BR0109958A - Análogos de didemnina e tamandarina e métodos de preparação e uso deles - Google Patents

Análogos de didemnina e tamandarina e métodos de preparação e uso deles

Info

Publication number
BR0109958A
BR0109958A BR0109958-2A BR0109958A BR0109958A BR 0109958 A BR0109958 A BR 0109958A BR 0109958 A BR0109958 A BR 0109958A BR 0109958 A BR0109958 A BR 0109958A
Authority
BR
Brazil
Prior art keywords
analogs
methods
didemnin
preparation
tamandarin
Prior art date
Application number
BR0109958-2A
Other languages
English (en)
Inventor
Madeleine M Joullie
Bo Liang
Xiaobin Ding
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/545,848 external-priority patent/US6509315B1/en
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of BR0109958A publication Critical patent/BR0109958A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

"ANáLOGOS DE DIDEMNINA E TAMANDARINA E MéTODOS DE PREPARAçãO E USO DELES". A presente invenção refere-se aos análogos de tamandarina, incluindo os análogos de tamandarina e didemnina que tem um resíduo de deoxo-prolina ou um resíduo de deidro-prolina em sua estrutura. Estes análogos são úteis como agentes anti-cânceres e para outros propósitos. O método de preparação destes análogos e métodos de uso deles como inibidores de síntese de proteína, crescimento celular, e tumorigênese e como realçadores de apoptose são da mesma forma fornecidos.
BR0109958-2A 2000-04-07 2001-04-09 Análogos de didemnina e tamandarina e métodos de preparação e uso deles BR0109958A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/545,848 US6509315B1 (en) 2000-04-07 2000-04-07 Didemnin analogs and fragments and methods of making and using them
US09/767,080 US7064105B2 (en) 2000-04-07 2001-01-22 Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them
PCT/US2001/011607 WO2001076616A1 (en) 2000-04-07 2001-04-09 Tamandarin and didemnin analogs and methods of making and using them

Publications (1)

Publication Number Publication Date
BR0109958A true BR0109958A (pt) 2003-05-27

Family

ID=27068046

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0109958-2A BR0109958A (pt) 2000-04-07 2001-04-09 Análogos de didemnina e tamandarina e métodos de preparação e uso deles

Country Status (17)

Country Link
US (1) US7651997B2 (pt)
EP (1) EP1276491B9 (pt)
JP (1) JP2003535048A (pt)
AT (1) ATE339963T1 (pt)
AU (1) AU2001251498A1 (pt)
BR (1) BR0109958A (pt)
CA (1) CA2405779A1 (pt)
CY (1) CY1105866T1 (pt)
DE (1) DE60123232T2 (pt)
DK (1) DK1276491T3 (pt)
ES (1) ES2272462T3 (pt)
IL (1) IL152111A0 (pt)
MX (1) MXPA02009943A (pt)
NZ (1) NZ521844A (pt)
PL (1) PL358579A1 (pt)
RU (1) RU2323000C2 (pt)
WO (1) WO2001076616A1 (pt)

