JP2003511670A5 - - Google Patents
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- Publication number
- JP2003511670A5 JP2003511670A5 JP2001528704A JP2001528704A JP2003511670A5 JP 2003511670 A5 JP2003511670 A5 JP 2003511670A5 JP 2001528704 A JP2001528704 A JP 2001528704A JP 2001528704 A JP2001528704 A JP 2001528704A JP 2003511670 A5 JP2003511670 A5 JP 2003511670A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- cell
- sequence
- cytokine
- celiac disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 description 41
- 238000000034 method Methods 0.000 description 27
- 210000004027 cell Anatomy 0.000 description 18
- 241000196324 Embryophyta Species 0.000 description 13
- 102000004127 Cytokines Human genes 0.000 description 12
- 108090000695 Cytokines Proteins 0.000 description 12
- 210000001744 T-lymphocyte Anatomy 0.000 description 12
- 208000015943 Coeliac disease Diseases 0.000 description 10
- 108091033319 polynucleotide Proteins 0.000 description 9
- 102000040430 polynucleotide Human genes 0.000 description 9
- 239000002157 polynucleotide Substances 0.000 description 9
- 108010061711 Gliadin Proteins 0.000 description 8
- 108091026890 Coding region Proteins 0.000 description 6
- 150000001413 amino acids Chemical group 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000009261 transgenic effect Effects 0.000 description 6
- 241000209140 Triticum Species 0.000 description 5
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- 235000007319 Avena orientalis Nutrition 0.000 description 4
- 244000075850 Avena orientalis Species 0.000 description 4
- 240000005979 Hordeum vulgare Species 0.000 description 4
- 235000007340 Hordeum vulgare Nutrition 0.000 description 4
- 241000209056 Secale Species 0.000 description 4
- 235000007238 Secale cereale Nutrition 0.000 description 4
- 235000019714 Triticale Nutrition 0.000 description 4
- 235000021307 Triticum Nutrition 0.000 description 4
- 241000228158 x Triticosecale Species 0.000 description 4
- 108091008874 T cell receptors Proteins 0.000 description 3
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 208000032309 susceptibility to 1 celiac disease Diseases 0.000 description 3
- 235000007558 Avena sp Nutrition 0.000 description 2
- 206010020649 Hyperkeratosis Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 210000001236 prokaryotic cell Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 241000894007 species Species 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical group OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical group NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical group C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical group OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Chemical group NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Chemical group 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical group OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 108060008539 Transglutaminase Proteins 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Chemical group C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 235000011868 grain product Nutrition 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 102000003601 transglutaminase Human genes 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Chemical group OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9923306.6A GB9923306D0 (en) | 1999-10-01 | 1999-10-01 | Diagnostic and therapeutic epitope, and transgenic plant |
| GB9923306.6 | 1999-10-01 | ||
| PCT/GB2000/003760 WO2001025793A2 (en) | 1999-10-01 | 2000-10-02 | Diagnosis of coeliac disease using a gliadin epitope |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010135844A Division JP5371890B2 (ja) | 1999-10-01 | 2010-06-15 | 診断及び治療用エピトープ並びにトランスジェニック植物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003511670A JP2003511670A (ja) | 2003-03-25 |
| JP2003511670A5 true JP2003511670A5 (https=) | 2007-11-22 |
| JP4932112B2 JP4932112B2 (ja) | 2012-05-16 |
Family
ID=10861989
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001528704A Expired - Lifetime JP4932112B2 (ja) | 1999-10-01 | 2000-10-02 | 診断及び治療用エピトープ並びにトランスジェニック植物 |
| JP2010135844A Expired - Lifetime JP5371890B2 (ja) | 1999-10-01 | 2010-06-15 | 診断及び治療用エピトープ並びにトランスジェニック植物 |
| JP2013018731A Expired - Lifetime JP6139154B2 (ja) | 1999-10-01 | 2013-02-01 | 診断及び治療用エピトープ並びにトランスジェニック植物 |
| JP2016053617A Pending JP2016164169A (ja) | 1999-10-01 | 2016-03-17 | 診断及び治療用エピトープ並びにトランスジェニック植物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010135844A Expired - Lifetime JP5371890B2 (ja) | 1999-10-01 | 2010-06-15 | 診断及び治療用エピトープ並びにトランスジェニック植物 |
