AU781113B2 - Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease - Google Patents
Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease Download PDFInfo
- Publication number
- AU781113B2 AU781113B2 AU22878/01A AU2287801A AU781113B2 AU 781113 B2 AU781113 B2 AU 781113B2 AU 22878/01 A AU22878/01 A AU 22878/01A AU 2287801 A AU2287801 A AU 2287801A AU 781113 B2 AU781113 B2 AU 781113B2
- Authority
- AU
- Australia
- Prior art keywords
- biologically active
- compound
- subject
- vitamin
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/469,985 US6358939B1 (en) | 1999-12-21 | 1999-12-21 | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| US09/469985 | 1999-12-21 | ||
| PCT/US2000/034913 WO2001046132A1 (en) | 1999-12-21 | 2000-12-21 | Use of biologically active vitamin d compounds for the prevention and treatment of inflammatory bowel disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2287801A AU2287801A (en) | 2001-07-03 |
| AU781113B2 true AU781113B2 (en) | 2005-05-05 |
Family
ID=23865828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU22878/01A Ceased AU781113B2 (en) | 1999-12-21 | 2000-12-21 | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6358939B1 (enExample) |
| EP (1) | EP1240136A4 (enExample) |
| JP (1) | JP2004502638A (enExample) |
| KR (1) | KR100660508B1 (enExample) |
| AU (1) | AU781113B2 (enExample) |
| CA (1) | CA2395200A1 (enExample) |
| MX (1) | MXPA02006257A (enExample) |
| NO (1) | NO326517B1 (enExample) |
| WO (1) | WO2001046132A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6087350A (en) | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
| WO2001042205A2 (en) * | 1999-12-02 | 2001-06-14 | The Penn State Research Foundation | Treatment of inflammatory bowel disease with vitamin d compounds |
| US6989377B2 (en) * | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| EP2071332A1 (en) * | 2000-11-14 | 2009-06-17 | Techlab, Inc. | Method for monitoring persons with IBD using total endogeneous lactoferrin as a marker |
| US7582670B2 (en) * | 2001-12-13 | 2009-09-01 | Natrogen Therapeutics, Inc. | Methods of treating an inflammatory-related disease |
| EP1587906A2 (en) * | 2003-01-10 | 2005-10-26 | Eli Lilly And Company | Vesicant treatment with phenyl-phenyl type vitamin d receptor modulators |
| EP1603530A1 (en) * | 2003-03-04 | 2005-12-14 | Teva Pharmaceutical Industries Limited | Combination therapy with glatiramer acetate and alphacalcidol for the treatment of multiple sclerosis |
| GB0307865D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
| US20050148557A1 (en) * | 2003-07-29 | 2005-07-07 | Jin Tian | Use of Vitamin Ds to treat kidney disease |
| US20050209203A1 (en) * | 2003-07-30 | 2005-09-22 | Jin Tian | Use of vitamin Ds or vitamin D analogs to treat cardiovascular disease |
| US20060171983A1 (en) * | 2003-07-30 | 2006-08-03 | Jin Tian | Use of Vitamin D receptor activators or Vitamin D analogs to treat cardiovascular disease |
| US20050192255A1 (en) * | 2003-07-30 | 2005-09-01 | Jin Tian | Use of Vitamin Ds or Vitamin D analogs to treat cardiovascular disease |
| US7704980B2 (en) * | 2003-10-08 | 2010-04-27 | Wisconsin Alumni Research Foundation | Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds |
| GB0513984D0 (en) * | 2005-07-07 | 2005-08-17 | Teva Pharma | Dosage form |
| US10716798B2 (en) | 2007-02-21 | 2020-07-21 | The Regents Of The University Of Michigan | Compositions and methods for tranquilizing heart muscle |
| EP2139462B1 (en) * | 2007-03-30 | 2014-01-22 | Amgen Inc. | Calcimimetic compounds for use in the treatment of bowel disorders |
| JP2010524973A (ja) * | 2007-04-18 | 2010-07-22 | ジョンズ ホプキンス ユニバーシティ | カルシトリオールの低カルシウム血性、高抗増殖性類似体 |
| US8318708B2 (en) * | 2007-11-06 | 2012-11-27 | Salk Institute For Biological Studies | Use of vitamin D receptor agonists, ligands, and precursors to treat pancreatic fibrosis |
