JP2003529044A5 - - Google Patents

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Publication number
JP2003529044A5
JP2003529044A5 JP2000612736A JP2000612736A JP2003529044A5 JP 2003529044 A5 JP2003529044 A5 JP 2003529044A5 JP 2000612736 A JP2000612736 A JP 2000612736A JP 2000612736 A JP2000612736 A JP 2000612736A JP 2003529044 A5 JP2003529044 A5 JP 2003529044A5
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JP
Japan
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JP2000612736A
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Japanese (ja)
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JP2003529044A (ja
JP4723725B2 (ja
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Priority claimed from US09/513,395 external-priority patent/US6379971B1/en
Priority claimed from US09/513,907 external-priority patent/US6677114B1/en
Priority claimed from US09/513,486 external-priority patent/US6537432B1/en
Application filed filed Critical
Priority claimed from PCT/US2000/010504 external-priority patent/WO2000063683A1/en
Publication of JP2003529044A publication Critical patent/JP2003529044A/ja
Publication of JP2003529044A5 publication Critical patent/JP2003529044A5/ja
Application granted granted Critical
Publication of JP4723725B2 publication Critical patent/JP4723725B2/ja
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Expired - Fee Related legal-status Critical Current

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JP2000612736A 1999-04-20 2000-04-19 代謝経路を分析するための方法 Expired - Fee Related JP4723725B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US13023899P 1999-04-20 1999-04-20
US60/130,238 1999-04-20
US09/513,395 US6379971B1 (en) 1998-02-24 2000-02-25 Methods for sequencing proteins
US09/513,486 2000-02-25
US09/513,395 2000-02-25
US09/513,907 2000-02-25
US09/513,907 US6677114B1 (en) 1999-04-20 2000-02-25 Polypeptide fingerprinting methods and bioinformatics database system
US09/513,486 US6537432B1 (en) 1998-02-24 2000-02-25 Protein separation via multidimensional electrophoresis
PCT/US2000/010504 WO2000063683A1 (en) 1999-04-20 2000-04-19 Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010128894A Division JP2010249831A (ja) 1999-04-20 2010-06-04 ポリペプチドフィンガープリント法、代謝プロファイル、およびバイオインフォマティクスデータベース

Publications (3)

Publication Number Publication Date
JP2003529044A JP2003529044A (ja) 2003-09-30
JP2003529044A5 true JP2003529044A5 (enExample) 2007-07-05
JP4723725B2 JP4723725B2 (ja) 2011-07-13

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000612736A Expired - Fee Related JP4723725B2 (ja) 1999-04-20 2000-04-19 代謝経路を分析するための方法
JP2010128894A Pending JP2010249831A (ja) 1999-04-20 2010-06-04 ポリペプチドフィンガープリント法、代謝プロファイル、およびバイオインフォマティクスデータベース

Family Applications After (1)

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JP2010128894A Pending JP2010249831A (ja) 1999-04-20 2010-06-04 ポリペプチドフィンガープリント法、代謝プロファイル、およびバイオインフォマティクスデータベース

Country Status (6)

