JP2003535824A5 - - Google Patents
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- JP2003535824A5 JP2003535824A5 JP2001579836A JP2001579836A JP2003535824A5 JP 2003535824 A5 JP2003535824 A5 JP 2003535824A5 JP 2001579836 A JP2001579836 A JP 2001579836A JP 2001579836 A JP2001579836 A JP 2001579836A JP 2003535824 A5 JP2003535824 A5 JP 2003535824A5
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56157200A | 2000-04-28 | 2000-04-28 | |
| US56157100A | 2000-04-28 | 2000-04-28 | |
| US56046500A | 2000-04-28 | 2000-04-28 | |
| US09/561,074 | 2000-04-28 | ||
| US09/561,074 US6861234B1 (en) | 2000-04-28 | 2000-04-28 | Method of epitope discovery |
| US09/561,572 | 2000-04-28 | ||
| US09/561,571 | 2000-04-28 | ||
| US09/560,465 | 2000-04-28 | ||
| PCT/US2001/013806 WO2001082963A2 (en) | 2000-04-28 | 2001-04-27 | Method of identifying and producing antigen peptides and use thereof as vaccines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003535824A JP2003535824A (ja) | 2003-12-02 |
| JP2003535824A5 true JP2003535824A5 (https=) | 2011-02-03 |
Family
ID=27504814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001579836A Pending JP2003535824A (ja) | 2000-04-28 | 2001-04-27 | 抗原提示細胞におけるエピトープ同調 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20070269464A1 (https=) |
| EP (4) | EP1276896B1 (https=) |
| JP (1) | JP2003535824A (https=) |
| CN (1) | CN1440462A (https=) |
| AT (1) | ATE474931T1 (https=) |
| AU (3) | AU5741001A (https=) |
| CA (1) | CA2405363A1 (https=) |
| DE (1) | DE60142615D1 (https=) |
| DK (1) | DK1276896T3 (https=) |
| ES (1) | ES2347762T3 (https=) |
| NZ (1) | NZ521715A (https=) |
| WO (1) | WO2001082963A2 (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| US6977074B2 (en) | 1997-07-10 | 2005-12-20 | Mannkind Corporation | Method of inducing a CTL response |
| US20030138808A1 (en) * | 1998-02-19 | 2003-07-24 | Simard John J.L. | Expression vectors encoding epitopes of target-associated antigens |
| US20030215425A1 (en) * | 2001-12-07 | 2003-11-20 | Simard John J. L. | Epitope synchronization in antigen presenting cells |
| US6773695B2 (en) * | 2000-10-05 | 2004-08-10 | Mannkind Corporation | Modulation of allergic response |
| JP2005505242A (ja) * | 2001-03-07 | 2005-02-24 | マンカインド コーポレイション | 癌用抗新生血管系調製物 |
| EP1595548A3 (en) * | 2001-03-07 | 2006-02-22 | Mannkind Corporation | Anti-neovasculature preparations for treating cancer |
| WO2003008537A2 (en) * | 2001-04-06 | 2003-01-30 | Mannkind Corporation | Epitope sequences |
| EP1752160A3 (en) | 2001-04-06 | 2007-05-30 | Mannkind Corporation | Epitope sequences |
| US8637305B2 (en) | 2001-11-07 | 2014-01-28 | Mannkind Corporation | Expression vectors encoding epitopes of target-associated antigens and methods for their design |
| AU2008229888B2 (en) * | 2001-11-07 | 2012-07-05 | Mannkind Corporation | Expression vectors encoding epitopes of target-associated antigens and methods for their design |
| WO2004022709A2 (en) * | 2002-09-06 | 2004-03-18 | Mannkind Corporation | Epitope sequences |
| US8343502B2 (en) | 2002-12-16 | 2013-01-01 | Globeimmune, Inc. | Yeast-based vaccines as immunotherapy |
| CN102370974B (zh) | 2002-12-16 | 2014-09-17 | 全球免疫股份有限公司 | 用于免疫治疗的基于酵母的疫苗 |
| DE602004031116D1 (de) | 2003-07-22 | 2011-03-03 | Ludwig Inst For Cancer Res New York | Von hla-klasse-ii-molekülen präsentierte ssx-2-peptide |
| AU2005321898B2 (en) * | 2004-12-29 | 2012-07-19 | Mannkind Corporation | Use of compositions comprising various tumor-associated antigens as anti-cancer vaccines |
