JP2003519481A5 - - Google Patents

Download PDF

Info

Publication number
JP2003519481A5
JP2003519481A5 JP2001551104A JP2001551104A JP2003519481A5 JP 2003519481 A5 JP2003519481 A5 JP 2003519481A5 JP 2001551104 A JP2001551104 A JP 2001551104A JP 2001551104 A JP2001551104 A JP 2001551104A JP 2003519481 A5 JP2003519481 A5 JP 2003519481A5
Authority
JP
Japan
Prior art keywords
polypeptide
ngr
amino acids
seq
fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2001551104A
Other languages
English (en)
Japanese (ja)
Other versions
JP4763207B2 (ja
JP2003519481A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2001/001041 external-priority patent/WO2001051520A2/en
Publication of JP2003519481A publication Critical patent/JP2003519481A/ja
Publication of JP2003519481A5 publication Critical patent/JP2003519481A5/ja
Application granted granted Critical
Publication of JP4763207B2 publication Critical patent/JP4763207B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2001551104A 2000-01-12 2001-01-12 軸索成長のｎｏｇｏレセプター媒介妨害 Expired - Fee Related JP4763207B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17570700P 2000-01-12 2000-01-12
US60/175,707 2000-01-12
US20736600P 2000-05-26 2000-05-26
US60/207,366 2000-05-26
US23637800P 2000-09-29 2000-09-29
US60/236,378 2000-09-29
PCT/US2001/001041 WO2001051520A2 (en) 2000-01-12 2001-01-12 Nogo receptor-mediated blockade of axonal growth

Publications (3)

Publication Number Publication Date
JP2003519481A JP2003519481A (ja) 2003-06-24
JP2003519481A5 true JP2003519481A5 (OSRAM) 2006-05-11
JP4763207B2 JP4763207B2 (ja) 2011-08-31

Family

ID=27390581

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001551104A Expired - Fee Related JP4763207B2 (ja) 2000-01-12 2001-01-12 軸索成長のｎｏｇｏレセプター媒介妨害

Country Status (27)

