JP2003519099A5 - - Google Patents
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- Publication number
- JP2003519099A5 JP2003519099A5 JP2001518409A JP2001518409A JP2003519099A5 JP 2003519099 A5 JP2003519099 A5 JP 2003519099A5 JP 2001518409 A JP2001518409 A JP 2001518409A JP 2001518409 A JP2001518409 A JP 2001518409A JP 2003519099 A5 JP2003519099 A5 JP 2003519099A5
- Authority
- JP
- Japan
- Prior art keywords
- product
- thia
- boc
- glu
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19940130A DE19940130A1 (de) | 1999-08-24 | 1999-08-24 | Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung |
| DE19940130.6 | 1999-08-24 | ||
| PCT/EP2000/008118 WO2001014318A2 (de) | 1999-08-24 | 2000-08-20 | Neue effektoren der dipeptidyl peptidase iv zur topischen anwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003519099A JP2003519099A (ja) | 2003-06-17 |
| JP2003519099A5 true JP2003519099A5 (enExample) | 2007-10-04 |
Family
ID=7919444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001518409A Withdrawn JP2003519099A (ja) | 1999-08-24 | 2000-08-20 | 局所使用されるジペプチジルペプチダーゼivの新しいエフェクター |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6949515B2 (enExample) |
| EP (2) | EP1792910A2 (enExample) |
| JP (1) | JP2003519099A (enExample) |
| KR (1) | KR20020040787A (enExample) |
| CN (1) | CN1370181A (enExample) |
| AT (1) | ATE357455T1 (enExample) |
| AU (1) | AU769404B2 (enExample) |
| BR (1) | BR0013577A (enExample) |
| CA (1) | CA2379875A1 (enExample) |
| DE (2) | DE19940130A1 (enExample) |
| ES (1) | ES2282130T3 (enExample) |
| IL (1) | IL148170A0 (enExample) |
| MX (1) | MXPA02001800A (enExample) |
| NO (1) | NO20020858D0 (enExample) |
| NZ (1) | NZ528770A (enExample) |
| PT (1) | PT1206485E (enExample) |
| WO (1) | WO2001014318A2 (enExample) |
| ZA (1) | ZA200200794B (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6803357B1 (en) | 1998-02-02 | 2004-10-12 | New England Medical Center Hospitals, Inc. | Method of regulating glucose metabolism, and reagents related thereto |
| US6979697B1 (en) | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
| GB0010183D0 (en) | 2000-04-26 | 2000-06-14 | Ferring Bv | Inhibitors of dipeptidyl peptidase IV |
| US7196201B2 (en) | 2001-06-27 | 2007-03-27 | Smithkline Beecham Corporation | Pyrrolidines as dipeptidyl peptidase inhibitors |
| DE60222667T2 (de) | 2001-06-27 | 2008-07-17 | Smithkline Beecham Corp. | Fluorpyrrolidine als dipeptidylpeptidaseinhibitoren |
| US7183290B2 (en) | 2001-06-27 | 2007-02-27 | Smithkline Beecham Corporation | Fluoropyrrolidines as dipeptidyl peptidase inhibitors |
| US7368421B2 (en) * | 2001-06-27 | 2008-05-06 | Probiodrug Ag | Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis |
| JP2005511636A (ja) * | 2001-11-26 | 2005-04-28 | トラスティーズ オブ タフツ カレッジ | 自己免疫疾患の治療方法及びそれに関する試薬 |
| WO2003045977A2 (en) | 2001-11-26 | 2003-06-05 | Trustees Of Tufts College | Peptidomimetic Inhibitors of Post-Proline Cleaving Enzymes |
| US20040242566A1 (en) * | 2003-03-25 | 2004-12-02 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
| WO2004099134A2 (en) * | 2003-05-05 | 2004-11-18 | Prosidion Ltd. | Glutaminyl based dp iv-inhibitors |
| US7371871B2 (en) | 2003-05-05 | 2008-05-13 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| JP2007511467A (ja) | 2003-05-14 | 2007-05-10 | タケダ サン ディエゴ インコーポレイテッド | ジペプチジルペプチダーゼインヒビター |
| MXPA06001601A (es) | 2003-08-13 | 2006-08-25 | Takeda Pharmaceutical | Derivados de 4-pirimidona y su uso como inhibidores de dipeptidilpeptidasa. |
| US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2005026148A1 (en) | 2003-09-08 | 2005-03-24 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| US20050065144A1 (en) * | 2003-09-08 | 2005-03-24 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
| US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| CN102127057A (zh) | 2004-03-15 | 2011-07-20 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
| WO2005118555A1 (en) | 2004-06-04 | 2005-12-15 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| AU2005267093B2 (en) | 2004-07-23 | 2009-10-01 | Nuada Llc | Peptidase inhibitors |
| EP1828192B1 (en) | 2004-12-21 | 2014-12-03 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| DOP2006000008A (es) | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
| KR20080000665A (ko) | 2005-04-22 | 2008-01-02 | 알란토스 파마슈티컬즈 홀딩, 인코포레이티드 | 디펩티딜 펩티다아제-ⅳ 억제제 |
| US20070060529A1 (en) * | 2005-09-14 | 2007-03-15 | Christopher Ronald J | Administration of dipeptidyl peptidase inhibitors |
| SI1942898T2 (sl) * | 2005-09-14 | 2014-08-29 | Takeda Pharmaceutical Company Limited | Dipeptidil-peptidazni inhibitorji za zdravljenje diabetesa |
