JP2003520856A5 - - Google Patents
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- Publication number
- JP2003520856A5 JP2003520856A5 JP2001555061A JP2001555061A JP2003520856A5 JP 2003520856 A5 JP2003520856 A5 JP 2003520856A5 JP 2001555061 A JP2001555061 A JP 2001555061A JP 2001555061 A JP2001555061 A JP 2001555061A JP 2003520856 A5 JP2003520856 A5 JP 2003520856A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- compound according
- alkyl
- compound
- heterocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17793300P | 2000-01-25 | 2000-01-25 | |
| US60/177,933 | 2000-01-25 | ||
| US23968300P | 2000-10-11 | 2000-10-11 | |
| US60/239,683 | 2000-10-11 | ||
| PCT/US2001/002740 WO2001055119A2 (en) | 2000-01-25 | 2001-01-25 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003520856A JP2003520856A (ja) | 2003-07-08 |
| JP2003520856A5 true JP2003520856A5 (https=) | 2008-03-13 |
| JP4931314B2 JP4931314B2 (ja) | 2012-05-16 |
Family
ID=26873790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001555061A Expired - Lifetime JP4931314B2 (ja) | 2000-01-25 | 2001-01-25 | 性腺刺激ホルモン放出ホルモンレセプタアンタゴニストおよびそれに関連した方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US6608197B2 (https=) |
| EP (1) | EP1255738B1 (https=) |
| JP (1) | JP4931314B2 (https=) |
| KR (1) | KR100814269B1 (https=) |
| AT (1) | ATE548357T1 (https=) |
| AU (1) | AU767585B2 (https=) |
| CA (1) | CA2398018C (https=) |
| CY (1) | CY1112815T1 (https=) |
| DK (1) | DK1255738T3 (https=) |
| ES (1) | ES2383954T3 (https=) |
| MX (1) | MXPA02006848A (https=) |
| NO (1) | NO20023525L (https=) |
| PT (1) | PT1255738E (https=) |
| WO (1) | WO2001055119A2 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001055119A2 (en) | 2000-01-25 | 2001-08-02 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| SE0100567D0 (sv) * | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | Compounds |
| US6939883B2 (en) | 2001-08-02 | 2005-09-06 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| EP1411941A2 (en) | 2001-08-02 | 2004-04-28 | Neurocrine Biosciences, Inc. | Pyridinone and pyridazinone derivatives as gonadotropin-releasing hormone receptor antagonists |
| EP1495768A4 (en) * | 2002-04-12 | 2007-12-05 | Takeda Pharmaceutical | MEANS FOR THE PREVENTION / TREATMENT OF HITZEWALLUNGEN |
| ES2387495T3 (es) * | 2003-07-07 | 2012-09-25 | Neurocrine Biosciences, Inc. | Arilpirimidinas útiles en el tratamiento de trastornos relacionados con las hormonas sexuales, tales como endometriosis, cáncer de próstata y similares |
| DE602004020638D1 (de) | 2003-07-07 | 2009-05-28 | Neurocrine Biosciences Inc | Pyrimidin-2,4-dion-derivate als gonadotropin freisetzende hormon-rezeptor-antagonisten |
| AU2004257639B2 (en) * | 2003-07-07 | 2011-01-06 | Neurocrine Biosciences, Inc. | Pyrimidine-2, 4-dione derivatives as gonadotropin-releasing hormone receptor antagonists |
| KR20060041309A (ko) | 2003-08-13 | 2006-05-11 | 다케다 야쿠힌 고교 가부시키가이샤 | 4-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도 |
| UA85871C2 (uk) * | 2004-03-15 | 2009-03-10 | Такеда Фармасьютікал Компані Лімітед | Інгібітори дипептидилпептидази |
| WO2005113516A1 (en) * | 2004-05-14 | 2005-12-01 | Neurocrine Biosciences, Inc. | Uracil-type gonadotropin-releasing hormone receptor antagonists and methods related thereto |