Country Link
US (1) US20020012965A1 (OSRAM)
EP (2) EP1248803B1 (OSRAM)
JP (1) JP4763207B2 (OSRAM)
KR (1) KR100828058B1 (OSRAM)
CN (1) CN100354307C (OSRAM)
AT (1) ATE466882T1 (OSRAM)
AU (1) AU784349C (OSRAM)
BG (1) BG106907A (OSRAM)
BR (1) BR0107613A (OSRAM)
CA (1) CA2397199C (OSRAM)
CZ (1) CZ20022438A3 (OSRAM)
DE (1) DE60142023D1 (OSRAM)
EA (1) EA008480B1 (OSRAM)
EE (1) EE200200386A (OSRAM)
ES (1) ES2341842T3 (OSRAM)
GE (1) GEP20063830B (OSRAM)
HK (1) HK1051543A1 (OSRAM)
HU (1) HUP0203863A3 (OSRAM)
IL (2) IL150566A0 (OSRAM)
IS (1) IS6455A (OSRAM)
MX (1) MXPA02006885A (OSRAM)
NO (1) NO20023387L (OSRAM)
NZ (2) NZ520065A (OSRAM)
PL (1) PL356887A1 (OSRAM)
SK (1) SK9992002A3 (OSRAM)
WO (1) WO2001051520A2 (OSRAM)
YU (1) YU53502A (OSRAM)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999066041A1 (en) 1998-06-16 1999-12-23 Human Genome Sciences, Inc. 94 human secreted proteins
US7371836B2 (en) 1998-03-27 2008-05-13 Genentech, Inc. PRO526 nucleic acids
US7723488B2 (en) 1998-03-27 2010-05-25 Genentech, Inc. Monoclonal antibodies to secreted and transmembrane polypeptides
US20020072493A1 (en) * 1998-05-19 2002-06-13 Yeda Research And Development Co. Ltd. Activated T cells, nervous system-specific antigens and their uses
US7034132B2 (en) 2001-06-04 2006-04-25 Anderson David W Therapeutic polypeptides, nucleic acids encoding same, and methods of use
EA008480B1 (ru) * 2000-01-12 2007-06-29 Йейл Юниверсити Выделенный полинуклеотид (варианты), содержащий его вектор и клетка-хозяин, кодируемый им полипептид рецептора nogo, уменьшающий опосредованное этим рецептором ингибирование роста аксонов (варианты), выделенное антитело и фармацевтическая композиция на их основе
US7119165B2 (en) * 2000-01-12 2006-10-10 Yale University Nogo receptor-mediated blockade of axonal growth
PT1325130E (pt) 2000-10-06 2010-05-31 Biogen Idec Inc Homólogos do receptor de nogo
GB0101312D0 (en) * 2001-01-18 2001-02-28 Glaxo Group Ltd Assay
GB0101313D0 (en) * 2001-01-18 2001-02-28 Glaxo Group Ltd Assay
EP1386004A4 (en) 2001-04-05 2005-02-16 Ribozyme Pharm Inc MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATORY PROLIFERATION AND GROWTH OF NEURITIES BY METHODS INVOLVING NUCLEIC ACID
AU2002331180A1 (en) * 2001-08-27 2003-03-10 Novartis Pharma Gmbh Nogo receptor homologues and their use
US7309485B2 (en) * 2001-12-03 2007-12-18 Children's Medical Center Corporation Reducing myelin-mediated inhibition of axon regeneration
FR2841261B1 (fr) * 2002-06-25 2004-08-27 Univ Pasteur Compositions et methodes pour detecter les pathologies affectant la transmission neuromusculaire
EP1534736B1 (en) * 2002-08-10 2010-06-02 Yale University Nogo receptor antagonists
ATE469913T1 (de) * 2002-08-10 2010-06-15 Univ Yale Antagonisten des nogo-rezeptors
GB0228832D0 (en) * 2002-12-10 2003-01-15 Novartis Ag Organic compound
AU2003288434B2 (en) * 2002-12-06 2011-03-17 IRP Health Pty Ltd Peptides, antibodies thereto, and their use in the treatment of central nervous system damage
US7842666B2 (en) * 2002-12-20 2010-11-30 Research Foundation Of City University Of New York Inhibitors of myelin-associated glycoprotein (MAG) activity for regulating neural growth and regeneration
PL378582A1 (pl) 2003-03-19 2006-05-02 Biogen Idec Ma Inc. Białko wiążące receptor Nogo
