JP2003516930A5 - - Google Patents
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- Publication number
- JP2003516930A5 JP2003516930A5 JP2001516518A JP2001516518A JP2003516930A5 JP 2003516930 A5 JP2003516930 A5 JP 2003516930A5 JP 2001516518 A JP2001516518 A JP 2001516518A JP 2001516518 A JP2001516518 A JP 2001516518A JP 2003516930 A5 JP2003516930 A5 JP 2003516930A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- epha2
- antibody
- metastatic
- cell density
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 description 22
- 102000051096 EphA2 Receptor Human genes 0.000 description 10
- 108010055196 EphA2 Receptor Proteins 0.000 description 10
- 230000001394 metastastic effect Effects 0.000 description 5
- 206010061289 metastatic neoplasm Diseases 0.000 description 5
- 208000037819 metastatic cancer Diseases 0.000 description 4
- 208000011575 metastatic malignant neoplasm Diseases 0.000 description 4
- 230000007423 decrease Effects 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000010420 art technique Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 238000001114 immunoprecipitation Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000004264 monolayer culture Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14925899P | 1999-08-17 | 1999-08-17 | |
| US60/149,258 | 1999-08-17 | ||
| PCT/US2000/022670 WO2001012172A1 (en) | 1999-08-17 | 2000-08-17 | Treatment of metastatic disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007211840A Division JP2007306938A (ja) | 1999-08-17 | 2007-08-15 | 転移性疾患の治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003516930A JP2003516930A (ja) | 2003-05-20 |
| JP2003516930A5 true JP2003516930A5 (enExample) | 2008-06-05 |
Family
ID=22529456
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001516518A Pending JP2003516930A (ja) | 1999-08-17 | 2000-08-17 | 転移性疾患の治療 |
| JP2007211840A Pending JP2007306938A (ja) | 1999-08-17 | 2007-08-15 | 転移性疾患の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007211840A Pending JP2007306938A (ja) | 1999-08-17 | 2007-08-15 | 転移性疾患の治療 |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP1242060B1 (enExample) |
| JP (2) | JP2003516930A (enExample) |
| AT (1) | ATE324877T1 (enExample) |
| AU (1) | AU6784400A (enExample) |
| CA (1) | CA2380888A1 (enExample) |
| DE (1) | DE60027768T2 (enExample) |
| DK (1) | DK1242060T3 (enExample) |
| ES (1) | ES2261230T3 (enExample) |
| PT (1) | PT1242060E (enExample) |
| WO (1) | WO2001012172A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192698B1 (en) | 1999-08-17 | 2007-03-20 | Purdue Research Foundation | EphA2 as a diagnostic target for metastatic cancer |
| US6927203B1 (en) | 1999-08-17 | 2005-08-09 | Purdue Research Foundation | Treatment of metastatic disease |
| NZ521898A (en) | 2000-03-31 | 2004-11-26 | Purdue Research Foundation | Use of a ligand-immunogen conjugate such as folate-FITC for enhancing an endogenous immune response |
| US7101976B1 (en) | 2000-09-12 | 2006-09-05 | Purdue Research Foundation | EphA2 monoclonal antibodies and methods of making and using same |
| EP1298221A1 (en) * | 2001-09-28 | 2003-04-02 | PrimaGen Holding B.V. | Means and methods for treatment evaluation |
| EP1225233A3 (en) * | 2001-01-23 | 2003-01-08 | Amsterdam Support Diagnostics B.V. | Means and methods for treatment evaluation |
| NZ537458A (en) * | 2001-01-23 | 2007-02-23 | Primagen Holding B | Means and methods for treatment evaluation |
| ES2338305T3 (es) * | 2001-09-28 | 2010-05-06 | Purdue Research Foundation | Metodo de tratamiento que utiliza conjugados ligando-inmunogeno. |
| JP2005535289A (ja) * | 2002-02-15 | 2005-11-24 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | １４１４分子、１４８１分子、１５５３分子、３４０２１分子、１７２０分子、１６８３分子、１５５２分子、１６８２分子、１６７５分子、１２８２５分子、９９５２分子、５８１６分子、１０００２分子、１６１１分子、１３７１分子、１４３２４分子、１２６分子、２７０分子、３１２分子、１６７分子、３２６分子、１８９２６分子、６７４７分子、１７９３分子、１７８４分子または２０４５分子を用いて、ａｉｄｓおよびｈｉｖ関連障害を処置するための方法および組成物 |
| ATE525398T1 (de) * | 2002-05-10 | 2011-10-15 | Medimmune Inc | Epha2 monoklonale antikörper und deren anwendungsverfahren |
| EP1575509B1 (en) * | 2002-05-10 | 2011-10-26 | Purdue Research Foundation | Epha2 agonistic monoclonal antibodies and methods of use thereof |
| JP2006501153A (ja) | 2002-05-23 | 2006-01-12 | パーデュー・リサーチ・ファウンデーション | 診断及び治療用標的としての低分子量タンパク質チロシンホスファターゼ（ｌｍｗ−ｐｔｐ） |