| EP1655288A1 (en) * | 2004-11-05 | 2006-05-10 | Institut Pasteur | Aryl pyrimidyl compounds, pharmaceutical compositions comprising them, their use as antimicrobial agents |
| MY147393A (en) | 2005-09-14 | 2012-11-30 | Takeda Pharmaceutical | Administration of dipeptidyl peptidase inhibitors |
| CA2622642C (en) | 2005-09-16 | 2013-12-31 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2007122634A2 (en) * | 2006-04-24 | 2007-11-01 | Jubilant Biosys Limited | Pyrimidinediones as tyrosine kinase inhibitors |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| EP2155194B1 (en) | 2007-04-06 | 2015-01-21 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| CL2008000986A1 (es) | 2007-04-06 | 2008-10-17 | Neurocrine Biosciences Inc | COMPUESTO DERIVADO DE HETEROCICLOS DE NITROGENO, AGONISTAS DEL RECEPTOR GnRH; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHO COMPUESTO; Y USO PARA TRATAR UNA AFECCION RELACIONADA CON LAS HORMONAS SEXUALES, ENDOMETRIOSIS, DISMENORREA, ENFERMEDAD DE OV |
| EP2147922B1 (en) * | 2007-04-18 | 2017-08-02 | Kissei Pharmaceutical Co., Ltd. | Fused heterocyclic derivative, pharmaceutical composition comprising the derivative, and use of the composition for medical purposes |
| EP2145889A4 (en) * | 2007-04-18 | 2012-04-18 | Kissei Pharmaceutical | HETEROCYCLIC FUSED CORE DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE DERIVATIVE, AND USE OF THE COMPOSITION FOR MEDICAL PURPOSES |
| US8765948B2 (en) | 2007-11-07 | 2014-07-01 | Neurocrine Biosciences, Inc. | Processes for the preparation of uracil derivatives |
| DE102008030091B4 (de) * | 2008-06-25 | 2011-03-03 | Resprotect Gmbh | Uracilderivate und deren Verwendung |
| WO2010029299A1 (en) * | 2008-09-12 | 2010-03-18 | Biolipox Ab | Pyrimidinone derivaties for use as medicaments |
| JP5757956B2 (ja) * | 2009-11-20 | 2015-08-05 | エスケー ケミカルス シーオー., エルティーディー.Sk Chemicals Co., Ltd. | ゴナドトロピン放出ホルモン受容体拮抗剤、その製造方法及びそれを含む医薬組成物 |
| TW201130854A (en) | 2009-12-22 | 2011-09-16 | Bayer Schering Pharma Ag | Pyridinone derivatives and pharmaceutical compositions thereof |
| WO2012175514A1 (en) | 2011-06-21 | 2012-12-27 | Bayer Intellectual Property Gmbh | Pyridinone derivatives and pharmaceutical compositions thereof |
| IL241595B2 (en) | 2013-03-15 | 2025-10-01 | Abbvie Inc | Composition for use in methods of treating heavy menstrual bleeding associated with uterine fibroids |
| US20200113901A1 (en) * | 2017-03-31 | 2020-04-16 | Epizyme, Inc. | Methods of using ehmt2 inhibitors |
| CN110621316B (zh) | 2017-04-21 | 2024-01-26 | Epizyme股份有限公司 | 用ehmt2抑制剂进行的组合疗法 |
| US20190054088A1 (en) | 2017-08-18 | 2019-02-21 | Abbvie Inc. | Pharmaceutical Formulations for Treating Endometriosis, Uterine Fibroids, Polycystic Ovary Syndrome or Adenomyosis |
| TW201912157A (zh) | 2017-08-18 | 2019-04-01 | 美商艾伯維有限公司 | 治療子宮內膜異位症、子宮纖維瘤、多囊性卵巢症候群及子宮腺肌症之固體醫藥調配物 |
| CN111698992A (zh) | 2017-08-18 | 2020-09-22 | 艾伯维公司 | 用于治疗子宫内膜异位症、子宫肌瘤、多囊卵巢综合症或子宫腺肌症的药物配制物 |
| AU2018419533A1 (en) | 2018-04-19 | 2020-11-12 | Abbvie Inc. | Methods of treating heavy menstrual bleeding |
| BR112021000973A2 (pt) | 2018-07-23 | 2021-04-20 | Abbvie Inc. | composições e processos de sódio de elagolix |