| EP1838342A2 (en) * | 2004-12-29 | 2007-10-03 | Mannkind Corporation | Methods to bypass cd+4 cells in the induction of an immune response |
| MX2007015933A (es) * | 2005-06-17 | 2008-04-21 | Mannkind Corp | Metodos y composiciones para generar respuestas inmunes multivalentes contra espitopes dominantes y subdominantes, expresados en celulas cancerigenas y estromas tumorales. |
| CN101687020A (zh) * | 2005-06-17 | 2010-03-31 | 曼康公司 | 用于癌症的多价引发-和-增强免疫治疗剂 |
| ES2579762T3 (es) * | 2006-03-01 | 2016-08-16 | Janssen Pharmaceutica N.V. | Tratamiento del cáncer combinando agente linfo - reductor con CLTs y citoquinas |
| WO2007109321A2 (en) | 2006-03-20 | 2007-09-27 | The Regents Of The University Of California | Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting |
| WO2008008541A2 (en) * | 2006-07-14 | 2008-01-17 | Mannkind Corporation | Methods to elicit, enhance and sustain immune responses against mhc class-i restricted epitopes, for prophylactic or therapeutic purposes |
| CA2665816C (en) | 2006-09-21 | 2016-07-12 | Vaxil Biotherapeutics Ltd. | Antigen specific multi epitope vaccines |
| CN101246176B (zh) * | 2007-02-13 | 2013-06-05 | 许洋 | 鳞状细胞癌抗原阴性宫颈癌血清蛋白质检测的质谱试剂及其制备方法 |
| US8940298B2 (en) | 2007-09-04 | 2015-01-27 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection |
| EP2398504B1 (en) | 2009-02-17 | 2018-11-28 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| CA2782333C (en) | 2009-12-02 | 2019-06-04 | Imaginab, Inc. | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use |
| WO2012031076A1 (en) * | 2010-09-02 | 2012-03-08 | Ludwig Institute For Cancer Research, Ltd. | Recombinant trypanosoma cruzi cells useful as anti-cancer immune agents |
| CN103906531A (zh) * | 2011-05-26 | 2014-07-02 | 金纽斯生物科技投资有限责任公司 | 调节的免疫优势疗法 |
| EP2893061B1 (en) * | 2012-09-05 | 2019-05-22 | Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University | Methods for discovering therapeutic targets |
| AU2014228405B2 (en) * | 2013-03-15 | 2017-05-11 | The Trustees Of The University Of Pennsylvania | Cancer vaccines and methods of treatment using the same |
| JP2016535989A (ja) * | 2013-11-01 | 2016-11-24 | ファイザー・インク | 前立腺関連抗原を発現させるためのベクター |
| CN104761644A (zh) * | 2014-01-03 | 2015-07-08 | 百奇生物科技(苏州)有限公司 | 大肠杆菌表达的融合蛋白mbp-mart-1及其制备和应用 |
| CN103837688A (zh) * | 2014-03-27 | 2014-06-04 | 吉林农业大学 | 一种检测犬猫弓形虫抗体的间接elisa试剂盒 |
| DK3122375T3 (da) | 2014-03-28 | 2021-05-25 | Univ Washington Through Its Center For Commercialization | Vacciner mod bryst- og ovariecancer |
| WO2015149010A1 (en) * | 2014-03-28 | 2015-10-01 | University Of Washington Through Its Center For Commercialization | Methods of identifying antigens for vaccines |
| US9549914B2 (en) | 2014-04-03 | 2017-01-24 | The Johns Hopkins University | Treatment of human cytomegalovirus by modulating Wnt |
| EP3152235B1 (en) * | 2014-05-29 | 2021-08-25 | MacroGenics, Inc. | Tri-specific binding molecules and methods of use thereof |
| CN104142401B (zh) * | 2014-07-25 | 2016-04-20 | 北京普恩光德生物科技开发有限公司 | 膀胱肿瘤相关抗原检测试剂盒 |
| WO2016128060A1 (en) * | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
| CN105067731B (zh) * | 2015-06-05 | 2017-06-16 | 中国农业科学院兰州兽医研究所 | 一种弓形虫感染后血清中生物标记物的筛选方法及筛选出的生物标记物的应用 |
| WO2017027325A1 (en) | 2015-08-07 | 2017-02-16 | Imaginab, Inc. | Antigen binding constructs to target molecules |
| CN105175498A (zh) * | 2015-10-09 | 2015-12-23 | 深圳市康尔诺生物技术有限公司 | 一种宫颈癌相关的热休克蛋白复合物及其应用 |
| WO2017096247A1 (en) | 2015-12-04 | 2017-06-08 | Mayo Foundation For Medical Education And Research | Methods and vaccines for inducing immune responses to multiple different mhc molecules |