| AU2004210463B2 (en) * | 2003-02-07 | 2009-07-16 | Ludwig Institute For Cancer Research Limited | Eph/ephrin mediated modulation of cell adhesion and tumour cell metastasis |
| AU2003900541A0 (en) * | 2003-02-07 | 2003-02-20 | Ludwig Institute For Cancer Research | Modulation of cell adhesion and tumour cell metastasis |
| WO2004091375A2 (en) * | 2003-04-11 | 2004-10-28 | Medimmune, Inc. | Epha2 and non-neoplastic hyperproliferative cell disorders |
| US20050049176A1 (en) * | 2003-04-11 | 2005-03-03 | Kiener Peter A. | EphA2, hypoproliferative cell disorders and epithelial and endothelial reconstitution |
| US8012681B2 (en) | 2003-05-13 | 2011-09-06 | Novartis Vaccines And Diagnostics, Inc. | Methods of modulating metastasis and skeletal related events resulting from metastases |
| WO2005016381A2 (en) * | 2003-07-21 | 2005-02-24 | Medimmune, Inc. | Combination therapy for the treatment and prevention of cancer using epha2, pcdgf, and haah |
| CN1905899B (zh) * | 2003-11-20 | 2011-09-28 | 医学免疫公司 | EphA2激动性单克隆抗体及其使用方法 |
| ES2321212T3 (es) | 2004-05-18 | 2009-06-03 | Alphavax, Inc. | Vectores alfavirus derivados de tc-83, particulas y metodos antecentes de la invencion. |
| AU2005277641A1 (en) | 2004-08-16 | 2006-03-02 | Medimmune, Llc | Eph receptor Fc variants with enhanced antibody dependent cell-mediated cytotoxicity activity |
| KR101363252B1 (ko) | 2005-02-04 | 2014-02-13 | 레이븐 바이오테크놀로지스, 인코퍼레이티드 | Ｅｐｈａ2에 결합하는 항체 및 그것의 사용방법 |
| US8168164B2 (en) | 2006-02-03 | 2012-05-01 | Purdue Research Foundation | Targeted conjugates and radiation |
| EA020324B1 (ru) | 2006-07-18 | 2014-10-30 | Санофи-Авентис | АНТИТЕЛА К РЕЦЕПТОРУ ЭФРИНА EphA2 И ИХ ПРИМЕНЕНИЕ |
| ES2517869T3 (es) | 2006-09-12 | 2014-11-04 | Alphavax, Inc. | Partículas de replicones de alfavirus emparejadas con antígenos proteicos como adyuvantes inmunológicos |
| AU2007342333B2 (en) | 2006-09-12 | 2013-02-28 | Alphavax, Inc. | Alphavirus replicon particles encoding IL- 12 as immunological adjuvants |
| CA2668417A1 (en) | 2006-11-03 | 2008-05-15 | Alphavax, Inc. | Alphavirus and alphavirus replicon particle formulations and methods |
| SI2199390T1 (sl) | 2007-08-30 | 2017-02-28 | Daiichi Sankyo Company, Limited | Proti-epha2 protitelo |
| UY32914A (es) | 2009-10-02 | 2011-04-29 | Sanofi Aventis | Anticuerpos que se usan específicamente al receptor epha2 |
| JP5875054B2 (ja) * | 2013-02-13 | 2016-03-02 | 国立大学法人 東京大学 | がんの検査方法及び検査用キット |
| JP6729917B2 (ja) * | 2016-08-19 | 2020-07-29 | 国立大学法人 東京大学 | ＥｐｈＡ２ Ｎ末端フラグメント抗体 |
| WO2020028749A1 (en) | 2018-08-03 | 2020-02-06 | Uab Research Foundation | Methods and compositions for alphavirus vaccine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2096417C (en) | 1991-08-22 | 2000-10-10 | Sarah S. Bacus | Methods and compositions for cancer therapy and for prognosticating responses to cancer therapy |
| CA2103323A1 (en) * | 1992-11-24 | 1994-05-25 | Gregory D. Plowman | Her4 human receptor tyrosine kinase |
| US5811098A (en) | 1992-11-24 | 1998-09-22 | Bristol-Myers Squibb Company | Antibodies to HER4, human receptor tyrosine kinase |
| US5587459A (en) | 1994-08-19 | 1996-12-24 | Regents Of The University Of Minnesota | Immunoconjugates comprising tyrosine kinase inhibitors |
| ATE293989T1 (de) * | 1998-11-20 | 2005-05-15 | Genentech Inc | Verwendung von eph-rezeptor-antagonisten und agonisten zur behandlung von vaskulären krankheiten |
-
2000
- 2000-08-17 AU AU67844/00A patent/AU6784400A/en not_active Abandoned
- 2000-08-17 EP EP00955687A patent/EP1242060B1/en not_active Revoked
- 2000-08-17 AT AT00955687T patent/ATE324877T1/de not_active IP Right Cessation
- 2000-08-17 WO PCT/US2000/022670 patent/WO2001012172A1/en not_active Ceased
- 2000-08-17 DE DE60027768T patent/DE60027768T2/de not_active Revoked
- 2000-08-17 JP JP2001516518A patent/JP2003516930A/ja active Pending
- 2000-08-17 PT PT00955687T patent/PT1242060E/pt unknown
- 2000-08-17 ES ES00955687T patent/ES2261230T3/es not_active Expired - Lifetime
- 2000-08-17 DK DK00955687T patent/DK1242060T3/da active
- 2000-08-17 EP EP10010861A patent/EP2289940A3/en not_active Withdrawn
- 2000-08-17 CA CA002380888A patent/CA2380888A1/en not_active Abandoned
-
2007
- 2007-08-15 JP JP2007211840A patent/JP2007306938A/ja active Pending
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