JP2004500390A5 - - Google Patents
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- Publication number
- JP2004500390A5 JP2004500390A5 JP2001564775A JP2001564775A JP2004500390A5 JP 2004500390 A5 JP2004500390 A5 JP 2004500390A5 JP 2001564775 A JP2001564775 A JP 2001564775A JP 2001564775 A JP2001564775 A JP 2001564775A JP 2004500390 A5 JP2004500390 A5 JP 2004500390A5
- Authority
- JP
- Japan
- Prior art keywords
- chemotherapeutic
- administered
- herbal preparation
- combination according
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000973 chemotherapeutic effect Effects 0.000 description 14
- 238000009472 formulation Methods 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 5
- 239000000890 drug combination Substances 0.000 description 5
- 241000202807 Glycyrrhiza Species 0.000 description 3
- 241000736199 Paeonia Species 0.000 description 3
- 241000207929 Scutellaria Species 0.000 description 3
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 description 3
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 description 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 2
- 229960002949 fluorouracil Drugs 0.000 description 2
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 description 2
- 235000008191 folinic acid Nutrition 0.000 description 2
- 239000011672 folinic acid Substances 0.000 description 2
- 229960001691 leucovorin Drugs 0.000 description 2
- RXRGZNYSEHTMHC-NKWVEPMBSA-N 4-amino-1-[(2r,4s)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@H](CO)OC1 RXRGZNYSEHTMHC-NKWVEPMBSA-N 0.000 description 1
- 240000008917 Glycyrrhiza uralensis Species 0.000 description 1
- 235000000554 Glycyrrhiza uralensis Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 244000236658 Paeonia lactiflora Species 0.000 description 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 1
- 240000004534 Scutellaria baicalensis Species 0.000 description 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 1
- 229960004768 irinotecan Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52205500A | 2000-03-09 | 2000-03-09 | |
| US09/522,055 | 2000-03-09 | ||
| PCT/US2001/007353 WO2001066123A2 (en) | 2000-03-09 | 2001-03-08 | Composition consisting of phy906 and chemotherapeutic agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012095816A Division JP2012167101A (ja) | 2000-03-09 | 2012-04-19 | 薬草組成物ｐｈｙ９０６および化学療法におけるその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004500390A JP2004500390A (ja) | 2004-01-08 |
| JP2004500390A5 true JP2004500390A5 (enExample) | 2010-05-27 |
| JP5064630B2 JP5064630B2 (ja) | 2012-10-31 |
Family
ID=24079273
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001564775A Expired - Lifetime JP5064630B2 (ja) | 2000-03-09 | 2001-03-08 | 薬草組成物ｐｈｙ９０６および化学療法におけるその使用 |
| JP2012095816A Pending JP2012167101A (ja) | 2000-03-09 | 2012-04-19 | 薬草組成物ｐｈｙ９０６および化学療法におけるその使用 |
| JP2014136932A Pending JP2014208684A (ja) | 2000-03-09 | 2014-07-02 | 薬草組成物ｐｈｙ９０６および化学療法におけるその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012095816A Pending JP2012167101A (ja) | 2000-03-09 | 2012-04-19 | 薬草組成物ｐｈｙ９０６および化学療法におけるその使用 |
| JP2014136932A Pending JP2014208684A (ja) | 2000-03-09 | 2014-07-02 | 薬草組成物ｐｈｙ９０６および化学療法におけるその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7025993B2 (enExample) |