| HUE053674T2 (hu) * | 2015-12-23 | 2021-07-28 | Medigene Immunotherapies Gmbh | Antigén-specifikus TCR receptorok új generációja |
| WO2017194170A1 (en) * | 2016-05-13 | 2017-11-16 | Biontech Rna Pharmaceuticals Gmbh | Methods for predicting the usefulness of proteins or protein fragments for immunotherapy |
| WO2018005559A1 (en) * | 2016-06-27 | 2018-01-04 | Juno Therapeutics, Inc. | Method of identifying peptide epitopes, molecules that bind such epitopes and related uses |
| EP3573997A4 (en) * | 2017-01-24 | 2020-12-09 | Abexxa Biologics, Inc. | METHODS AND COMPOSITIONS INTENDED TO TARGE A COMPLEX INCLUDING A NON-CLASSIC HLA-I AND A NEO-ANTIGEN IN THE TREATMENT OF CANCER |
| WO2018147960A1 (en) | 2017-02-08 | 2018-08-16 | Imaginab, Inc. | Extension sequences for diabodies |
| WO2018217852A1 (en) * | 2017-05-23 | 2018-11-29 | Gettysburg College | Crispr based tool for characterizing bacterial serovar diversity |
| WO2018224166A1 (en) | 2017-06-09 | 2018-12-13 | Biontech Rna Pharmaceuticals Gmbh | Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy |
| CN112813099A (zh) * | 2019-11-15 | 2021-05-18 | 上海细胞治疗集团有限公司 | 一种在活化的t细胞中具有高活性的启动子 |
| CN115916248A (zh) * | 2020-03-03 | 2023-04-04 | 穆罕默德·塔雷克 | Custommune:设计个性化和群体靶向肽疫苗的网络工具 |
| WO2024050547A2 (en) * | 2022-09-02 | 2024-03-07 | Hunterian Medicine Llc | Compact bidirectional promoters for gene expression |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4439199A (en) * | 1980-02-19 | 1984-03-27 | Alza Corporation | Method for administering immunopotentiator |
| US4683199A (en) * | 1983-01-31 | 1987-07-28 | Sloan-Kettering Institute For Cancer Research | Interleukin-2 dependent cytotoxic T-cell clones |
| US5168062A (en) * | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US5093242A (en) * | 1986-10-02 | 1992-03-03 | Massachusetts Institute Of Technology | Methods of generating desired amino-terminal residues in proteins |
| US5196321A (en) * | 1986-10-02 | 1993-03-23 | Massachusetts Institute Of Technology | Methods for in vitro cleavage of ubiquitin fusion proteins |
| US5132213A (en) * | 1986-10-02 | 1992-07-21 | Massachusetts Institute Of Technology | Method for producing proteins and polypeptides using ubiquitin fusions |
| US4937190A (en) * | 1987-10-15 | 1990-06-26 | Wisconsin Alumni Research Foundation | Translation enhancer |
| NZ227934A (en) * | 1988-02-12 | 1991-06-25 | Commw Scient Ind Res Org | Fowlpox virus vectors |
| US6723832B1 (en) * | 1996-10-03 | 2004-04-20 | Ludwig Institute For Cancer Research | Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof |
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| WO1991006866A2 (en) | 1989-11-03 | 1991-05-16 | Morton Donald L | Urinary tumor associated antigen, antigenic subunits uses and methods of detection |
| DE4143467C2 (de) * | 1991-05-17 | 1995-02-09 | Max Planck Gesellschaft | Peptidmotiv und dessen Verwendung |
| US6037135A (en) * | 1992-08-07 | 2000-03-14 | Epimmune Inc. | Methods for making HLA binding peptides and their uses |
| DE4228458A1 (de) * | 1992-08-27 | 1994-06-01 | Beiersdorf Ag | Multicistronische Expressionseinheiten und deren Verwendung |
| US5744316A (en) * | 1992-12-22 | 1998-04-28 | Ludwig Institute For Cancer Research | Isolated, tyrosinase derived peptides and uses thereof |
| US5989565A (en) | 1993-01-29 | 1999-11-23 | University Of Pittsburgh | Elution and identification of T cell epitopes from viable cells |
