JP2003528808A - カンプトセシン誘導体を含むリポソームプロドラッグおよびこれらのプロドラッグを使用する癌治療方法 - Google Patents

カンプトセシン誘導体を含むリポソームプロドラッグおよびこれらのプロドラッグを使用する癌治療方法

Info

Publication number
JP2003528808A
JP2003528808A JP2001513393A JP2001513393A JP2003528808A JP 2003528808 A JP2003528808 A JP 2003528808A JP 2001513393 A JP2001513393 A JP 2001513393A JP 2001513393 A JP2001513393 A JP 2001513393A JP 2003528808 A JP2003528808 A JP 2003528808A
Authority
JP
Japan
Prior art keywords
group
compound
prodrug
liposome
linear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001513393A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003528808A5 (enExample
Inventor
カオ，ジサン
ジイオバネラ，ベッピーノ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stehlin Foundation for Cancer Research
Original Assignee
Stehlin Foundation for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/365,632 external-priority patent/US6096336A/en
Application filed by Stehlin Foundation for Cancer Research filed Critical Stehlin Foundation for Cancer Research
Publication of JP2003528808A publication Critical patent/JP2003528808A/ja
Publication of JP2003528808A5 publication Critical patent/JP2003528808A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2001513393A 1999-08-03 2000-07-25 カンプトセシン誘導体を含むリポソームプロドラッグおよびこれらのプロドラッグを使用する癌治療方法 Pending JP2003528808A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/365,632 1999-08-03
US09/365,632 US6096336A (en) 1996-01-30 1999-08-03 Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US09/499,684 2000-02-08
US09/499,684 US6352996B1 (en) 1999-08-03 2000-02-08 Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
PCT/US2000/020136 WO2001008663A2 (en) 1999-08-03 2000-07-25 Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs

Publications (2)

Publication Number Publication Date
JP2003528808A true JP2003528808A (ja) 2003-09-30
JP2003528808A5 JP2003528808A5 (enExample) 2007-06-28

Family

ID=43706143

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001513393A Pending JP2003528808A (ja) 1999-08-03 2000-07-25 カンプトセシン誘導体を含むリポソームプロドラッグおよびこれらのプロドラッグを使用する癌治療方法

Country Status (6)

Country Link
US (1) US6352996B1 (enExample)
EP (1) EP1200068A2 (enExample)
JP (1) JP2003528808A (enExample)
AU (1) AU6492600A (enExample)
CA (1) CA2379660A1 (enExample)
WO (1) WO2001008663A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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JPWO2013180253A1 (ja) * 2012-05-31 2016-01-21 テルモ株式会社 ｐＨ感受性担体およびその製造方法、並びに該担体を含むｐＨ感受性医薬、ｐＨ感受性医薬組成物およびこれを用いた培養方法

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TWI678213B (zh) 2015-07-22 2019-12-01 美商史倍壯製藥公司 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物
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Also Published As

Publication number Publication date
US6352996B1 (en) 2002-03-05
AU6492600A (en) 2001-02-19
WO2001008663A3 (en) 2001-07-26
EP1200068A2 (en) 2002-05-02
WO2001008663A2 (en) 2001-02-08
CA2379660A1 (en) 2001-02-08

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