JP2003524389A5 - - Google Patents
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- Publication number
- JP2003524389A5 JP2003524389A5 JP2000588367A JP2000588367A JP2003524389A5 JP 2003524389 A5 JP2003524389 A5 JP 2003524389A5 JP 2000588367 A JP2000588367 A JP 2000588367A JP 2000588367 A JP2000588367 A JP 2000588367A JP 2003524389 A5 JP2003524389 A5 JP 2003524389A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nucleotides
- polypeptide
- group
- nucleotide sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000002773 nucleotide Substances 0.000 description 19
- 125000003729 nucleotide group Chemical group 0.000 description 19
- 229920001184 polypeptide Polymers 0.000 description 15
- 108090000765 processed proteins & peptides Proteins 0.000 description 15
- 102000004196 processed proteins & peptides Human genes 0.000 description 15
- 108090000623 proteins and genes Proteins 0.000 description 13
- 150000001413 amino acids Chemical class 0.000 description 9
- 239000002299 complementary DNA Substances 0.000 description 7
- 108091033319 polynucleotide Proteins 0.000 description 6
- 239000002157 polynucleotide Substances 0.000 description 6
- 102000040430 polynucleotide Human genes 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 125000003275 alpha amino acid group Chemical group 0.000 description 5
- 108091026890 Coding region Proteins 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 230000009826 neoplastic cell growth Effects 0.000 description 3
- 230000035897 transcription Effects 0.000 description 3
- 238000013518 transcription Methods 0.000 description 3
- 230000005026 transcription initiation Effects 0.000 description 3
- 108091027544 Subgenomic mRNA Proteins 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108020005067 RNA Splice Sites Proteins 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000006801 homologous recombination Effects 0.000 description 1
- 238000002744 homologous recombination Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11249798P | 1998-12-16 | 1998-12-16 | |
| US60/112,497 | 1998-12-16 | ||
| US46406599A | 1999-12-15 | 1999-12-15 | |
| US09/464,065 | 1999-12-15 | ||
| PCT/US1999/030113 WO2000036118A2 (en) | 1998-12-16 | 1999-12-16 | HUMAN CYCLIN-DEPENDENT KINASE (hPNQALRE) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010048410A Division JP2010162036A (ja) | 1998-12-16 | 2010-03-04 | ヒトサイクリン依存的キナーゼ（ｈＰＮＱＡＬＲＥ） |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003524389A JP2003524389A (ja) | 2003-08-19 |
| JP2003524389A5 true JP2003524389A5 (https=) | 2007-02-01 |
Family
ID=26810024
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000588367A Withdrawn JP2003524389A (ja) | 1998-12-16 | 1999-12-16 | ヒトサイクリン依存的キナーゼ（ｈＰＮＱＡＬＲＥ） |
| JP2010048410A Withdrawn JP2010162036A (ja) | 1998-12-16 | 2010-03-04 | ヒトサイクリン依存的キナーゼ（ｈＰＮＱＡＬＲＥ） |
| JP2013097306A Pending JP2013162795A (ja) | 1998-12-16 | 2013-05-07 | ヒトサイクリン依存的キナーゼ（ｈＰＮＱＡＬＲＥ） |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010048410A Withdrawn JP2010162036A (ja) | 1998-12-16 | 2010-03-04 | ヒトサイクリン依存的キナーゼ（ｈＰＮＱＡＬＲＥ） |
| JP2013097306A Pending JP2013162795A (ja) | 1998-12-16 | 2013-05-07 | ヒトサイクリン依存的キナーゼ（ｈＰＮＱＡＬＲＥ） |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7250256B2 (https=) |
| EP (2) | EP1961813B1 (https=) |
| JP (3) | JP2003524389A (https=) |
| AT (2) | ATE519840T1 (https=) |
| AU (1) | AU2367600A (https=) |
| CY (1) | CY1108662T1 (https=) |
| DE (1) | DE69939599D1 (https=) |
| DK (1) | DK1141331T3 (https=) |
| ES (1) | ES2310055T3 (https=) |
| PT (1) | PT1141331E (https=) |
| WO (1) | WO2000036118A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1961813B1 (en) * | 1998-12-16 | 2011-08-10 | Novartis Vaccines and Diagnostics, Inc. | Human cyclin-dependent kinase (hPNQALRE) |
| US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| WO2007087370A2 (en) * | 2006-01-25 | 2007-08-02 | Caprion Pharmaceuticals, Inc. | Tat-038 and methods of assessing and treating cancer |
| EP2029779A4 (en) | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS |
| US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
| EP2589668A1 (en) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
| US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| MX2010003371A (es) | 2007-09-28 | 2010-05-05 | Intrexon Corp | Constructos interruptores genicos terapeuticos y biorreactores para la expresion de moleculas bioterapeuticas y usos de los mismos. |
