JP2004502421A5 - - Google Patents
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- Publication number
- JP2004502421A5 JP2004502421A5 JP2002507891A JP2002507891A JP2004502421A5 JP 2004502421 A5 JP2004502421 A5 JP 2004502421A5 JP 2002507891 A JP2002507891 A JP 2002507891A JP 2002507891 A JP2002507891 A JP 2002507891A JP 2004502421 A5 JP2004502421 A5 JP 2004502421A5
- Authority
- JP
- Japan
- Prior art keywords
- ser
- amino acid
- acid sequence
- gly
- asp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 18
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims description 12
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims description 12
- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 2
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 1
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 101100504320 Caenorhabditis elegans mcp-1 gene Proteins 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0016138.0A GB0016138D0 (en) | 2000-06-30 | 2000-06-30 | Organic compounds |
| PCT/EP2001/007468 WO2002002640A2 (en) | 2000-06-30 | 2001-06-29 | Antibodies to human mcp-1 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006314441A Division JP2007054079A (ja) | 2000-06-30 | 2006-11-21 | ヒトｍｃｐ−１に対する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004502421A JP2004502421A (ja) | 2004-01-29 |
| JP2004502421A5 true JP2004502421A5 (enExample) | 2007-03-01 |
| JP3920215B2 JP3920215B2 (ja) | 2007-05-30 |
Family
ID=9894801
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002507891A Expired - Fee Related JP3920215B2 (ja) | 2000-06-30 | 2001-06-29 | ヒトｍｃｐ−１に対する抗体 |
| JP2006314441A Pending JP2007054079A (ja) | 2000-06-30 | 2006-11-21 | ヒトｍｃｐ−１に対する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006314441A Pending JP2007054079A (ja) | 2000-06-30 | 2006-11-21 | ヒトｍｃｐ−１に対する抗体 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20040047860A1 (enExample) |
| EP (1) | EP1299421B1 (enExample) |
| JP (2) | JP3920215B2 (enExample) |
| KR (1) | KR100603899B1 (enExample) |
| CN (1) | CN100486996C (enExample) |
| AR (1) | AR046379A1 (enExample) |
| AT (1) | ATE426616T1 (enExample) |
| AU (2) | AU2001283903B2 (enExample) |
| BR (1) | BR0112086A (enExample) |
| CA (1) | CA2412775A1 (enExample) |
| CZ (1) | CZ20024256A3 (enExample) |
| DE (1) | DE60138102D1 (enExample) |
| EC (1) | ECSP024402A (enExample) |
| ES (1) | ES2322643T3 (enExample) |
| GB (1) | GB0016138D0 (enExample) |
| HU (1) | HUP0301477A3 (enExample) |
| IL (1) | IL153721A0 (enExample) |
| MX (1) | MXPA03000201A (enExample) |
| NO (1) | NO20026063L (enExample) |
| NZ (1) | NZ523195A (enExample) |
| PE (1) | PE20020125A1 (enExample) |
| PL (1) | PL207133B1 (enExample) |
| PT (1) | PT1299421E (enExample) |
| RU (1) | RU2314316C2 (enExample) |
| SK (1) | SK18122002A3 (enExample) |
| WO (1) | WO2002002640A2 (enExample) |
| ZA (1) | ZA200300199B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL151499A0 (en) | 2000-03-03 | 2003-04-10 | Cambridge Antibody Tech | Human antibodies against eotaxin and their use |
| US6946546B2 (en) | 2000-03-06 | 2005-09-20 | Cambridge Antibody Technology Limited | Human antibodies against eotaxin |
