JP2003519197A5 - - Google Patents
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- Publication number
- JP2003519197A5 JP2003519197A5 JP2001549684A JP2001549684A JP2003519197A5 JP 2003519197 A5 JP2003519197 A5 JP 2003519197A5 JP 2001549684 A JP2001549684 A JP 2001549684A JP 2001549684 A JP2001549684 A JP 2001549684A JP 2003519197 A5 JP2003519197 A5 JP 2003519197A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antigen
- inducer
- administration
- antigens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000427 antigen Substances 0.000 description 33
- 102000036639 antigens Human genes 0.000 description 30
- 108091007433 antigens Proteins 0.000 description 30
- 238000000034 method Methods 0.000 description 27
- 239000000411 inducer Substances 0.000 description 15
- 150000007523 nucleic acids Chemical class 0.000 description 12
- 108020004707 nucleic acids Proteins 0.000 description 11
- 102000039446 nucleic acids Human genes 0.000 description 11
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 5
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 5
- 102100022430 Melanocyte protein PMEL Human genes 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 101800001271 Surface protein Proteins 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 2
- 229960003983 diphtheria toxoid Drugs 0.000 description 2
- 229960000814 tetanus toxoid Drugs 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- 239000013603 viral vector Substances 0.000 description 2
- LKKMLIBUAXYLOY-UHFFFAOYSA-N 3-Amino-1-methyl-5H-pyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1C=C(N)N=C2C LKKMLIBUAXYLOY-UHFFFAOYSA-N 0.000 description 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 description 1
- 101710163881 5,6-dihydroxyindole-2-carboxylic acid oxidase Proteins 0.000 description 1
- 241000710929 Alphavirus Species 0.000 description 1
- 241000700663 Avipoxvirus Species 0.000 description 1
- 102000039506 BAGE family Human genes 0.000 description 1
- 108091067183 BAGE family Proteins 0.000 description 1
- 108020000946 Bacterial DNA Proteins 0.000 description 1
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000040452 GAGE family Human genes 0.000 description 1
- 108091072337 GAGE family Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 1
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 description 1
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 1
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 description 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
- 102100031413 L-dopachrome tautomerase Human genes 0.000 description 1
- 101710093778 L-dopachrome tautomerase Proteins 0.000 description 1
- 102000008072 Lymphokines Human genes 0.000 description 1
- 108010074338 Lymphokines Proteins 0.000 description 1
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 description 1
- 102100034256 Mucin-1 Human genes 0.000 description 1
- 108010008707 Mucin-1 Proteins 0.000 description 1
- 102100034263 Mucin-2 Human genes 0.000 description 1
- 108010008705 Mucin-2 Proteins 0.000 description 1
- 101000856426 Mus musculus Cullin-7 Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- -1 RAGE family Proteins 0.000 description 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 1
- 101710173693 Short transient receptor potential channel 1 Proteins 0.000 description 1
- 101710173694 Short transient receptor potential channel 2 Proteins 0.000 description 1
- LVTKHGUGBGNBPL-UHFFFAOYSA-N Trp-P-1 Chemical compound N1C2=CC=CC=C2C2=C1C(C)=C(N)N=C2C LVTKHGUGBGNBPL-UHFFFAOYSA-N 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 229940023860 canarypox virus HIV vaccine Drugs 0.000 description 1
- 230000000139 costimulatory effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17458700P | 2000-01-05 | 2000-01-05 | |
| US60/174,587 | 2000-01-05 | ||
| PCT/CA2001/000005 WO2001049317A2 (en) | 2000-01-05 | 2001-01-05 | Enhancing the immune response to an antigen by presensitizing with an inducing agent prior to immunizing with the inducing agent and the antigen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003519197A JP2003519197A (ja) | 2003-06-17 |
| JP2003519197A5 true JP2003519197A5 (https=) | 2008-03-13 |
Family