| CA3069082C (en) | 2008-09-20 | 2022-03-22 | The Board Of Trustees Of The Leland Stanford Junior University | Noninvasive diagnosis of fetal aneuploidy by sequencing |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| US4551433A (en) | 1981-05-18 | 1985-11-05 | Genentech, Inc. | Microbial hybrid promoters |
| US4405712A (en) | 1981-07-01 | 1983-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | LTR-Vectors |
| US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
| US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| EP0127839B1 (en) | 1983-05-27 | 1992-07-15 | THE TEXAS A&M UNIVERSITY SYSTEM | Method for producing a recombinant baculovirus expression vector |
| US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| ZA848495B (en) | 1984-01-31 | 1985-09-25 | Idaho Res Found | Production of polypeptides in insect cells |
| US4837148A (en) | 1984-10-30 | 1989-06-06 | Phillips Petroleum Company | Autonomous replication sequences for yeast strains of the genus pichia |
| US4762915A (en) | 1985-01-18 | 1988-08-09 | Liposome Technology, Inc. | Protein-liposome conjugates |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| US4777127A (en) | 1985-09-30 | 1988-10-11 | Labsystems Oy | Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus |
| IL77186A0 (en) | 1985-11-29 | 1986-04-29 | Touitou Elka | Pharmaceutical insulin composition |
| US5091309A (en) | 1986-01-16 | 1992-02-25 | Washington University | Sindbis virus vectors |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
| GB2189699A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| GB8702816D0 (en) | 1987-02-07 | 1987-03-11 | Al Sumidaie A M K | Obtaining retrovirus-containing fraction |
| US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| US4980289A (en) | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
| WO1989001973A2 (en) | 1987-09-02 | 1989-03-09 | Applied Biotechnology, Inc. | Recombinant pox virus for immunization against tumor-associated antigens |
| ATE117375T1 (de) | 1987-09-11 | 1995-02-15 | Whitehead Biomedical Inst | Transduktionsveränderte fibroblasten und ihre anwendung. |
| US4929555A (en) | 1987-10-19 | 1990-05-29 | Phillips Petroleum Company | Pichia transformation |
| WO1989005349A1 (en) | 1987-12-09 | 1989-06-15 | The Australian National University | Method of combating viral infections |
| MC2115A1 (fr) | 1987-12-15 | 1991-07-05 | Gene Shears Pty Ltd | Ribozynes |
| US5662896A (en) | 1988-03-21 | 1997-09-02 | Chiron Viagene, Inc. | Compositions and methods for cancer immunotherapy |
| US5422120A (en) | 1988-05-30 | 1995-06-06 | Depotech Corporation | Heterovesicular liposomes |
| AP129A (en) | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
| WO1990002806A1 (en) | 1988-09-01 | 1990-03-22 | Whitehead Institute For Biomedical Research | Recombinant retroviruses with amphotropic and ecotropic host ranges |
| ATE135397T1 (de) | 1988-09-23 | 1996-03-15 | Cetus Oncology Corp | Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte |
| US5217879A (en) | 1989-01-12 | 1993-06-08 | Washington University | Infectious Sindbis virus vectors |
| WO1990007936A1 (en) | 1989-01-23 | 1990-07-26 | Chiron Corporation | Recombinant therapies for infection and hyperproliferative disorders |
| JP3140757B2 (ja) | 1989-02-06 | 2001-03-05 | デイナ・フアーバー・キヤンサー・インステイテユート | パッケージング欠陥ｈｉｖプロウイルス、細胞系及びその使用 |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| CA2489769A1 (en) | 1989-03-21 | 1990-10-04 | Philip L. Felgner | Expression of exogenous polynucleotide sequences in a vertebrate |
| FR2649120B1 (fr) | 1989-06-30 | 1994-01-28 | Cayla | Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede |
| AU648261B2 (en) | 1989-08-18 | 1994-04-21 | Novartis Vaccines And Diagnostics, Inc. | Recombinant retroviruses delivering vector constructs to target cells |
| GB8919607D0 (en) | 1989-08-30 | 1989-10-11 | Wellcome Found | Novel entities for cancer therapy |
| AU7007491A (en) | 1990-02-02 | 1991-08-08 | Schweiz. Serum- & Impfinstitut Bern | Cdna corresponding to the genome of negative-strand rna viruses, and process for the production of infectious negative-strand rna viruses |
| ZA911974B (en) | 1990-03-21 | 1994-08-22 | Res Dev Foundation | Heterovesicular liposomes |
| EP0854193A1 (en) | 1990-09-21 | 1998-07-22 | Chiron Corporation | Human retroviral packaging cell line |
| SE9003978D0 (sv) | 1990-12-13 | 1990-12-13 | Henrik Garoff | Dna expressionssystem baserade paa ett virus replikon |