| JP2013018731A Expired - Lifetime JP6139154B2 (ja) | 1999-10-01 | 2013-02-01 | 診断及び治療用エピトープ並びにトランスジェニック植物 |
| JP2016053617A Pending JP2016164169A (ja) | 1999-10-01 | 2016-03-17 | 診断及び治療用エピトープ並びにトランスジェニック植物 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US7144569B1 (https=) |
| EP (2) | EP1218751B1 (https=) |
| JP (4) | JP4932112B2 (https=) |
| AT (2) | ATE449965T1 (https=) |
| AU (1) | AU782262B2 (https=) |
| CA (1) | CA2386089C (https=) |
| CY (2) | CY1105282T1 (https=) |
| DE (2) | DE60026332T2 (https=) |
| DK (2) | DK1672368T3 (https=) |
| ES (2) | ES2335895T3 (https=) |
| GB (1) | GB9923306D0 (https=) |
| MX (1) | MXPA02003295A (https=) |
| PT (2) | PT1218751E (https=) |
| WO (1) | WO2001025793A2 (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9923306D0 (en) * | 1999-10-01 | 1999-12-08 | Isis Innovation | Diagnostic and therapeutic epitope, and transgenic plant |
| US7320788B2 (en) | 2002-02-14 | 2008-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for Celiac Sprue |
| US8143210B2 (en) | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| DE60336754D1 (de) | 2002-02-14 | 2011-05-26 | Univ R | Enzymbehandlung von nahrungsmitteln für zöliakie-sprue |
| US7605150B2 (en) | 2002-05-14 | 2009-10-20 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for Celiac Sprue |
| US7202216B2 (en) | 2002-05-14 | 2007-04-10 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| US7265093B2 (en) * | 2002-05-14 | 2007-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for Celiac Sprue |
| US7462688B2 (en) | 2002-05-14 | 2008-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides for diagnostic and therapeutic methods for celiac sprue |
| GB0212885D0 (en) * | 2002-06-05 | 2002-07-17 | Isis Innovation | Therapeutic epitopes and uses thereof |
| EP1563300B1 (en) * | 2002-11-20 | 2012-04-18 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnostic method for celiac sprue |
| US7579313B2 (en) * | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
| WO2005066345A1 (en) * | 2004-01-09 | 2005-07-21 | Ottawa Health Research Institute | Diabetogenic epitopes |
| US7563864B2 (en) * | 2004-04-26 | 2009-07-21 | Celiac Sprue Research Foundation | Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten |
| US7534426B2 (en) | 2004-04-26 | 2009-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Glutenase enzyme assays |
| US7628985B2 (en) * | 2004-04-26 | 2009-12-08 | The Board Of Regents Of The Leland Stanford Junior University | Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis |
| AU2011247868B2 (en) * | 2004-04-28 | 2014-05-22 | Btg International Limited | Epitopes related to coeliac disease |
| US10105437B2 (en) | 2004-04-28 | 2018-10-23 | Btg International Limited | Epitopes related to coeliac disease |
| EP2486935B1 (en) * | 2004-04-28 | 2021-04-07 | BTG International Limited | Epitopes related to Coeliac Disease |
| EP1612558A1 (en) * | 2004-06-30 | 2006-01-04 | Academisch Ziekenhuis Leiden | Method for detecting gluten |
| WO2007105024A1 (en) * | 2006-03-15 | 2007-09-20 | Isocell Pharma S.A. | Pharmaceutical compositions comprising sods and prolamine based peptide fragments |
| US7576040B2 (en) * | 2007-01-11 | 2009-08-18 | Halliburton Energy Services, Inc. | Cement compositions comprising humic acid grafted fluid loss control additives |
| CA2680590C (en) * | 2007-03-16 | 2017-10-17 | Jonathan David Gass | Combination enzyme therapy for digestion of dietary gluten |
| MX351410B (es) | 2007-08-13 | 2017-10-13 | Commw Scient Ind Res Org | Proceso para obtener una bebida a base de cebada con bajos niveles de hordeínas. |
| CN102438643B (zh) | 2008-11-30 | 2015-07-01 | 免疫桑特公司 | 用于治疗乳糜泻的组合物和方法 |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| WO2012021512A2 (en) | 2010-08-10 | 2012-02-16 | Ecole Polytechnique Federale De Lausanne | Erythrocyte-binding therapeutics |
| JP5937106B2 (ja) | 2011-01-20 | 2016-06-22 | サイレックス ラボラトリーズ，エルエルシー | グルテン感受性の検出およびグルテン感受性とセリアック病を鑑別するための方法ならびに装置 |
| US20140037661A1 (en) * | 2011-02-08 | 2014-02-06 | Phadia Ab | Wheat Antigens and Peptides for Diagnosis of Wheat Induced Hypersensitivity |
| WO2012162697A1 (en) * | 2011-05-26 | 2012-11-29 | The Regents Of The University Of Colorado, A Body Corporate | Compounds that modulate autoimmunity and methods of using the same |
| WO2014179202A1 (en) * | 2013-05-02 | 2014-11-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for diagnosis of celiac disease |
