JP2003509378A - IL−1raとIL−1プロセシング・放出阻害化合物の併用療法 - Google Patents
IL−1raとIL−1プロセシング・放出阻害化合物の併用療法Info
- Publication number
- JP2003509378A JP2003509378A JP2001523022A JP2001523022A JP2003509378A JP 2003509378 A JP2003509378 A JP 2003509378A JP 2001523022 A JP2001523022 A JP 2001523022A JP 2001523022 A JP2001523022 A JP 2001523022A JP 2003509378 A JP2003509378 A JP 2003509378A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- urea
- hydroxy
- aryl
- sulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15401099P | 1999-09-14 | 1999-09-14 | |
US60/154,010 | 1999-09-14 | ||
PCT/IB2000/001192 WO2001019390A1 (fr) | 1999-09-14 | 2000-08-28 | Traitement combine au moyen de il-1ra et de composes de diarylsulfonyluree |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2003509378A true JP2003509378A (ja) | 2003-03-11 |
Family
ID=22549650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001523022A Pending JP2003509378A (ja) | 1999-09-14 | 2000-08-28 | IL−1raとIL−1プロセシング・放出阻害化合物の併用療法 |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1214087A1 (fr) |
JP (1) | JP2003509378A (fr) |
AR (1) | AR033650A1 (fr) |
AU (1) | AU6464400A (fr) |
BR (1) | BR0014003A (fr) |
CA (1) | CA2383026A1 (fr) |
CO (1) | CO5190701A1 (fr) |
EC (1) | ECSP003652A (fr) |
GT (1) | GT200000155A (fr) |
PA (1) | PA8502901A1 (fr) |
PE (1) | PE20010685A1 (fr) |
TN (1) | TNSN00183A1 (fr) |
WO (1) | WO2001019390A1 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019515952A (ja) * | 2016-04-18 | 2019-06-13 | アイエフエム トレ インコーポレイテッド | Nlrp活性に関連する状態を処置するための化合物および組成物 |
JP2020531453A (ja) * | 2017-08-15 | 2020-11-05 | インフレイゾーム リミテッド | Nlrp3阻害剤としてのスルホニルウレアおよびスルホニルチオウレア |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7619066B2 (en) | 2004-04-02 | 2009-11-17 | Amgen Inc. | IL-1ra variants |
WO2008129288A2 (fr) * | 2007-04-19 | 2008-10-30 | Boehringer Ingelheim International Gmbh | Disulfonamides utiles dans le traitement de l'inflammation |
EP3578547B1 (fr) * | 2015-02-16 | 2021-05-26 | The University of Queensland | Sulfonylurées, composés apparentés, et leur utilisation |
SG11201806745RA (en) | 2016-02-16 | 2018-09-27 | Univ Queensland | Sulfonylureas and related compounds and use of same |
CA3047336A1 (fr) | 2017-01-23 | 2018-07-26 | Jecure Therapeutics, Inc. | Composes chimiques comme inhibiteurs de l'activite interleukine-1 |
AU2017416068A1 (en) | 2017-05-24 | 2019-10-31 | The Provost, Fellows, Foundation Scholars, And Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Novel compounds and uses |
EP3634951A1 (fr) | 2017-06-09 | 2020-04-15 | Cadila Healthcare Limited | Nouveaux composés de sulfoximine substitués |
EP3649112A1 (fr) | 2017-07-07 | 2020-05-13 | Inflazome Limited | Sulfonylurées et sulfonylthiourées en tant qu'inhibiteurs de nlrp3 |
WO2019008025A1 (fr) | 2017-07-07 | 2019-01-10 | Inflazome Limited | Nouveaux composés de sulfonamide carboxamide |
US11203579B2 (en) | 2017-07-24 | 2021-12-21 | Novartis Ag | Compounds and compositions for treating conditions associated with NLRP activity |
UY37848A (es) | 2017-08-15 | 2019-03-29 | Inflazome Ltd | Sulfonilureas y sulfoniltioureas útiles como inhibidores de nlrp3 |
EP3668840A1 (fr) | 2017-08-15 | 2020-06-24 | Inflazome Limited | Nouveaux composés de sulfonamide carboxamide |
WO2019034693A1 (fr) | 2017-08-15 | 2019-02-21 | Inflazome Limited | Sulfonylurées et sulfonylthiourées utilisés en tant qu'inhibiteurs de nlrp3 |
MX2020001778A (es) | 2017-08-15 | 2020-03-24 | Inflazome Ltd | Nuevos compuestos de sulfonamida carboxamida. |
WO2019043610A1 (fr) | 2017-08-31 | 2019-03-07 | Cadila Healthcare Limited | Nouveaux dérivés de sulfonylurées substitués |
