JP2003517015A5 - - Google Patents
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- Publication number
- JP2003517015A5 JP2003517015A5 JP2001544888A JP2001544888A JP2003517015A5 JP 2003517015 A5 JP2003517015 A5 JP 2003517015A5 JP 2001544888 A JP2001544888 A JP 2001544888A JP 2001544888 A JP2001544888 A JP 2001544888A JP 2003517015 A5 JP2003517015 A5 JP 2003517015A5
- Authority
- JP
- Japan
- Prior art keywords
- binding substance
- helicobacter pylori
- binding
- pharmaceutical composition
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000126 substance Substances 0.000 description 49
- 239000008194 pharmaceutical composition Substances 0.000 description 19
- 241000590002 Helicobacter pylori Species 0.000 description 14
- 229940037467 helicobacter pylori Drugs 0.000 description 14
- 238000000034 method Methods 0.000 description 14
- 241000589989 Helicobacter Species 0.000 description 7
- 150000002482 oligosaccharides Chemical class 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 235000020939 nutritional additive Nutrition 0.000 description 4
- 150000002016 disaccharides Chemical class 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 235000013373 food additive Nutrition 0.000 description 3
- 150000004676 glycans Chemical group 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 208000007882 Gastritis Diseases 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 208000007107 Stomach Ulcer Diseases 0.000 description 2
- 208000034972 Sudden Infant Death Diseases 0.000 description 2
- 206010042440 Sudden infant death syndrome Diseases 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- WQZGKKKJIJFFOK-FPRJBGLDSA-N beta-D-galactose Chemical group OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-FPRJBGLDSA-N 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 208000000718 duodenal ulcer Diseases 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 201000006585 gastric adenocarcinoma Diseases 0.000 description 2
- 201000005917 gastric ulcer Diseases 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 208000019622 heart disease Diseases 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 208000019423 liver disease Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 150000002772 monosaccharides Chemical group 0.000 description 2
- 229920001542 oligosaccharide Polymers 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 1
- 108010037833 Bacterial Adhesins Proteins 0.000 description 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- 0 CCC(*)(CC)*C(C)(C)*C(C)(C)OO[C@](*C(CO)[C@@](C1O)O)C1O Chemical compound CCC(*)(CC)*C(C)(C)*C(C)(C)OO[C@](*C(CO)[C@@](C1O)O)C1O 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- FGIWFDOOHZAKDV-HLDZVPRBSA-N lactogangliotetraosylceramide Chemical compound CCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3NC(C)=O)[C@H](O)[C@H]2O)[C@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2NC(C)=O)[C@H]1O)[C@H](O)\C=C\CCCCCCCCCCCCC FGIWFDOOHZAKDV-HLDZVPRBSA-N 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9904581A SE9904581D0 (sv) | 1999-12-15 | 1999-12-15 | A novel helicobacter pylori-binding substance and use thereof |
| SE9904581-7 | 1999-12-15 | ||
| PCT/SE2000/002567 WO2001043751A1 (en) | 1999-12-15 | 2000-12-15 | Novel helicobacter pylori-binding substances and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003517015A JP2003517015A (ja) | 2003-05-20 |
| JP2003517015A5 true JP2003517015A5 (cg-RX-API-DMAC7.html) | 2008-02-14 |
