JP2003514859A5 - - Google Patents
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- Publication number
- JP2003514859A5 JP2003514859A5 JP2001539448A JP2001539448A JP2003514859A5 JP 2003514859 A5 JP2003514859 A5 JP 2003514859A5 JP 2001539448 A JP2001539448 A JP 2001539448A JP 2001539448 A JP2001539448 A JP 2001539448A JP 2003514859 A5 JP2003514859 A5 JP 2003514859A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- chemical
- polymorph
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 10
- 239000013078 crystal Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 5
- 239000003937 drug carrier Substances 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 238000000113 differential scanning calorimetry Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000000634 powder X-ray diffraction Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16792299P | 1999-11-29 | 1999-11-29 | |
| US60/167,922 | 1999-11-29 | ||
| PCT/US2000/032353 WO2001037833A1 (en) | 1999-11-29 | 2000-11-27 | Polymorphic, amorphous and hydrated forms of 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridinyl |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003514859A JP2003514859A (ja) | 2003-04-22 |
| JP2003514859A5 true JP2003514859A5 (https=) | 2005-12-22 |
| JP4425514B2 JP4425514B2 (ja) | 2010-03-03 |
Family
ID=22609368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001539448A Expired - Lifetime JP4425514B2 (ja) | 1999-11-29 | 2000-11-27 | ５−クロロ−３−（４−メタンスルホニルフェニル）−６′−メチル−［２，３′］ビピリジニルの多形型、非晶質型および水和型 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6441002B1 (https=) |
| EP (1) | EP1248618B1 (https=) |
| JP (1) | JP4425514B2 (https=) |
| AT (1) | ATE320809T1 (https=) |
| AU (1) | AU776544B2 (https=) |
| CA (1) | CA2391650C (https=) |
| DE (1) | DE60026877T2 (https=) |
| DK (1) | DK1248618T3 (https=) |
| ES (1) | ES2259295T3 (https=) |
| PT (1) | PT1248618E (https=) |
| WO (1) | WO2001037833A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12001001175B1 (en) * | 2000-05-26 | 2006-08-10 | Merck Sharp & Dohme | 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl- (2,3')bipyridinyl in pure crystalline form and process for synthesis |
| US6521642B2 (en) | 2000-05-26 | 2003-02-18 | Merck & Co., Inc. | 5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-[2,3′]bipyridinyl in pure crystalline form and process for synthesis |
| WO2005085199A1 (en) * | 2004-01-14 | 2005-09-15 | Cadila Healthcare Limited | Novel polymorphs of etoricoxib |
| PL2479166T3 (pl) | 2009-02-27 | 2014-11-28 | Cadila Healthcare Ltd | Sposób otrzymywania etorykoksybu |
| WO2012163839A1 (en) | 2011-05-27 | 2012-12-06 | Farma Grs, D.O.O. | A process for the preparation of polymorphic form i of etoricoxib |
| EP2773618A1 (en) | 2011-11-03 | 2014-09-10 | Cadila Healthcare Limited | An improved process for the preparation of etoricoxib and polymorphs thereof |
| WO2013075732A1 (en) | 2011-11-21 | 2013-05-30 | Synthon Bv | Process for making crystalline form i of etoricoxib |
| EP2601952A1 (en) | 2011-12-07 | 2013-06-12 | Zentiva, k.s. | Novel pharmaceutically acceptable salts and cocrystals of 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridinyl and their therapeutic uses |
| EP2831045A2 (en) * | 2012-03-30 | 2015-02-04 | Mylan Laboratories, Limited | An improved process for the preparation of etoricoxib |
| EP2888231B1 (en) | 2012-08-27 | 2019-01-09 | Glenmark Pharmaceuticals Limited | Process for preparation of crystalline etoricoxib |
| CN104418799A (zh) * | 2013-09-03 | 2015-03-18 | 天津药物研究院 | 一种依托考昔的晶型及其制备方法和应用 |
| WO2015036550A1 (en) | 2013-09-13 | 2015-03-19 | Synthon B.V. | Process for making etoricoxib |
| CN107056691B (zh) * | 2017-06-21 | 2020-03-10 | 四川尚锐生物医药有限公司 | 一种制备依托考昔晶型v的方法 |
| MX2018013070A (es) | 2017-12-29 | 2019-10-15 | Gruenenthal Gmbh | Combinación farmacéutica que comprende clorhidrato de tramadol de liberación extendida y etoricoxib de liberación inmediata, y su uso para el tratamiento del dolor. |
| CN111410629A (zh) * | 2020-03-31 | 2020-07-14 | 天津大学 | 依托考昔溶剂化物及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5321033A (en) | 1991-11-15 | 1994-06-14 | Merck Frosst Canada, Inc. | Amorphous (quinolin-2-ylmethoxy)indole compounds useful for treating inflammatory diseases |
| IL127441A (en) | 1996-07-18 | 2003-02-12 | Merck Frosst Canada Inc | Substituted pyridines, pharmaceutical compositions comprising them and their use in the preparation of anti-inflammatory medicaments or as selective cyclooxygenase-2 inhibitors |
| US5861419A (en) * | 1996-07-18 | 1999-01-19 | Merck Frosst Canad, Inc. | Substituted pyridines as selective cyclooxygenase-2 inhibitors |
| US6127545A (en) | 1997-04-18 | 2000-10-03 | Merck & Co., Inc. | Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors |
| US6130334A (en) | 1998-04-15 | 2000-10-10 | Merck & Co., Inc. | Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors |
| US6040450A (en) | 1997-09-25 | 2000-03-21 | Merck & Co., Inc. | Process for making diaryl pyridines useful as cox-2-inhibitors |
| HU227627B1 (en) * | 1998-04-24 | 2011-10-28 | Merck Sharp & Dohme | Process for synthesizing pyridine derivatives as cox-2 inhibitors and the intermediates |
| US6521642B2 (en) * | 2000-05-26 | 2003-02-18 | Merck & Co., Inc. | 5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-[2,3′]bipyridinyl in pure crystalline form and process for synthesis |
| PH12001001175B1 (en) * | 2000-05-26 | 2006-08-10 | Merck Sharp & Dohme | 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl- (2,3')bipyridinyl in pure crystalline form and process for synthesis |
-
2000
- 2000-11-27 CA CA2391650A patent/CA2391650C/en not_active Expired - Lifetime
- 2000-11-27 AT AT00980817T patent/ATE320809T1/de active
- 2000-11-27 EP EP00980817A patent/EP1248618B1/en not_active Expired - Lifetime
- 2000-11-27 PT PT00980817T patent/PT1248618E/pt unknown
- 2000-11-27 DK DK00980817T patent/DK1248618T3/da active
- 2000-11-27 WO PCT/US2000/032353 patent/WO2001037833A1/en not_active Ceased
- 2000-11-27 DE DE60026877T patent/DE60026877T2/de not_active Expired - Lifetime
- 2000-11-27 JP JP2001539448A patent/JP4425514B2/ja not_active Expired - Lifetime
- 2000-11-27 AU AU18031/01A patent/AU776544B2/en not_active Expired
- 2000-11-27 ES ES00980817T patent/ES2259295T3/es not_active Expired - Lifetime
- 2000-11-28 US US09/724,522 patent/US6441002B1/en not_active Expired - Lifetime
-
2002
- 2002-06-26 US US10/180,399 patent/US20020198238A1/en not_active Abandoned
-
2003
- 2003-01-14 US US10/342,379 patent/US20030144327A1/en not_active Abandoned
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