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EP (2) EP2293056A3 (enExample)
JP (2) JP4723725B2 (enExample)
AU (2) AU774662B2 (enExample)
CA (1) CA2370749A1 (enExample)
IL (1) IL146093A0 (enExample)
WO (1) WO2000063683A1 (enExample)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2298181C (en) 2000-02-02 2006-09-19 Dayan Burke Goodnough Non-targeted complex sample analysis
ES2385335T3 (es) 2000-10-19 2012-07-23 Target Discovery, Inc. Marcaje de defecto de masa para la determinación de secuencias de oligómeros
DE10123711A1 (de) * 2001-05-15 2003-02-27 Wolfgang Altmeyer Verfahren zur Bestimmung der Herkunft biologischer Materialien
US6800449B1 (en) 2001-07-13 2004-10-05 Syngenta Participations Ag High throughput functional proteomics
JP4873801B2 (ja) * 2001-08-10 2012-02-08 サントリーホールディングス株式会社 有機化合物の構造解析方法
IL161498A0 (en) 2001-10-24 2004-09-27 Univ California Measurement of protein synthesis rates in humans and experimental system by use of isotopically labeled water
US7449171B2 (en) 2002-02-12 2008-11-11 The Regents Of The University Of California Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or not easily accessible to direct sampling, non-invasively, by label incorporation into metabolic derivatives and catabolic products
US20070233391A1 (en) * 2002-03-07 2007-10-04 Cambridge University Technical Service Limited (CUTS) Scd fingerprints
CA2485563A1 (en) * 2002-05-10 2003-11-20 Proteome Factory Ag Solid-phase assisted spectroscopic and spectrometric analysis of complex mixtures of biopolymers
EP1361438A1 (de) * 2002-05-10 2003-11-12 Proteome Factory AG Festphasenassistierte spektroskopische und spektrometrische Analyse komplexer Peptidgemische
EP1546364A4 (en) 2002-07-30 2006-09-06 Univ California METHOD FOR THE AUTOMATIC MEASUREMENT OF THE MOLECULAR FLOW RATE SPEED OF THE PROTEOM OR ORGANOMA BY MEANS OF MASS SPECTROMETRY
AU2003267283B2 (en) 2002-09-13 2009-09-03 The Regents Of The University Of California Methods for measuring rates of reserve cholesterol transport in vivo, as an index of anti-atherogenesis
WO2004034049A1 (en) * 2002-10-09 2004-04-22 Waters Investments Limited Methods and apparatus for identifying compounds in a sample
WO2004042360A2 (en) 2002-11-04 2004-05-21 The Regents Of The Univeristy Of California Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
US7425700B2 (en) 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
US8021308B2 (en) 2003-06-19 2011-09-20 Capnia, Inc. Breath end-tidal gas monitor
US7262020B2 (en) 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
US20050202406A1 (en) 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
JP2007514173A (ja) * 2003-12-15 2007-05-31 ユニバーシティ オブ ペンシルベニア Ｍａｌｄｉ質量分析に向けたターゲットプレート上で反応を行うための方法および装置
US8510054B2 (en) 2004-02-05 2013-08-13 Ajinomoto Co., Inc. Intracellular metabolic flux analysis method using substrate labeled with isotope
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
US20050201937A1 (en) * 2004-03-11 2005-09-15 The Regents Of The University Of California Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients
KR100611313B1 (ko) * 2004-06-30 2006-08-10 고려대학교 산학협력단 폴리펩티드의 ｎ-말단 치환용 화합물, 이를 이용한폴리펩티드 내의 아미노산 서열분석 및 정량방법
JP4512745B2 (ja) * 2004-10-29 2010-07-28 独立行政法人産業技術総合研究所 細胞の分離、同定装置及び方法
JP2008064459A (ja) * 2004-12-24 2008-03-21 Univ Kurume 色素上皮由来因子の定量法
JP2006308523A (ja) * 2005-05-02 2006-11-09 Ebara Corp 電気泳動用マイクロチップのマイクロチャンネル内のコーティング方法および該方法によりコーティングが施された電気泳動用マイクロチップ
CA2772688A1 (en) 2005-09-12 2007-03-22 Phenomenome Discoveries Inc. Methods for the diagnosis of colorectal cancer and ovarian cancer health states
