JP2003535048A - タマンダリンおよびジデムニン同族体およびそれらの作成および使用法 - Google Patents
タマンダリンおよびジデムニン同族体およびそれらの作成および使用法Info
- Publication number
- JP2003535048A JP2003535048A JP2001574132A JP2001574132A JP2003535048A JP 2003535048 A JP2003535048 A JP 2003535048A JP 2001574132 A JP2001574132 A JP 2001574132A JP 2001574132 A JP2001574132 A JP 2001574132A JP 2003535048 A JP2003535048 A JP 2003535048A
- Authority
- JP
- Japan
- Prior art keywords
- leucine
- methyl
- proline
- lactate
- side chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/545,848 US6509315B1 (en) | 2000-04-07 | 2000-04-07 | Didemnin analogs and fragments and methods of making and using them |
| US09/545,848 | 2000-04-07 | ||
| US09/767,080 | 2001-01-22 | ||
| US09/767,080 US7064105B2 (en) | 2000-04-07 | 2001-01-22 | Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them |
| PCT/US2001/011607 WO2001076616A1 (en) | 2000-04-07 | 2001-04-09 | Tamandarin and didemnin analogs and methods of making and using them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2003535048A true JP2003535048A (ja) | 2003-11-25 |
Family
ID=27068046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001574132A Pending JP2003535048A (ja) | 2000-04-07 | 2001-04-09 | タマンダリンおよびジデムニン同族体およびそれらの作成および使用法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7651997B2 (ru) |
| EP (1) | EP1276491B9 (ru) |
| JP (1) | JP2003535048A (ru) |
| AT (1) | ATE339963T1 (ru) |
| AU (1) | AU2001251498A1 (ru) |
| BR (1) | BR0109958A (ru) |
| CA (1) | CA2405779A1 (ru) |
| CY (1) | CY1105866T1 (ru) |
| DE (1) | DE60123232T2 (ru) |
| DK (1) | DK1276491T3 (ru) |
| ES (1) | ES2272462T3 (ru) |
| IL (1) | IL152111A0 (ru) |
| MX (1) | MXPA02009943A (ru) |
| NZ (1) | NZ521844A (ru) |
| PL (1) | PL358579A1 (ru) |
| RU (1) | RU2323000C2 (ru) |
| WO (1) | WO2001076616A1 (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017142040A1 (ja) * | 2016-02-16 | 2017-08-24 | 国立大学法人東北大学 | 環状デプシペプチド化合物 |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030148933A1 (en) | 1990-10-01 | 2003-08-07 | Pharma Mar S.A. | Derivatives of dehydrodidemnin B |
| GB9803448D0 (en) | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
| SI1229922T1 (sl) * | 1999-11-15 | 2008-04-30 | Pharma Mar Sa | Zdravljenje raka z aplidinom |
| US6509315B1 (en) | 2000-04-07 | 2003-01-21 | The Trustees Of The University Of Pennsylvania | Didemnin analogs and fragments and methods of making and using them |
| UA76718C2 (ru) * | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Противоопухолевые производные аплидина |
| CN1479622A (zh) | 2000-10-12 | 2004-03-03 | 联合使用阿普里汀和肌肉保护剂来治疗癌症 | |
| JP2006519848A (ja) | 2003-03-12 | 2006-08-31 | ファルマ・マール・ソシエダード・アノニマ | 改良された抗腫瘍治療 |
| AU2004218883B2 (en) | 2003-03-12 | 2009-10-01 | Dana-Farber Cancer Institute, Inc. | Aplidine for multiple myeloma treatment |
| JP2006523214A (ja) * | 2003-03-21 | 2006-10-12 | ジユーリー，マデレーン・エム | タマンダリン類似物およびこれらのフラグメントそして製造方法および使用方法 |
| US8258098B2 (en) | 2006-02-28 | 2012-09-04 | Pharma Mar, S.A. | Antitumoral treatments |
| US20100240595A1 (en) * | 2007-10-19 | 2010-09-23 | Pharma Mar ,S.A. | Improved Antitumoral Treatments |
| WO2009111698A1 (en) * | 2008-03-07 | 2009-09-11 | Pharma Mar, S.A. | Improved anticancer treatments |
| WO2010009334A1 (en) | 2008-07-17 | 2010-01-21 | Colorado State University Research Foundation | Method for preparing largazole analogs and uses thereof |
| WO2011020913A2 (en) | 2009-08-21 | 2011-02-24 | Pharma Mar, S.A. | Cyclodepsipeptide antiviral compounds |
| WO2013041969A2 (en) * | 2011-09-21 | 2013-03-28 | King Abdullah University Of Science And Technology | Didemnin biosynthetic gene cluster in tistrella mobilis |
| CA2978730A1 (en) | 2015-03-06 | 2016-09-15 | Colorado State University Research Foundation | Synthesis and utility of new capgroup largazole analogs |
| AU2016229324B2 (en) | 2015-03-06 | 2020-01-16 | Colorado State University Research Foundation | Method for preparing largazole analogs and uses thereof |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
| CN115666615A (zh) | 2020-03-02 | 2023-01-31 | 法马马有限公司 | 用于治疗冠状病毒感染的化合物 |
