JP2003525281A5 - - Google Patents
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- Publication number
- JP2003525281A5 JP2003525281A5 JP2001563500A JP2001563500A JP2003525281A5 JP 2003525281 A5 JP2003525281 A5 JP 2003525281A5 JP 2001563500 A JP2001563500 A JP 2001563500A JP 2001563500 A JP2001563500 A JP 2001563500A JP 2003525281 A5 JP2003525281 A5 JP 2003525281A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- compound according
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 description 28
- 125000000217 alkyl group Chemical group 0.000 description 26
- 125000003118 aryl group Chemical group 0.000 description 17
- 125000001072 heteroaryl group Chemical group 0.000 description 16
- 150000001204 N-oxides Chemical class 0.000 description 15
- 239000000651 prodrug Substances 0.000 description 15
- 229940002612 prodrug Drugs 0.000 description 15
- 229910052739 hydrogen Inorganic materials 0.000 description 13
- 239000001257 hydrogen Substances 0.000 description 13
- -1 cycloalkenylalkyl Chemical group 0.000 description 12
- 125000000753 cycloalkyl group Chemical group 0.000 description 10
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 9
- 125000003545 alkoxy group Chemical group 0.000 description 8
- 150000002431 hydrogen Chemical class 0.000 description 7
- 150000003839 salts Chemical class 0.000 description 7
- 239000012453 solvate Substances 0.000 description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 6
- 230000002378 acidificating effect Effects 0.000 description 6
- 125000002947 alkylene group Chemical group 0.000 description 6
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 6
- 125000003710 aryl alkyl group Chemical group 0.000 description 5
- 125000004093 cyano group Chemical group *C#N 0.000 description 5
- 125000000524 functional group Chemical group 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 229910052717 sulfur Inorganic materials 0.000 description 5
- 125000004450 alkenylene group Chemical group 0.000 description 4
- 125000004414 alkyl thio group Chemical group 0.000 description 4
- 125000004419 alkynylene group Chemical group 0.000 description 4
- 125000002619 bicyclic group Chemical group 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 125000005843 halogen group Chemical group 0.000 description 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 description 4
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 description 3
- 125000003342 alkenyl group Chemical group 0.000 description 3
- 125000004104 aryloxy group Chemical group 0.000 description 3
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 3
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 description 3
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 125000004043 oxo group Chemical group O=* 0.000 description 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 125000004442 acylamino group Chemical group 0.000 description 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 description 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 2
- 125000005530 alkylenedioxy group Chemical group 0.000 description 2
- 125000000304 alkynyl group Chemical group 0.000 description 2
- 125000003435 aroyl group Chemical group 0.000 description 2
- 125000005239 aroylamino group Chemical group 0.000 description 2
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 description 2
- 125000004659 aryl alkyl thio group Chemical group 0.000 description 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 description 2
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 description 2
- 125000005135 aryl sulfinyl group Chemical group 0.000 description 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 description 2
- 125000005110 aryl thio group Chemical group 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000021164 cell adhesion Effects 0.000 description 2
- 125000000392 cycloalkenyl group Chemical group 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 125000005114 heteroarylalkoxy group Chemical group 0.000 description 2