CA2521469A1 (en) * 2003-04-04 2004-10-21 University Of Rochester Identification of novel nogo-receptors and methods related thereto
EP1615654A2 (en) * 2003-04-16 2006-01-18 Yale University Nogo-receptor antagonists for the treatment of conditions involving amyloid plaques
CA2525966A1 (en) * 2003-05-15 2004-12-23 The Board Of Trustees Of The Leland Stanford Junior University Novel immunomodulating peptide
EP3211084B1 (en) * 2003-05-16 2019-03-27 Acorda Therapeutics, Inc. Proteoglycan degrading mutants for treatment of cns
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
GB0321997D0 (en) * 2003-09-19 2003-10-22 Novartis Ag Organic compound
WO2005059515A2 (en) * 2003-12-16 2005-06-30 Children's Medical Center Corporation Method for treating neurological disorders
US8912144B2 (en) * 2003-12-16 2014-12-16 Children's Medical Center Corporation Method for treating stroke via administration of NEP1-40 and inosine
EP2474317A1 (en) 2004-06-24 2012-07-11 Biogen Idec MA Inc. Treatment of conditions involving demyelination
WO2006017673A2 (en) 2004-08-03 2006-02-16 Biogen Idec Ma Inc. Taj in neuronal function
CA2582581A1 (en) * 2004-10-01 2006-05-04 Yale University Nogo-a polypeptide fragments, variant nogo receptor-1 polypeptides, and uses thereof
WO2006059959A1 (en) * 2004-12-01 2006-06-08 National University Of Singapore Nogo a protein fragments as neuronal network-interacting peptides
EP1904091A4 (en) 2005-07-07 2009-12-23 Univ Yale COMPOSITIONS AND METHODS FOR SUPPRESSING THE INHIBITION OF AXON GROWTH
ES2434470T3 (es) 2005-07-08 2013-12-16 Biogen Idec Ma Inc. Anticuerpos SP35 y usos de éstos
WO2007038548A2 (en) 2005-09-26 2007-04-05 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase abci mutants
CN103215293B (zh) 2006-01-27 2015-10-28 比奥根Ma公司 Nogo受体拮抗剂
EP2023735A4 (en) * 2006-05-15 2011-05-25 Biogen Idec Inc USE OF ANTAGONISTS OF THE NOGO RECEPTOR 1 (NGR1) TO PROMOTE THE SURVIVAL OF OLIGODENDROCYTES
EP2068866A4 (en) 2006-07-24 2010-04-07 Biogen Idec Inc METHODS FOR PROMOTING MYELINIZATION, NEURONAL SURVIVAL AND DIFFERENTIATION OF OLIGODENDROCYTES BY ADMINISTERING SP35 OR TRKA ANTAGONISTS
JP5653622B2 (ja) * 2006-11-21 2015-01-14 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ Ｎｏｇｏ−６６受容体（ＮＧＲ）に対する中和モノクローナル抗体及びその使用
EP2276500A4 (en) 2008-03-13 2015-03-04 Univ Yale REACTIVATION OF AXON GROWTH AND AXON RECOVERY IN CHRONIC REVERSE MARKET INJURIES
CL2009001155A1 (es) * 2008-05-13 2010-06-04 Genentech Inc Anticuerpo anti-pirb/lilrb aislado; polinucleotido que lo codifica; vector; celula huesped; metodo de obtencion; composicion farmaceutica que lo comprende; kit; y su uso para tratar enfermedades neurodegenerativas.
NZ590605A (en) 2008-07-09 2012-11-30 Biogen Idec Inc Compositions comprising antibodies to lingo or fragments thereof
KR102142161B1 (ko) 2012-05-14 2020-08-06 바이오젠 엠에이 인코포레이티드 운동 뉴런 관련 병태 치료용 lingo-2 길항제
CN104935294B (zh) * 2014-03-20 2018-07-20 晶宏半导体股份有限公司 振荡器
US10435467B2 (en) 2015-01-08 2019-10-08 Biogen Ma Inc. LINGO-1 antagonists and uses for treatment of demyelinating disorders
CN109354605B (zh) * 2015-07-17 2021-02-05 暨南大学 一种Nogo-A受体结合肽及其衍生物与应用
CN113527462B (zh) * 2020-04-22 2023-05-23 北京大学 一种具有镇痛作用的小分子肽及其特异性抗体

