JP2004501639A5 - - Google Patents
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- JP2004501639A5 JP2004501639A5 JP2002506184A JP2002506184A JP2004501639A5 JP 2004501639 A5 JP2004501639 A5 JP 2004501639A5 JP 2002506184 A JP2002506184 A JP 2002506184A JP 2002506184 A JP2002506184 A JP 2002506184A JP 2004501639 A5 JP2004501639 A5 JP 2004501639A5
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- JP
- Japan
- Prior art keywords
- virus
- gene
- order
- replication
- wild
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000700605 Viruses Species 0.000 description 72
- 108090000623 proteins and genes Proteins 0.000 description 68
- 238000000034 method Methods 0.000 description 35
- 230000010076 replication Effects 0.000 description 23
- 230000002238 attenuated effect Effects 0.000 description 11
- 230000028993 immune response Effects 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 7
- 108700005077 Viral Genes Proteins 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 230000002829 reductive effect Effects 0.000 description 7
- 241000711975 Vesicular stomatitis virus Species 0.000 description 6
- 239000000427 antigen Substances 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 230000001939 inductive effect Effects 0.000 description 6
- 101150082239 G gene Proteins 0.000 description 5
- 230000000670 limiting effect Effects 0.000 description 5
- 229960005486 vaccine Drugs 0.000 description 5
- 208000010201 Exanthema Diseases 0.000 description 4
- 101710141454 Nucleoprotein Proteins 0.000 description 4
- 208000002606 Paramyxoviridae Infections Diseases 0.000 description 4
- 241000711798 Rabies lyssavirus Species 0.000 description 4
- 201000005884 exanthem Diseases 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 206010037844 rash Diseases 0.000 description 4
- 230000000241 respiratory effect Effects 0.000 description 4
- 241000712079 Measles morbillivirus Species 0.000 description 3
- 241000711386 Mumps virus Species 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000011081 inoculation Methods 0.000 description 3
- 108020004999 messenger RNA Proteins 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 101710154606 Hemagglutinin Proteins 0.000 description 2
- 102000012750 Membrane Glycoproteins Human genes 0.000 description 2
- 108010090054 Membrane Glycoproteins Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 108010006232 Neuraminidase Proteins 0.000 description 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 2
- 101710176177 Protein A56 Proteins 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 239000000185 hemagglutinin Substances 0.000 description 2
- 230000028996 humoral immune response Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000005945 translocation Effects 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 241001115402 Ebolavirus Species 0.000 description 1
- 241000711950 Filoviridae Species 0.000 description 1
- 241001115401 Marburgvirus Species 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 101150084044 P gene Proteins 0.000 description 1
- 230000006819 RNA synthesis Effects 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000009291 secondary effect Effects 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/602,288 US6596529B1 (en) | 1997-05-02 | 2000-06-23 | Manipulation of negative stranded RNA viruses by rearrangement of their genes and uses thereof |
| PCT/US2001/019901 WO2002000868A1 (en) | 2000-06-23 | 2001-06-22 | Manipulation of negative stranded rna viruses by rearrangement of their genes and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004501639A JP2004501639A (ja) | 2004-01-22 |
| JP2004501639A5 true JP2004501639A5 (enExample) | 2008-08-07 |
Family
ID=24410755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002506184A Pending JP2004501639A (ja) | 2000-06-23 | 2001-06-22 | 遺伝子再編成によるマイナス鎖ｒｎａウイルスの操作及び当該ウイルスの使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6596529B1 (enExample) |
| EP (1) | EP1292329A4 (enExample) |
| JP (1) | JP2004501639A (enExample) |
| KR (2) | KR20030071482A (enExample) |
| CN (1) | CN1441842A (enExample) |
| AU (1) | AU2001270056A1 (enExample) |
| BR (1) | BR0112390A (enExample) |
| CA (1) | CA2413800A1 (enExample) |
| IL (1) | IL153388A0 (enExample) |
| MX (1) | MXPA03000061A (enExample) |
| WO (1) | WO2002000868A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003262824B2 (en) | 2002-08-22 | 2007-08-23 | Applied Biosystems Inc. | Method for characterizing biomolecules utilizing a result driven strategy |