| EP2994480A4 (en) * | 2013-05-08 | 2017-05-17 | JM Biologicals | Compositions and methods for the production of gluten free food products |
| US10677794B2 (en) | 2013-05-14 | 2020-06-09 | Oslo Universitetssykehus Hf | Detection of gluten-specific t-cells |
| BR112015031257A2 (pt) | 2013-06-13 | 2017-08-29 | Commw Scient Ind Res Org | Cevada com níveis muito baixos de hordeínas |
| WO2015038624A1 (en) | 2013-09-10 | 2015-03-19 | Immusant, Inc. | Dosage of a gluten peptide composition |
| KR102717969B1 (ko) | 2014-02-21 | 2024-10-15 | 에꼴 뽈리떼끄닉 뻬데랄 드 로잔느 (으뻬에프엘) | 글리코타겟팅 치료제 |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| WO2015164714A1 (en) * | 2014-04-24 | 2015-10-29 | Immusant, Inc. | Use of interleukin-2 for diagnosis of celiac disease |
| WO2016054038A1 (en) | 2014-09-29 | 2016-04-07 | Immusant, Inc. | Use of hla genetic status to assess or select treatment of celiac disease |
| EP3221344A2 (en) | 2014-11-21 | 2017-09-27 | Immusant Inc. | Peptides for use in treatment and diagnosis of type 1 diabetes |
| US10363288B2 (en) | 2015-01-14 | 2019-07-30 | National Jewish Health | Insulin mimotopes and methods of using the same |
| DE102015204012A1 (de) | 2015-03-05 | 2016-09-08 | Clariant International Ltd. | SCR-Katalysator mit verbesserter Haftung |
| EP3432877B1 (en) | 2016-03-24 | 2023-01-11 | ImmunoMolecular Therapeutics, Inc. | D-alpha-methyldopa for treating autoimmune disease |
| US20200002709A1 (en) * | 2016-09-01 | 2020-01-02 | Cellectis | Methods for altering amino acid content in plants |
| US11253579B2 (en) | 2017-06-16 | 2022-02-22 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| US11052060B2 (en) | 2018-02-12 | 2021-07-06 | The Regents Of The University Of Colorado, A Body Corporate | Compounds and methods for treating autoimmunity |
| US11013707B2 (en) | 2018-03-23 | 2021-05-25 | The Regents Of The University Of Colorado, A Body Corporate | Administration of oral methyldopa |
| EA202092723A1 (ru) | 2018-05-09 | 2021-04-09 | Зе Юниверсити Оф Чикаго | Композиции и способы, касающиеся иммунной толерантности |
| CN110128549B (zh) * | 2019-05-27 | 2021-07-06 | 深圳市亚辉龙生物科技股份有限公司 | 脱酰胺基麦胶蛋白多肽重组抗原、重组抗原表达基因、重组表达载体及其制备方法和应用 |
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1999
- 1999-10-01 GB GBGB9923306.6A patent/GB9923306D0/en not_active Ceased
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2000
- 2000-10-02 EP EP00964460A patent/EP1218751B1/en not_active Expired - Lifetime
- 2000-10-02 DE DE60026332T patent/DE60026332T2/de not_active Expired - Lifetime
- 2000-10-02 DE DE60043402T patent/DE60043402D1/de not_active Expired - Lifetime
- 2000-10-02 AU AU75394/00A patent/AU782262B2/en not_active Expired
- 2000-10-02 PT PT00964460T patent/PT1218751E/pt unknown
- 2000-10-02 AT AT05027922T patent/ATE449965T1/de active
- 2000-10-02 DK DK05027922T patent/DK1672368T3/da active
- 2000-10-02 DK DK00964460T patent/DK1218751T3/da active
- 2000-10-02 AT AT00964460T patent/ATE319091T1/de active
- 2000-10-02 WO PCT/GB2000/003760 patent/WO2001025793A2/en not_active Ceased
- 2000-10-02 ES ES05027922T patent/ES2335895T3/es not_active Expired - Lifetime
- 2000-10-02 PT PT05027922T patent/PT1672368E/pt unknown
- 2000-10-02 CA CA2386089A patent/CA2386089C/en not_active Expired - Lifetime
- 2000-10-02 MX MXPA02003295A patent/MXPA02003295A/es active IP Right Grant
- 2000-10-02 ES ES00964460T patent/ES2256042T3/es not_active Expired - Lifetime
- 2000-10-02 JP JP2001528704A patent/JP4932112B2/ja not_active Expired - Lifetime
- 2000-10-02 EP EP05027922A patent/EP1672368B1/en not_active Expired - Lifetime
- 2000-10-02 US US10/089,700 patent/US7144569B1/en not_active Expired - Lifetime
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2006
- 2006-05-29 CY CY20061100681T patent/CY1105282T1/el unknown
- 2006-11-03 US US11/556,218 patent/US7888460B2/en not_active Expired - Lifetime
- 2006-11-03 US US11/556,208 patent/US8329144B2/en not_active Expired - Fee Related
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2010
- 2010-02-24 CY CY20101100177T patent/CY1109837T1/el unknown
- 2010-06-15 JP JP2010135844A patent/JP5371890B2/ja not_active Expired - Lifetime
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2012
- 2012-11-08 US US13/672,183 patent/US20130318648A1/en not_active Abandoned
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2013
- 2013-02-01 JP JP2013018731A patent/JP6139154B2/ja not_active Expired - Lifetime
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2016
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