Family
ID=20418126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001544888A Pending JP2003517015A (ja) | 1999-12-15 | 2000-12-15 | ヘリコバクターピロリ結合性新規物質およびその用途 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20040086514A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1237558A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2003517015A (cg-RX-API-DMAC7.html) |
| CN (1) | CN100389773C (cg-RX-API-DMAC7.html) |
| AU (1) | AU783876B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2392766A1 (cg-RX-API-DMAC7.html) |
| CZ (1) | CZ20021989A3 (cg-RX-API-DMAC7.html) |
| EE (1) | EE200200312A (cg-RX-API-DMAC7.html) |
| HU (1) | HUP0204243A3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL150247A0 (cg-RX-API-DMAC7.html) |
| NO (1) | NO20022890L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ520111A (cg-RX-API-DMAC7.html) |
| PL (1) | PL356329A1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2283115C2 (cg-RX-API-DMAC7.html) |
| SE (1) | SE9904581D0 (cg-RX-API-DMAC7.html) |
| SK (1) | SK8152002A3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2001043751A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200204251B (cg-RX-API-DMAC7.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904581D0 (sv) * | 1999-12-15 | 1999-12-15 | A & Science Invest Ab | A novel helicobacter pylori-binding substance and use thereof |
| FI20010118L (fi) * | 2001-01-19 | 2002-07-20 | Carbion Oy | Uudet helicobacter pylori reseptorit ja niiden käyttö |
| EP1411952B1 (en) * | 2001-06-29 | 2009-04-22 | Glykos Finland Oy | Use of at least one glycoinhibitor substance against infectious diseases |
| FI20011403L (fi) * | 2001-06-29 | 2002-12-30 | Carbion Oy | Menetelmä ja koostumukset vatsan sairauksien hoitoon |
| AU2003201619A1 (en) * | 2002-01-18 | 2003-07-30 | Biotie Therapies Corporation | Novel binding epitopes for helicobacter pylori and use thereof |
| EP1332759B1 (en) * | 2002-02-04 | 2005-09-28 | Kyowa Hakko Kogyo Co., Ltd. | Pharmaceutical and nutritional compositions containing a di- or oligosaccharide as insulin secretion promoter |
| EP2272522B1 (en) * | 2002-06-28 | 2017-09-06 | Nestec S.A. | Therapeutic compositions for use in prophylaxis or treatment of diarrheas |
| FI20021989A0 (fi) * | 2002-11-06 | 2002-11-06 | Halina Miller-Podraza | Korkean affiniteetin Helicobacter pylori-reseptorit ja niiden käyttö |
| EP1866071A4 (en) * | 2005-03-03 | 2013-04-24 | Univ Indiana Res & Tech Corp | PERMETHYLATION OF OLIGOSACCHARIDES |
| JP4677525B2 (ja) * | 2005-08-23 | 2011-04-27 | 国立大学法人 長崎大学 | ヘリコバクター・ピロリの空胞化毒素の検出試薬および検出方法 |
| FR2906808B1 (fr) * | 2006-10-10 | 2012-10-05 | Univ Nantes | Utilisation d'anticorps monoclonaux specifiques de la forme o-acetylee du ganglioside gd2 dans le traitement de certains cancers |
| JP5014018B2 (ja) * | 2006-10-18 | 2012-08-29 | 旭化成ケミカルズ株式会社 | ピロリ菌の抑制剤または静菌剤 |
| EP2098238B1 (en) * | 2007-01-12 | 2012-10-17 | The Noguchi Institute | Helicobacter pylori growth inhibitor containing a monosaccharide derivative having an n-acetylglucosaminyl-group linked at the alpha position |
| EP2060257A1 (en) | 2007-11-08 | 2009-05-20 | Nestec S.A. | Prevention and treatment of secondary infections following viral infection |
| GB0817908D0 (en) * | 2008-10-01 | 2008-11-05 | Univ Ghent | Blood group a/b/h determinant on type 1 core glycosphinglipids chain as recognition point for the fedf protein of f18-fimbriated enterotoxigenic |
| JP5383692B2 (ja) | 2008-10-10 | 2014-01-08 | 公益財団法人野口研究所 | ピロリ菌増殖抑制剤 |
