JP2004502638A - 炎症性腸疾患の予防および治療のための生物学的活性ビタミンd化合物の使用 - Google Patents
炎症性腸疾患の予防および治療のための生物学的活性ビタミンd化合物の使用 Download PDFInfo
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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| PCT/US2000/034913 WO2001046132A1 (en) | 1999-12-21 | 2000-12-21 | Use of biologically active vitamin d compounds for the prevention and treatment of inflammatory bowel disease |
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| US20050148557A1 (en) * | 2003-07-29 | 2005-07-07 | Jin Tian | Use of Vitamin Ds to treat kidney disease |
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| US20060171983A1 (en) * | 2003-07-30 | 2006-08-03 | Jin Tian | Use of Vitamin D receptor activators or Vitamin D analogs to treat cardiovascular disease |
| US7704980B2 (en) * | 2003-10-08 | 2010-04-27 | Wisconsin Alumni Research Foundation | Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds |
| GB0513984D0 (en) * | 2005-07-07 | 2005-08-17 | Teva Pharma | Dosage form |
| WO2008103420A1 (en) | 2007-02-21 | 2008-08-28 | The Regents Of The University Of Michigan | Compositions and methods for tranquilizing heart muscle |
| CA2681582C (en) * | 2007-03-30 | 2015-07-14 | Amgen Inc. | Methods of treating bowel disorders |
| EP2144872A2 (en) * | 2007-04-18 | 2010-01-20 | Johns Hopkins University | Low calcemic, highly antiproliferative, analogs of calcitriol |
| US8318708B2 (en) * | 2007-11-06 | 2012-11-27 | Salk Institute For Biological Studies | Use of vitamin D receptor agonists, ligands, and precursors to treat pancreatic fibrosis |
| JP2011503104A (ja) | 2007-11-09 | 2011-01-27 | カリフォルニア インスティテュート オブ テクノロジー | 免疫調節化合物ならびに関連組成物および方法 |
| CA2981549A1 (en) | 2009-01-27 | 2010-08-05 | Berg Llc | Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy |
| AU2010282731C1 (en) | 2009-08-14 | 2016-04-21 | Berg Llc | Vitamin D3 and analogs thereof for treating alopecia |
| EP2501705B1 (en) | 2009-11-20 | 2014-08-27 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds and prodrugs thereof and their uses |
| WO2011127302A2 (en) | 2010-04-07 | 2011-10-13 | Yue Shen | Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems |
| US8618095B2 (en) | 2010-04-13 | 2013-12-31 | Rigel Pharmaceuticals, Inc. | 2, 4-pyrimidinediamine compounds and prodrugs thereof and their uses |
| US20130064859A1 (en) * | 2011-01-28 | 2013-03-14 | Sarkis K. Mazmanian | Combinatorial vitamin d and probiotic therapy for inflammatory bowel disease |
| WO2013009945A1 (en) | 2011-07-12 | 2013-01-17 | The Brigham And Women's Hospital, Inc. | Lipid-containing psa compositions, methods of isolation and methods of use thereof |
| PL2723330T3 (pl) * | 2011-08-19 | 2015-12-31 | Maria Clementine Martin Klosterfrau Vertriebsges Mbh | Lek kombinowany zawierający środek naczynioskurczowy |
| EP2988752A4 (en) | 2013-04-24 | 2017-01-18 | Salk Institute for Biological Studies | Vitamin d receptor/smad genomic circuit gates fibrotic response |
| EP2994161B1 (en) | 2013-05-10 | 2020-10-28 | California Institute of Technology | Probiotic prevention and treatment of colon cancer |
| CA2913543C (en) | 2013-05-29 | 2024-01-09 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
| CN105451818A (zh) | 2013-06-05 | 2016-03-30 | 萨克生物研究学院 | 治疗涉及cxcl12活性的疾病的维生素d受体激动剂 |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| KR102343093B1 (ko) | 2015-02-23 | 2021-12-24 | 삼성전자주식회사 | 식기 세척기 및 그 제어방법 |
| WO2016201342A1 (en) | 2015-06-10 | 2016-12-15 | California Institute Of Technology | Sepsis treatment and related compositions methods and systems |
| CA2997211A1 (en) | 2015-08-19 | 2017-02-23 | President And Fellows Of Harvard College | Lipidated psa compositions and methods |
| CA3030974A1 (en) | 2016-07-15 | 2018-01-18 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
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Family Cites Families (53)
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| US4312806A (en) | 1981-03-02 | 1982-01-26 | G. D. Searle & Co. | Method and compounds for treating inflammatory bowel disease |