US11623922B2 (en) | 2017-10-03 | 2023-04-11 | Inflazome Limited | Compounds |
WO2019166619A1 (fr) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Nouveaux composés |
US11834433B2 (en) | 2018-03-02 | 2023-12-05 | Inflazome Limited | Compounds |
US11884645B2 (en) | 2018-03-02 | 2024-01-30 | Inflazome Limited | Sulfonyl acetamides as NLRP3 inhibitors |
US11530200B2 (en) | 2018-03-02 | 2022-12-20 | Inflazome Limited | Compounds |
WO2020010143A1 (fr) | 2018-07-03 | 2020-01-09 | Novartis Inflammasome Research, Inc. | Modulateurs de nlrp |
PE20211049A1 (es) | 2018-07-20 | 2021-06-04 | Hoffmann La Roche | Compuestos de sulfonilurea como inhibidores de la actividad de interleucina 1 |
EP3870565A1 (fr) | 2018-10-24 | 2021-09-01 | Novartis AG | Composés et compositions pour traiter des états associés à l'activité des nlrp |
EP3911631A4 (fr) | 2019-01-14 | 2022-09-28 | Cadila Healthcare Limited | Nouveaux dérivés de sulfonylurées substitués |
KR20230015418A (ko) * | 2020-05-25 | 2023-01-31 | 베이징 브이디제이바이오 컴퍼니 리미티드 | 인터루킨-1 수용체 길항제 및 이를 포함하는 융합 단백질 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5874424A (en) * | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
WO1998032733A1 (fr) * | 1997-01-29 | 1998-07-30 | Pfizer Inc. | Derives de sulfonyluree et leur application en matiere de regulation de l'activite de l'interleukine-1 |
US6015790A (en) * | 1997-10-06 | 2000-01-18 | Basf Aktiengesellschaft | Methods and compositions for treating rheumatoid arthritis |
EP0987552A3 (fr) * | 1998-08-31 | 2000-06-07 | Pfizer Products Inc. | Protéines de liaison pour diarylsulfonylurée |
-
2000
- 2000-08-28 EP EP00951799A patent/EP1214087A1/fr not_active Withdrawn
- 2000-08-28 BR BR0014003-1A patent/BR0014003A/pt not_active IP Right Cessation
- 2000-08-28 AU AU64644/00A patent/AU6464400A/en not_active Abandoned
- 2000-08-28 JP JP2001523022A patent/JP2003509378A/ja active Pending
- 2000-08-28 WO PCT/IB2000/001192 patent/WO2001019390A1/fr not_active Application Discontinuation
- 2000-08-28 CA CA002383026A patent/CA2383026A1/fr not_active Abandoned
- 2000-09-05 CO CO00066883A patent/CO5190701A1/es not_active Application Discontinuation
- 2000-09-11 PA PA20008502901A patent/PA8502901A1/es unknown
- 2000-09-12 PE PE2000000942A patent/PE20010685A1/es not_active Application Discontinuation
- 2000-09-12 AR ARP000104779A patent/AR033650A1/es not_active Application Discontinuation
- 2000-09-12 EC EC2000003652A patent/ECSP003652A/es unknown
- 2000-09-13 TN TNTNSN00183A patent/TNSN00183A1/fr unknown
- 2000-09-14 GT GT200000155A patent/GT200000155A/es unknown
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019515952A (ja) * | 2016-04-18 | 2019-06-13 | アイエフエム トレ インコーポレイテッド | Nlrp活性に関連する状態を処置するための化合物および組成物 |
JP2019518071A (ja) * | 2016-04-18 | 2019-06-27 | アイエフエム トレ インコーポレイテッド | Nlrp活性に関連する状態を処置するための化合物および組成物 |
JP7050751B2 (ja) | 2016-04-18 | 2022-04-08 | ノバルティス アーゲー | Nlrp活性に関連する状態を処置するための化合物および組成物 |
JP2020531453A (ja) * | 2017-08-15 | 2020-11-05 | インフレイゾーム リミテッド | Nlrp3阻害剤としてのスルホニルウレアおよびスルホニルチオウレア |
Also Published As
Publication number | Publication date |
---|---|
PE20010685A1 (es) | 2001-07-03 |
EP1214087A1 (fr) | 2002-06-19 |
AU6464400A (en) | 2001-04-17 |
TNSN00183A1 (fr) | 2005-11-10 |
WO2001019390A1 (fr) | 2001-03-22 |
CO5190701A1 (es) | 2002-08-29 |
AR033650A1 (es) | 2004-01-07 |
PA8502901A1 (es) | 2002-02-21 |
CA2383026A1 (fr) | 2001-03-22 |
BR0014003A (pt) | 2002-05-21 |
ECSP003652A (es) | 2002-04-23 |
GT200000155A (es) | 2002-03-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20060110 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20060606 |