JP2004500320A5 - - Google Patents
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- JP2004500320A5 JP2004500320A5 JP2000593639A JP2000593639A JP2004500320A5 JP 2004500320 A5 JP2004500320 A5 JP 2004500320A5 JP 2000593639 A JP2000593639 A JP 2000593639A JP 2000593639 A JP2000593639 A JP 2000593639A JP 2004500320 A5 JP2004500320 A5 JP 2004500320A5
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- JP
- Japan
- Prior art keywords
- antibody
- tweak
- composition
- monoclonal antibody
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 208000026278 immune system disease Diseases 0.000 description 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 4
- 101000830598 Homo sapiens Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 4
- 102000058177 human TNFSF12 Human genes 0.000 description 4
- 210000004408 hybridoma Anatomy 0.000 description 4
- 201000006417 multiple sclerosis Diseases 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 108010001857 Cell Surface Receptors Proteins 0.000 description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 102000006240 membrane receptors Human genes 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 206010001935 American trypanosomiasis Diseases 0.000 description 1
- 208000023328 Basedow disease Diseases 0.000 description 1
- 208000024699 Chagas disease Diseases 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 206010014950 Eosinophilia Diseases 0.000 description 1
- 206010018378 Glomerulonephritis rapidly progressive Diseases 0.000 description 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 description 1
- 208000015023 Graves' disease Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 101000830601 Mus musculus Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 description 1
- 206010036030 Polyarthritis Diseases 0.000 description 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 description 1
- 101710097155 Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 description 1
- 102100024584 Tumor necrosis factor ligand superfamily member 12 Human genes 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 206010046851 Uveitis Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 1
- 201000005637 crescentic glomerulonephritis Diseases 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 208000007475 hemolytic anemia Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229940126619 mouse monoclonal antibody Drugs 0.000 description 1
- 208000030428 polyarticular arthritis Diseases 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11616899P | 1999-01-15 | 1999-01-15 | |
| US60/116,168 | 1999-01-15 | ||
| PCT/US2000/001044 WO2000042073A1 (en) | 1999-01-15 | 2000-01-14 | Antagonists of tweak and of tweak receptor and their use to treat immunological disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010188938A Division JP5592195B2 (ja) | 1999-01-15 | 2010-08-25 | Ｔｗｅａｋのアンタゴニストおよびｔｗｅａｋレセプターのアンタゴニスト、ならびに免疫学的障害を処置するためのこれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004500320A JP2004500320A (ja) | 2004-01-08 |
| JP2004500320A5 true JP2004500320A5 (cg-RX-API-DMAC10.html) | 2009-08-20 |
| JP5550799B2 JP5550799B2 (ja) | 2014-07-16 |
Family
ID=22365656
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000593639A Expired - Fee Related JP5550799B2 (ja) | 1999-01-15 | 2000-01-14 | Ｔｗｅａｋのアンタゴニストおよびｔｗｅａｋレセプターのアンタゴニスト、ならびに免疫学的障害を処置するためのこれらの使用 |
| JP2010188938A Expired - Lifetime JP5592195B2 (ja) | 1999-01-15 | 2010-08-25 | Ｔｗｅａｋのアンタゴニストおよびｔｗｅａｋレセプターのアンタゴニスト、ならびに免疫学的障害を処置するためのこれらの使用 |
| JP2013006243A Withdrawn JP2013075916A (ja) | 1999-01-15 | 2013-01-17 | Ｔｗｅａｋのアンタゴニストおよびｔｗｅａｋレセプターのアンタゴニスト、ならびに免疫学的障害を処置するためのこれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010188938A Expired - Lifetime JP5592195B2 (ja) | 1999-01-15 | 2010-08-25 | Ｔｗｅａｋのアンタゴニストおよびｔｗｅａｋレセプターのアンタゴニスト、ならびに免疫学的障害を処置するためのこれらの使用 |
| JP2013006243A Withdrawn JP2013075916A (ja) | 1999-01-15 | 2013-01-17 | Ｔｗｅａｋのアンタゴニストおよびｔｗｅａｋレセプターのアンタゴニスト、ならびに免疫学的障害を処置するためのこれらの使用 |
Country Status (21)
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7129061B1 (en) * | 1996-08-07 | 2006-10-31 | Biogen Idec Ma Inc. | Tumor necrosis factor related ligand |