| US4638043A (en) | 1984-11-13 | 1987-01-20 | Thermedics, Inc. | Drug release system |
| US5310732A (en) | 1986-02-03 | 1994-05-10 | The Scripps Research Institute | 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis |
| US5824313A (en) | 1989-09-25 | 1998-10-20 | University Of Utah Research Foundation | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination |
| US5518725A (en) | 1989-09-25 | 1996-05-21 | University Of Utah Research Foundation | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination |
| US5643602A (en) | 1989-11-22 | 1997-07-01 | Astra Aktiebolag | Oral composition for the treatment of inflammatory bowel disease |
| US5216002A (en) | 1989-12-21 | 1993-06-01 | Eli Lilly And Company | Method of treating inflammatory bowel disease |
| JP2811353B2 (ja) | 1990-07-06 | 1998-10-15 | ゼリア新薬工業株式会社 | 炎症性腸疾患予防・治療剤 |
| ZA916555B (en) | 1990-08-27 | 1993-04-28 | Lilly Co Eli | Method of treating inflammatory bowel disease |
| US5391555A (en) | 1991-11-12 | 1995-02-21 | Miles Inc. | Methods for treating inflammatory bowel disease with leukotriene synthesis inhibitors |
| DE4141746A1 (de) | 1991-12-13 | 1993-06-17 | Schering Ag | 20-methyl-substituierte vitamin d-derivate |
| US5932214A (en) | 1994-08-11 | 1999-08-03 | Biogen, Inc. | Treatment for inflammatory bowel disease with VLA-4 blockers |
| DK64592D0 (da) | 1992-05-14 | 1992-05-14 | Carlbiotech Ltd As | Peptider til terapeutisk behandling |
| DE4221961A1 (de) * | 1992-06-30 | 1994-01-05 | Schering Ag | 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel |
| US5294630A (en) | 1992-07-07 | 1994-03-15 | Eli Lilly And Company | Treatment of inflammatory bowel disease |
| US5368854A (en) | 1992-08-20 | 1994-11-29 | Schering Corporation | Use of IL-10 to treat inflammatory bowel disease |
| IL107185A (en) * | 1992-10-06 | 1998-02-22 | Schering Ag | Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same |
| GB9223061D0 (en) | 1992-11-04 | 1992-12-16 | Leo Pharm Prod Ltd | Chemical compounds |
| ATE163262T1 (de) | 1993-04-20 | 1998-03-15 | Hexal Ag | Wirkstoffplaster |
| GB9309422D0 (en) | 1993-05-07 | 1993-06-23 | Res Inst Medicine Chem | Chemical compounds |
| GB9314400D0 (en) | 1993-07-12 | 1993-08-25 | Leo Pharm Prod Ltd | Produktionsaktieselskab) chemical compounds |
| GB9315253D0 (en) | 1993-07-23 | 1993-09-08 | Res Inst Medicine Chem | Chemical compounds |
| US5420109A (en) | 1993-11-12 | 1995-05-30 | Houghten Pharmaceuticals, Inc. | Cytokine restraining agents |
| GB9325415D0 (en) | 1993-12-13 | 1994-02-16 | Res Inst Medicine Chem | Chemical compounds |
| DE4405545A1 (de) * | 1994-02-22 | 1995-08-31 | Dietl Hans | Fettlösliche Vitamine enthaltende Zubereitung zur oralen Applikation |
| GB9405715D0 (en) | 1994-03-23 | 1994-05-11 | Res Inst Medicine Chem | Chemical compounds |
| GB2292079B (en) | 1994-08-12 | 1998-07-15 | Flexpharm Ltd | Coated prednisolone preparation for the treatment of inflamatory bowel disease |
| DK0717034T3 (da) | 1994-12-14 | 1999-10-18 | Duphar Int Res | Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser |
| PT806413E (pt) | 1995-01-23 | 2002-03-28 | Chugai Pharmaceutical Co Ltd | Derivados de vitamina d3 substituidos na posicao 2 |
| US5877168A (en) | 1995-02-10 | 1999-03-02 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivative with substituent at the 2β-position |
| US5569680A (en) | 1995-02-13 | 1996-10-29 | Trustees Of The Univ. Of Penna | Method of treating inflammatory bowel disease with tributyrin |
| US5981597A (en) * | 1995-02-13 | 1999-11-09 | Trustees Of The University Of Pennsylvania | Differentiating agents for the treatment of inflammatory intestinal diseases |
| GB9509764D0 (en) | 1995-05-15 | 1995-07-05 | Tillotts Pharma Ag | Treatment of inflammatory bowel disease using oral dosage forms of omega-3 polyunsaturated acids |
| US5851548A (en) | 1995-06-07 | 1998-12-22 | Gen-Probe Incorporated | Liposomes containing cationic lipids and vitamin D |
| UA48973C2 (uk) | 1995-06-07 | 2002-09-16 | Орто-Макнейл Фармасьютікалз Інк. | Трансдермальний пластир на основі 17-деацетилноргестимату для попередження овуляції |
