JP2003533537A5 - - Google Patents
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- Publication number
- JP2003533537A5 JP2003533537A5 JP2001585141A JP2001585141A JP2003533537A5 JP 2003533537 A5 JP2003533537 A5 JP 2003533537A5 JP 2001585141 A JP2001585141 A JP 2001585141A JP 2001585141 A JP2001585141 A JP 2001585141A JP 2003533537 A5 JP2003533537 A5 JP 2003533537A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- polysialic
- groups
- denaturing agent
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 25
- 102000004169 proteins and genes Human genes 0.000 description 11
- 108090000623 proteins and genes Proteins 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 239000002253 acid Substances 0.000 description 3
- 125000003277 amino group Chemical group 0.000 description 3
- 125000005629 sialic acid group Chemical group 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000001212 derivatisation Methods 0.000 description 2
- 125000001288 lysyl group Chemical group 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- -1 alkali metal salt Chemical class 0.000 description 1
- 125000000266 alpha-aminoacyl group Chemical group 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003398 denaturant Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00304108.4 | 2000-05-16 | ||
| EP00304108 | 2000-05-16 | ||
| PCT/GB2001/002115 WO2001087922A2 (en) | 2000-05-16 | 2001-05-14 | Derivatisation of proteins in aqueous solution |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003533537A JP2003533537A (ja) | 2003-11-11 |
| JP2003533537A5 true JP2003533537A5 (https=) | 2008-06-05 |
Family
ID=8172993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001585141A Pending JP2003533537A (ja) | 2000-05-16 | 2001-05-14 | タンパク質の誘導体化 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6962972B2 (https=) |
| EP (1) | EP1335931B1 (https=) |
| JP (1) | JP2003533537A (https=) |
| AT (1) | ATE313554T1 (https=) |
| AU (1) | AU2001258536A1 (https=) |
| DE (1) | DE60116137T2 (https=) |
| ES (1) | ES2256234T3 (https=) |
| WO (1) | WO2001087922A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007501888A (ja) * | 2003-08-12 | 2007-02-01 | リポクセン テクノロジーズ リミテッド | ポリシアル酸誘導体 |
| WO2005016974A1 (en) | 2003-08-12 | 2005-02-24 | Lipoxen Technologies Limited | Sialic acid derivatives for protein derivatisation and conjugation |
| US8652334B2 (en) * | 2004-08-12 | 2014-02-18 | Lipoxen Technologies Limited | Fractionation of charged polysaccharide |
| WO2006016168A2 (en) * | 2004-08-12 | 2006-02-16 | Lipoxen Technologies Limited | Sialic acid derivatives |
| TWI376234B (en) | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
| CN101160326B (zh) | 2005-02-23 | 2013-04-10 | 利普生技术有限公司 | 用于蛋白质衍生和缀合的活化的唾液酸衍生物 |
| WO2008012528A1 (en) * | 2006-07-25 | 2008-01-31 | Lipoxen Technologies Limited | N-terminal polysialylation |
| JP2010520320A (ja) | 2007-02-28 | 2010-06-10 | リポクセン テクノロジーズ リミテッド | ポリシアル酸におけるエンドトキシンの低減 |
| CN106110311A (zh) * | 2009-07-27 | 2016-11-16 | 百深公司 | 凝血蛋白缀合物 |
| KR101912335B1 (ko) | 2009-07-27 | 2018-10-26 | 리폭센 테크놀로지즈 리미티드 | 비혈액 응고 단백질의 글리코폴리시알화 |
| AU2010290131C1 (en) | 2009-08-24 | 2015-12-03 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
| DK2598172T3 (da) | 2010-07-30 | 2019-07-01 | Baxalta GmbH | Nukleofile katalysatorer til oximforbindelse |
| EP3808378A1 (en) | 2011-05-27 | 2021-04-21 | Baxalta GmbH | Therapeutic proteins with increased half-life and methods of preparing same |
| CA2838833A1 (en) | 2011-06-10 | 2012-12-13 | Biogen Idec Ma Inc. | Pro-coagulant compounds and methods of use thereof |
| DK2804623T3 (da) | 2012-01-12 | 2019-11-11 | Bioverativ Therapeutics Inc | Kimære faktor viii-polypeptider og anvendelser deraf |
| BR112014020694A2 (pt) | 2012-02-15 | 2018-05-08 | Amunix Operating Inc. | proteína de fusão do fator viii compreendendo polipeptídeo do fator viii fusionado a polipeptí-deo recombinante estendido (xten) e seu método de fabricação, ácido nucleico, vetores, célula hospedeira, bem como composição farmacêutica e seu uso no tratamento de coagulopatia, episódio de hemorragia e hemofilia a |
