JP2004502663A5 - - Google Patents
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- Publication number
- JP2004502663A5 JP2004502663A5 JP2002507758A JP2002507758A JP2004502663A5 JP 2004502663 A5 JP2004502663 A5 JP 2004502663A5 JP 2002507758 A JP2002507758 A JP 2002507758A JP 2002507758 A JP2002507758 A JP 2002507758A JP 2004502663 A5 JP2004502663 A5 JP 2004502663A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- methoxy
- compound
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 13
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 16
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 7
- VURFVHCLMJOLKN-UHFFFAOYSA-N diphosphane Chemical compound PP VURFVHCLMJOLKN-UHFFFAOYSA-N 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- -1 1-methoxyprop-3-yloxy Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 229910052703 rhodium Inorganic materials 0.000 claims 3
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 150000004696 coordination complex Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 239000011541 reaction mixture Substances 0.000 claims 2
- 239000010948 rhodium Substances 0.000 claims 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims 1
- 230000010933 acylation Effects 0.000 claims 1
- 238000005917 acylation reaction Methods 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 238000009876 asymmetric hydrogenation reaction Methods 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 150000001993 dienes Chemical class 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 229910052741 iridium Inorganic materials 0.000 claims 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 claims 1
- AFRJJFRNGGLMDW-UHFFFAOYSA-N lithium amide Chemical compound [Li+].[NH2-] AFRJJFRNGGLMDW-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- FVZVCSNXTFCBQU-UHFFFAOYSA-N phosphanyl Chemical group [PH2] FVZVCSNXTFCBQU-UHFFFAOYSA-N 0.000 claims 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N phosphine group Chemical group P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims 1
- 229910052707 ruthenium Inorganic materials 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH13172000 | 2000-07-03 | ||
| PCT/CH2001/000397 WO2002002500A1 (en) | 2000-07-03 | 2001-06-26 | Preparation of (r)-2-alkyl-3-phenylpropionic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004502663A JP2004502663A (ja) | 2004-01-29 |
| JP2004502663A5 true JP2004502663A5 (enExample) | 2005-02-03 |
Family
ID=4565374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002507758A Pending JP2004502663A (ja) | 2000-07-03 | 2001-06-26 | （ｒ）−２−アルキル−３−フェニルプロピオン酸の調製 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6683206B2 (enExample) |
| EP (1) | EP1296927B1 (enExample) |
| JP (1) | JP2004502663A (enExample) |
| CN (1) | CN100482632C (enExample) |
| AR (1) | AR028783A1 (enExample) |
| AT (1) | ATE546425T1 (enExample) |
| AU (1) | AU2001273761A1 (enExample) |
| BR (1) | BR0112146A (enExample) |
| CA (1) | CA2414839C (enExample) |
| TW (1) | TWI271398B (enExample) |
| WO (1) | WO2002002500A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH694251A5 (de) * | 1999-07-14 | 2004-10-15 | Eprova Ag | Herstellung von Tetrahydropterin und Derivaten. |
| BR0112128A (pt) * | 2000-07-03 | 2003-05-13 | Speedel Pharma Ag | Processo para a preparação de (r)-2-alquil-3-fenil-1-propanóis |
| CA2412910C (en) * | 2000-07-03 | 2010-11-16 | Solvias Ag | Ferrocenyl diphosphines and their use |
| AT501193B1 (de) | 2004-12-27 | 2007-03-15 | Dsm Fine Chem Austria Gmbh | Verfahen zur übergangsmetall - katalysierten asymmetrischen hydrierung von acrylsäurederivaten |