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US20030148933A1 (en) 1990-10-01 2003-08-07 Pharma Mar S.A. Derivatives of dehydrodidemnin B
GB9803448D0 (en) 1998-02-18 1998-04-15 Pharma Mar Sa Pharmaceutical formulation
KR100518986B1 (ko) * 1999-11-15 2005-10-06 파르마 마르, 에스.에이. 아플리딘을 사용하여 암을 치료하는 방법
US6509315B1 (en) 2000-04-07 2003-01-21 The Trustees Of The University Of Pennsylvania Didemnin analogs and fragments and methods of making and using them
UA76718C2 (uk) * 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
US7507766B2 (en) 2000-10-12 2009-03-24 Pharma Mar, S.A. Treatment of cancers
JP2006519848A (ja) 2003-03-12 2006-08-31 ファルマ・マール・ソシエダード・アノニマ 改良された抗腫瘍治療
NZ541611A (en) 2003-03-12 2008-04-30 Dana Farber Cancer Inst Inc Aplidine for multiple myeloma treatment
JP2006523214A (ja) * 2003-03-21 2006-10-12 ジユーリー，マデレーン・エム タマンダリン類似物およびこれらのフラグメントそして製造方法および使用方法
DK2029155T3 (en) 2006-02-28 2016-08-01 Pharma Mar Sa IMPROVED treatment of multiple myeloma
EP2205263A1 (en) * 2007-10-19 2010-07-14 Pharma Mar, S.A. Improved antitumoral treatments
JP2011513429A (ja) * 2008-03-07 2011-04-28 ファルマ・マール・ソシエダード・アノニマ 改善された抗癌治療法
WO2010009334A1 (en) * 2008-07-17 2010-01-21 Colorado State University Research Foundation Method for preparing largazole analogs and uses thereof
WO2011020913A2 (en) 2009-08-21 2011-02-24 Pharma Mar, S.A. Cyclodepsipeptide antiviral compounds
WO2013041969A2 (en) * 2011-09-21 2013-03-28 King Abdullah University Of Science And Technology Didemnin biosynthetic gene cluster in tistrella mobilis
CA2978698A1 (en) 2015-03-06 2016-09-15 Colorado State University Research Foundation Method for preparing largazole analogs and uses thereof
CA2978730A1 (en) 2015-03-06 2016-09-15 Colorado State University Research Foundation Synthesis and utility of new capgroup largazole analogs
JP2019064920A (ja) * 2016-02-16 2019-04-25 国立大学法人東北大学 環状デプシペプチド化合物
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
US20230158104A1 (en) 2020-03-02 2023-05-25 Pharma Mar, S.A. Compounds for use in autoimmune conditions
EP4114436A1 (en) 2020-03-02 2023-01-11 Pharma Mar S.A. Compounds for use in the treatment of coronavirus infection
KR20220150350A (ko) 2020-03-02 2022-11-10 파르마 마르, 에스.에이. 염증성 질환에 사용하기 위한 화합물

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US4256108A (en) * 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4160452A (en) * 1977-04-07 1979-07-10 Alza Corporation Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
US4265874A (en) * 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US5137870A (en) * 1980-09-12 1992-08-11 The Board Of Trustees Of The University Of Illinois Didemnins and nordidemnins
US4782135A (en) * 1980-09-12 1988-11-01 Board Of Trustees, University Of Illinois Composition of matter and process
US4493796A (en) * 1980-09-12 1985-01-15 Board Of Trustees, Univ. Of Ill. Didemnins A, B, C, and derivatives thereof, as antiviral agents
DE4120327A1 (de) * 1991-06-20 1992-12-24 Basf Ag Neue peptide, ihre herstellung und verwendung
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JP2001503746A (ja) 1996-10-24 2001-03-21 ザ・ボード・オブ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・イリノイ ジデムニン類似体の半合成法
CA2269878A1 (en) 1996-10-24 1998-04-30 The Board Of Trustees Of The University Of Illinois Total synthesis of the amino hip analogue of didemnin a
US6509315B1 (en) * 2000-04-07 2003-01-21 The Trustees Of The University Of Pennsylvania Didemnin analogs and fragments and methods of making and using them
UA76718C2 (uk) 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
JP2006523214A (ja) * 2003-03-21 2006-10-12 ジユーリー，マデレーン・エム タマンダリン類似物およびこれらのフラグメントそして製造方法および使用方法

Also Published As

Publication number Publication date
AU2001251498A1 (en) 2001-10-23
US20070129289A1 (en) 2007-06-07
RU2323000C2 (ru) 2008-04-27
EP1276491A1 (en) 2003-01-22
IL152111A0 (en) 2003-07-31
RU2002129885A (ru) 2004-03-27
DE60123232T2 (de) 2007-11-08
CA2405779A1 (en) 2001-10-18
JP2003535048A (ja) 2003-11-25
ES2272462T3 (es) 2007-05-01
MXPA02009943A (es) 2003-04-25
DE60123232D1 (de) 2006-11-02
NZ521844A (en) 2004-07-30
PL358579A1 (en) 2004-08-09
ATE339963T1 (de) 2006-10-15
US7651997B2 (en) 2010-01-26
EP1276491B9 (en) 2007-02-28
WO2001076616A1 (en) 2001-10-18
EP1276491B1 (en) 2006-09-20
DK1276491T3 (da) 2007-02-05
CY1105866T1 (el) 2011-02-02
EP1276491A4 (en) 2004-08-25

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.