ID=22636709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001549684A Abandoned JP2003519197A (ja) | 2000-01-05 | 2001-01-05 | 誘導物質および抗原で免疫する前に誘導物質で予備感作することによる、抗原に対する免疫応答の増強 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040009185A1 (https=) |
| EP (1) | EP1246646A2 (https=) |
| JP (1) | JP2003519197A (https=) |
| AU (1) | AU2658801A (https=) |
| CA (1) | CA2394597A1 (https=) |
| WO (1) | WO2001049317A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070048860A1 (en) * | 1997-10-10 | 2007-03-01 | The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services | Carcinoembryonic antigen (CEA) peptides |
| US20030022854A1 (en) * | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
| DK1282702T3 (da) * | 2000-05-10 | 2007-04-02 | Sanofi Pasteur Ltd | Immunogene polypeptider, som er kodet af KAGE-minigener, og anvendelser deraf |
| EP1305414A2 (en) * | 2000-07-31 | 2003-05-02 | Aventis Pasteur Limited | Modified cea and uses thereof |
| US20040091995A1 (en) * | 2001-06-15 | 2004-05-13 | Jeffrey Schlom | Recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses |
| JP5230891B2 (ja) * | 2001-09-28 | 2013-07-10 | 株式会社癌免疫研究所 | 抗原特異的ｔ細胞の新規な誘導方法 |
| US20050002951A1 (en) * | 2001-09-28 | 2005-01-06 | Haruo Sugiyama | Novel method of inducing antigen-specific t cells |
| WO2003059379A2 (en) * | 2002-01-17 | 2003-07-24 | Pharmexa A/S | Immunogenic carcinoembryonic antigen (cea) |
| ES2290449T3 (es) | 2002-04-09 | 2008-02-16 | Sanofi Pasteur Limited | Acido nucleico de cea modificado y vectores de expresion. |
| US20070196346A1 (en) * | 2003-08-21 | 2007-08-23 | Brown Michael P | Poxvirus Vector Encoding Prostate Specific Antigens For Treatment Of Prostate Cancer |
| CA2550583C (en) * | 2003-10-08 | 2013-01-15 | Sanofi Pasteur, Inc. | Modified cea /b7 vector |
| JP2008526763A (ja) * | 2004-12-29 | 2008-07-24 | マンカインド コーポレイション | 予防又は治療目的のｍｈｃクラスｉ拘束性エピトープに対する免疫応答の誘導、増強及び保持方法 |
| EP2772267B1 (en) | 2007-08-27 | 2016-04-27 | Longhorn Vaccines and Diagnostics, LLC | Immunogenic compositions and methods |
| US10004799B2 (en) | 2007-08-27 | 2018-06-26 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| GB201016471D0 (en) * | 2010-09-30 | 2010-11-17 | Isis Innovation | Viral vector immunogenic compositions |
| EP3049092A4 (en) * | 2013-09-24 | 2017-09-06 | Duke University | Compositions, methods and kits for eliciting an immune response |
| WO2020017962A1 (en) | 2018-07-16 | 2020-01-23 | Dcprime B.V. | A combination product for use in tumor vaccination. |
| CA3133410A1 (en) | 2019-04-25 | 2020-10-29 | Dcprime B.V. | Methods of tumor vaccination |
| CN115916963A (zh) | 2020-03-27 | 2023-04-04 | 门德斯有限公司 | 白血病来源的经修饰细胞用于增强过继性细胞治疗的效力的离体用途 |
| EP4171617A1 (en) | 2020-06-30 | 2023-05-03 | Mendus B.V. | Use of leukemia-derived cells in ovarian cancer vaccines |
| JP2024506249A (ja) | 2021-01-22 | 2024-02-13 | メンドゥス・ベスローテン・フェンノートシャップ | 腫瘍ワクチン接種の方法 |
| CN116162173B (zh) * | 2022-10-28 | 2024-06-04 | 安徽农业大学 | 一种GnRH6-CRM197重组蛋白去势疫苗及制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5360897A (en) * | 1981-08-31 | 1994-11-01 | The University Of Rochester | Immunogenic conjugates of streptococcus pneumonial capsular polymer and toxin or in toxiad |
| JP2849632B2 (ja) * | 1988-04-08 | 1999-01-20 | 社団法人北里研究所 | ワクチン製剤 |
| US5688914A (en) * | 1989-08-18 | 1997-11-18 | Institut Pasteur | Composition containing a B epitope of the envelope glycoprotein of a retrovirus and a T epitope of another distinct protein of this retrovirus |
| DE69233158T2 (de) * | 1991-03-07 | 2004-05-13 | Connaught Technology Corp., Greenville | Gentechnologisch hergestellter stamm für impfstoffe |
| GB9326174D0 (en) * | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
| WO2000011140A1 (en) * | 1998-08-20 | 2000-03-02 | The Wistar Institute Of Anatomy And Biology | Methods of augmenting mucosal immunity through systemic priming and mucosal boosting |
-
2001
- 2001-01-05 WO PCT/CA2001/000005 patent/WO2001049317A2/en not_active Ceased
- 2001-01-05 JP JP2001549684A patent/JP2003519197A/ja not_active Abandoned
- 2001-01-05 CA CA002394597A patent/CA2394597A1/en not_active Abandoned
- 2001-01-05 EP EP01901075A patent/EP1246646A2/en not_active Withdrawn
- 2001-01-05 AU AU26588/01A patent/AU2658801A/en not_active Abandoned
- 2001-01-05 US US10/168,417 patent/US20040009185A1/en not_active Abandoned
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