| WO2003048083A2 (en) | 2001-11-30 | 2003-06-12 | Biogen Idec Ma Inc. | Antibodies against monocyte chemotactic proteins |
| WO2004016769A2 (en) * | 2002-08-19 | 2004-02-26 | Abgenix, Inc. | Antibodies directed to monocyte chemo-attractant protein-1 (mcp-1) and uses thereof |
| DK1538207T3 (da) * | 2002-09-12 | 2010-07-05 | Chemo Sero Therapeut Res Inst | Humant anti-human MCP-1-antistof og antistoffragment deraf |
| US20050232923A1 (en) * | 2003-11-05 | 2005-10-20 | Li Yan | Methods and compositions for treating MCP-1 related pathologies |
| WO2005108431A1 (en) * | 2004-05-04 | 2005-11-17 | University Of Kentucky Research Foundation | Methods and compositions for the treatment of ocular neovascularization |
| GB0412400D0 (en) * | 2004-06-03 | 2004-07-07 | Univ Newcastle | Treatment of inflammatory conditions |
| US8114964B2 (en) | 2005-05-19 | 2012-02-14 | Centocor, Inc. | Anti-MCP-1 antibodies, compositions, methods and uses |
| PE20110071A1 (es) * | 2005-05-19 | 2011-01-31 | Centocor Inc | Anticuerpos anti-mcp-1, composiciones y metodos |
| EP2041568A4 (en) * | 2006-06-15 | 2009-08-12 | CCR2 ANTAGONISTS FOR CHRONIC BREATHING REACTIONS IN ORGAN TRANSPLANTATIONS | |
| ES2434039T3 (es) * | 2006-07-24 | 2013-12-13 | Yeda Research And Development Co. Ltd. | Composiciones farmacéuticas que comprenden ccl2 para su uso en el tratamiento de la inflamación |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| US20100074886A1 (en) * | 2006-10-05 | 2010-03-25 | Anuk Das | Ccr2 antagonists for treatment of fibrosis |
| AU2007337983A1 (en) * | 2006-12-22 | 2008-07-03 | Ablynx N.V. | Anti-chemokine (CCL2, CCL3, CCL5, CXCL11, CXCL12) single-domain antibodies |
| AU2008269954A1 (en) * | 2007-06-29 | 2009-01-08 | Centocor Ortho Biotech Inc. | Anti- MCP-1 antibodies, compositions, methods and uses |
| US20090170770A1 (en) * | 2007-11-06 | 2009-07-02 | Ali Hafezi-Moghadam | Methods and compositions for treating conditions associated with angiogenesis using a vascular adhesion protein-1 (vap 1) inhibitor |
| CN102239180B (zh) | 2008-08-18 | 2014-12-31 | 辉瑞大药厂 | 抗ccr2抗体 |
| NZ591187A (en) | 2008-08-20 | 2012-07-27 | Probiodrug Ag | Antibodies directed against pyroglutamate monocyte chemoattractant protein-1 (mcp-1 n1pe) |
| SG176691A1 (en) * | 2009-06-25 | 2012-01-30 | Hutchinson Fred Cancer Res | Method of measuring adaptive immunity |
| CN105051065A (zh) | 2012-06-22 | 2015-11-11 | 索伦托治疗有限公司 | 与ccr2结合的抗原结合蛋白 |
| BR112017002980A2 (pt) * | 2014-08-15 | 2017-12-12 | Pixarbio Corp | composição para inibir a inflamação em um indivíduo com um dano na coluna vertebral, método para tratar inflamação em um indivíduo tendo um dano na coluna vertebral e kit para produzir a composição |
| CN104198727A (zh) * | 2014-08-22 | 2014-12-10 | 广西南宁隆吉维特生物科技有限公司 | 人血清ccl2酶联免疫检测试剂盒及其制备和使用方法 |
| EP3613435A1 (en) | 2015-01-28 | 2020-02-26 | Universite De Bordeaux | Chemokine receptor cxcr4 inhibitors for treating and/or preventing chronic obstructive pulmonary disease |
| CN105695495B (zh) * | 2015-12-07 | 2020-02-18 | 中国石油大学(华东) | 一种高活性人趋化因子的制备方法及用途 |
| EP3551034A1 (en) | 2016-12-07 | 2019-10-16 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| WO2018112264A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| CN108048408B (zh) * | 2018-01-26 | 2020-02-07 | 扬州大学 | 牛单核细胞趋化蛋白-1杂交瘤细胞株、其分泌的单克隆抗体及应用 |
