JP2003510078A5 - - Google Patents
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- Publication number
- JP2003510078A5 JP2003510078A5 JP2001526947A JP2001526947A JP2003510078A5 JP 2003510078 A5 JP2003510078 A5 JP 2003510078A5 JP 2001526947 A JP2001526947 A JP 2001526947A JP 2001526947 A JP2001526947 A JP 2001526947A JP 2003510078 A5 JP2003510078 A5 JP 2003510078A5
- Authority
- JP
- Japan
- Prior art keywords
- glycoprotein
- seq
- polypeptide
- nucleic acid
- acid molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 description 52
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 description 40
- 238000000034 method Methods 0.000 description 30
- 102000039446 nucleic acids Human genes 0.000 description 16
- 108020004707 nucleic acids Proteins 0.000 description 16
- 150000007523 nucleic acids Chemical class 0.000 description 16
- 229920001184 polypeptide Polymers 0.000 description 16
- 102000004196 processed proteins & peptides Human genes 0.000 description 16
- 108090000765 processed proteins & peptides Proteins 0.000 description 16
- 150000001875 compounds Chemical class 0.000 description 13
- 239000012634 fragment Substances 0.000 description 12
- 150000001413 amino acids Chemical class 0.000 description 10
- 210000004027 cell Anatomy 0.000 description 10
- 239000003814 drug Substances 0.000 description 8
- 239000002831 pharmacologic agent Substances 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 108091006112 ATPases Proteins 0.000 description 4
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 4
- 239000013604 expression vector Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 230000032258 transport Effects 0.000 description 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 150000002611 lead compounds Chemical class 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 230000032895 transmembrane transport Effects 0.000 description 3
- 241000282465 Canis Species 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 241000282567 Macaca fascicularis Species 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 102000040811 transporter activity Human genes 0.000 description 1
- 108091092194 transporter activity Proteins 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15692199P | 1999-09-28 | 1999-09-28 | |
| US60/156,921 | 1999-09-28 | ||
| US15881899P | 1999-10-12 | 1999-10-12 | |
| US60/158,818 | 1999-10-12 | ||
| PCT/US2000/026592 WO2001023565A1 (en) | 1999-09-28 | 2000-09-28 | P-glycoproteins from macaca fascicularis and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011284048A Division JP2012065671A (ja) | 1999-09-28 | 2011-12-26 | Ｍａｃａｃａｆａｓｃｉｃｕｌａｒｉｓ由来のＰ−糖タンパク質およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003510078A JP2003510078A (ja) | 2003-03-18 |
| JP2003510078A5 true JP2003510078A5 (enExample) | 2007-11-29 |
Family
ID=26853651
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001526947A Pending JP2003510078A (ja) | 1999-09-28 | 2000-09-28 | Ｍａｃａｃａｆａｓｃｉｃｕｌａｒｉｓ由来のＰ−糖タンパク質およびその使用 |
| JP2011284048A Withdrawn JP2012065671A (ja) | 1999-09-28 | 2011-12-26 | Ｍａｃａｃａｆａｓｃｉｃｕｌａｒｉｓ由来のＰ−糖タンパク質およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011284048A Withdrawn JP2012065671A (ja) | 1999-09-28 | 2011-12-26 | Ｍａｃａｃａｆａｓｃｉｃｕｌａｒｉｓ由来のＰ−糖タンパク質およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6617450B1 (enExample) |
| EP (1) | EP1220917A1 (enExample) |
| JP (2) | JP2003510078A (enExample) |
| AU (1) | AU7835600A (enExample) |
| CA (1) | CA2386029A1 (enExample) |