- 125000005553 heteroaryloxy group Chemical group 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 125000003107 substituted aryl group Chemical group 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 description 1
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 description 1
- ZECUUNNZGILYFD-UHFFFAOYSA-N 2-[5-[[2-[2-(2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]amino]-2,3-dihydro-1h-inden-1-yl]acetic acid Chemical compound CC1=CC=CC=C1NC(OC1=C2)=NC1=CC=C2CC(=O)NC1=CC=C(C(CC(O)=O)CC2)C2=C1 ZECUUNNZGILYFD-UHFFFAOYSA-N 0.000 description 1
- JBWFHRXDNZFCHV-UHFFFAOYSA-N 2-[5-[[2-[2-(2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]amino]-2,3-dihydro-1h-inden-2-yl]acetic acid Chemical compound CC1=CC=CC=C1NC(OC1=C2)=NC1=CC=C2CC(=O)NC1=CC=C(CC(CC(O)=O)C2)C2=C1 JBWFHRXDNZFCHV-UHFFFAOYSA-N 0.000 description 1
- SOQXZOVUQAAKEC-UHFFFAOYSA-N 3-[7-[[2-[2-(2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]amino]-2,3-dihydro-1h-inden-4-yl]butanoic acid Chemical compound C1=2CCCC=2C(C(CC(O)=O)C)=CC=C1NC(=O)CC(C=C1O2)=CC=C1N=C2NC1=CC=CC=C1C SOQXZOVUQAAKEC-UHFFFAOYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 125000005018 aryl alkenyl group Chemical group 0.000 description 1
- 125000005015 aryl alkynyl group Chemical group 0.000 description 1
- 125000000732 arylene group Chemical group 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 150000001555 benzenes Chemical class 0.000 description 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 description 1
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical group C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 description 1
- 150000003857 carboxamides Chemical class 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 125000005724 cycloalkenylene group Chemical group 0.000 description 1
- 125000005356 cycloalkylalkenyl group Chemical group 0.000 description 1
- 125000005357 cycloalkylalkynyl group Chemical group 0.000 description 1
- 125000002993 cycloalkylene group Chemical group 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- YGCOXELGOCAPTL-UHFFFAOYSA-N ethyl 2-[5-[[2-[2-(2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]amino]-2,3-dihydro-1h-inden-1-yl]acetate Chemical compound C=1C=C2C(CC(=O)OCC)CCC2=CC=1NC(=O)CC(C=C1O2)=CC=C1N=C2NC1=CC=CC=C1C YGCOXELGOCAPTL-UHFFFAOYSA-N 0.000 description 1
- BWFHWRFHEBANMZ-UHFFFAOYSA-N ethyl 3-[7-[[2-[2-(2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]amino]-2,3-dihydro-1h-inden-4-yl]butanoate Chemical compound C1=2CCCC=2C(C(C)CC(=O)OCC)=CC=C1NC(=O)CC(C=C1O2)=CC=C1N=C2NC1=CC=CC=C1C BWFHWRFHEBANMZ-UHFFFAOYSA-N 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000004447 heteroarylalkenyl group Chemical group 0.000 description 1
- 125000005312 heteroarylalkynyl group Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 125000005835 indanylene group Chemical group 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Chemical group CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0004686.2 | 2000-02-28 | ||
| GBGB0004686.2A GB0004686D0 (en) | 2000-02-28 | 2000-02-28 | Chemical compounds |
| PCT/GB2001/000844 WO2001064659A2 (en) | 2000-02-28 | 2001-02-28 | Indane derivatives and their use as cell adhesion inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003525281A JP2003525281A (ja) | 2003-08-26 |
| JP2003525281A5 true JP2003525281A5 (https=) | 2008-03-27 |
| JP5021133B2 JP5021133B2 (ja) | 2012-09-05 |
Family
ID=9886551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001563500A Expired - Lifetime JP5021133B2 (ja) | 2000-02-28 | 2001-02-28 | インダン誘導体および細胞接着抑制物質としてのそれらの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6762199B2 (https=) |
| EP (1) | EP1259495B1 (https=) |
| JP (1) | JP5021133B2 (https=) |
| AR (1) | AR027578A1 (https=) |
| AT (1) | ATE277023T1 (https=) |
| AU (1) | AU3579001A (https=) |
| CA (1) | CA2401441C (https=) |
| DE (1) | DE60105771T2 (https=) |