| PH12021551685A1 (en) | 2019-01-15 | 2022-05-16 | Lupin Inc | Deuterated elagolix-like compositions and methods |
| CN111333586A (zh) * | 2020-02-19 | 2020-06-26 | 诚达药业股份有限公司 | 一种含有6-甲基尿嘧啶结构化合物的制备方法 |
| CN111333587B (zh) * | 2020-04-11 | 2023-04-07 | 东莞市东阳光新药研发有限公司 | 取代的嘧啶-2,4(1h,3h)-二酮衍生物及其用途 |
| CN113527213B (zh) * | 2020-04-20 | 2023-01-03 | 上海英诺富成生物科技有限公司 | 促性激素释放激素受体拮抗剂及其用途 |
| LT4122926T (lt) * | 2021-04-14 | 2025-07-25 | Shionogi & Co., Ltd. | Triazino dariniai, turintys virusų replikaciją slopinantį poveikį, ir juos apimanti farmacinė kompozicija |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2631625B1 (fr) * | 1988-05-17 | 1992-10-16 | Synthelabo | Derives de phenyl-6 piperazinylalkyl-3 1h,3h-pyrimidinedione-2,4, leur preparation et leur application en therapeutique |
| US5140029A (en) | 1989-01-09 | 1992-08-18 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
| US5476855A (en) * | 1993-11-02 | 1995-12-19 | Mahmoud H. el Kouni | Enzyme inhibitors, their synthesis and methods for use |
| UY23948A1 (es) * | 1995-02-08 | 2001-10-25 | Takeda Chemical Industries Ltd | Derivados de anillos condensados de tiofeno su producción y uso. |
| AU5844896A (en) | 1995-06-01 | 1996-12-18 | Takeda Chemical Industries Ltd. | Tricyclic diazepines useful as gnrh receptor antagonists |
| US5859014A (en) * | 1995-06-09 | 1999-01-12 | Syntex (U.S.A.) Inc. | Pyrimidinedione, pyrimidinetrione, triazinedione and tetrahydroquinazolinedione derivatives as α1 -adrenergic receptor antagonists |
| ATE201016T1 (de) * | 1995-06-09 | 2001-05-15 | Hoffmann La Roche | Pyrimidindion-, pyrimidintrion-, triazindion- derivate als alpha-1-adrenergische rezeptorantagonisten |
| CN1063446C (zh) | 1995-10-19 | 2001-03-21 | 武田药品工业株式会社 | 作为促性腺激素释放激素拮抗剂的噻吩并吡啶衍生物 |
| CN1200114A (zh) | 1995-10-19 | 1998-11-25 | 武田药品工业株式会社 | 作为gnrh拮抗剂的喹啉衍生物 |
| JP3092946B2 (ja) | 1995-12-14 | 2000-09-25 | メルク エンド カンパニー インコーポレーテッド | ゴナドトロピン放出ホルモン拮抗剤 |
| SK77598A3 (en) | 1995-12-14 | 1999-01-11 | Merck & Co Inc | Nonpeptide derivatives, pharmaceutical composition containing them and their use |
| WO1997021435A1 (en) | 1995-12-14 | 1997-06-19 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| CN1208412A (zh) | 1995-12-14 | 1999-02-17 | 麦克公司 | 促性腺激素释放激素拮抗剂 |
| US5780437A (en) | 1995-12-14 | 1998-07-14 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US5849764A (en) | 1995-12-14 | 1998-12-15 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| JPH09286786A (ja) * | 1996-04-18 | 1997-11-04 | Nippon Paper Ind Co Ltd | ピリミジン誘導体及びその抗腫瘍剤としての用途 |
| WO1997044041A1 (en) | 1996-05-20 | 1997-11-27 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| JP2000511533A (ja) | 1996-05-20 | 2000-09-05 | メルク エンド カンパニー インコーポレーテッド | ゴナドトロピン放出ホルモン拮抗薬 |
| AU710926B2 (en) | 1996-05-20 | 1999-09-30 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| AU3071397A (en) | 1996-05-20 | 1997-12-09 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| EP0986385A4 (en) | 1997-06-05 | 2001-05-16 | Merck & Co Inc | GONADORELIN ANTAGONISTS |
| AU729752B2 (en) | 1997-06-05 | 2001-02-08 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| AU7806998A (en) | 1997-06-05 | 1998-12-21 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| WO1998055479A1 (en) | 1997-06-05 | 1998-12-10 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US6313301B1 (en) | 1997-08-13 | 2001-11-06 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives, their intermediates and production thereof |