| WO2004113517A2 (en) | 2003-06-09 | 2004-12-29 | Wyeth | IMPROVED METHOD FOR THE RECOVERY OF NON-SEGMENTED, NEGATIVE-STRANDED RNA VIRUSES FROM cDNA |
| WO2005071092A1 (ja) * | 2004-01-22 | 2005-08-04 | Dnavec Research Inc. | サイトメガロウイルスエンハンサーおよびニワトリβ-アクチンプロモーターを含むハイブリッドプロモーターを利用したマイナス鎖RNAウイルスベクターの製造方法 |
| ES2535310T3 (es) | 2004-04-09 | 2015-05-07 | Wyeth Llc | Atenuación sinérgica del virus de la estomatitis vesicular, vectores del mismo y composiciones inmunogénicas del mismo |
| US7385186B2 (en) * | 2005-05-13 | 2008-06-10 | Applera Corporation | Methods of operating ion optics for mass spectrometry |
| US7351959B2 (en) * | 2005-05-13 | 2008-04-01 | Applera Corporation | Mass analyzer systems and methods for their operation |
| US7405396B2 (en) * | 2005-05-13 | 2008-07-29 | Applera Corporation | Sample handling mechanisms and methods for mass spectrometry |
| US20070185025A1 (en) * | 2005-09-11 | 2007-08-09 | The Trustees Of Columbia University In The City Of New York | Filoviral immunosuppressive peptides and uses thereof |
| CN105441483B (zh) * | 2005-10-14 | 2019-05-10 | 美国政府健康及人类服务部，疾病控制和预防中心 | 狂犬病病毒组合物和方法 |
| CN102026645B (zh) | 2006-09-15 | 2016-01-27 | 渥太华医院研究机构 | 溶瘤弹状病毒 |
| WO2008100292A2 (en) | 2006-10-16 | 2008-08-21 | Genelux Corporation | Modified vaccinia virus strains for use in diagnostic and therapeutic methods |
| WO2009012155A2 (en) * | 2007-07-13 | 2009-01-22 | Medimmune, Llc | Preparation of negative-stranded rna viruses by electroporation |
| JP5045416B2 (ja) * | 2007-12-17 | 2012-10-10 | 富士通株式会社 | 光導波路素子およびそれを用いた光学装置 |
| US20090175900A1 (en) * | 2007-12-20 | 2009-07-09 | Wyeth | Methods for packaging propagation-defective vesicular stomatitis virus vectors |
| US20090162321A1 (en) * | 2007-12-20 | 2009-06-25 | Wyeth | Methods for packaging propagation-defective vesicular stomatitis virus vectors using a stable cell line that expresses g protein |
| AU2008340319A1 (en) * | 2007-12-21 | 2009-07-02 | Wyeth Llc | Genetically modified attenuated vesicular stomatitis virus, compositions and methods of use thereof |
| US9610346B2 (en) | 2012-03-23 | 2017-04-04 | International Aids Vaccine Initiative | Recombinant viral vectors |
| US10953083B2 (en) | 2015-12-11 | 2021-03-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant respiratory syncytial virus strains comprising NS1 and NS2 gene shifts |
| CN107557340A (zh) * | 2017-09-26 | 2018-01-09 | 南京普菲科医药科技有限公司 | 一种可诱导性拯救弹状病毒的细胞系及其构建方法与应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6923971B2 (en) * | 1995-09-27 | 2005-08-02 | The United States Of America As Represented By The Department Of Health & Human Services | Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes |
| CA2230033C (en) * | 1995-09-27 | 2010-01-26 | Peter L. Collins | Production of infectious respiratory syncytial virus from cloned nucleotide sequences |
| EP0912724B1 (en) * | 1996-07-15 | 2009-12-09 | The Government of The United States of America, as represented by The Department of Health and Human Services | Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences |
| EP1005535B1 (en) * | 1997-05-02 | 2015-11-11 | The Uab Research Foundation | Attenuation of negative stranded rna viruses by rearrangement of their genes and uses thereof |
-
2000
- 2000-06-23 US US09/602,288 patent/US6596529B1/en not_active Expired - Lifetime
-
2001
- 2001-06-22 KR KR1020027017583A patent/KR20030071482A/ko not_active Ceased
- 2001-06-22 AU AU2001270056A patent/AU2001270056A1/en not_active Abandoned
- 2001-06-22 KR KR1020087028976A patent/KR20080106485A/ko not_active Ceased
- 2001-06-22 JP JP2002506184A patent/JP2004501639A/ja active Pending
- 2001-06-22 MX MXPA03000061A patent/MXPA03000061A/es active IP Right Grant
- 2001-06-22 CA CA002413800A patent/CA2413800A1/en not_active Abandoned
- 2001-06-22 EP EP01948594A patent/EP1292329A4/en not_active Withdrawn
- 2001-06-22 WO PCT/US2001/019901 patent/WO2002000868A1/en not_active Ceased
- 2001-06-22 CN CN01811575A patent/CN1441842A/zh active Pending
- 2001-06-22 BR BR0112390-4A patent/BR0112390A/pt not_active IP Right Cessation
- 2001-06-23 IL IL15338801A patent/IL153388A0/xx unknown
-
2002
- 2002-07-18 US US10/198,371 patent/US6777220B2/en not_active Expired - Fee Related
-
2004
- 2004-06-21 US US10/872,706 patent/US20040235135A1/en not_active Abandoned
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