| ES (1) | ES2227137T3 (https=) |
| GB (1) | GB0004686D0 (https=) |
| IL (1) | IL150724A0 (https=) |
| MX (1) | MXPA02008375A (https=) |
| WO (1) | WO2001064659A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4212358B2 (ja) | 2000-12-28 | 2009-01-21 | 第一三共株式会社 | Ｖｌａ−４阻害薬 |
| GB0123765D0 (en) * | 2001-10-03 | 2001-11-21 | Bayer Ag | Para-amino benzoic acids |
| US8005919B2 (en) | 2002-11-18 | 2011-08-23 | Aol Inc. | Host-based intelligent results related to a character stream |
| CA2506585A1 (en) | 2002-11-18 | 2004-06-03 | Valerie Kucharewski | People lists |
| CA2528586A1 (en) | 2003-07-24 | 2005-02-03 | Daiichi Pharmaceutical Co., Ltd. | Cyclohexanecarboxylic acid compound |
| JP2006056830A (ja) * | 2004-08-20 | 2006-03-02 | Dai Ichi Seiyaku Co Ltd | ２−アリールアミノベンゾオキサゾール誘導体 |
| WO2012074980A2 (en) * | 2010-12-01 | 2012-06-07 | Dara Biosciences, Inc. | Methods of treating or preventing autoimmune disorders and liver disorders using indane acetic acid derivatives |
| US12522583B2 (en) | 2018-11-07 | 2026-01-13 | Dana-Farber Cancer Institute, Inc. | Benzimidazole derivatives and aza-benzimidazole derivatives as Janus kinase 2 inhibitors and uses thereof |
| EP3877371A4 (en) | 2018-11-07 | 2022-07-27 | Dana-Farber Cancer Institute, Inc. | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF |
| EP3876939A4 (en) | 2018-11-07 | 2022-08-10 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| US11691963B2 (en) | 2020-05-06 | 2023-07-04 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| US12043632B2 (en) | 2020-12-23 | 2024-07-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| US12162881B2 (en) | 2021-11-09 | 2024-12-10 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of JAK2 |
| WO2023086319A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
Family Cites Families (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2041594A5 (https=) * | 1969-04-30 | 1971-01-29 | Expanscience | |
| US4331692A (en) * | 1971-07-23 | 1982-05-25 | Ulla Drevici | Cocoa fruits and products |
| GB1541463A (en) * | 1975-10-11 | 1979-02-28 | Lion Dentifrice Co Ltd | Process for prparing a multiple emulsion having a dispersing form of water-phase/oil-phase/water-phase |
| US4151304A (en) * | 1976-11-05 | 1979-04-24 | Lever Brothers Company | Method and composition for moisturizing the skin |
| FR2380775A1 (fr) * | 1977-02-22 | 1978-09-15 | Sederma Sarl | Composition " apres-epilation " favorisant un ralentissement progressif de la repousse des poils |
| US4190671A (en) * | 1977-03-17 | 1980-02-26 | Biorex Laboratories Limited | Chalcone derivatives |
| US4279930A (en) * | 1978-10-10 | 1981-07-21 | The Upjohn Company | Process for treating inflammation |
| DE3040246C2 (de) * | 1979-10-29 | 1985-01-10 | Osaka Chemical Laboratory Co., Ltd., Osaka | Sojasaponine A↓1↓ und A↓2↓ und ihre Verwendung |
| JPS56135416A (en) * | 1980-03-27 | 1981-10-22 | Mitsubishi Chem Ind Ltd | Pharmaceutical preparation for skin |
| US4272544A (en) * | 1980-08-20 | 1981-06-09 | Eli Lilly And Company | Skin cell renewal regime |
| US4278570A (en) * | 1980-08-20 | 1981-07-14 | Eli Lilly And Company | Cosmetic cleanser formulation |
| DE3109420A1 (de) * | 1981-03-12 | 1982-09-23 | Kastell, Wolfgang, 2000 Hamburg | Mittel zum anhalten des haarausfalls und zum foerdern des haarwuchses |
| FR2509988B1 (fr) * | 1981-07-23 | 1986-05-30 | Oreal | Melange d'huiles vegetales a base d'huile de jojoba comme agent de stabilisation a l'oxydation et compositions cosmetiques le contenant |
| DE3129867A1 (de) * | 1981-07-29 | 1983-02-17 | Henkel Kgaa | "ungesaettigte arylketone als antiseborrhoische zusaetze fuer kosmetische mittel" |
| US4382960A (en) * | 1981-08-03 | 1983-05-10 | Eli Lilly And Company | Cosmetic cleanser formulation |
| US4368187A (en) * | 1981-08-03 | 1983-01-11 | Eli Lilly And Company | Sensitive-skin care regime |
| US4578267A (en) * | 1981-09-15 | 1986-03-25 | Morton Thiokol, Inc. | Skin conditioning polymer containing alkoxylated nitrogen salts of sulfonic acid |