| EP0689551B1 (en) * | 1993-03-17 | 2008-02-20 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Immunogenic chimeras comprising nucleic acid sequences encoding endoplasmic reticulum signal sequence peptides and at least one other peptide, and their uses in vaccines and disease treatments |
| US5679647A (en) * | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
| US5478556A (en) * | 1994-02-28 | 1995-12-26 | Elliott; Robert L. | Vaccination of cancer patients using tumor-associated antigens mixed with interleukin-2 and granulocyte-macrophage colony stimulating factor |
| US5874560A (en) * | 1994-04-22 | 1999-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Melanoma antigens and their use in diagnostic and therapeutic methods |
| DE4423392A1 (de) * | 1994-07-04 | 1996-01-11 | Birsner & Grob Biotech Gmbh | Verfahren zur Identifizierung antigener Peptide |
| FR2722208B1 (fr) * | 1994-07-05 | 1996-10-04 | Inst Nat Sante Rech Med | Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique |
| US5962428A (en) * | 1995-03-30 | 1999-10-05 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US5698396A (en) * | 1995-06-07 | 1997-12-16 | Ludwig Institute For Cancer Research | Method for identifying auto-immunoreactive substances from a subject |
| JP4108126B2 (ja) * | 1996-04-26 | 2008-06-25 | リュクスウニヴェルシテート テ レイデン | T細胞ペプチド・エピトープの選択と産生方法および選択したエピトープを組込むワクチン |
| US6287756B1 (en) * | 1997-05-05 | 2001-09-11 | Ludwig Institute For Cancer Research | Methods for determining presence of cancer in a sample by determining expression of an SSX gene |
| CN1100673C (zh) | 1997-07-03 | 2003-02-05 | 松下电器产业株式会社 | 喷墨打印头及其制造方法 |
| FR2794370B1 (fr) * | 1999-06-03 | 2003-10-17 | Biovector Therapeutics | Fragments proteiques polyepitopiques, leur obtention et leurs utilisations notamment en vaccination |
| EP1118860A1 (en) * | 2000-01-21 | 2001-07-25 | Rijksuniversiteit te Leiden | Methods for selecting and producing T cell peptide epitopes and vaccines incorporating said selected epitopes |
| US6861234B1 (en) * | 2000-04-28 | 2005-03-01 | Mannkind Corporation | Method of epitope discovery |
| US20030215425A1 (en) * | 2001-12-07 | 2003-11-20 | Simard John J. L. | Epitope synchronization in antigen presenting cells |
| US20040236514A1 (en) * | 2001-12-13 | 2004-11-25 | Lee Stephen C. | Controlling distribution of epitopes in polypeptide sequences |
-
2001
- 2001-04-27 DE DE60142615T patent/DE60142615D1/de not_active Expired - Lifetime
- 2001-04-27 ES ES01930922T patent/ES2347762T3/es not_active Expired - Lifetime
- 2001-04-27 CA CA002405363A patent/CA2405363A1/en not_active Abandoned
- 2001-04-27 AU AU5741001A patent/AU5741001A/xx active Pending
- 2001-04-27 CN CN01812119A patent/CN1440462A/zh active Pending
- 2001-04-27 AT AT01930922T patent/ATE474931T1/de not_active IP Right Cessation
- 2001-04-27 NZ NZ521715A patent/NZ521715A/en not_active IP Right Cessation
- 2001-04-27 EP EP01930922A patent/EP1276896B1/en not_active Expired - Lifetime
- 2001-04-27 JP JP2001579836A patent/JP2003535824A/ja active Pending
- 2001-04-27 EP EP10178766A patent/EP2278024A1/en not_active Withdrawn
- 2001-04-27 EP EP10170170A patent/EP2248910A1/en not_active Withdrawn
- 2001-04-27 AU AU2001257410A patent/AU2001257410B8/en not_active Ceased
- 2001-04-27 WO PCT/US2001/013806 patent/WO2001082963A2/en not_active Ceased
- 2001-04-27 EP EP10178756A patent/EP2278023A1/en not_active Withdrawn
- 2001-04-27 DK DK01930922.8T patent/DK1276896T3/da active
-
2007
- 2007-03-07 US US11/683,397 patent/US20070269464A1/en not_active Abandoned
-
2010
- 2010-12-14 AU AU2010251790A patent/AU2010251790B2/en not_active Ceased
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