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4736866B1 (en) 1984-06-22 1988-04-12 Transgenic non-human mammals
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US4839288A (en) 1986-01-22 1989-06-13 Institut Pasteur Retrovirus capable of causing AIDS, antigens obtained from this retrovirus and corresponding antibodies and their application for diagnostic purposes
US5466585A (en) 1986-04-15 1995-11-14 Ciba-Geigy Corporation Interferon-induced human protein in pure form, monoclonal antibodies thereto, and test kits containing these antibodies
US4861719A (en) 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
WO1989007150A1 (en) 1988-02-05 1989-08-10 The Trustees Of Columbia University In The City Of Retroviral packaging cell lines and processes of using same
JP3082204B2 (ja) 1988-09-01 2000-08-28 ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ 両栄養性および環境栄養性宿主域を持つ組換え体レトロウイルス
WO1990005191A1 (en) 1988-11-04 1990-05-17 Erziehungsdirektion Of The Canton Zurich Neurite growth regulatory factors
US5250414A (en) 1988-11-04 1993-10-05 Erziehungsdirektion Of The Canton Zurich Diagnostic methods using neurite growth regulatory factors
CA1341050C (en) 1988-11-04 2000-07-11 Martin E. Schwab Neurite growth regulatory factors
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5723719A (en) 1991-08-08 1998-03-03 Health Research Inc. Transgenic mouse as model for diseases involving dopaminergic dysfunction
DE4126968A1 (de) 1991-08-14 1993-02-18 Detlev Prof Dr Med Ganten Transgene ratten, die in ihrem genom mindestens ein menschliches gen enthalten, das an der blutdruckregulation beteiligt ist
US5449755A (en) 1991-09-20 1995-09-12 Fred Hutchinson Cancer Research Center Human cyclin E
ATE243746T1 (de) 1992-01-07 2003-07-15 Elan Pharm Inc Transgene tiermodelle fur alzheimer-krankheit
US5733720A (en) 1992-06-18 1998-03-31 Washington University Genetically engineered cell lines for detecting infectious herpesvirus and methods therefor
US5602307A (en) 1992-08-12 1997-02-11 Baylor College Of Medicine Non-human animal having predefined allele of a cellular adhesion gene
US5731490A (en) 1992-09-29 1998-03-24 The Ontario Cancer Institute Mutant mouse lacking the expression of interferon regulatory factor 1 (IRF-1)
EP0634939A1 (en) 1993-02-11 1995-01-25 Erziehungsdirektion Of The Canton Zurich A combination of neurotrophin and antibody directed toward myelin-associated neurite growth inhibitory protein promotes central nervous system regeneration
FR2705361B1 (fr) 1993-05-18 1995-08-04 Centre Nat Rech Scient Vecteurs viraux et utilisation en thérapie génique.
DK75393D0 (da) 1993-06-24 1993-06-24 Symbicom Ab Production of protein
CA2174140C (en) 1993-10-28 2004-04-06 Kenneth L. Beattie Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
WO1995024488A1 (en) 1994-03-09 1995-09-14 Abbott Laboratories Transgenic animals producing oligosaccharides and glycoconjugates
FR2718329B1 (fr) 1994-03-21 2002-09-20 Rhone Poulenc Rorer Sa Lapin transgénique sensibilisé aux dyslipoprotéinémies.
US5908969A (en) 1994-05-13 1999-06-01 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
WO2000073452A2 (en) * 1999-06-02 2000-12-07 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
WO2000032221A2 (en) * 1998-12-01 2000-06-08 Genentech, Inc. Promotion or inhibition of angiogenesis and cardiovascularization
US5728915A (en) 1995-05-08 1998-03-17 Children's Hospital, Inc. Transgenic mice which express simian SV 40 T-antigen under control of the retinoblastoma gene promoter
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US5961976A (en) 1996-06-03 1999-10-05 United Biomedical, Inc. Antibodies against a host cell antigen complex for pre- and post-exposure protection from infection by HIV
US5858708A (en) 1996-08-12 1999-01-12 Bandman; Olga Polynucleotides encoding two novel human neuroendocrine-specific proteins
WO1999066041A1 (en) * 1998-06-16 1999-12-23 Human Genome Sciences, Inc. 94 human secreted proteins
WO1999055868A2 (en) * 1998-04-24 1999-11-04 Genentech, Inc. Fizz proteins
IL136216A0 (en) * 1997-12-03 2001-05-20 Genentech Inc Polypeptides and nucleic acids encoding the same
AU762055B2 (en) * 1998-03-10 2003-06-19 Genentech Inc. Novel polypeptides and nucleic acids encoding the same
JP3868740B2 (ja) * 1998-03-10 2007-01-17 ジェネンテック・インコーポレーテッド 新規なポリペプチド及びそれをコードする核酸
AU3134799A (en) 1998-04-16 1999-11-08 Peter Erich Braun Nevron growth inhibitory molecules or derivatives thereof used to immunize mammals thereby promoting axon regeneration
WO1999054467A1 (en) * 1998-04-23 1999-10-28 Genentech, Inc. Sh2 domain-containing peptides
AU761340B2 (en) * 1998-06-02 2003-06-05 Genentech Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
CN101684155A (zh) * 1998-11-06 2010-03-31 苏黎世大学 Nogo基因的核苷酸序列和蛋白序列以及基于其的方法
DK1484338T3 (da) * 1998-12-22 2007-06-11 Genentech Inc Fremgangsmåder og sammensætninger til inhibition af neoplastisk cellevækst
JP2004516227A (ja) * 1999-03-08 2004-06-03 ジェネンテック・インコーポレーテッド 免疫関連疾患を治療するための組成物と方法
JP2004513602A (ja) * 1999-03-08 2004-05-13 ジェネンテック・インコーポレーテッド 分泌及び膜貫通ポリペプチドとそれをコードしている核酸
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'
AU3632600A (en) * 1999-05-14 2000-12-05 Genentech Inc. Compositions and methods for the treatment of immune related diseases
AU6394400A (en) * 1999-07-30 2001-02-19 Millennium Pharmaceuticals, Inc. Secreted proteins and uses thereof
EA008480B1 (ru) * 2000-01-12 2007-06-29 Йейл Юниверсити Выделенный полинуклеотид (варианты), содержащий его вектор и клетка-хозяин, кодируемый им полипептид рецептора nogo, уменьшающий опосредованное этим рецептором ингибирование роста аксонов (варианты), выделенное антитело и фармацевтическая композиция на их основе

