JP2003517467A - ホスホチオエーテトリエステル及びオリゴヌクレオチドの調製方法 - Google Patents

ホスホチオエーテトリエステル及びオリゴヌクレオチドの調製方法

Info

Publication number
JP2003517467A
JP2003517467A JP2001530344A JP2001530344A JP2003517467A JP 2003517467 A JP2003517467 A JP 2003517467A JP 2001530344 A JP2001530344 A JP 2001530344A JP 2001530344 A JP2001530344 A JP 2001530344A JP 2003517467 A JP2003517467 A JP 2003517467A
Authority
JP
Japan
Prior art keywords
group
phosphonate
alkyl
groups
diester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001530344A
Other languages
English (en)
Japanese (ja)
Inventor
ダグラス，マーク・エドワード
スコット，ケビン・ゼラルド
ムーディー，デビッド・ジョン
メロー，ベン・ジェイムス
Original Assignee
アベシア・リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アベシア・リミテッド filed Critical アベシア・リミテッド
Publication of JP2003517467A publication Critical patent/JP2003517467A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
JP2001530344A 1999-10-14 2000-10-12 ホスホチオエーテトリエステル及びオリゴヌクレオチドの調製方法 Pending JP2003517467A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9924285.1 1999-10-14
GBGB9924285.1A GB9924285D0 (en) 1999-10-14 1999-10-14 Process
PCT/GB2000/003912 WO2001027126A1 (fr) 1999-10-14 2000-10-12 Preparation de phosphorothioate triesters et d'oligonucleotides

Publications (1)

Publication Number Publication Date
JP2003517467A true JP2003517467A (ja) 2003-05-27

Family

ID=10862710

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001530344A Pending JP2003517467A (ja) 1999-10-14 2000-10-12 ホスホチオエーテトリエステル及びオリゴヌクレオチドの調製方法

Country Status (7)

Country Link
EP (1) EP1224193A1 (fr)
JP (1) JP2003517467A (fr)
CN (1) CN1409719A (fr)
AU (1) AU7803500A (fr)
CA (1) CA2386867A1 (fr)
GB (1) GB9924285D0 (fr)
WO (1) WO2001027126A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0004889D0 (en) 2000-03-01 2000-04-19 Avecia Ltd Synthesis of oligonucleotides
EP2332954A3 (fr) * 2000-12-05 2011-12-21 Avecia Biotechnology, Inc. Procede de preparation d'oligonucleotides phosphorothionate
GB0229423D0 (en) * 2002-12-18 2003-01-22 Avecia Ltd Process
CN101684136A (zh) * 2008-09-23 2010-03-31 苏州瑞博生物技术有限公司 一种寡核苷酸的制备方法
BRPI0923225A2 (pt) 2008-12-02 2016-10-04 Chiralgen Ltd metodo para sintese de acidos nucleicos modificados no atomo de fosforo
BR112012000828A8 (pt) 2009-07-06 2017-10-10 Ontorii Inc Novas pró-drogas de ácido nucleico e métodos de uso das mesmas
WO2012039448A1 (fr) 2010-09-24 2012-03-29 株式会社キラルジェン Groupe auxiliaire asymétrique
EP3248982A1 (fr) 2011-07-19 2017-11-29 Wave Life Sciences Ltd. Reactifs de type thiosulfonate pour la synthèse d'acides nucléiques fonctionnalisés
PT2872485T (pt) 2012-07-13 2021-03-05 Wave Life Sciences Ltd Grupo auxiliar assimétrico
SG11201500243WA (en) 2012-07-13 2015-04-29 Shin Nippon Biomedical Lab Ltd Chiral nucleic acid adjuvant
RU2015104762A (ru) 2012-07-13 2018-08-31 Уэйв Лайф Сайенсес Лтд. Хиральный контроль
EP3095461A4 (fr) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Adjuvant d'acide nucléique chiral possédant une activité d'induction d'immunité, et activateur d'induction d'immunité
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
KR20230152178A (ko) 2014-01-16 2023-11-02 웨이브 라이프 사이언시스 리미티드 키랄 디자인

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2976436B2 (ja) * 1988-04-27 1999-11-10 味の素株式会社 新規オリゴリボヌクレオチド誘導体及び抗ウイルス剤への使用
GB9717158D0 (en) * 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues

Also Published As

Publication number Publication date
EP1224193A1 (fr) 2002-07-24
CN1409719A (zh) 2003-04-09
CA2386867A1 (fr) 2001-04-19
AU7803500A (en) 2001-04-23
WO2001027126A1 (fr) 2001-04-19
GB9924285D0 (en) 1999-12-15

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