| US4462981A (en) * | 1982-12-10 | 1984-07-31 | Creative Products Resource, Associates Ltd. | Cosmetic applicator useful for skin moisturizing and deodorizing |
| US5192332A (en) * | 1983-10-14 | 1993-03-09 | L'oreal | Cosmetic temporary coloring compositions containing protein derivatives |
| JPS60109544A (ja) * | 1983-11-17 | 1985-06-15 | Kao Corp | 新規カルコン誘導体及びこれを含有する紫外線吸収剤 |
| FR2580478B1 (fr) * | 1985-04-17 | 1989-05-12 | Christian Chapoton | Dispositif de traitement capillaire liberant une substance active et procede de fabrication |
| US4760096A (en) * | 1985-09-27 | 1988-07-26 | Schering Corporation | Moisturizing skin preparation |
| US4847267A (en) * | 1986-03-17 | 1989-07-11 | Charles Of The Ritz Group Ltd. | Skin treatment composition and method |
| IT1203515B (it) * | 1987-02-26 | 1989-02-15 | Indena Spa | Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono |
| US4824662A (en) * | 1987-06-15 | 1989-04-25 | Vi-Jon Laboratories, Inc. | Nail polish remover |
| IT1222012B (it) * | 1987-07-10 | 1990-08-31 | Indena Spa | Composizioni farmaceutiche e cosmetiche contenenti complessi di flavonolignani con fosfolipidi |
| IT1223290B (it) * | 1987-07-27 | 1990-09-19 | Indena Spa | Acidi poliinsaturi ad azione vasocinetica e relative formulazioni farmaceutiche e cosmetiche |
| LU86997A1 (fr) * | 1987-09-21 | 1989-04-06 | Oreal | Composition cosmetique filtrante photostable contenant de la bixine associee a un filtre uv liposoluble et son utilisation pour la protection de l'epiderme humain contre les radiations ultraviolettes |
| EP0317667B1 (en) * | 1987-11-24 | 1993-02-17 | Agfa-Gevaert N.V. | Magnetic carrier particles |
| CH676470A5 (https=) * | 1988-02-03 | 1991-01-31 | Nestle Sa | |
| DE3814839A1 (de) * | 1988-05-02 | 1989-11-16 | Henkel Kgaa | Haarbehandlungsmittel mit natuerlichen inhaltsstoffen |
| US4906457A (en) * | 1988-09-06 | 1990-03-06 | Washington State University Research Foundation, Inc. | Compositions and methods for reducing the risk of sunlight and ultraviolet induced skin cancer |
| US4851214A (en) * | 1988-09-07 | 1989-07-25 | Ici Americas Inc. | Deodorants containing N-soya-N-ethyl morpholinium ethosulfate |
| US4943462A (en) * | 1989-01-17 | 1990-07-24 | Semex Medical, Inc. | Nail treatment device |
| US5116605A (en) * | 1989-03-09 | 1992-05-26 | Alt John P | Composition and skin treatment method therewith for mitigating acne and male-pattern baldness |
| US5194252A (en) * | 1989-07-27 | 1993-03-16 | Vijon Laboratories, Inc. | Moisture retaining aftershave |
| US5032400A (en) * | 1989-11-02 | 1991-07-16 | Erie Laboratories | Shark liver oil and garlic oil topical analgesic |
| US5622690A (en) * | 1990-04-05 | 1997-04-22 | Nurture, Inc. | Seed-derived proteinaceous compositions for reduction of sunburn cell formation |
| FR2663633B1 (fr) * | 1990-06-22 | 1994-06-17 | Adir | Nouvelles chalcones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5231090A (en) * | 1990-07-30 | 1993-07-27 | University Of Miami | Treatment for hypercholesterolemia |
| US5407675A (en) * | 1990-08-10 | 1995-04-18 | Etemad-Moghadam; Parviz | Method and composition for use on the scalp and eyebrow region of a subject |
| CA2049728A1 (en) * | 1990-08-24 | 1992-02-25 | Kenji Kitamura | Washing composition capable of preventing and ameliorating skin irritation |
| US5217717A (en) * | 1990-09-06 | 1993-06-08 | Central Soya Company, Inc. | Method of making soybean Bowman-Birk inhibitor concentrate and use of same as a human cancer preventative and therapy |
| EP0510165B1 (fr) * | 1990-11-14 | 1995-01-25 | L'oreal | Composes amphiphiles non-ioniques derives du glycerol, leur procede de preparation, composes intermediaires correspondants et compositions contenant lesdits composes |
| US5110603A (en) * | 1991-01-31 | 1992-05-05 | Kao Corporation | Bathing preparation for colloidal material |
| US5188823A (en) * | 1991-02-07 | 1993-02-23 | Stepan Company | Antiperspirant formulations |