| US7001992B2 (en) * | 1997-05-30 | 2006-02-21 | Human Genome Sciences, Inc. | Antibodies to secreted protein HEMCM42 |
| EA004590B1 (ru) * | 1999-01-15 | 2004-06-24 | Байоджен, Инк. | Способ блокировки развития, или снижения тяжести, или проявлений заболевания "трасплантат против хозяина" |
| US7495086B2 (en) | 1999-12-20 | 2009-02-24 | Immunex Corporation | TWEAK receptor |
| CA2394015C (en) | 1999-12-20 | 2013-11-05 | Immunex Corporation | Tweak receptor |
| US6727225B2 (en) | 1999-12-20 | 2004-04-27 | Immunex Corporation | TWEAK receptor |
| US6943146B2 (en) | 2000-05-08 | 2005-09-13 | Biogen Idec Ma Inc. | Method for promoting neovascularization |
| US7208151B2 (en) | 2001-09-12 | 2007-04-24 | Biogen Idec Ma Inc. | Tweak receptor agonists as anti-angiogenic agents |
| AU8901901A (en) * | 2000-09-14 | 2002-03-26 | Biogen Inc | Tweak receptor agonists as anti-angiogenic agents background |
| AU2003224950B2 (en) * | 2002-04-09 | 2006-09-14 | Biogen Ma Inc. | Methods for treating tweak-related conditions |
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| JP4823060B2 (ja) | 2003-07-24 | 2011-11-24 | アムジェン インコーポレイテッド | Ｔｗｅａｋ受容体のマルチマー化およびオリゴマー化可溶性断片に関する組成物および方法 |
| DK1667730T3 (da) * | 2003-08-20 | 2013-09-23 | Univ Miami | Sammensætninger og fremgangsmåder til behandling af inflammatorisk lungesygdom |
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| US7939490B2 (en) | 2004-12-13 | 2011-05-10 | University Of Maryland, Baltimore | TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
| WO2006088890A2 (en) * | 2005-02-17 | 2006-08-24 | Biogen Idec Ma Inc. | Treating stroke |
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| WO2006122187A2 (en) * | 2005-05-10 | 2006-11-16 | Biogen Idec Ma Inc. | Treating and evaluating inflammatory disorders |
| AU2013200995B2 (en) * | 2005-05-27 | 2016-08-04 | Biogen Ma Inc. | Tweak binding antibodies |
| WO2006130429A2 (en) * | 2005-05-27 | 2006-12-07 | Biogen Idec Ma Inc. | Treatment of cancer |
| WO2006130374A2 (en) * | 2005-05-27 | 2006-12-07 | Biogen Idec Ma Inc. | Tweak binding antibodies |
| WO2006138219A2 (en) | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
| DK1919954T3 (en) | 2005-08-30 | 2017-01-30 | Univ Miami | Immune modulating tumor necrosis factor receptor (TNFR25) - agonists, antagonists and immunotoxins |
| WO2008048924A2 (en) * | 2006-10-16 | 2008-04-24 | Biogen Idec Ma Inc. | Biomarkers of multiple sclerosis |
| EP2545938A1 (en) | 2007-08-03 | 2013-01-16 | Abbott Biotherapeutics Corp. | Therapeutic use of anti-tweak receptor antibodies |
| JP2011526794A (ja) * | 2008-07-02 | 2011-10-20 | エマージェント プロダクト デベロップメント シアトル， エルエルシー | ＴＧＦ−βアンタゴニスト多重標的結合性分子 |
| KR20110044991A (ko) * | 2008-07-02 | 2011-05-03 | 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 | ＴＮＦ-α 길항제 다-표적 결합 단백질 |
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| US8093006B2 (en) * | 2009-04-02 | 2012-01-10 | Hoffmann-La Roche Inc. | Antibodies against human tweak and uses thereof |
| ES2586837T3 (es) | 2009-08-03 | 2016-10-19 | University Of Miami | Método para la expansión in vivo de linfocitos T reguladores |
| WO2011097500A2 (en) | 2010-02-04 | 2011-08-11 | University Of Louisville Research Foundation, Inc. | The tweak/fn14 system regulates skeletal muscle atrophy and regeneration |
| BR112013007293A2 (pt) * | 2010-10-05 | 2016-06-14 | Hoffmann La Roche | anticorpos contra a tweak de seres humanos e suas utilizações |
| US8609818B2 (en) | 2011-03-10 | 2013-12-17 | Omeros Corporation | Generation of anti-FN14 monoclonal antibodies by ex-vivo accelerated antibody evolution |
| US9456755B2 (en) | 2011-04-29 | 2016-10-04 | Medtronic, Inc. | Method and device to monitor patients with kidney disease |
| KR101674784B1 (ko) | 2012-04-05 | 2016-11-09 | 에프. 호프만-라 로슈 아게 | 인간 tweak 및 인간 il17에 대한 이중특이적 항체 및 이의 용도 |
| EP2943253B1 (en) | 2013-01-09 | 2021-10-20 | University Of Miami | Compositions and methods for the regulation of t regulatory cells using tl1a-ig fusion protein and il-2 |