Similar Documents

Publication Publication Date Title
JP2003519481A5 (OSRAM)
JP2005508165A5 (OSRAM)
JP5738294B2 (ja) 抗ｖｅｇｆモノクローナル抗体およびその抗体を含む薬学的組成物
Honda et al. The coxsackievirus-adenovirus receptor protein as a cell adhesion molecule in the developing mouse brain
EP1181318B1 (en) Monoclonal antibodies, synthetic and biotechnological derivatives thereof acting as ngf-antagonist molecules
JP4938957B2 (ja) Ｃｄ３０またはｃｄ３０ｌのアンタゴニストを使用する自己免疫および慢性炎症性状態の処置法
JP6955721B2 (ja) ＲＧＭａ結合タンパク質及びその使用
KR20190127703A (ko) 수의학적 용도를 위한 항-il31 항체
JP2011527572A5 (OSRAM)
JP2024026683A (ja) 末梢神経障害又は末梢神経障害若しくはアストロサイト障害が認められる疾患に伴う疼痛の予防又は治療方法
KR20180134876A (ko) 인간화 항 clever-1 항체 및 이의 용도
UA76396C2 (en) Monoclonal antibody, which is able to be bound with receptor ifn -, block the biological activity of ifn- and ifn- and create higher antiviral titer against fn-, than against ifn- (variants), pharmaceutical composition for modulation or blocking biological activity of ifn-, hybridoma expressing denoted antibody (variants), and set for carrying out elisa-analysis of ifnab-bpi and/or ifnab-bpi
CN115666644A (zh) 长效兽用抗il31抗体
US20250134959A1 (en) Granulocyte-macrophage colony-stimulating factor-based treatments for neurodegenerative or neurological diseases or disorders
King et al. Immunohistochemical expression of the α5 integrin subunit in the normal adult rat central nervous system
JP2003510078A5 (OSRAM)
Nakao et al. Distribution of OL-protocadherin in axon fibers in the developing chick nervous system
JP2004515215A5 (OSRAM)
CN103638521A (zh) 神经延长促进剂及延长抑制剂
RU2822199C2 (ru) Способ предупреждения или лечения периферической нейропатии или боли, сопровождающей заболевание, при котором выявлена периферическая нейропатия или нарушение астроцитов
US20230110188A1 (en) MuSK AGONIST ANTIBODY
US20170128536A1 (en) New pharmaceutical compositions and their use for the treatment of autoimmune disorders
HK40088130A (zh) 长效兽用抗il31抗体