JP2003522121A5 - - Google Patents
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- Publication number
- JP2003522121A5 JP2003522121A5 JP2001501213A JP2001501213A JP2003522121A5 JP 2003522121 A5 JP2003522121 A5 JP 2003522121A5 JP 2001501213 A JP2001501213 A JP 2001501213A JP 2001501213 A JP2001501213 A JP 2001501213A JP 2003522121 A5 JP2003522121 A5 JP 2003522121A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- benzothiazolamine
- trifluoromethoxy
- agent
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 description 32
- 239000003814 drug Substances 0.000 description 22
- 239000008194 pharmaceutical composition Substances 0.000 description 20
- FTALBRSUTCGOEG-UHFFFAOYSA-N Riluzole Chemical compound C1=C(OC(F)(F)F)C=C2SC(N)=NC2=C1 FTALBRSUTCGOEG-UHFFFAOYSA-N 0.000 description 19
- 239000003795 chemical substances by application Substances 0.000 description 18
- 150000003839 salts Chemical class 0.000 description 16
- 238000000034 method Methods 0.000 description 7
- 108010072051 Glatiramer Acetate Proteins 0.000 description 6
- 108010005716 Interferon beta-1a Proteins 0.000 description 6
- 108010005714 Interferon beta-1b Proteins 0.000 description 6
- 229940038717 copaxone Drugs 0.000 description 6
- 229960004461 interferon beta-1a Drugs 0.000 description 6
- 229960003161 interferon beta-1b Drugs 0.000 description 6
- 201000006417 multiple sclerosis Diseases 0.000 description 6
- 229960003444 immunosuppressant agent Drugs 0.000 description 4
- 239000003018 immunosuppressive agent Substances 0.000 description 4
- 239000003158 myorelaxant agent Substances 0.000 description 4
- 150000003431 steroids Chemical class 0.000 description 4
- 230000000202 analgesic effect Effects 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 208000007118 chronic progressive multiple sclerosis Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000001861 immunosuppressant effect Effects 0.000 description 2
- 229940035363 muscle relaxants Drugs 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 206010063401 primary progressive multiple sclerosis Diseases 0.000 description 1
- 201000008628 secondary progressive multiple sclerosis Diseases 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99201788 | 1999-06-04 | ||
| EP99201788.9 | 1999-06-04 | ||
| US17432800P | 2000-01-04 | 2000-01-04 | |
| US60/174,328 | 2000-01-04 | ||
| PCT/IB2000/000933 WO2000074676A1 (en) | 1999-06-04 | 2000-06-02 | Use of riluzole for the treatment of multiple sclerosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007146265A Division JP2007262082A (ja) | 1999-06-04 | 2007-05-31 | 多発性硬化症の処置のためのリルゾールの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003522121A JP2003522121A (ja) | 2003-07-22 |
| JP2003522121A5 true JP2003522121A5 (cg-RX-API-DMAC7.html) | 2007-07-19 |
Family
ID=56290027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001501213A Pending JP2003522121A (ja) | 1999-06-04 | 2000-06-02 | 多発性硬化症の処置のためのリルゾールの使用 |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP1552831B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2003522121A (cg-RX-API-DMAC7.html) |
| AT (2) | ATE287713T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU777537B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2375874A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE60017733T2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2235896T3 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ515685A (cg-RX-API-DMAC7.html) |
| PT (1) | PT1187612E (cg-RX-API-DMAC7.html) |
| SI (1) | SI1187612T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2000074676A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002519373A (ja) | 1998-07-02 | 2002-07-02 | エーザイ株式会社 | 製薬組成物及びそれらの使用 |
| DE60041365D1 (de) * | 1999-06-04 | 2009-02-26 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Verwendung von Riluzol zur Behandlung Multipler Sklerose |
| IL136687A0 (en) * | 2000-06-12 | 2001-06-14 | Mor Research Applic Ltd | Pharmaceutical composition for the treatment of multiple sclerosis |
| EP1778286A4 (en) * | 2004-03-03 | 2009-04-08 | Teva Pharma | COMBINATION THERAPY WITH ACETATE OF GLATIRAMER AND RILUZOLE |
| ITMI20061274A1 (it) * | 2006-06-30 | 2008-01-01 | Consiglio Nazionale Ricerche | Vettori nanoparticellari lipidici contenenti riluzolo e composizioni farmaceutiche che li contengono |
| EP2228054A1 (en) | 2009-03-13 | 2010-09-15 | ITALFARMACO S.p.A. | Riluzole aqueous suspensions |
| WO2010113225A1 (en) * | 2009-03-30 | 2010-10-07 | Yutoku Pharmaceutical Industries Co., Ltd. | Riluzole-containing transdermal patch |
| CN107735077A (zh) * | 2014-11-21 | 2018-02-23 | 拜尔哈文制药股份有限公司 | 利鲁唑的舌下给药 |
| WO2016085998A1 (en) * | 2014-11-26 | 2016-06-02 | Medicinova, Inc. | Combination of ibudilast and riluzole and methods of using same |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2688138B1 (fr) * | 1992-03-06 | 1995-05-05 | Rhone Poulenc Rorer Sa | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique. |
| JPH11513698A (ja) * | 1995-10-25 | 1999-11-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 神経保護物質およびパーフルオロケミカルの注射剤 |
| US6133258A (en) * | 1995-11-05 | 2000-10-17 | Yamanouchi Pharmaceutical Co., Ltd. | Inhibitor of kainic acid neurotoxicity and pyridothiazine derivative |
| US5728728A (en) * | 1996-04-10 | 1998-03-17 | Kozachuk; Walter E. | Methods of providing neuroprotection |
| IL119989A0 (en) * | 1997-01-10 | 1997-04-15 | Yeda Res & Dev | Pharmaceutical compositions for oral treatment of multiple sclerosis |
| JP4120713B2 (ja) * | 1997-09-04 | 2008-07-16 | 大塚製薬株式会社 | 多発性硬化症治療剤 |
| DE60041365D1 (de) * | 1999-06-04 | 2009-02-26 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Verwendung von Riluzol zur Behandlung Multipler Sklerose |
-
2000
- 2000-06-02 JP JP2001501213A patent/JP2003522121A/ja active Pending
- 2000-06-02 PT PT00939007T patent/PT1187612E/pt unknown
- 2000-06-02 WO PCT/IB2000/000933 patent/WO2000074676A1/en not_active Ceased
- 2000-06-02 AU AU54219/00A patent/AU777537B2/en not_active Ceased
- 2000-06-02 EP EP05001476A patent/EP1552831B1/en not_active Expired - Lifetime
- 2000-06-02 CA CA002375874A patent/CA2375874A1/en not_active Abandoned
- 2000-06-02 NZ NZ515685A patent/NZ515685A/xx not_active IP Right Cessation
- 2000-06-02 AT AT00939007T patent/ATE287713T1/de active
- 2000-06-02 ES ES00939007T patent/ES2235896T3/es not_active Expired - Lifetime
- 2000-06-02 EP EP00939007A patent/EP1187612B1/en not_active Expired - Lifetime
- 2000-06-02 DE DE60017733T patent/DE60017733T2/de not_active Expired - Lifetime
- 2000-06-02 SI SI200030601T patent/SI1187612T1/xx unknown
- 2000-06-02 AT AT05001476T patent/ATE419851T1/de not_active IP Right Cessation
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