-26 EP EP01945472A patent/EP1294732B1/en not_active Expired - Lifetime
- 2001-06-26 ES ES01945472T patent/ES2227225T3/es not_active Expired - Lifetime
- 2001-06-26 BR BR0112122-7A patent/BR0112122A/pt not_active Application Discontinuation
- 2001-06-26 JP JP2002507824A patent/JP2004502696A/ja active Pending
- 2001-06-26 AT AT01945472T patent/ATE273985T1/de not_active IP Right Cessation
- 2001-06-26 WO PCT/GB2001/002824 patent/WO2002002572A1/en not_active Ceased
- 2001-06-26 AU AU2001267687A patent/AU2001267687A1/en not_active Abandoned
- 2001-06-26 PT PT01945472T patent/PT1294732E/pt unknown
- 2001-06-26 CA CA002414446A patent/CA2414446A1/en not_active Abandoned
- 2001-06-26 DE DE60105028T patent/DE60105028T2/de not_active Expired - Fee Related
- 2001-06-26 DK DK01945472T patent/DK1294732T3/da active
- 2001-06-26 MX MXPA02012911A patent/MXPA02012911A/es active IP Right Grant
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