| US5711964A (en) | 1995-06-07 | 1998-01-27 | United States Of America | Method for the intracellular delivery of biomolecules using liposomes containing cationic lipids and vitamin D |
| US5952317A (en) | 1995-09-21 | 1999-09-14 | Wisconsin Alumni Research Foundation | Calcitriol derivatives and their uses |
| ES2144183T3 (es) | 1995-10-30 | 2000-06-01 | Hoffmann La Roche | 1-alfa,26-dihidroxi-d-homo-vitamina d3. |
| US5889028A (en) | 1996-02-09 | 1999-03-30 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
| US5716946A (en) | 1996-02-13 | 1998-02-10 | Wisconsin Alumni Research Foundation | Multiple sclerosis treatment |
| AU710931B2 (en) | 1996-02-28 | 1999-09-30 | Sumitomo Pharmaceuticals Company, Limited | Crystalline vitamin D derivative |
| GB9607034D0 (en) | 1996-04-03 | 1996-06-05 | Leo Pharm Prod Ltd | Chemical compounds |
| ATE227564T1 (de) | 1996-04-04 | 2002-11-15 | Cilag Ag | Topische vitamin d zusammensetzung auf liposomenbasis |
| US5891865A (en) | 1996-10-04 | 1999-04-06 | Wisconsin Alumni Research Foundation | Treatment of arthritic disease induced by infectious agents |
| JP2002505668A (ja) * | 1997-05-16 | 2002-02-19 | ウィメン アンド インファンツ ホスピタル | 環状エーテルビタミンD3化合物、1α(OH)3−エピ−ビタミンD3化合物及びそれらの使用法 |
| NL1006072C2 (nl) | 1997-05-16 | 1998-11-17 | Jacobs Johannes J | Vergister voor het onder aërobe omstandigheden vergisten van dierlijke mest, inrichting en werkwijze voor het onder aërobe omstandigheden vergisten van dierlijke mest onder toepassing van een dergelijke vergister. |
| US6017908A (en) * | 1997-05-16 | 2000-01-25 | Women And Infants Hospital | 3-EPI vitamin D2 compounds and uses thereof |
| US5936105A (en) | 1997-06-13 | 1999-08-10 | Tetrionics, Inc. | 14-EPI-19-nor-vitamin D compounds and methods |
| EP0927721A1 (de) * | 1997-12-17 | 1999-07-07 | Schering Aktiengesellschaft | Neue Vitamin D-Derivate mit Phosphoratomen in den Seitenketten, Zwischenprodukte bei ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| US6214373B1 (en) * | 1999-10-07 | 2001-04-10 | Snowden-Sutton Associates, Inc. | Nutritional composition for treating inflammatory bowel diseases |
| US20030188756A1 (en) * | 2002-08-19 | 2003-10-09 | Cantorna Margherita T | Treatment of inflammatory bowel disease with vitamin d compounds |
| AU4510001A (en) * | 1999-12-02 | 2001-06-18 | Penn State Research Foundation, The | Treatment of inflammatory bowel disease with vitamin d compounds |
| AU7544501A (en) * | 2000-09-08 | 2002-03-22 | Wisconsin Alumni Res Found | 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications |
-
1999
- 1999-12-21 US US09/469,985 patent/US6358939B1/en not_active Expired - Fee Related
-
2000
- 2000-12-21 CA CA002395200A patent/CA2395200A1/en not_active Abandoned
- 2000-12-21 WO PCT/US2000/034913 patent/WO2001046132A1/en not_active Ceased
- 2000-12-21 KR KR1020027008018A patent/KR100660508B1/ko not_active Expired - Fee Related
- 2000-12-21 EP EP00986687A patent/EP1240136A4/en not_active Ceased
- 2000-12-21 JP JP2001547043A patent/JP2004502638A/ja not_active Withdrawn
- 2000-12-21 AU AU22878/01A patent/AU781113B2/en not_active Ceased
- 2000-12-21 MX MXPA02006257A patent/MXPA02006257A/es active IP Right Grant
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2001
- 2001-12-21 US US10/036,819 patent/US6858595B2/en not_active Expired - Fee Related
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2002
- 2002-06-20 NO NO20022974A patent/NO326517B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1240136A4 (en) | 2004-05-26 |
| US20020128241A1 (en) | 2002-09-12 |
| EP1240136A1 (en) | 2002-09-18 |
| WO2001046132A1 (en) | 2001-06-28 |
| AU2287801A (en) | 2001-07-03 |
| KR100660508B1 (ko) | 2006-12-22 |
| CA2395200A1 (en) | 2001-06-28 |
| NO20022974D0 (no) | 2002-06-20 |
| NO326517B1 (no) | 2008-12-22 |
| MXPA02006257A (es) | 2004-12-06 |
| NO20022974L (no) | 2002-08-20 |
| US6858595B2 (en) | 2005-02-22 |
| KR20020084075A (ko) | 2002-11-04 |
| AU781113B2 (en) | 2005-05-05 |
| US6358939B1 (en) | 2002-03-19 |
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