| US5498420A (en) * | 1991-04-12 | 1996-03-12 | Merz & Co. Gmbh & Co. | Stable small particle liposome preparations, their production and use in topical cosmetic, and pharmaceutical compositions |
| US5229104A (en) * | 1991-04-29 | 1993-07-20 | Richardson-Vicks Inc. | Artificial tanning compositions containing positively charged paucilamellar vesicles |
| EP0514576A1 (fr) * | 1991-05-24 | 1992-11-25 | Societe Des Produits Nestle S.A. | Mélange antioxydant liposoluble |
| US5310734A (en) * | 1991-07-05 | 1994-05-10 | Rhone-Poulenc Rorer | Phospholipid composition |
| ES2179038T3 (es) * | 1991-09-13 | 2003-01-16 | Pentapharm Ag | Fraccion porteinica para el tratamiento cosmetico y dermatologico de la piel. |
| WO1993010755A1 (en) * | 1991-11-25 | 1993-06-10 | Richardson-Vicks, Inc. | Compositions for regulating skin wrinkles and/or skin atrophy |
| WO1993010756A1 (en) * | 1991-11-25 | 1993-06-10 | Richardson-Vicks, Inc. | Use of salicylic acid for regulating skin wrinkles and/or skin atrophy |
| FR2687314A1 (fr) * | 1992-02-18 | 1993-08-20 | Oreal | Dispersion de vesicules lipidiques, composition cosmetique et/ou pharmaceutique la contenant et procede de preparation de ladite dispersion. |
| US5766628A (en) * | 1992-02-24 | 1998-06-16 | Merz + Co. Gmbh & Co. | Bath and shower composition having vesicle-forming properties and method for the production and use thereof |
| US5393519A (en) * | 1992-03-27 | 1995-02-28 | Helene Curtis, Inc. | Shampoo compositions |
| DE4226173A1 (de) * | 1992-08-07 | 1994-02-10 | Solvay Fluor & Derivate | Badezusatzpräparat |
| FR2694934B1 (fr) * | 1992-08-24 | 1994-11-10 | Oreal | Composition pour le traitement de l'acné contenant un dérivé d'acide salicylique et dérivés d'acide salicylique. |
| US6048520A (en) * | 1992-09-24 | 2000-04-11 | Helene Curtis, Inc. | Clear leave-on hair treatment composition and method |
| US5753612A (en) * | 1992-10-27 | 1998-05-19 | Yissum Research Development Co. Of The Hebrew University Of Jerusalem | Pharmaceutical composition and method for inhibiting hair growth by administration of activin or activin agonists |
| CA2119064A1 (en) * | 1993-03-17 | 1994-09-18 | Richard A. Berg | Dermal-epidermal in vitro test system |
| US5276058A (en) * | 1993-06-09 | 1994-01-04 | Nippon Hypox Laboratories Incorporated | 3,4-dihydroxychalcone derivatives |
| FR2710264B1 (fr) * | 1993-09-21 | 1995-12-08 | Rocher Yves Biolog Vegetale | Utilisation pour le traitement des peaux mixtes d'une quantité efficace de substances actives. |
| DE4343431C1 (de) * | 1993-12-18 | 1995-05-04 | Henkel Kgaa | Kosmetische und/oder pharamzeutische Zubereitungen |
| FR2714596B1 (fr) * | 1993-12-30 | 1996-02-09 | Oreal | Composition cosmétique pour le traitement simultané des couches superficielles et profondes de la peau, son utilisation. |
| US6013255A (en) * | 1994-04-18 | 2000-01-11 | Gist-Brocades B.V. | Stable water-in-oil emulsions |
| GB9414045D0 (en) * | 1994-07-12 | 1994-08-31 | Berwind Pharma Service | Moisture barrier film coating composition, method, and coated form |
| DE4444238A1 (de) * | 1994-12-13 | 1996-06-20 | Beiersdorf Ag | Kosmetische oder dermatologische Wirkstoffkombinationen aus Zimtsäurederivaten und Flavonglycosiden |
| US5523308A (en) * | 1995-06-07 | 1996-06-04 | Costanzo; Michael J. | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
| US5639785A (en) * | 1995-06-07 | 1997-06-17 | Global Pharma, Ltd. | Methods for the treatment of baldness and gray hair using isoflavonoid derivatives |
| US6013250A (en) * | 1995-06-28 | 2000-01-11 | L'oreal S. A. | Composition for treating hair against chemical and photo damage |
| US6063398A (en) * | 1995-09-20 | 2000-05-16 | L'oreal | Cosmetic or dermopharmaceutical patch containing, in an anhydrous polymeric matrix, at least one active compound which is, in particular, unstable in oxidizing mediums, and at least one water-absorbing agent |