| CA2864126A1 (en) | 2012-02-15 | 2013-08-22 | Biogen Idec Ma Inc. | Recombinant factor viii proteins |
| AU2013204754C1 (en) | 2012-05-16 | 2018-10-11 | Takeda Pharmaceutical Company Limited | Nucleophilic Catalysts for Oxime Linkage |
| JP2015525222A (ja) | 2012-06-08 | 2015-09-03 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | キメラ性凝固因子 |
| EP2858659B1 (en) | 2012-06-08 | 2019-12-25 | Bioverativ Therapeutics Inc. | Procoagulant compounds |
| HRP20200007T1 (hr) | 2012-07-11 | 2020-03-20 | Bioverativ Therapeutics Inc. | Kompleks proteina faktora viii s xten i von willebrandovim faktorom, te njegova uporaba |
| SG10201710616XA (en) | 2013-06-28 | 2018-02-27 | Biogen Ma Inc | Thrombin cleavable linker with xten and its uses thereof |
| US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
| WO2015048330A2 (en) | 2013-09-25 | 2015-04-02 | Biogen Idec Ma Inc. | On-column viral inactivation methods |
| US10584147B2 (en) | 2013-11-08 | 2020-03-10 | Biovertiv Therapeutics Inc. | Procoagulant fusion compound |
| AU2015204646B2 (en) | 2014-01-10 | 2020-08-27 | Bioverativ Therapeutics Inc. | Factor VIII chimeric proteins and uses thereof |
| WO2015130963A2 (en) | 2014-02-27 | 2015-09-03 | Xenetic Biosciences, Inc. | Compositions and methods for administering insulin or insulin-like protein to the brain |
| US20180022780A1 (en) | 2014-09-26 | 2018-01-25 | Bayer Pharma Aktiengesellschaft | Stabilization adrenomedullin derivatives and use thereof |
| ES2753391T3 (es) | 2014-10-14 | 2020-04-08 | Halozyme Inc | Composiciones de adenosina desaminasa 2 (ADA2), variantes de la misma y métodos de uso de las mismas |
| MA40835A (fr) | 2014-10-23 | 2017-08-29 | Biogen Ma Inc | Anticorps anti-gpiib/iiia et leurs utilisations |
| MA40861A (fr) | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | Anticorps anti-glycoprotéines iib/iiia |
| BR112018002150A2 (pt) | 2015-08-03 | 2018-09-18 | Bioverativ Therapeutics Inc | proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas |
| CA3007364A1 (en) | 2015-12-03 | 2017-06-08 | Baxalta Incorporated | Factor viii with extended half-life and reduced ligand-binding properties |
| EA201892249A1 (ru) | 2016-04-04 | 2019-05-31 | Шайр Хьюман Дженетик Терапиз, Инк. | Конъюгированный ингибитор c1-эстеразы и пути его применения |
| JP7464530B2 (ja) | 2018-03-28 | 2024-04-09 | ブリストル－マイヤーズ スクイブ カンパニー | インターロイキン－２／インターロイキン－２受容体アルファ融合タンパク質および使用方法 |
| BR112020022164A2 (pt) | 2018-05-18 | 2021-02-02 | Bioverativ Therapeutics Inc. | métodos de tratamento de hemofilia a |
| CA3104686A1 (en) | 2018-07-03 | 2020-01-09 | Bristol-Myers Squibb Company | Fgf-21 formulations |
| CA3143584A1 (en) | 2019-06-18 | 2020-12-24 | Bayer Aktiengesellschaft | Adrenomedullin-analogues for long-term stabilization and their use |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US4727136A (en) | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
| US5846951A (en) * | 1991-06-06 | 1998-12-08 | The School Of Pharmacy, University Of London | Pharmaceutical compositions |
| GB9112212D0 (en) | 1991-06-06 | 1991-07-24 | Gregoriadis Gregory | Pharmaceutical compositions |
| US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
| US5738846A (en) * | 1994-11-10 | 1998-04-14 | Enzon, Inc. | Interferon polymer conjugates and process for preparing the same |
| US5705364A (en) | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
-
2001
- 2001-05-14 AU AU2001258536A patent/AU2001258536A1/en not_active Abandoned
- 2001-05-14 US US10/276,552 patent/US6962972B2/en not_active Expired - Lifetime
- 2001-05-14 EP EP01931843A patent/EP1335931B1/en not_active Expired - Lifetime
- 2001-05-14 DE DE60116137T patent/DE60116137T2/de not_active Expired - Lifetime
- 2001-05-14 AT AT01931843T patent/ATE313554T1/de not_active IP Right Cessation
- 2001-05-14 WO PCT/GB2001/002115 patent/WO2001087922A2/en not_active Ceased
- 2001-05-14 ES ES01931843T patent/ES2256234T3/es not_active Expired - Lifetime
- 2001-05-14 JP JP2001585141A patent/JP2003533537A/ja active Pending
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