| SI1931350T2 (sl) * | 2005-09-14 | 2021-11-30 | Takeda Pharmaceutical Company Limited | Uporaba inhibitorjev dipeptidil peptidaze |
| TW200745080A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor |
| TW200745079A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor |
| EP1924567B1 (en) | 2005-09-16 | 2012-08-22 | Takeda Pharmaceutical Company Limited | Process for the preparation of pyrimidinedione derivatives |
| WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| JP2009531456A (ja) * | 2006-03-28 | 2009-09-03 | 武田薬品工業株式会社 | (r)−3−アミノピペリジン二塩酸塩の調製 |
| PE20071221A1 (es) | 2006-04-11 | 2007-12-14 | Arena Pharm Inc | Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas |
| DE602007010420D1 (de) | 2006-04-11 | 2010-12-23 | Arena Pharm Inc | Verfahren zur verwendung des gpr119-rezeptors zur identifizierung von verbindungen zur erhöhung der knochenmasse bei einer person |
| RS51965B (sr) * | 2006-09-13 | 2012-02-29 | Takeda Pharmaceutical Company Limited | Upotreba 2-6-(3-amino-piperidin-1-il)-3-metil-2,4-diokso-3,4-dihidro-2h-pirimidin-1-ilmetil-4-fluoro-benzonitrila za lečenje dijabetesa, kancera, autoimunih poremećaja i hiv infekcije |
| US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| EP2091948B1 (en) | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| CN101279955B (zh) * | 2007-04-03 | 2012-11-28 | 北京摩力克科技有限公司 | 作为二肽肽激酶-iv抑制剂的n-取代硫吗啉衍生物及其医药用途 |
| US9656991B2 (en) | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| EP2146210A1 (en) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY |
| ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| CA2789440C (en) | 2010-03-10 | 2020-03-24 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| JP5945532B2 (ja) | 2010-04-21 | 2016-07-05 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| CA2979033A1 (en) | 2015-03-09 | 2016-09-15 | Intekrin Therapeutics, Inc. | Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy |
| CN110996951A (zh) | 2017-04-03 | 2020-04-10 | 科赫罗斯生物科学股份有限公司 | 治疗进行性核上性麻痹的PPARγ激动剂 |
| EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| CN110607336B (zh) * | 2019-10-17 | 2024-01-26 | 江南大学 | 酶催化制备半胱氨酸寡肽及其膜敷料的制备方法 |
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| DE296075C (enExample) | ||||
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| US3879541A (en) * | 1970-03-03 | 1975-04-22 | Bayer Ag | Antihyperglycemic methods and compositions |
| US3960949A (en) * | 1971-04-02 | 1976-06-01 | Schering Aktiengesellschaft | 1,2-Biguanides |
| CH602612A5 (enExample) * | 1974-10-11 | 1978-07-31 | Hoffmann La Roche | |
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| WO2003016335A2 (en) | 2001-08-13 | 2003-02-27 | Probiodrug Ag | Irreversible cysteine protease inhibitors of legumain |
| JP2005523288A (ja) | 2002-02-19 | 2005-08-04 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 疾病治療用の縮合した二環式−n−架橋−複素環式芳香族カルボキサミド |
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-
1999
- 1999-08-24 DE DE19940130A patent/DE19940130A1/de not_active Withdrawn
-
2000
- 2000-08-20 AU AU65721/00A patent/AU769404B2/en not_active Ceased
- 2000-08-20 EP EP07104464A patent/EP1792910A2/de not_active Withdrawn
- 2000-08-20 NZ NZ528770A patent/NZ528770A/en unknown
- 2000-08-20 CN CN00811936A patent/CN1370181A/zh active Pending
- 2000-08-20 BR BR0013577-1A patent/BR0013577A/pt not_active Application Discontinuation
- 2000-08-20 KR KR1020027002338A patent/KR20020040787A/ko not_active Withdrawn
- 2000-08-20 PT PT00953186T patent/PT1206485E/pt unknown
- 2000-08-20 IL IL14817000A patent/IL148170A0/xx unknown
- 2000-08-20 WO PCT/EP2000/008118 patent/WO2001014318A2/de not_active Ceased
- 2000-08-20 AT AT00953186T patent/ATE357455T1/de not_active IP Right Cessation
- 2000-08-20 DE DE50014187T patent/DE50014187D1/de not_active Expired - Fee Related
- 2000-08-20 MX MXPA02001800A patent/MXPA02001800A/es unknown
- 2000-08-20 CA CA002379875A patent/CA2379875A1/en not_active Abandoned
- 2000-08-20 JP JP2001518409A patent/JP2003519099A/ja not_active Withdrawn
- 2000-08-20 EP EP00953186A patent/EP1206485B1/de not_active Expired - Lifetime
- 2000-08-20 ES ES00953186T patent/ES2282130T3/es not_active Expired - Lifetime
-
2002
- 2002-01-29 ZA ZA200200794A patent/ZA200200794B/en unknown
- 2002-02-22 NO NO20020858A patent/NO20020858D0/no not_active Application Discontinuation
- 2002-02-22 US US10/082,001 patent/US6949515B2/en not_active Expired - Fee Related
-
2005
- 2005-03-01 US US11/069,926 patent/US7335645B2/en not_active Expired - Fee Related
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