JP2003533504A - ７置換型縮合環テトラサイクリン化合物 - Google Patents

７置換型縮合環テトラサイクリン化合物

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Publication number
JP2003533504A
JP2003533504A JP2001584221A JP2001584221A JP2003533504A JP 2003533504 A JP2003533504 A JP 2003533504A JP 2001584221 A JP2001584221 A JP 2001584221A JP 2001584221 A JP2001584221 A JP 2001584221A JP 2003533504 A JP2003533504 A JP 2003533504A
Authority
JP
Japan
Prior art keywords
group
compound
groups
tetracycline
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2001584221A
Other languages
English (en)
Japanese (ja)
Inventor
マーク エル． ネルソン
ローラ マクィンタイア
Original Assignee
パラテック ファーマシューティカルズ インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by パラテック ファーマシューティカルズ インコーポレイテッド filed Critical パラテック ファーマシューティカルズ インコーポレイテッド
Publication of JP2003533504A publication Critical patent/JP2003533504A/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C07D323/02—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
JP2001584221A 2000-05-15 2001-05-10 ７置換型縮合環テトラサイクリン化合物 Ceased JP2003533504A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20415800P 2000-05-15 2000-05-15
US60/204,158 2000-05-15
PCT/US2001/015068 WO2001087824A2 (en) 2000-05-15 2001-05-10 7-substituted fused ring tetracycline compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012200322A Division JP2013040173A (ja) 2000-05-15 2012-09-12 ７置換型縮合環テトラサイクリン化合物

Publications (1)

Publication Number Publication Date
JP2003533504A true JP2003533504A (ja) 2003-11-11

Family

ID=22756861

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001584221A Ceased JP2003533504A (ja) 2000-05-15 2001-05-10 ７置換型縮合環テトラサイクリン化合物
JP2012200322A Pending JP2013040173A (ja) 2000-05-15 2012-09-12 ７置換型縮合環テトラサイクリン化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012200322A Pending JP2013040173A (ja) 2000-05-15 2012-09-12 ７置換型縮合環テトラサイクリン化合物

Country Status (8)

Country Link
US (5) US6642270B2 (US07893282-20110222-C00010.png)
EP (2) EP1286954B1 (US07893282-20110222-C00010.png)
JP (2) JP2003533504A (US07893282-20110222-C00010.png)
AT (1) ATE264295T1 (US07893282-20110222-C00010.png)
AU (1) AU2001259701A1 (US07893282-20110222-C00010.png)
CA (1) CA2409063A1 (US07893282-20110222-C00010.png)
DE (1) DE60102815D1 (US07893282-20110222-C00010.png)
WO (1) WO2001087824A2 (US07893282-20110222-C00010.png)

Cited By (3)

* Cited by examiner, † Cited by third party
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JP2010168377A (ja) * 2008-12-26 2010-08-05 Otsuka Pharmaceut Co Ltd 医薬及び医薬製剤
JP2010531293A (ja) * 2007-06-26 2010-09-24 大塚製薬株式会社 バソプレシン拮抗剤として使用されるベンゾアゼピン誘導体
JP2017088633A (ja) * 2010-11-16 2017-05-25 ユニバーシティー オブ サザン カリフォルニア 体性幹細胞の非対称分裂を促進するためのｃｂｐ／カテニン拮抗剤