| EP (1) | EP1401458B1 (enExample) |
| JP (3) | JP5064630B2 (enExample) |
| KR (1) | KR100840213B1 (enExample) |
| CN (1) | CN100490845C (enExample) |
| AT (1) | ATE494899T1 (enExample) |
| AU (1) | AU4550801A (enExample) |
| CA (1) | CA2402466C (enExample) |
| DE (1) | DE60143857D1 (enExample) |
| DK (1) | DK1401458T3 (enExample) |
| ES (1) | ES2358639T3 (enExample) |
| TW (1) | TWI324069B (enExample) |
| WO (1) | WO2001066123A2 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7534455B2 (en) * | 2000-03-09 | 2009-05-19 | Yale University | Herbal composition PHY906 and its use in chemotherapy |
| US8871279B2 (en) | 2000-03-09 | 2014-10-28 | Yale University | Use of the combination of PHY906 and a tyrosine kinase inhibitor as a cancer treatment regimen |
| AU2003217982A1 (en) * | 2002-03-06 | 2003-09-22 | The Medical Research And Education Trust | Botanical extract compositions with anti-cancer or phytoestrogenic activity comprising wogonin, isoliquiritigenin and/or coumestrol |
| RU2209062C1 (ru) * | 2002-03-19 | 2003-07-27 | Институт физиологии им. И.П.Павлова РАН | Вещество, обладающее седативным действием |
| EP1714653B1 (en) * | 2004-02-13 | 2010-11-24 | Kabushiki Kaisha Yakult Honsha | Aqueous solution preparation containing a camptothecin |
| CN101730535A (zh) | 2007-02-15 | 2010-06-09 | 耶鲁大学 | 草药组合物phy906及其在化疗中的用途 |
| CN101918017B (zh) * | 2007-10-25 | 2013-07-31 | 植物药学公司 | Phy906用于治疗炎性肠病和/或肠易激综合征的用途 |
| US9778276B2 (en) * | 2007-11-20 | 2017-10-03 | Hewlett-Packard Development Company, L.P. | Liquid handling device |
| KR100915457B1 (ko) * | 2008-01-31 | 2009-09-04 | 세종대학교산학협력단 | 한국산 겨우살이 추출물이 함유된 미세캡슐을 유효성분으로포함하는 기능성 식품 |
| TWI366466B (en) * | 2008-05-08 | 2012-06-21 | Ind Tech Res Inst | Herbal extracts capable of inducing immune cells to produce interferon and activating toll-like receptors and the preparation thereof |
| EP2341918B1 (en) | 2008-09-25 | 2018-02-28 | Life Biotech Medical Research Ltd | Herbal formulations |
| KR101138461B1 (ko) * | 2010-02-12 | 2012-04-26 | 한국생명공학연구원 | 감초 추출물을 포함하는 로타바이러스 감염의 예방 또는 치료용 조성물 |
| US8734859B1 (en) | 2010-11-13 | 2014-05-27 | Sirbal Ltd. | Molecular combinations for cancer or other disease treatment |
| US8541382B2 (en) | 2010-11-13 | 2013-09-24 | Sirbal Ltd. | Cardiac glycoside analogs in combination with emodin for cancer therapy |
| US9095606B1 (en) | 2010-11-13 | 2015-08-04 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| US9066974B1 (en) | 2010-11-13 | 2015-06-30 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| US20170049687A1 (en) | 2015-07-29 | 2017-02-23 | Sirbal Ltd. | Herbal Combinations For Treating Scalp Conditions |
| CN102716421A (zh) * | 2012-06-21 | 2012-10-10 | 中国人民解放军第三军医大学第一附属医院 | 治疗扁平疣的中药口服液及其制备方法 |
| CN102698068B (zh) * | 2012-07-02 | 2013-07-24 | 张秀香 | 一种预防化疗所致口腔黏膜炎的口腔护理液制备方法 |
| KR101350143B1 (ko) * | 2013-05-30 | 2014-01-16 | 재단법인 통합의료진흥원 | 반하 및 황금 생약 추출물을 포함하는 항암제로 인한 부작용의 경감용 조성물 |
| WO2015082950A1 (en) | 2013-12-02 | 2015-06-11 | Sirbal Ltd. | Herbal combinations for treatment of a skin condition |
| CA2995575A1 (en) * | 2015-08-21 | 2017-03-02 | The Methodist Hospital | Compositions and methods for selectively inhibiting intestinal carboxylesterase 2 enzyme activity |
