JP2004189733A5 - - Google Patents

Claims (15)

Formula (I)

[Wherein, R ₁ is two alkyl groups having 1 to 3 carbon atoms which may be the same or different, or, when R ₁ is two adjacent groups, they are bonded together to form sulfur, A saturated 5- or 6-membered cyclic group that may contain 1 or 2 heteroatoms selected from the group consisting of nitrogen and oxygen atoms may be formed:
X is an oxygen atom or a sulfur atom:
R ₂ is selected from the group consisting of optionally substituted phenyl, benzyl, pyridyl, pyridylmethyl, pyrimidinyl, cyclohexyl, methylpiperazinyl, indanyl, 1,3-benzodioxolyl and naphthyl; However, when R ₂ is a phenyl group, the 3-position and 4-position of the phenyl group are not simultaneously substituted with alkoxy:

Is a single bond or a double bond: and
L is - _{(CH 2)} n -H
(Where n is a number from 1 to 8);

(Wherein R ₃ is hydrogen, linear or branched alkyl having 1 to 8 carbon atoms, alkyl substituted with one or more fluorines having 1 to 3 carbon atoms, cyclopentyl, cyclohexyl, cycloheptyl, cyclohexylmethyl, Selected from the group consisting of benzyl, 2-pyridyl and 2-pyrimidinyl, n ′ is a number from 1 to 3);

Wherein W is an oxygen or sulfur atom, A is a linear or branched alkyl having 1 to 5 carbon atoms, 2-dimethylaminoethylamino, 2-thiazolylamino, 4-methylhomopiperazinyl, 4-piperidin Nopiperidino, dimethylaminoanilino, pyridylamino, piperidino, 4-ethoxycarbonylpiperidino, 4-carboxypiperidino, and formula (J)

(Wherein R ₃ is the same as above), n ″ is a number from 0 to 3);

(In the formula, E is hydrogen, linear or branched alkyl or alkenyl having 1 to 6 carbon atoms, alkyl substituted with one or more fluorines having 1 to 3 carbon atoms, 2-methoxyethyl, 2-methylthioethyl) , 2-dimethylaminoethyl, phenyl, pyridyl, benzyl, pyridylmethyl, cyclopentyl, cyclohexyl, tetrahydro -2 H - pyranyl, cyclohexylmethyl, 1-methyl-4-piperidyl, indanyl, 1,3-benzodioxolyl and 1 Selected from the group consisting of H -indolyl, wherein phenyl and pyridyl may be substituted with a group selected from the group consisting of halogen, methyl, methoxy, isopropyl and allyl, n ″ is a number from 0 to 3) ;
_{- (CH 2) n '-T} -G
(Wherein T is oxygen, sulfur or NH, G is hydrogen, linear or branched alkyl having 1 to 5 carbon atoms, alkyl substituted with one or more fluorines having 1 to 3 carbon atoms, 2-methoxy Selected from the group consisting of ethyl and alkylcarbonyl, n ′ is a number from 1 to 3);

(Wherein R ₃ is as defined above);

(Wherein E is as defined above);

(Wherein R ₃ is as defined above): or

(Wherein E is as defined above)]
Or a salt thereof. The compound according to claim 1, wherein R ₁ is two groups selected from the group consisting of methyl and ethyl. The compound according to claim 2, wherein R ₁ is 5,6-dimethyl. Formula (I-1):

[Wherein, M is a group which forms a saturated 5-membered or 6-membered cyclic group which may contain 1 or 2 heteroatoms selected from the group consisting of sulfur, nitrogen and oxygen atoms together with an isoindoline ring. ,
X, R ₂ and L are as defined in claim 1]
The compound or its salt of Claim 1 represented by these. M is —CH ₂ CH ₂ CH ₂ —.
—CH ₂ OCH ₂ — and —OCH ₂ O—
5. A compound according to claim 4 selected from the group consisting of And R ₂ is is an optionally substituted phenyl or pyridyl, A compound according to any claims 1-5. L is

[Wherein W is oxygen, A is a linear or branched alkyl having 1 to 5 carbon atoms, and formula (J)

(In the formula (J), R ₃ is selected from the group consisting of methyl or isopropyl)]
The compound according to any one of claims 1 to 6, wherein L is

Wherein E is selected from the group consisting of propyl, isobutyl and a phenyl group substituted with one or more methyl and / or methoxy.
The compound according to any one of claims 1 to 6, wherein L is — (CH ₂ ) ₂ —TG
[Wherein T is oxygen or sulfur, and G is an ethyl or propyl group]
The compound according to any one of claims 1 to 6, wherein The following formula:

Wherein R ₂ and L are selected from the following combinations

The compound of Claim 1 which is a compound represented by these, or its pharmaceutically acceptable salt. The following formula:

Wherein R ₂ and L are selected from the following combinations

The compound of Claim 1 which is a compound represented by these, or its pharmaceutically acceptable salt. The following formula

Or

[Wherein R ₂ is

(R ₄ is selected from the group consisting of an alkyl group having 1 to 5 carbon atoms, optionally substituted phenyl and benzyl), L is

Is]
The compound of Claim 1 represented by these.   An anesthetic / sedative composition for mammals comprising an anesthetic effective amount of the compound according to any one of claims 1 to 12 and a pharmaceutically acceptable carrier.   14. A composition according to claim 13, which is for intravenous administration.   Use of the compound according to any one of claims 1 to 12 for producing an anesthetic / sedative composition for mammals.