| EP2217250A4 (en) | 2007-11-09 | 2011-01-05 | California Inst Of Techn | IMMUNOMODULATING COMPOUNDS AND RELEVANT COMPOSITIONS AND METHODS |
| AU2010208323B2 (en) | 2009-01-27 | 2016-03-10 | Berg Llc | Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy |
| EP2464357B1 (en) | 2009-08-14 | 2019-05-22 | Berg LLC | Vitamin d3 and analogs thereof for treating alopecia |
| ES2524127T3 (es) | 2009-11-20 | 2014-12-04 | Rigel Pharmaceuticals, Inc. | Compuestos de 2,4-pirimidinodiamina y sus profármacos y sus usos |
| HUE040658T2 (hu) | 2010-04-07 | 2019-03-28 | California Inst Of Techn | Vivõanyag vegyület mukózus membránhoz juttatásához és kapcsolódó készítmények, eljárások és rendszerek |
| CA2792278C (en) | 2010-04-13 | 2019-05-14 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds and prodrugs thereof and their uses |
| US20130064859A1 (en) * | 2011-01-28 | 2013-03-14 | Sarkis K. Mazmanian | Combinatorial vitamin d and probiotic therapy for inflammatory bowel disease |
| EP2731617A4 (en) | 2011-07-12 | 2015-07-01 | Brigham & Womens Hospital | LIPID-BASED PSA COMPOSITIONS, METHOD FOR THEIR INSULATION AND USE METHOD THEREFOR |
| HUE025567T2 (en) * | 2011-08-19 | 2016-02-29 | Maria Clementine Martin Klosterfrau Vertriebsges Mbh | Agents containing vasoconstrictors for combination therapy |
| CA2909941A1 (en) | 2013-04-24 | 2014-10-30 | Salk Institute For Biological Studies | Vitamin d receptor/smad genomic circuit gates fibrotic response |
| WO2014182966A1 (en) | 2013-05-10 | 2014-11-13 | California Institute Of Technology | Probiotic prevention and treatment of colon cancer |
| SG10201709894RA (en) | 2013-05-29 | 2018-01-30 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
| BR112015030518A2 (pt) | 2013-06-05 | 2017-08-29 | Salk Inst For Biological Studi | Composição farmacêutica, uso de um ou mais agonistas do receptor da vitamina d (vdr), e, método para a redução da atividade biológica do ligante 12 do motivo c-x-c (cxcl12) |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| KR102343093B1 (ko) | 2015-02-23 | 2021-12-24 | 삼성전자주식회사 | 식기 세척기 및 그 제어방법 |
| US11331335B2 (en) | 2015-06-10 | 2022-05-17 | California Institute Of Technology | Sepsis treatment and related compositions methods and systems |
| JP6918365B2 (ja) | 2015-08-19 | 2021-08-11 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 脂質化psa組成物および方法 |
| US11491181B2 (en) | 2016-07-15 | 2022-11-08 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
| WO2019023149A1 (en) | 2017-07-24 | 2019-01-31 | Salk Institute For Biological Studies | USE OF BROMODOMAIN-CONTAINING PROTEIN-9 ANTAGONISTS IN ASSOCIATION WITH VITAMIN D RECEPTOR AGONISTS IN THE TREATMENT OF DIABETES |
| EP4593867A2 (en) | 2022-09-30 | 2025-08-06 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996030326A1 (en) * | 1995-03-30 | 1996-10-03 | The Trustees Of The University Of Pennsylvania | Differentiating agents for the treatment of inflammatory intestinal diseases |
| EP0927721A1 (de) * | 1997-12-17 | 1999-07-07 | Schering Aktiengesellschaft | Neue Vitamin D-Derivate mit Phosphoratomen in den Seitenketten, Zwischenprodukte bei ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| AU4510001A (en) * | 1999-12-02 | 2001-06-18 | Penn State Research Foundation, The | Treatment of inflammatory bowel disease with vitamin d compounds |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4312806A (en) | 1981-03-02 | 1982-01-26 | G. D. Searle & Co. | Method and compounds for treating inflammatory bowel disease |
| US4638043A (en) | 1984-11-13 | 1987-01-20 | Thermedics, Inc. | Drug release system |
| US5310732A (en) | 1986-02-03 | 1994-05-10 | The Scripps Research Institute | 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis |
| US5824313A (en) | 1989-09-25 | 1998-10-20 | University Of Utah Research Foundation | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination |
| US5518725A (en) | 1989-09-25 | 1996-05-21 | University Of Utah Research Foundation | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination |
| US5643602A (en) | 1989-11-22 | 1997-07-01 | Astra Aktiebolag | Oral composition for the treatment of inflammatory bowel disease |
| US5216002A (en) | 1989-12-21 | 1993-06-01 | Eli Lilly And Company | Method of treating inflammatory bowel disease |
| JP2811353B2 (ja) | 1990-07-06 | 1998-10-15 | ゼリア新薬工業株式会社 | 炎症性腸疾患予防・治療剤 |
| ZA916555B (en) | 1990-08-27 | 1993-04-28 | Lilly Co Eli | Method of treating inflammatory bowel disease |
| US5391555A (en) | 1991-11-12 | 1995-02-21 | Miles Inc. | Methods for treating inflammatory bowel disease with leukotriene synthesis inhibitors |
| DE4141746A1 (de) | 1991-12-13 | 1993-06-17 | Schering Ag | 20-methyl-substituierte vitamin d-derivate |
| US5932214A (en) | 1994-08-11 | 1999-08-03 | Biogen, Inc. | Treatment for inflammatory bowel disease with VLA-4 blockers |
| DK64592D0 (da) | 1992-05-14 | 1992-05-14 | Carlbiotech Ltd As | Peptider til terapeutisk behandling |
| DE4221961A1 (de) * | 1992-06-30 | 1994-01-05 | Schering Ag | 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel |
| US5294630A (en) | 1992-07-07 | 1994-03-15 | Eli Lilly And Company | Treatment of inflammatory bowel disease |
| US5368854A (en) | 1992-08-20 | 1994-11-29 | Schering Corporation | Use of IL-10 to treat inflammatory bowel disease |
| IL107185A (en) * | 1992-10-06 | 1998-02-22 | Schering Ag | Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same |
| GB9223061D0 (en) | 1992-11-04 | 1992-12-16 | Leo Pharm Prod Ltd | Chemical compounds |
| DE59409873D1 (de) | 1993-04-20 | 2001-10-25 | Hexal Ag | Wirkstoffpflaster |
| GB9309422D0 (en) | 1993-05-07 | 1993-06-23 | Res Inst Medicine Chem | Chemical compounds |
| GB9314400D0 (en) | 1993-07-12 | 1993-08-25 | Leo Pharm Prod Ltd | Produktionsaktieselskab) chemical compounds |
| GB9315253D0 (en) | 1993-07-23 | 1993-09-08 | Res Inst Medicine Chem | Chemical compounds |
| US5420109A (en) | 1993-11-12 | 1995-05-30 | Houghten Pharmaceuticals, Inc. | Cytokine restraining agents |
| GB9325415D0 (en) | 1993-12-13 | 1994-02-16 | Res Inst Medicine Chem | Chemical compounds |
| DE4405545A1 (de) * | 1994-02-22 | 1995-08-31 | Dietl Hans | Fettlösliche Vitamine enthaltende Zubereitung zur oralen Applikation |
| GB9405715D0 (en) | 1994-03-23 | 1994-05-11 | Res Inst Medicine Chem | Chemical compounds |
| GB2292079B (en) | 1994-08-12 | 1998-07-15 | Flexpharm Ltd | Coated prednisolone preparation for the treatment of inflamatory bowel disease |
| ES2130522T3 (es) | 1994-12-14 | 1999-07-01 | Duphar Int Res | Compuestos de vitamina d y metodo para preparar estos compuestos. |
| WO1996022973A1 (fr) | 1995-01-23 | 1996-08-01 | Chugai Seiyaku Kabushiki Kaisha | Derives de vitamine d3 de 2-substitution |
| US5877168A (en) | 1995-02-10 | 1999-03-02 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivative with substituent at the 2β-position |
| US5569680A (en) | 1995-02-13 | 1996-10-29 | Trustees Of The Univ. Of Penna | Method of treating inflammatory bowel disease with tributyrin |
| GB9509764D0 (en) | 1995-05-15 | 1995-07-05 | Tillotts Pharma Ag | Treatment of inflammatory bowel disease using oral dosage forms of omega-3 polyunsaturated acids |
| US5851548A (en) | 1995-06-07 | 1998-12-22 | Gen-Probe Incorporated | Liposomes containing cationic lipids and vitamin D |
| DK0836506T4 (da) | 1995-06-07 | 2012-01-30 | Ortho Mcneil Pharm Inc | Transdermalt plaster til indgivelse af 17-deacetyl norgestimat alene eller i kombination med et østrogen |
| US5711964A (en) | 1995-06-07 | 1998-01-27 | United States Of America | Method for the intracellular delivery of biomolecules using liposomes containing cationic lipids and vitamin D |
| US5952317A (en) | 1995-09-21 | 1999-09-14 | Wisconsin Alumni Research Foundation | Calcitriol derivatives and their uses |
| DE69606680T2 (de) | 1995-10-30 | 2000-08-17 | F. Hoffmann-La Roche Ag, Basel | 1-Alpha, 26-dihydroxy-D-homo-vitamin D3 |