| AU2021231197A1 (en) | 2020-03-02 | 2022-10-06 | Pharma Mar, S.A. | Compounds for use in inflammatory conditions |
| US20230158104A1 (en) | 2020-03-02 | 2023-05-25 | Pharma Mar, S.A. | Compounds for use in autoimmune conditions |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4160452A (en) * | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
| US4256108A (en) * | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) * | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US4493796A (en) * | 1980-09-12 | 1985-01-15 | Board Of Trustees, Univ. Of Ill. | Didemnins A, B, C, and derivatives thereof, as antiviral agents |
| US4782135A (en) * | 1980-09-12 | 1988-11-01 | Board Of Trustees, University Of Illinois | Composition of matter and process |
| US5137870A (en) * | 1980-09-12 | 1992-08-11 | The Board Of Trustees Of The University Of Illinois | Didemnins and nordidemnins |
| DE4120327A1 (de) * | 1991-06-20 | 1992-12-24 | Basf Ag | Neue peptide, ihre herstellung und verwendung |
| ES2102322B1 (es) | 1995-07-13 | 1998-03-01 | Pharma Mar Sa | Procedimiento de preparacion de didemnina a. |
| WO1998017302A1 (en) | 1996-10-24 | 1998-04-30 | The Board Of Trustees Of The University Of Illinois | Total synthesis of the amino hip analogue of didemnin a |
| CA2269881A1 (en) | 1996-10-24 | 1998-04-30 | The Board Of Trustees Of The University Of Illinois | Semi-synthetic studies toward didemnin analogues |
| US6509315B1 (en) * | 2000-04-07 | 2003-01-21 | The Trustees Of The University Of Pennsylvania | Didemnin analogs and fragments and methods of making and using them |
| UA76718C2 (ru) | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Противоопухолевые производные аплидина |
| JP2006523214A (ja) * | 2003-03-21 | 2006-10-12 | ジユーリー，マデレーン・エム | タマンダリン類似物およびこれらのフラグメントそして製造方法および使用方法 |
-
2001
- 2001-04-09 AU AU2001251498A patent/AU2001251498A1/en not_active Abandoned
- 2001-04-09 DE DE60123232T patent/DE60123232T2/de not_active Expired - Fee Related
- 2001-04-09 PL PL01358579A patent/PL358579A1/xx not_active IP Right Cessation
- 2001-04-09 EP EP01924886A patent/EP1276491B9/en not_active Expired - Lifetime
- 2001-04-09 WO PCT/US2001/011607 patent/WO2001076616A1/en active Application Filing
- 2001-04-09 NZ NZ521844A patent/NZ521844A/en unknown
- 2001-04-09 RU RU2002129885/15A patent/RU2323000C2/ru active
- 2001-04-09 MX MXPA02009943A patent/MXPA02009943A/es active IP Right Grant
- 2001-04-09 IL IL15211101A patent/IL152111A0/xx unknown
- 2001-04-09 AT AT01924886T patent/ATE339963T1/de not_active IP Right Cessation
- 2001-04-09 DK DK01924886T patent/DK1276491T3/da active
- 2001-04-09 JP JP2001574132A patent/JP2003535048A/ja active Pending
- 2001-04-09 BR BR0109958-2A patent/BR0109958A/pt not_active IP Right Cessation
- 2001-04-09 CA CA002405779A patent/CA2405779A1/en not_active Abandoned
- 2001-04-09 ES ES01924886T patent/ES2272462T3/es not_active Expired - Lifetime
-
2006
- 2006-06-20 US US11/455,937 patent/US7651997B2/en not_active Expired - Fee Related
- 2006-12-20 CY CY20061101824T patent/CY1105866T1/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017142040A1 (ja) * | 2016-02-16 | 2017-08-24 | 国立大学法人東北大学 | 環状デプシペプチド化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| PL358579A1 (en) | 2004-08-09 |
| RU2323000C2 (ru) | 2008-04-27 |
| RU2002129885A (ru) | 2004-03-27 |
| DE60123232T2 (de) | 2007-11-08 |
| EP1276491A4 (en) | 2004-08-25 |
| MXPA02009943A (es) | 2003-04-25 |
| WO2001076616A1 (en) | 2001-10-18 |
| EP1276491B9 (en) | 2007-02-28 |
| ES2272462T3 (es) | 2007-05-01 |
| BR0109958A (pt) | 2003-05-27 |
| NZ521844A (en) | 2004-07-30 |
| DK1276491T3 (da) | 2007-02-05 |
| CY1105866T1 (el) | 2011-02-02 |
| US7651997B2 (en) | 2010-01-26 |
| CA2405779A1 (en) | 2001-10-18 |
| EP1276491B1 (en) | 2006-09-20 |
| US20070129289A1 (en) | 2007-06-07 |
| IL152111A0 (en) | 2003-07-31 |
| AU2001251498A1 (en) | 2001-10-23 |
| ATE339963T1 (de) | 2006-10-15 |
| EP1276491A1 (en) | 2003-01-22 |
| DE60123232D1 (de) | 2006-11-02 |
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