| US6194419B1 (en) | 1997-12-26 | 2001-02-27 | Takeda Chemical Industries, Ltd. | Nitrogen-containing heterocyclic compounds, their production and use |
| CA2326143A1 (en) | 1998-04-02 | 1999-10-14 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| WO2000029386A1 (en) * | 1998-11-12 | 2000-05-25 | Merck & Co., Inc. | Pyrimidinedione derivatives useful as alpha 1a adrenoceptor antagonists |
| CA2372044A1 (en) | 1999-05-14 | 2000-11-23 | Neurocrine Biosciences, Inc. | Imidazo- and pyrrolo[1,2-a]pyrimid-4-ones as gonadotropin-releasing hormone receptor antagonists |
| NZ514877A (en) | 1999-05-19 | 2004-10-29 | Pharmacia Corp | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| ES1043085Y (es) * | 1999-06-03 | 2001-02-01 | Nueva Ceramica Arb Sa | Teja planoconvexa |
| MXPA02003614A (es) | 1999-10-15 | 2002-10-23 | Neurocrine Biosciences Inc | Antagonistas del receptor de la hormona liberadora de ganadotropina y metodos relacionados con los mismos.. |
| WO2001055119A2 (en) * | 2000-01-25 | 2001-08-02 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| ES2387495T3 (es) * | 2003-07-07 | 2012-09-25 | Neurocrine Biosciences, Inc. | Arilpirimidinas útiles en el tratamiento de trastornos relacionados con las hormonas sexuales, tales como endometriosis, cáncer de próstata y similares |
| DE602004020638D1 (de) * | 2003-07-07 | 2009-05-28 | Neurocrine Biosciences Inc | Pyrimidin-2,4-dion-derivate als gonadotropin freisetzende hormon-rezeptor-antagonisten |
| AU2004257639B2 (en) * | 2003-07-07 | 2011-01-06 | Neurocrine Biosciences, Inc. | Pyrimidine-2, 4-dione derivatives as gonadotropin-releasing hormone receptor antagonists |
-
2001
- 2001-01-25 WO PCT/US2001/002740 patent/WO2001055119A2/en not_active Ceased
- 2001-01-25 DK DK01910362.1T patent/DK1255738T3/da active
- 2001-01-25 AT AT01910362T patent/ATE548357T1/de active
- 2001-01-25 JP JP2001555061A patent/JP4931314B2/ja not_active Expired - Lifetime
- 2001-01-25 EP EP01910362A patent/EP1255738B1/en not_active Expired - Lifetime
- 2001-01-25 CA CA2398018A patent/CA2398018C/en not_active Expired - Fee Related
- 2001-01-25 US US09/771,107 patent/US6608197B2/en not_active Expired - Lifetime
- 2001-01-25 ES ES01910362T patent/ES2383954T3/es not_active Expired - Lifetime
- 2001-01-25 KR KR1020027009582A patent/KR100814269B1/ko not_active Expired - Lifetime
- 2001-01-25 PT PT01910362T patent/PT1255738E/pt unknown
- 2001-01-25 MX MXPA02006848A patent/MXPA02006848A/es active IP Right Grant
- 2001-01-25 AU AU37975/01A patent/AU767585B2/en not_active Expired
-
2002
- 2002-07-24 NO NO20023525A patent/NO20023525L/no not_active Application Discontinuation
-
2003
- 2003-02-06 US US10/361,144 patent/US6872728B2/en not_active Expired - Lifetime
-
2004
- 2004-12-17 US US11/016,551 patent/US7179815B2/en not_active Expired - Lifetime
-
2006
- 2006-09-11 US US11/520,022 patent/US7462625B2/en not_active Expired - Lifetime
-
2012
- 2012-06-01 CY CY20121100499T patent/CY1112815T1/el unknown
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