| US5889028A (en) | 1996-02-09 | 1999-03-30 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
| US5716946A (en) | 1996-02-13 | 1998-02-10 | Wisconsin Alumni Research Foundation | Multiple sclerosis treatment |
| AU710931B2 (en) | 1996-02-28 | 1999-09-30 | Sumitomo Pharmaceuticals Company, Limited | Crystalline vitamin D derivative |
| GB9607034D0 (en) | 1996-04-03 | 1996-06-05 | Leo Pharm Prod Ltd | Chemical compounds |
| US5834016A (en) | 1996-04-04 | 1998-11-10 | Cilag Ag | Liposome-based topical vitamin D formulation |
| US5891865A (en) | 1996-10-04 | 1999-04-06 | Wisconsin Alumni Research Foundation | Treatment of arthritic disease induced by infectious agents |
| DE69834109T2 (de) * | 1997-05-16 | 2007-04-19 | Woman & Infants Hospital | 3-epi-vitamin d2 verbindungen und ihre anwendungen |
| NL1006072C2 (nl) | 1997-05-16 | 1998-11-17 | Jacobs Johannes J | Vergister voor het onder aërobe omstandigheden vergisten van dierlijke mest, inrichting en werkwijze voor het onder aërobe omstandigheden vergisten van dierlijke mest onder toepassing van een dergelijke vergister. |
| WO1998051678A1 (en) * | 1997-05-16 | 1998-11-19 | Women & Infants Hospital | CYCLIC ETHER VITAMIN D3 COMPOUNDS, 1α (OH) 3-EPI-VITAMIN D3 COMPOUNDS AND USES THEREOF |
| US5936105A (en) | 1997-06-13 | 1999-08-10 | Tetrionics, Inc. | 14-EPI-19-nor-vitamin D compounds and methods |
| US6214373B1 (en) * | 1999-10-07 | 2001-04-10 | Snowden-Sutton Associates, Inc. | Nutritional composition for treating inflammatory bowel diseases |
| US20030188756A1 (en) * | 2002-08-19 | 2003-10-09 | Cantorna Margherita T | Treatment of inflammatory bowel disease with vitamin d compounds |
| MXPA03001969A (es) * | 2000-09-08 | 2003-06-24 | Wisconsin Alumni Res Found | 1-alfa-hidroxi-2-metilen-19-nor-homopregnacalciferol y sus aplicaciones terapeuticas. |
-
1999
- 1999-12-21 US US09/469,985 patent/US6358939B1/en not_active Expired - Fee Related
-
2000
- 2000-12-21 WO PCT/US2000/034913 patent/WO2001046132A1/en not_active Ceased
- 2000-12-21 AU AU22878/01A patent/AU781113B2/en not_active Ceased
- 2000-12-21 KR KR1020027008018A patent/KR100660508B1/ko not_active Expired - Fee Related
- 2000-12-21 CA CA002395200A patent/CA2395200A1/en not_active Abandoned
- 2000-12-21 EP EP00986687A patent/EP1240136A4/en not_active Ceased
- 2000-12-21 MX MXPA02006257A patent/MXPA02006257A/es active IP Right Grant
- 2000-12-21 JP JP2001547043A patent/JP2004502638A/ja not_active Withdrawn
-
2001
- 2001-12-21 US US10/036,819 patent/US6858595B2/en not_active Expired - Fee Related
-
2002
- 2002-06-20 NO NO20022974A patent/NO326517B1/no not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996030326A1 (en) * | 1995-03-30 | 1996-10-03 | The Trustees Of The University Of Pennsylvania | Differentiating agents for the treatment of inflammatory intestinal diseases |
| EP0927721A1 (de) * | 1997-12-17 | 1999-07-07 | Schering Aktiengesellschaft | Neue Vitamin D-Derivate mit Phosphoratomen in den Seitenketten, Zwischenprodukte bei ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| AU4510001A (en) * | 1999-12-02 | 2001-06-18 | Penn State Research Foundation, The | Treatment of inflammatory bowel disease with vitamin d compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| US6358939B1 (en) | 2002-03-19 |
| KR100660508B1 (ko) | 2006-12-22 |
| JP2004502638A (ja) | 2004-01-29 |
| NO20022974L (no) | 2002-08-20 |
| EP1240136A1 (en) | 2002-09-18 |
| US20020128241A1 (en) | 2002-09-12 |
| NO20022974D0 (no) | 2002-06-20 |
| KR20020084075A (ko) | 2002-11-04 |
| AU2287801A (en) | 2001-07-03 |
| WO2001046132A1 (en) | 2001-06-28 |
| EP1240136A4 (en) | 2004-05-26 |
| NO326517B1 (no) | 2008-12-22 |
| MXPA02006257A (es) | 2004-12-06 |
| CA2395200A1 (en) | 2001-06-28 |
| US6858595B2 (en) | 2005-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: WISCONSIN ALUMNI RESEARCH FOUNDATION Free format text: THE FORMER OWNER WAS: NORTHERN LIGHTS PHARMACEUTICALS, LLC |