| EP2844301A2 (en) * | 2012-05-04 | 2015-03-11 | Ineb-instituto de Engenharia Biomédica | Microspheres for treating helicobacter pylori infections |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1544908A (en) * | 1975-07-08 | 1979-04-25 | Chembiomed Ltd | Artificial oligosaccharide antigenic determinants |
| EP0058665B1 (en) * | 1980-05-09 | 1986-02-26 | LEFFLER, Hakon | Carbohydrate derivatives for inhibiting bacterial adherence |
| US4678747A (en) * | 1983-02-18 | 1987-07-07 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies for detection of an H (O) blood group antigen |
| SE8304006D0 (sv) * | 1983-07-15 | 1983-07-15 | Karlsson Karl Anders | Forening och komposition for terapeutisk eller diagnostisk anvendning samt forfarande for terapeutisk behandling |
| DK17885D0 (da) * | 1985-01-14 | 1985-01-14 | Karlsson Karl Anders | Antiviralt middel |
| US4971905A (en) * | 1987-08-11 | 1990-11-20 | Pacific Northwest Research Foundation | Diagnosis of cancerous or precancerous conditions in human secretory epithelia by enzyme activity of β-1-3N-acetylglucosaminyltransferase |
| US4895838A (en) * | 1988-03-09 | 1990-01-23 | Trustees Of Boston University | Method for provoking angiogenesis by administration of angiogenically active oligosaccharides |
| US4957741A (en) * | 1988-08-02 | 1990-09-18 | Angio-Medical Corp. | Method for the treatment of gastric ulcer |
| US5877028A (en) * | 1991-05-29 | 1999-03-02 | Smithkline Diagnostics, Inc. | Immunochromatographic assay device |
| MX9304638A (es) * | 1992-07-31 | 1994-05-31 | Neose Pharm Inc | Composicion para tratar e inhibir las ulceras gastricas y duodenales. |
| US6406894B1 (en) * | 1992-12-11 | 2002-06-18 | Glycorex Ab | Process for preparing polyvalent and physiologically degradable carbohydrate-containing polymers by enzymatic glycosylation reactions and the use thereof for preparing carbohydrate building blocks |
| EP0601417A3 (de) * | 1992-12-11 | 1998-07-01 | Hoechst Aktiengesellschaft | Physiologisch verträglicher und physiologisch abbaubarer, Kohlenhydratrezeptorblocker auf Polymerbasis, ein Verfahren zu seiner Herstellung und seine Verwendung |
| US6300113B1 (en) * | 1995-11-21 | 2001-10-09 | New England Biolabs Inc. | Isolation and composition of novel glycosidases |
| DE4408248A1 (de) * | 1994-03-11 | 1995-09-14 | Hoechst Ag | Physiologisch verträgliche und physiologisch abbaubare Kohlenhydrat-Mimetika, ein Verfahren zur Herstellung und ihre Verwendung |
| US5679769A (en) * | 1994-03-15 | 1997-10-21 | Sloan-Kettering Institute For Cancer Research | Synthesis of asparagine-linked glycopeptides on a polymeric solid support |
| WO1995029927A2 (en) * | 1994-05-02 | 1995-11-09 | Biomira, Inc. | Process for preparation of glycosides of tumor-associated carbohydrate antigens |
| PL325873A1 (en) * | 1995-09-29 | 1998-08-17 | Glycim Oy | Synthetic multivalent polysaccharide slex containing polylactose amines and methods of obtaining same |
| DE69737496D1 (de) * | 1996-01-30 | 2007-05-03 | Glycomimetics Inc | SIALYL-LEWISa UND SIALYL LEWISx EPITOP-ANALOGE |
| US6841543B1 (en) * | 1996-01-31 | 2005-01-11 | President And Fellows Of Harvard College | Methods of inhibiting production of T helper type 2 cytokines in human immune cells |
| US6709656B1 (en) * | 1996-06-10 | 2004-03-23 | Thomas Boren | Helicobacter pylori adhesin binding group antigen |
| EP0926154B1 (en) * | 1996-07-23 | 2010-01-27 | Seikagaku Corporation | Novel lactosamine oligosaccharides and process for the preparation thereof |
