JP2004189733A5 - - Google Patents

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Publication number

JP2004189733A5

JP2004189733A5 JP2003393809A JP2003393809A JP2004189733A5 JP 2004189733 A5 JP2004189733 A5 JP 2004189733A5 JP 2003393809 A JP2003393809 A JP 2003393809A JP 2003393809 A JP2003393809 A JP 2003393809A JP 2004189733 A5 JP2004189733 A5 JP 2004189733A5

Authority

JP

Japan

Prior art keywords

group

carbon atoms

compound according

formula

compound

Prior art date

2003-11-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

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• 150000001875 compounds Chemical class 0.000 claims 15
• 125000000217 alkyl group Chemical group 0.000 claims 10
• 125000004432 carbon atom Chemical group C* 0.000 claims 10
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
• -1 methylpiperazinyl Chemical group 0.000 claims 7
• 229910052717 sulfur Inorganic materials 0.000 claims 6
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
• 229910052739 hydrogen Inorganic materials 0.000 claims 4
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
• 229910052760 oxygen Inorganic materials 0.000 claims 4
• 239000001301 oxygen Substances 0.000 claims 4
• 125000004076 pyridyl group Chemical group 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 239000011593 sulfur Substances 0.000 claims 4
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
• 230000003444 anaesthetic effect Effects 0.000 claims 3
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
• 235000019000 fluorine Nutrition 0.000 claims 3
• 125000001153 fluoro group Chemical group F* 0.000 claims 3
• 239000001257 hydrogen Substances 0.000 claims 3
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 3
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
• 125000004430 oxygen atom Chemical group O* 0.000 claims 3
• 125000004434 sulfur atom Chemical group 0.000 claims 3
• 125000005871 1,3-benzodioxolyl group Chemical group 0.000 claims 2
• 241000124008 Mammalia Species 0.000 claims 2
• 125000004122 cyclic group Chemical group 0.000 claims 2
• 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
• 125000005842 heteroatom Chemical group 0.000 claims 2
• 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
• 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims 2
• 229920006395 saturated elastomer Polymers 0.000 claims 2
• 239000000932 sedative agent Substances 0.000 claims 2
• 230000001624 sedative effect Effects 0.000 claims 2
• 125000003006 2-dimethylaminoethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 1
• 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 1
• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
• MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
• 125000003342 alkenyl group Chemical group 0.000 claims 1
• 125000003545 alkoxy group Chemical group 0.000 claims 1
• 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
• 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 229910052736 halogen Inorganic materials 0.000 claims 1
• 150000002367 halogens Chemical class 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
• GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical group C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 claims 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
• 125000001624 naphthyl group Chemical group 0.000 claims 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
• 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 1
• 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
• 0 *N(C(c1c2cc3Nc3c1)I)C2=* Chemical compound *N(C(c1c2cc3Nc3c1)I)C2=* 0.000 description 20
• BTQZKHUEUDPRST-UHFFFAOYSA-N Cc1cccc(F)c1 Chemical compound Cc1cccc(F)c1 BTQZKHUEUDPRST-UHFFFAOYSA-N 0.000 description 4
• INTDQTYSKQLTRJ-UHFFFAOYSA-N CCCCN(CCC)C(C=C)=O Chemical compound CCCCN(CCC)C(C=C)=O INTDQTYSKQLTRJ-UHFFFAOYSA-N 0.000 description 2