| US5885593A (en) * | 1995-09-28 | 1999-03-23 | The Andrew Jergens Company | Skin care composition including cyclodextrin materials and method for treating skin therewith |
| US6019962A (en) * | 1995-11-07 | 2000-02-01 | The Procter & Gamble Co. | Compositions and methods for improving cosmetic products |
| ES2154844T3 (es) * | 1995-11-24 | 2001-04-16 | Mitsui Chemicals Inc | Derivados de hidrocalcona, composiciones cosmeticas que contienen dichos derivados y procedimientos para producir los mismos. |
| US5643587A (en) * | 1996-02-15 | 1997-07-01 | Avon Products, Inc. | Composition and method for under-eye skin lightening |
| FR2747568B1 (fr) * | 1996-04-17 | 1999-09-17 | Oreal | Utilisation d'au moins un inhibiteur de lipoxygenase et d'au moins un inhibiteur de cyclo-oxygenase pour modifier la pousse des poils et/ou des cheveux |
| IL119535A (en) * | 1996-10-31 | 2001-01-11 | Chajuss Daniel | Soy molasses and modified soy molasses for topical application |
| FR2757767B1 (fr) * | 1996-12-27 | 1999-02-05 | Oreal | Composition topique contenant au moins une proteine d'origine vegetale et/ou une proteine d'origine animale et une poly(acide 2-acrylamido 2-methylpropane sulfonique) reticule |
| US5863546A (en) * | 1997-03-02 | 1999-01-26 | Swinehart; James M | Cosmetic composition |
| US5885600A (en) * | 1997-04-01 | 1999-03-23 | Burlington Bio-Medical & Scientific Corp. | Natural insect repellent formula and method of making same |
| US5885596A (en) * | 1997-07-23 | 1999-03-23 | Bristol-Myers Squibb Company | Methods and compositions for fine lines and/or wrinkles |
| US6017893A (en) * | 1997-08-29 | 2000-01-25 | Natures Sunshine Products, Inc. | Use of isoflavones to prevent hair loss and preserve the integrity of existing hair |
| US5928658A (en) * | 1997-12-05 | 1999-07-27 | U.S. Cosmetics | Oil-free wax-free solid cosmetic composition |
| FR2772613B1 (fr) * | 1997-12-19 | 2003-05-09 | Oreal | Utilisation du phloroglucinol dans une composition cosmetique |
| US6030931A (en) * | 1998-02-03 | 2000-02-29 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Foaming cleansing skin product |
| US5928889A (en) * | 1998-02-13 | 1999-07-27 | S.C. Johnson & Son, Inc. | Protocol for simulated natural biofilm formation |
| BR9908870A (pt) * | 1998-03-16 | 2000-11-21 | Procter & Gamble | Processos para regularizarem a aparência da pele |
| CO5090829A1 (es) * | 1998-07-21 | 2001-10-30 | Novartis Ag | Compuestos organicos de la formula i, utiles como inhibido res de la proteina de transferencia de triglicerido microso mal y de la secrecion de la apolipoproteina b. |
| GB9916374D0 (en) * | 1998-07-23 | 1999-09-15 | Zeneca Ltd | Chemical compounds |
| JP2002521375A (ja) * | 1998-07-23 | 2002-07-16 | アストラゼネカ アクチエボラーク | 化合物 |
| WO2000049005A1 (en) * | 1999-02-16 | 2000-08-24 | Aventis Pharma Limited | Bicyclic compounds and their use as integrin receptor ligands |
| ES2321055T3 (es) * | 1999-05-05 | 2009-06-02 | Aventis Pharma Limited | Compuestos biblicos sustituidos. |
-
2000
- 2000-02-28 GB GBGB0004686.2A patent/GB0004686D0/en not_active Ceased
-
2001
- 2001-02-28 AR ARP010100942A patent/AR027578A1/es unknown
- 2001-02-28 DE DE60105771T patent/DE60105771T2/de not_active Expired - Lifetime
- 2001-02-28 ES ES01907923T patent/ES2227137T3/es not_active Expired - Lifetime
- 2001-02-28 JP JP2001563500A patent/JP5021133B2/ja not_active Expired - Lifetime
- 2001-02-28 EP EP01907923A patent/EP1259495B1/en not_active Expired - Lifetime
- 2001-02-28 CA CA2401441A patent/CA2401441C/en not_active Expired - Lifetime
- 2001-02-28 AT AT01907923T patent/ATE277023T1/de not_active IP Right Cessation
- 2001-02-28 WO PCT/GB2001/000844 patent/WO2001064659A2/en not_active Ceased
- 2001-02-28 MX MXPA02008375A patent/MXPA02008375A/es active IP Right Grant
- 2001-02-28 IL IL15072401A patent/IL150724A0/xx unknown
- 2001-02-28 AU AU35790/01A patent/AU3579001A/en not_active Abandoned
-
2002
- 2002-08-28 US US10/229,592 patent/US6762199B2/en not_active Expired - Lifetime
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