| NZ314630A (en) | 1991-01-17 | 2000-11-24 | Harvard College | Use of trans-splicing ribozymes for genetic modification and cell ablation in a host cell |
| DE69228247T2 (de) | 1991-08-10 | 1999-07-08 | Medical Research Council, London | Behandlung von Zellpopulationen |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| FR2681786A1 (fr) | 1991-09-27 | 1993-04-02 | Centre Nat Rech Scient | Vecteurs recombinants d'origine virale, leur procede d'obtention et leur utilisation pour l'expression de polypeptides dans des cellules musculaires. |
| IL103059A0 (en) | 1991-09-30 | 1993-02-21 | Boehringer Ingelheim Int | Conjugates for introducing nucleic acid into higher eucaryotic cells |
| NZ244306A (en) | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| WO1993010218A1 (en) | 1991-11-14 | 1993-05-27 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Vectors including foreign genes and negative selective markers |
| GB9125623D0 (en) | 1991-12-02 | 1992-01-29 | Dynal As | Cell modification |
| EP0650370A4 (en) | 1992-06-08 | 1995-11-22 | Univ California | METHODS AND COMPOSITIONS TARGETED ON SPECIFIC TISSUES. |
| CA2137361A1 (en) | 1992-06-10 | 1993-12-23 | W. French Anderson | Vector particles resistant to inactivation by human serum |
| GB2269175A (en) | 1992-07-31 | 1994-02-02 | Imperial College | Retroviral vectors |
| ES2156149T3 (es) | 1992-12-04 | 2001-06-16 | Medical Res Council | Proteinas de union multivalente y multiespecificas, su fabricacion y su uso. |
| DK0814154T3 (da) | 1993-09-15 | 2009-08-31 | Novartis Vaccines & Diagnostic | Rekombinante alfavirusvektorer |
| AU686277B2 (en) | 1993-11-16 | 1998-02-05 | Pacira Pharmaceuticals, Inc. | Vesicles with controlled release of actives |
| US6105575A (en) | 1994-06-03 | 2000-08-22 | Respironics, Inc. | Method and apparatus for providing positive airway pressure to a patient |
| US5674748A (en) * | 1995-03-14 | 1997-10-07 | Thomas Jefferson University | Human cyclin-dependent kinase-like proteins and methods of using the same |
| AU1526897A (en) * | 1996-01-05 | 1997-08-01 | Eli Lilly And Company | Fusion proteins comprising cell cycle regulatory proteins |
| CA2280206A1 (en) * | 1997-02-07 | 1998-08-13 | Merck & Co., Inc. | Cyclin-dependent protein kinase |
| US5968800A (en) * | 1997-02-07 | 1999-10-19 | Merck & Co., Inc. | Cyclin-dependent protein kinase |
| AU6552198A (en) * | 1997-03-14 | 1998-09-29 | Human Genome Sciences, Inc. | 28 human secreted proteins |
| FR2774994B1 (fr) | 1998-02-13 | 2000-05-05 | Rhodia Chimie Sa | Particules composites comprenant un coeur a base d'un polymere organique contenant une matiere active et un revetement externe a base d'au moins un oxyde et/ou un hydroxyde, leur procede de preparation et leurs utilisations |
| EP1961813B1 (en) * | 1998-12-16 | 2011-08-10 | Novartis Vaccines and Diagnostics, Inc. | Human cyclin-dependent kinase (hPNQALRE) |
| US20070011783A1 (en) * | 1999-05-06 | 2007-01-11 | Jingdong Liu | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
-
1999
- 1999-12-16 EP EP08006175A patent/EP1961813B1/en not_active Expired - Lifetime
- 1999-12-16 ES ES99967389T patent/ES2310055T3/es not_active Expired - Lifetime
- 1999-12-16 DK DK99967389T patent/DK1141331T3/da active
- 1999-12-16 DE DE69939599T patent/DE69939599D1/de not_active Expired - Lifetime
- 1999-12-16 JP JP2000588367A patent/JP2003524389A/ja not_active Withdrawn
- 1999-12-16 AT AT08006175T patent/ATE519840T1/de not_active IP Right Cessation
- 1999-12-16 EP EP99967389A patent/EP1141331B1/en not_active Expired - Lifetime
- 1999-12-16 WO PCT/US1999/030113 patent/WO2000036118A2/en not_active Ceased
- 1999-12-16 PT PT99967389T patent/PT1141331E/pt unknown
- 1999-12-16 AT AT99967389T patent/ATE408695T1/de active
- 1999-12-16 AU AU23676/00A patent/AU2367600A/en not_active Abandoned
-
2003
- 2003-09-16 US US10/663,896 patent/US7250256B2/en not_active Expired - Fee Related
-
2007
- 2007-06-07 US US11/759,726 patent/US7855058B2/en not_active Expired - Fee Related
- 2007-07-06 US US11/774,306 patent/US7566559B2/en not_active Expired - Fee Related
-
2008
- 2008-12-16 CY CY20081101453T patent/CY1108662T1/el unknown
-
2010
- 2010-03-04 JP JP2010048410A patent/JP2010162036A/ja not_active Withdrawn
-
2013
- 2013-05-07 JP JP2013097306A patent/JP2013162795A/ja active Pending
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