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US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP2327686A3 (en) * 1999-09-14 2012-08-22 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
EP1263442A1 (en) * 2000-01-24 2002-12-11 Trustees Of Tufts College TETRACYCLINE COMPOUNDS FOR TREATMENT OF i CRYPTOSPORIDIUM PARVUM /i RELATED DISORDERS
JP2004505012A (ja) * 2000-03-31 2004-02-19 トラスティーズ・オブ・タフツ・カレッジ ７−および９−カルバメート、尿素、チオ尿素、チオカルバメート、およびヘテロアリール−アミノ置換テトラサイクリン化合物
EP1286954B1 (en) * 2000-05-15 2004-04-14 Paratek Pharmaceuticals, Inc. 7-substituted fused ring tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
WO2001098236A2 (en) * 2000-06-16 2001-12-27 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
AU2001271642B2 (en) * 2000-07-07 2006-01-05 Paratek Pharmaceuticals, Inc. 7-substituted tetracycline compounds
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JP2005506291A (ja) * 2001-03-13 2005-03-03 パラテック ファーマシューティカルズ， インク． ７，９−置換テトラサイクリン化合物
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EP1379255A2 (en) * 2001-03-14 2004-01-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2332550A1 (en) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of neurodegenerative diseases
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
WO2003055441A2 (en) * 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
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IL163931A0 (en) * 2002-03-08 2005-12-18 Paratek Pharm Innc Amino-methyl substituted tetracyline compounds
CN1653037A (zh) * 2002-03-21 2005-08-10 帕拉特克药品公司 取代的四环素化合物
EA012136B1 (ru) * 2002-07-12 2009-08-28 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
JP4686189B2 (ja) 2002-10-24 2011-05-18 パラテック ファーマシューティカルズ インコーポレイテッド Ｒｎａを調節するための置換テトラサイクリン化合物の使用方法
DE60311678T2 (de) * 2002-12-20 2007-11-22 Cree, Inc. Verfahren zur herstellung von halbleitervorrichtungen mit mesastrukturen und vielfachen passivierungsschichten und verwandte vorrichtungen
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US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
KR101171408B1 (ko) 2004-05-21 2012-08-08 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 테트라사이클린 및 이의 유사체의 합성
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EP2295419A3 (en) * 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
AU2006210406C1 (en) 2005-02-04 2013-03-07 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
US8486921B2 (en) * 2006-04-07 2013-07-16 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
EP2537934A3 (en) * 2006-05-15 2013-04-10 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
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DK2120963T3 (en) 2006-12-21 2019-01-14 Paratek Pharm Innc SUBSTITUTED TETRACYCLINE COMPOUNDS FOR TREATMENT OF INFLAMMATORY SKIN DISORDERS
EP2144614A1 (en) * 2007-04-12 2010-01-20 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
US9434680B2 (en) * 2007-04-27 2016-09-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
CN101811980A (zh) 2007-07-06 2010-08-25 帕拉特克药品公司 合成取代的四环素化合物的方法
RU2483072C2 (ru) 2007-11-29 2013-05-27 Актелион Фармасьютиклз Лтд Производные фосфоновой кислоты и их применение в качестве антагонистов рецептора p2y12
KR20100126469A (ko) * 2008-03-05 2010-12-01 파라테크 파마슈티컬스, 인크. 미노사이클린 화합물 및 이들의 사용 방법
US20100022483A1 (en) * 2008-04-14 2010-01-28 Paratek Pharmaceuticals, Inc. Substituted Tetracycline Compounds
CN102215681A (zh) * 2008-09-19 2011-10-12 帕拉特克药品公司 用于治疗类风湿性关节炎的四环素化合物和相关的治疗方法
US9073829B2 (en) 2009-04-30 2015-07-07 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
EP3534908A4 (en) 2016-11-01 2020-05-27 Paratek Pharmaceuticals, Inc. 9-AMINOMETHYL-MINOCYCLINE COMPOUNDS AND USE THEREOF IN THE TREATMENT OF AMBULANTLY ACQUIRED BACTERIAL PNEUMONIA (CABP)

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WO2001087824A2 (en) 2001-11-22
US20040048835A1 (en) 2004-03-11
WO2001087824A3 (en) 2002-04-11
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US6642270B2 (en) 2003-11-04
EP1286954A2 (en) 2003-03-05
ATE264295T1 (de) 2004-04-15
US8288570B2 (en) 2012-10-16
US20060148765A1 (en) 2006-07-06
AU2001259701A1 (en) 2001-11-26
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US20110207951A1 (en) 2011-08-25

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