| JPH1045602A (ja) * | 1996-07-31 | 1998-02-17 | Motoyasu Murakami | ヘリコバクター・ピロリ接着阻害剤またはインターロイキン−８産生阻害剤 |
| US6902903B1 (en) * | 1996-12-19 | 2005-06-07 | Chiron Corporation | Helicobacter pylori diagnostics |
| CN1281355A (zh) * | 1997-12-12 | 2001-01-24 | 三阳株式会社 | 用于基因递送的生物可降解性混合聚合胶束 |
| US6410057B1 (en) * | 1997-12-12 | 2002-06-25 | Samyang Corporation | Biodegradable mixed polymeric micelles for drug delivery |
| JP4318765B2 (ja) * | 1998-04-01 | 2009-08-26 | 雪印乳業株式会社 | ピロリ菌感染防御剤 |
| KR100460173B1 (ko) * | 1998-12-11 | 2004-12-04 | 겐 코오포레이션 | 헬리코박터 파일로리 정착 억제제 |
| US20010051349A1 (en) * | 2000-02-17 | 2001-12-13 | Glycominds Ltd. | Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof |
| US20030100508A1 (en) * | 1999-02-24 | 2003-05-29 | Maryline Simon | Carbohydrate epitope mimic compounds and uses thereof |
| WO2000070060A1 (en) * | 1999-05-18 | 2000-11-23 | University Of Iowa Research Foundation | Production of complex carbohydrates |
| AUPQ275799A0 (en) * | 1999-09-10 | 1999-10-07 | Luminis Pty Limited | Recombinant bacterium expressing an oligosaccharide receptor mimic |
| FI19992070A7 (fi) * | 1999-09-28 | 2001-03-29 | Carbion Oy | Uudet fukosyloidut oligosakkaridit ja menetelmä niiden valmistamiseksi |
| SE9904581D0 (sv) * | 1999-12-15 | 1999-12-15 | A & Science Invest Ab | A novel helicobacter pylori-binding substance and use thereof |
| FI20010118L (fi) * | 2001-01-19 | 2002-07-20 | Carbion Oy | Uudet helicobacter pylori reseptorit ja niiden käyttö |
| EP1417965A1 (en) * | 2002-11-07 | 2004-05-12 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | C-type lectin binding molecules, identification and uses thereof |
| ES2344114T3 (es) * | 2004-05-11 | 2010-08-18 | De Staat Der Nederlanden, Vert. Door De Minister Van Vws | Lipooligosacaridos de neisseria meningitidis igtb como adyuvante. |
| EP1787128A2 (en) * | 2004-07-09 | 2007-05-23 | Amaox, Inc. | Immune cell biosensors and methods of using same |
| US8273357B2 (en) * | 2004-07-16 | 2012-09-25 | Massachusetts Institute Of Technology | Antigen-carbohydrate conjugates |
-
1999
- 1999-12-15 SE SE9904581A patent/SE9904581D0/xx unknown
-
2000
- 2000-12-15 EE EEP200200312A patent/EE200200312A/xx unknown
- 2000-12-15 RU RU2002118703/15A patent/RU2283115C2/ru not_active IP Right Cessation
- 2000-12-15 EP EP00987920A patent/EP1237558A1/en not_active Withdrawn
- 2000-12-15 NZ NZ520111A patent/NZ520111A/en unknown
- 2000-12-15 CA CA002392766A patent/CA2392766A1/en not_active Abandoned
- 2000-12-15 JP JP2001544888A patent/JP2003517015A/ja active Pending
- 2000-12-15 PL PL00356329A patent/PL356329A1/xx not_active IP Right Cessation
- 2000-12-15 AU AU24188/01A patent/AU783876B2/en not_active Ceased
- 2000-12-15 IL IL15024700A patent/IL150247A0/xx unknown
- 2000-12-15 WO PCT/SE2000/002567 patent/WO2001043751A1/en not_active Ceased
- 2000-12-15 CZ CZ20021989A patent/CZ20021989A3/cs unknown
- 2000-12-15 US US10/149,608 patent/US20040086514A1/en not_active Abandoned
- 2000-12-15 SK SK815-2002A patent/SK8152002A3/sk not_active Application Discontinuation
- 2000-12-15 CN CNB008172927A patent/CN100389773C/zh not_active Expired - Fee Related
- 2000-12-15 HU HU0204243A patent/HUP0204243A3/hu unknown
-
2002
- 2002-05-28 ZA ZA200204251A patent/ZA200204251B/en unknown
- 2002-06-17 NO NO20022890A patent/NO20022890L/no not_active Application Discontinuation
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