JP2007163423A (ja) * 2005-12-16 2007-06-28 Ajinomoto Co Inc 質量分析計によるアミノ酸分析方法
US8648294B2 (en) 2006-10-17 2014-02-11 The Regents Of The University Of California Compact aerosol time-of-flight mass spectrometer
US20100312487A1 (en) * 2006-11-15 2010-12-09 Shimadzu Corporation Mass analysis data analyzing method and apparatus thereof
FR2936316B1 (fr) * 2008-09-25 2015-05-01 Etat Francais Dga Dispositif de preconcentration selective/detection d'analytes chargees contenues dans un electrolyte et procede associe.
WO2011119235A1 (en) * 2010-03-24 2011-09-29 Glendon John Parker Methods for conducting genetic analysis using protein polymorphism
GB201019337D0 (en) * 2010-11-16 2010-12-29 Micromass Ltd Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis
EP2753707A4 (en) 2011-09-08 2015-03-04 Univ California METABOLIC FLOW MEASUREMENT, IMAGING AND MICROSCOPY
ES2668678T3 (es) 2011-12-07 2018-05-21 Glaxosmithkline Llc Procedimiento de determinación de la masa muscular esquelética corporal total
CN107874761A (zh) 2011-12-21 2018-04-06 卡普尼亚公司 在补偿呼吸参数频率的情况下收集并分析一定体积的呼出的气体
EP2841927B1 (en) 2012-04-27 2018-01-17 Bio-rad Laboratories, Inc. Stain-free protein quantification and normalization
CA2897533A1 (en) 2013-01-08 2014-07-17 Capnia, Inc. Breath selection for analysis
JP5977269B2 (ja) 2013-01-22 2016-08-24 アークレイ株式会社 試料の分析方法及びそれに用いる溶液
CA2900626A1 (en) * 2013-02-12 2014-08-21 Capnia, Inc. Sampling and storage registry device for breath gas analysis
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
SG11201601442UA (en) 2013-08-30 2016-03-30 Capnia Inc Neonatal carbon dioxide measurement system
JP6281349B2 (ja) * 2014-03-19 2018-02-21 株式会社島津製作所 質量分析用ペプチド混合物試料の調製方法
WO2016033382A1 (en) 2014-08-27 2016-03-03 Capnia, Inc. Methods for immune globulin administration
WO2016143283A1 (ja) 2015-03-09 2016-09-15 パナソニックＩｐマネジメント株式会社 マイクロ流体デバイス
EP3885368A1 (en) * 2015-05-12 2021-09-29 Regeneron Pharmaceuticals, Inc. Multimeric protein purity determination
WO2017163413A1 (ja) * 2016-03-25 2017-09-28 科健化学株式会社 中空カラム液体クロマトグラフィーシステム及び該システムを用いた物質の分離
DE102017130322B4 (de) 2017-12-18 2022-09-22 Jana Heise Verfahren und Kit zur spezifischen Detektion von diagnostisch relevanten Proteinen in biologischen Proben
SG11202108033TA (en) * 2019-01-31 2021-08-30 Regeneron Pharma Native microfluidic ce-ms analysis of antibody charge heterogeneity
AU2020326698A1 (en) 2019-08-05 2022-02-24 Seer, Inc. Systems and methods for sample preparation, data generation, and protein corona analysis
US12334190B2 (en) 2021-03-31 2025-06-17 PrognomIQ, Inc. Multi-omic assessment using proteins and nucleic acids
GB2607184B (en) * 2021-03-31 2024-07-17 Prognomiq Inc Multi-omic assessment
CN113433200A (zh) * 2021-06-16 2021-09-24 华南农业大学 一种电喷雾质谱技术鉴定交联聚合物的方法
CN114935609A (zh) * 2021-06-17 2022-08-23 上海阿趣生物科技有限公司 一种生物样本多胺及相关代谢物的高通量靶标检测方法
WO2023039479A1 (en) 2021-09-10 2023-03-16 PrognomIQ, Inc. Direct classification of raw biomolecule measurement data
CN115097038B (zh) * 2022-06-22 2023-08-01 山东国仓健生物科技有限公司 与大豆抗疫霉病相关的代谢产物的筛选鉴定方法及应用
US20240039912A1 (en) * 2022-07-29 2024-02-01 Arkose Labs Holdings, Inc. Security monitoring utilizing device signature detection
CN116735754A (zh) * 2023-08-04 2023-09-12 北京大学现代农业研究院 一种氨基酸类代谢物的高分辨液质联用分析方法及应用
WO2025085658A1 (en) * 2023-10-17 2025-04-24 Northeastern University System and method for proteomic analysis of limited samples
CN117169317B (zh) * 2023-10-30 2024-01-19 内蒙古蒙牛乳业（集团）股份有限公司 一种α-s1酪蛋白磷酸化程度检测方法、样品缓冲液及其应用
WO2025179149A1 (en) * 2024-02-22 2025-08-28 Toby, Inc. Training and use of machine-learning models for predicting biological conditions using volatile organic compounds