| AU2019383976B2 (en) | 2018-11-19 | 2025-07-03 | Bt Bidco, Inc. | Methods and devices for treating a disease with biotherapeutics |
| KR20220019670A (ko) | 2019-04-17 | 2022-02-17 | 고쿠리츠다이가쿠호진 히로시마다이가쿠 | Il-6 저해제 및 ccr2 저해제를 조합하여 투여하는 것을 특징으로 하는 비뇨기암의 치료제 |
| US11707610B2 (en) | 2019-12-13 | 2023-07-25 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| WO2021122733A1 (en) * | 2019-12-18 | 2021-06-24 | F. Hoffmann-La Roche Ag | Bispecific anti-ccl2 antibodies |
| CN112358547A (zh) * | 2020-09-30 | 2021-02-12 | 浙江大学 | 抗人cxcl-2单克隆抗体3-d3及其编码基因和应用 |
| CN119684454B (zh) * | 2024-12-25 | 2025-09-12 | 武汉爱博泰克生物科技有限公司 | 针对人mcp-1蛋白的抗体、抗体对和试剂盒及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9019552D0 (en) * | 1990-09-07 | 1990-10-24 | Unilever Plc | Specific binding agents |
| GB9115364D0 (en) * | 1991-07-16 | 1991-08-28 | Wellcome Found | Antibody |
| CA2572289A1 (en) * | 2004-06-30 | 2006-08-17 | Centocor, Inc. | Anti-mcp-1 antibodies, compositions, methods and uses |
-
2000
- 2000-06-30 GB GBGB0016138.0A patent/GB0016138D0/en not_active Ceased
-
2001
- 2001-06-28 AR ARP010103086A patent/AR046379A1/es not_active Application Discontinuation
- 2001-06-28 PE PE2001000649A patent/PE20020125A1/es not_active Application Discontinuation
- 2001-06-29 ES ES01962800T patent/ES2322643T3/es not_active Expired - Lifetime
- 2001-06-29 CN CNB018120652A patent/CN100486996C/zh not_active Expired - Fee Related
- 2001-06-29 PT PT01962800T patent/PT1299421E/pt unknown
- 2001-06-29 AT AT01962800T patent/ATE426616T1/de not_active IP Right Cessation
- 2001-06-29 HU HU0301477A patent/HUP0301477A3/hu unknown
- 2001-06-29 MX MXPA03000201A patent/MXPA03000201A/es active IP Right Grant
- 2001-06-29 JP JP2002507891A patent/JP3920215B2/ja not_active Expired - Fee Related
- 2001-06-29 WO PCT/EP2001/007468 patent/WO2002002640A2/en not_active Ceased
- 2001-06-29 NZ NZ523195A patent/NZ523195A/en unknown
- 2001-06-29 IL IL15372101A patent/IL153721A0/xx unknown
- 2001-06-29 DE DE60138102T patent/DE60138102D1/de not_active Expired - Lifetime
- 2001-06-29 CA CA002412775A patent/CA2412775A1/en not_active Abandoned
- 2001-06-29 CZ CZ20024256A patent/CZ20024256A3/cs unknown
- 2001-06-29 SK SK1812-2002A patent/SK18122002A3/sk unknown
- 2001-06-29 RU RU2003100512/13A patent/RU2314316C2/ru not_active IP Right Cessation
- 2001-06-29 EP EP01962800A patent/EP1299421B1/en not_active Expired - Lifetime
- 2001-06-29 AU AU2001283903A patent/AU2001283903B2/en not_active Ceased
- 2001-06-29 PL PL359854A patent/PL207133B1/pl not_active IP Right Cessation
- 2001-06-29 KR KR1020027017405A patent/KR100603899B1/ko not_active Expired - Fee Related
- 2001-06-29 AU AU8390301A patent/AU8390301A/xx active Pending
- 2001-06-29 US US10/312,022 patent/US20040047860A1/en not_active Abandoned
- 2001-06-29 BR BR0112086-7A patent/BR0112086A/pt not_active IP Right Cessation
-
2002
- 2002-12-17 NO NO20026063A patent/NO20026063L/no not_active Application Discontinuation
- 2002-12-24 EC EC2002004402A patent/ECSP024402A/es unknown
-
2003
- 2003-01-08 ZA ZA200300199A patent/ZA200300199B/en unknown
-
2006
- 2006-11-21 JP JP2006314441A patent/JP2007054079A/ja active Pending