| GB0500700D0 (en) * | 2005-01-14 | 2005-02-23 | Stylacats Ltd | Process for the manufacture of 2-alkyl-3-phenylpropionic acids and alcohols |
| JP4763771B2 (ja) * | 2005-03-17 | 2011-08-31 | ビーエーエスエフ ソシエタス・ヨーロピア | 光学活性３−フェニルプロピオン酸誘導体を生成する方法、およびその誘導体の後続生成物 |
| DE102005012408A1 (de) * | 2005-03-17 | 2006-09-21 | Basf Ag | Verfahren zur Herstellung von optisch aktiven 3-Phenylpropionsäurederivaten und Folgeprodukten davon |
| DE102005052195A1 (de) | 2005-10-28 | 2007-05-03 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von chiralen Octensäurederivaten |
| US7935841B2 (en) | 2006-04-21 | 2011-05-03 | Dr. Reddy's Laboratories Limited | Bisphospholanes for use as catalysts in asymmetric reactions |
| EP1939182A1 (de) * | 2006-12-22 | 2008-07-02 | Speedel Experimenta AG | Verfahren zur Herstellung von (R oder S)-2-Alkyl-3-heterocyclyl-1-propanolen |
| EP1958666A1 (en) | 2007-02-13 | 2008-08-20 | Speedel Experimenta AG | Heterocyclic-substituted alkanamides as therapeutic compounds |
| EP2178816A1 (en) * | 2007-07-11 | 2010-04-28 | DSM Fine Chemicals Austria Nfg GmbH & Co KG | Alpha-substituted , -unsaturated e- or z-aldehydes, use thereof, and processes for their preparation , |
| EP2173696A1 (en) | 2007-07-11 | 2010-04-14 | DSM IP Assets B.V. | Preparation of a saturated aldehyde |
| DE102007049039A1 (de) | 2007-10-11 | 2009-04-16 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung |
| US8203005B2 (en) | 2009-10-29 | 2012-06-19 | Carbo Design Llc | Manufacturing process for enantiomerically pure 8-aryloctanoic acids as Aliskiren |
| TW201202178A (en) | 2010-06-04 | 2012-01-16 | Chemo Iberica Sa | Process for producing Aliskiren |
| US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
| US9056816B2 (en) | 2011-10-25 | 2015-06-16 | Jubilant Life Sciences Limited | Process for the preparation of aliskiren |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4307232A (en) * | 1980-03-21 | 1981-12-22 | E. I. Du Pont De Nemours And Company | Preparation of dialkyl- and diarylphosphonoalkanoic acids and substituted acrylic acids |
| FR2671079B1 (fr) * | 1990-12-28 | 1994-06-03 | Elf Aquitaine | Procede d'hydrogenation de composes organiques et catalyseurs au ruthenium pour sa realisation. |
| US5659065A (en) * | 1994-04-18 | 1997-08-19 | Novartis Corporation | Alpha-aminoalkanoic acids and reduction products |
| JPH09309826A (ja) * | 1996-05-22 | 1997-12-02 | Kissei Pharmaceut Co Ltd | 糸球体疾患の予防および治療剤 |
| US6258833B1 (en) * | 1999-12-23 | 2001-07-10 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
-
2001
- 2001-06-26 CN CNB018122310A patent/CN100482632C/zh not_active Expired - Fee Related
- 2001-06-26 BR BR0112146-4A patent/BR0112146A/pt not_active Application Discontinuation
- 2001-06-26 AT AT01940045T patent/ATE546425T1/de active
- 2001-06-26 CA CA2414839A patent/CA2414839C/en not_active Expired - Fee Related
- 2001-06-26 WO PCT/CH2001/000397 patent/WO2002002500A1/en not_active Ceased
- 2001-06-26 US US10/312,855 patent/US6683206B2/en not_active Expired - Fee Related
- 2001-06-26 AU AU2001273761A patent/AU2001273761A1/en not_active Abandoned
- 2001-06-26 EP EP01940045A patent/EP1296927B1/en not_active Expired - Lifetime
- 2001-06-26 JP JP2002507758A patent/JP2004502663A/ja active Pending
- 2001-06-27 TW TW090115551A patent/TWI271398B/zh not_active IP Right Cessation
- 2001-07-03 AR ARP010103175A patent/AR028783A1/es active IP Right Grant
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