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4351760A (en) 1979-09-07 1982-09-28 Syva Company Novel alkyl substituted fluorescent compounds and polyamino acid conjugates
US4656133A (en) 1983-09-29 1987-04-07 Board Of Regents, University Of Texas System Method for enzymatic synthesis of isotopically labeled carbohydrates
JPH0828934B2 (ja) 1984-07-31 1996-03-21 株式会社東芝 保護制御装置
US4830010A (en) 1986-04-04 1989-05-16 Marshall Barry J Methods for the diagnosis of gastrointestinal disorders
US4842701A (en) * 1987-04-06 1989-06-27 Battelle Memorial Institute Combined electrophoretic-separation and electrospray method and system
US4994165A (en) * 1989-02-16 1991-02-19 Cornell Research Foundation, Inc. Liquid junction coupling for capillary zone electrophoresis/ion spray spectrometry
US5059702A (en) * 1989-09-29 1991-10-22 The United States Of America As Represented By The Secretary Of The Navy 124 Sn-labelled tetra-n-butyltin and tri-n-butyltin bromide
US5770029A (en) 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5858188A (en) 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5935401A (en) 1996-09-18 1999-08-10 Aclara Biosciences Surface modified electrophoretic chambers
US5133844A (en) 1990-03-15 1992-07-28 United States Department Of Energy Method of electric field flow fractionation wherein the polarity of the electric field is periodically reversed
SE9002480D0 (sv) 1990-07-23 1990-07-23 Hans Lilja Assay of free and complexed prostate-specific antigen
US5295261A (en) 1990-07-27 1994-03-15 Pacific Bell Corporation Hybrid database structure linking navigational fields having a hierarchial database structure to informational fields having a relational database structure
US5534440A (en) 1991-02-22 1996-07-09 Biomedical Research Centre Limited Compounds and methods for sequencing amino acids
EP0588952B1 (en) * 1991-05-21 1999-09-01 Analytica Of Branford, Inc. Method and apparatus for improving electrospray ionization of solute species
JP2844503B2 (ja) 1991-11-20 1999-01-06 東京瓦斯株式会社 ガス測定装置
US5140993A (en) 1991-12-27 1992-08-25 Baylor College Of Medicine Device for collecting a breath sample
US5317156A (en) 1992-01-29 1994-05-31 Sri International Diagnostic tests using near-infrared laser absorption spectroscopy
US5338686A (en) * 1992-04-29 1994-08-16 Hellerstein Marc K Method for measuring in vivo synthesis of biopolymers
AU687358B2 (en) * 1992-07-24 1998-02-26 United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The Peptides useful as internal standards for microsequencing and methods for their use
JP3509100B2 (ja) 1993-01-21 2004-03-22 プレジデント アンド フェローズ オブ ハーバード カレッジ 哺乳動物のストレスプロモーターを利用する化合物の毒性測定方法および診断用キット
US5439803A (en) 1993-08-13 1995-08-08 The Regents Of The University Of Michigan Isotope and assay for glycolysis and the pentose phosphate pathway
JPH0793370A (ja) 1993-09-27 1995-04-07 Hitachi Device Eng Co Ltd 遺伝子データベース検索システム
DE59410283D1 (de) * 1993-11-11 2003-06-18 Aclara Biosciences Inc Vorrichtung und Verfahren zur elektrophoretischen Trennung von fluiden Substanzgemischen
US5599677A (en) 1993-12-29 1997-02-04 Abbott Laboratories Immunoassays for prostate specific antigen
US5542419A (en) 1994-02-28 1996-08-06 Boston University Noninvasive method to detect gastric Helicobacter pylori
US6017693A (en) * 1994-03-14 2000-01-25 University Of Washington Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry
DE4415480C2 (de) * 1994-05-02 1999-09-02 Bruker Daltonik Gmbh Vorrichtung und Verfahren zur massenspektrometrischen Untersuchung von Substanzgemischen durch Kopplung kapillarelektrophoretischer Separation (CE) mit Elektrospray-Ionisierung (ESI)
US5856082A (en) * 1994-08-31 1999-01-05 University Of British Columbia Devices and methods for characterizing proteins and peptides
DE4433384C2 (de) * 1994-09-09 1996-12-19 Ufz Leipzighalle Gmbh Ökotoxikologischer Stoffwechseltest mit stabilen Isotopen
US5800692A (en) * 1995-04-17 1998-09-01 Mayo Foundation For Medical Education And Research Preseparation processor for use in capillary electrophoresis
US5628328A (en) * 1995-04-25 1997-05-13 Iowa State University Research Foundation Method for measuring muscle mass
US6004770A (en) * 1995-06-07 1999-12-21 Arizona State University Board Of Regents Sample presentation apparatus for mass spectrometry
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US5710007A (en) 1995-09-29 1998-01-20 Luderer; Albert A. Methods for diagnosing prostatic adenocarcinoma
JPH10291955A (ja) * 1997-04-22 1998-11-04 Sagami Chem Res Center １３ｃ標識ドコサヘキサエン酸及びその製造方法
US5800784A (en) 1996-07-09 1998-09-01 Horn; Marcus J. Chemical sample treatment system and cassette, and methods for effecting multistep treatment process
US6023659A (en) 1996-10-10 2000-02-08 Incyte Pharmaceuticals, Inc. Database system employing protein function hierarchies for viewing biomolecular sequence data
US5953727A (en) 1996-10-10 1999-09-14 Incyte Pharmaceuticals, Inc. Project-based full-length biomolecular sequence database
US5966712A (en) 1996-12-12 1999-10-12 Incyte Pharmaceuticals, Inc. Database and system for storing, comparing and displaying genomic information
JP2002505737A (ja) * 1997-02-14 2002-02-19 ジョージワシントン大学 Ｄｎａ合成速度測定のための分析
US5976336A (en) 1997-04-25 1999-11-02 Caliper Technologies Corp. Microfluidic devices incorporating improved channel geometries
US5910403A (en) 1997-05-15 1999-06-08 The Regents Of University Of California Methods for measuring cellular proliferation and destruction rates in vitro and in vivo
US5926818A (en) 1997-06-30 1999-07-20 International Business Machines Corporation Relational database implementation of a multi-dimensional database
JP3862366B2 (ja) * 1997-07-01 2006-12-27 東京瓦斯株式会社 肝機能診断剤
US6001231A (en) 1997-07-15 1999-12-14 Caliper Technologies Corp. Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems
US5876675A (en) 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US5924995A (en) 1997-11-10 1999-07-20 Meretek Diagnostics Non-invasive method for the functional assessment of infants and children with an inherited metabolic disorder

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