JP2003510071A5 - - Google Patents
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- Publication number
- JP2003510071A5 JP2003510071A5 JP2001526923A JP2001526923A JP2003510071A5 JP 2003510071 A5 JP2003510071 A5 JP 2003510071A5 JP 2001526923 A JP2001526923 A JP 2001526923A JP 2001526923 A JP2001526923 A JP 2001526923A JP 2003510071 A5 JP2003510071 A5 JP 2003510071A5
- Authority
- JP
- Japan
- Prior art keywords
- glycoprotein
- seq
- nucleic acid
- acid molecule
- isolated nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 description 45
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 description 32
- 108020004707 nucleic acids Proteins 0.000 description 29
- 102000039446 nucleic acids Human genes 0.000 description 29
- 150000007523 nucleic acids Chemical class 0.000 description 29
- 238000000034 method Methods 0.000 description 23
- 229920001184 polypeptide Polymers 0.000 description 14
- 102000004196 processed proteins & peptides Human genes 0.000 description 14
- 108090000765 processed proteins & peptides Proteins 0.000 description 14
- 150000001875 compounds Chemical class 0.000 description 13
- 239000012634 fragment Substances 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 9
- 239000003814 drug Substances 0.000 description 8
- 239000002831 pharmacologic agent Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000002773 nucleotide Substances 0.000 description 6
- 125000003729 nucleotide group Chemical group 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 108091006112 ATPases Proteins 0.000 description 4
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 4
- 241000282465 Canis Species 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 239000013604 expression vector Substances 0.000 description 4
- 230000032258 transport Effects 0.000 description 4
- 108090000288 Glycoproteins Proteins 0.000 description 3
- 102000003886 Glycoproteins Human genes 0.000 description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 150000002611 lead compounds Chemical class 0.000 description 3
- 230000032895 transmembrane transport Effects 0.000 description 3
- 108091026890 Coding region Proteins 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 108700028369 Alleles Proteins 0.000 description 1
- 102100034574 P protein Human genes 0.000 description 1
- 108010015724 Prephenate Dehydratase Proteins 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 102000040811 transporter activity Human genes 0.000 description 1
- 108091092194 transporter activity Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15651099P | 1999-09-28 | 1999-09-28 | |
| US60/156,510 | 1999-09-28 | ||
| PCT/US2000/026767 WO2001023540A2 (en) | 1999-09-28 | 2000-09-28 | P-glycoproteins and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011284080A Division JP2012061008A (ja) | 1999-09-28 | 2011-12-26 | Ｐ−糖タンパク質およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003510071A JP2003510071A (ja) | 2003-03-18 |
| JP2003510071A5 true JP2003510071A5 (enExample) | 2007-11-29 |
Family
ID=22559872
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001526923A Pending JP2003510071A (ja) | 1999-09-28 | 2000-09-28 | Ｐ−糖タンパク質およびその使用 |
| JP2011284080A Withdrawn JP2012061008A (ja) | 1999-09-28 | 2011-12-26 | Ｐ−糖タンパク質およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011284080A Withdrawn JP2012061008A (ja) | 1999-09-28 | 2011-12-26 | Ｐ−糖タンパク質およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1220911B1 (enExample) |
| JP (2) | JP2003510071A (enExample) |
| AT (1) | ATE346924T1 (enExample) |
| AU (1) | AU785363B2 (enExample) |
| CA (1) | CA2384981A1 (enExample) |
| DE (1) | DE60032161D1 (enExample) |
| WO (1) | WO2001023540A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2411101C (en) * | 2000-06-05 | 2018-01-16 | Brigham And Women's Hospital, Inc. | A gene encoding a multidrug resistance human p-glycoprotein homologue on chromosome 7p15-21 and uses thereof |
| US6855812B2 (en) * | 2001-03-19 | 2005-02-15 | Becton, Dickinson And Company | P-glycoproteins and uses thereof |
| ES2796111T3 (es) | 2008-11-14 | 2020-11-25 | Brigham & Womens Hospital Inc | Métodos terapéuticos relacionados con células madre cancerosas |
| US11542328B2 (en) | 2008-11-14 | 2023-01-03 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
| KR20210005118A (ko) | 2018-04-25 | 2021-01-13 | 칠드런'즈 메디컬 센터 코포레이션 | Abcb5 리간드 및 기질 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993024613A1 (en) * | 1992-05-22 | 1993-12-09 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Improved expression of human multidrug resistance genes and improved selection of cells transduced with such genes |
| US5830697A (en) * | 1997-01-21 | 1998-11-03 | The Board Of Trustees Of The Leland Stanford Junior University | P-glycoprotein mutant resistant to cyclosporin modulation |
-
2000
- 2000-09-28 AT AT00967072T patent/ATE346924T1/de not_active IP Right Cessation
- 2000-09-28 DE DE60032161T patent/DE60032161D1/de not_active Expired - Lifetime
- 2000-09-28 EP EP00967072A patent/EP1220911B1/en not_active Expired - Lifetime
- 2000-09-28 AU AU77327/00A patent/AU785363B2/en not_active Ceased
- 2000-09-28 WO PCT/US2000/026767 patent/WO2001023540A2/en not_active Ceased
- 2000-09-28 JP JP2001526923A patent/JP2003510071A/ja active Pending
- 2000-09-28 CA CA002384981A patent/CA2384981A1/en not_active Abandoned
-
2011
- 2011-12-26 JP JP2011284080A patent/JP2012061008A/ja not_active Withdrawn
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