| WO (1) | WO2001023565A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6855812B2 (en) | 2001-03-19 | 2005-02-15 | Becton, Dickinson And Company | P-glycoproteins and uses thereof |
| US20050153914A1 (en) * | 2001-05-18 | 2005-07-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of MDR P-glycoprotein gene expression using short interfering nucleic acid (siNA) |
| CA2820537C (en) | 2003-04-23 | 2015-10-20 | Valeritas, Inc. | Hydraulically actuated pump for fluid administration |
| US20060084799A1 (en) * | 2003-09-24 | 2006-04-20 | Williams Lewis T | Human cDNA clones comprising polynucleotides encoding polypeptides and methods of their use |
| CA2549295C (en) | 2003-12-04 | 2016-05-03 | University Of Utah Research Foundation | Modified macromolecules and methods of making and using thereof |
| US20100330143A1 (en) | 2003-12-04 | 2010-12-30 | University Of Utah Research Foundation | Modified macromolecules and methods of making and using thereof |
| US9089636B2 (en) | 2004-07-02 | 2015-07-28 | Valeritas, Inc. | Methods and devices for delivering GLP-1 and uses thereof |
| ES2656675T3 (es) | 2006-03-30 | 2018-02-28 | Valeritas, Inc. | Dispositivo de suministro de fluidos de múltiples cartuchos |
| EP2041312B1 (en) * | 2006-07-14 | 2010-12-01 | The Govt. of the USA as Represented by the Secretary of the Dept. of Health and Human Services | Abcbi genotyping to predict microtubule-stabilizing-agent-induced toxicity |
| JP2013545440A (ja) * | 2010-09-27 | 2013-12-26 | ヤンセン バイオテツク，インコーポレーテツド | マカカ・ファシキュラリス（Ｍａｃａｃａｆａｓｃｉｃｕｌａｒｉｓ）ＣＣＬ１７ |
| WO2013010045A1 (en) | 2011-07-12 | 2013-01-17 | Biotime Inc. | Novel methods and formulations for orthopedic cell therapy |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE122727T1 (de) * | 1986-03-28 | 1995-06-15 | Univ Illinois | Zubereitungen und verfahren für klone, die, mit mehrfacharzneimittelresistenz assoziierte, dna- sequenzen in menschlichen zellen enthalten. |
| US5429921A (en) | 1988-04-04 | 1995-07-04 | The Salk Institute Biotechnology/Industrial Assoc. Inc. | Assays for agonists and antagonists of recombinant human calcium channels |
| CA2113578A1 (en) * | 1991-07-19 | 1993-02-04 | Ann E. Huang | Trifunctional compounds having specificity for multi-drug resistant cells |
| WO1993024613A1 (en) * | 1992-05-22 | 1993-12-09 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Improved expression of human multidrug resistance genes and improved selection of cells transduced with such genes |
| WO1998013072A1 (en) * | 1996-09-24 | 1998-04-02 | Thomas Jefferson University | Compositions for and methods of treating multiple drug resistance |
| AU4214799A (en) * | 1998-05-28 | 1999-12-13 | St. Jude Children's Research Hospital | Expansion of hematopoietic stem cells transduced with mdr-1 and methods of use thereof |
| WO2000018886A1 (en) * | 1998-09-25 | 2000-04-06 | Wisconsin Alumni Research Foundation | Xenobiotic detoxification gene from plants |
-
2000
- 2000-09-28 US US09/672,810 patent/US6617450B1/en not_active Expired - Fee Related
- 2000-09-28 JP JP2001526947A patent/JP2003510078A/ja active Pending
- 2000-09-28 CA CA002386029A patent/CA2386029A1/en not_active Abandoned
- 2000-09-28 AU AU78356/00A patent/AU7835600A/en not_active Abandoned
- 2000-09-28 WO PCT/US2000/026592 patent/WO2001023565A1/en not_active Ceased
- 2000-09-28 EP EP00968443A patent/EP1220917A1/en not_active Withdrawn
-
2003
- 2003-07-14 US US10/619,359 patent/US20040077000A1/en not_active Abandoned
-
2011
- 2011-12-26 JP JP2011284048A patent/JP2012065671A/ja not_active Withdrawn