| US9797882B2 (en) | 2013-07-09 | 2017-10-24 | The Translational Genomics Research Institute | Method of screening for a compound for inhibitory activity of FN14-tweak interaction |
| EP3019874B1 (en) * | 2013-07-09 | 2019-08-21 | The Translational Genomics Research Institute | Compositions and methods of screening for compounds that modulate activity at a tweak binding site on a crd of fn14 |
| JP2017029001A (ja) * | 2013-12-19 | 2017-02-09 | 国立研究開発法人産業技術総合研究所 | プロテインｇの細胞膜外ドメインの新規な改変型タンパク質 |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| US9512229B2 (en) * | 2015-03-03 | 2016-12-06 | Kymab Limited | Synergistic combinations of OX40L antibodies for the treatment of GVHD |
| US9139653B1 (en) | 2015-04-30 | 2015-09-22 | Kymab Limited | Anti-human OX40L antibodies and methods of treatment |
| WO2017131972A1 (en) * | 2016-01-25 | 2017-08-03 | Oxytec Llc | Soil and water remediation method and apparatus for treatment of recalcitrant halogenated substances |
| KR102379464B1 (ko) | 2016-06-20 | 2022-03-29 | 키맵 리미티드 | 항-pd-l1 항체 |
| WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| US11661360B2 (en) | 2020-06-18 | 2023-05-30 | Wp&E Technologies And Solutions, Llc | System for removing per- and polyfluorinated alkyl substances from contaminated aqueous streams, via chemical aided filtration, and methods of use thereof |
| MX2024001877A (es) | 2021-08-10 | 2024-02-28 | Kymab Ltd | Tratamiento de dermatitis atopica. |
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| US7939490B2 (en) * | 2004-12-13 | 2011-05-10 | University Of Maryland, Baltimore | TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
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| AU2006214179A1 (en) * | 2005-02-17 | 2006-08-24 | Biogen Idec Ma Inc. | Treating neurological disorders |
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| MX2011007936A (es) | 2009-01-30 | 2011-08-17 | Biogen Idec Inc | Metodos para regeneracion de tejido pancreatico. |
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-
2000
- 2000-01-14 EA EA200100780A patent/EA004590B1/ru not_active IP Right Cessation
- 2000-01-14 HK HK02100180.8A patent/HK1038755A1/zh unknown
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- 2000-01-14 JP JP2000593639A patent/JP5550799B2/ja not_active Expired - Fee Related
- 2000-01-14 WO PCT/US2000/001044 patent/WO2000042073A1/en not_active Ceased
- 2000-01-14 TR TR2001/02021T patent/TR200102021T2/xx unknown
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- 2000-01-14 MX MXPA01007163A patent/MXPA01007163A/es unknown
- 2000-01-14 CZ CZ20012548A patent/CZ20012548A3/cs unknown
- 2000-01-14 CN CN00804735A patent/CN1387538A/zh active Pending
- 2000-01-14 NZ NZ529355A patent/NZ529355A/en not_active IP Right Cessation
- 2000-01-14 IL IL14400700A patent/IL144007A0/xx unknown
- 2000-01-14 BR BR0007556-6A patent/BR0007556A/pt not_active Application Discontinuation
- 2000-01-14 KR KR1020017008956A patent/KR20010102978A/ko not_active Withdrawn
- 2000-01-14 AU AU25077/00A patent/AU2507700A/en not_active Abandoned
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- 2000-01-14 EP EP00903307A patent/EP1141027A1/en not_active Withdrawn
- 2000-01-14 EE EEP200100372A patent/EE200100372A/xx unknown
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2001
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- 2001-07-05 NO NO20013340A patent/NO20013340L/no not_active Application Discontinuation
- 2001-07-13 US US09/905,810 patent/US20020015703A1/en not_active Abandoned
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- 2004-08-11 US US10/916,141 patent/US7169387B2/en not_active Expired - Lifetime
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2006
- 2006-10-04 US US11/542,745 patent/US7579001B2/en not_active Expired - Fee Related
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2009
- 2009-07-20 US US12/506,006 patent/US20100061985A1/en not_active Abandoned
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- 2010-08-25 JP JP2010188938A patent/JP5592195B2/ja not_active Expired - Lifetime
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