| CA3024301A1 (en) * | 2016-05-23 | 2017-11-30 | Yale University | Improved therapeutic index of anti-immune checkpoint inhibitors using combination therapy comprising a phy906 extract, a scutellaria baicalensis georgi (s) extract or a compound from such extracts |
| SG11201901540UA (en) * | 2016-06-22 | 2019-04-29 | Univ Yale | Mechanism based quality control for botanical medicine |
| KR102166949B1 (ko) | 2018-02-28 | 2020-10-16 | 중앙대학교 산학협력단 | 악액질 및 근손실 예방, 개선 또는 치료용 조성물 |
| US20190314431A1 (en) * | 2018-04-14 | 2019-10-17 | Jianyi Zhang | Method of Discovery of Potential Bioactive Compounds in Herbals by Regrouping after Chromatography |
| WO2019204471A1 (en) * | 2018-04-20 | 2019-10-24 | Yale University | Treatment of hepatitis c |
| WO2020255133A1 (en) * | 2019-06-18 | 2020-12-24 | The Cures Ltd. | Novel therapeutic preparations comprising scutellaria barbata |
| CN111011136B (zh) * | 2019-11-13 | 2021-11-02 | 云南中烟新材料科技有限公司 | 一种假秦艽的人工种植方法 |
| JP2023504202A (ja) * | 2019-12-09 | 2023-02-01 | イエール ユニバーシティ | がんの再発を予防するための組成物および方法 |
| TW202200183A (zh) * | 2020-03-30 | 2022-01-01 | 耶魯大學 | 治療炎性和纖維化疾病和病症的方法 |
| CN114642732A (zh) * | 2020-12-21 | 2022-06-21 | 苏州普瑞森生物科技有限公司 | 一种组合物及其在制备治疗肿瘤的药物中的应用 |
| TW202337484A (zh) * | 2022-03-01 | 2023-10-01 | 耶魯大學 | 用於調節t細胞之活化t細胞核因子（nfat）活性的組成物及方法 |
| CN116712507B (zh) * | 2023-08-10 | 2023-10-20 | 中国人民解放军总医院第六医学中心 | 一种辅助乳腺癌化疗的中药组合物及其制备方法、应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5936619A (ja) | 1982-08-23 | 1984-02-28 | Tsumura Juntendo Inc | 制癌補助剤 |
| JPS5936621A (ja) | 1982-08-25 | 1984-02-28 | Tsumura Juntendo Inc | 脂肪分解促進作用阻害剤 |
| DK0500739T3 (da) | 1989-11-03 | 1997-04-14 | Alexander S Sun | Urtebehandling af malignitet |
| US5665393A (en) | 1996-09-03 | 1997-09-09 | International Medical Research, Inc. | Herbal composition for treating prostate carcinoma |
| US6048847A (en) | 1997-09-30 | 2000-04-11 | Dabur Research Foundation | Use of betulinic acid and its derivatives for inhibiting cancer growth and a method of monitoring this |
-
2001
- 2001-03-08 TW TW090105449A patent/TWI324069B/zh not_active IP Right Cessation
- 2001-03-08 US US10/220,876 patent/US7025993B2/en not_active Expired - Lifetime
- 2001-03-08 AT AT01918429T patent/ATE494899T1/de not_active IP Right Cessation
- 2001-03-08 WO PCT/US2001/007353 patent/WO2001066123A2/en not_active Ceased
- 2001-03-08 CN CNB018081975A patent/CN100490845C/zh not_active Expired - Lifetime
- 2001-03-08 AU AU4550801A patent/AU4550801A/xx active Pending
- 2001-03-08 KR KR1020027011817A patent/KR100840213B1/ko not_active Expired - Lifetime
- 2001-03-08 DK DK01918429.0T patent/DK1401458T3/da active
- 2001-03-08 CA CA2402466A patent/CA2402466C/en not_active Expired - Lifetime
- 2001-03-08 EP EP01918429A patent/EP1401458B1/en not_active Expired - Lifetime
- 2001-03-08 JP JP2001564775A patent/JP5064630B2/ja not_active Expired - Lifetime
- 2001-03-08 ES ES01918429T patent/ES2358639T3/es not_active Expired - Lifetime
- 2001-03-08 DE DE60143857T patent/DE60143857D1/de not_active Expired - Lifetime
-
2012
- 2012-04-19 JP JP2012095816A patent/JP2012167101A/ja active Pending
-
2014
- 2014-07-02 JP JP2014136932A patent/JP2014208684A/ja active Pending
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