JP2003508434A5 - - Google Patents
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- Publication number
- JP2003508434A5 JP2003508434A5 JP2001519902A JP2001519902A JP2003508434A5 JP 2003508434 A5 JP2003508434 A5 JP 2003508434A5 JP 2001519902 A JP2001519902 A JP 2001519902A JP 2001519902 A JP2001519902 A JP 2001519902A JP 2003508434 A5 JP2003508434 A5 JP 2003508434A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- soft gel
- polyethylene glycol
- liquid
- ibuprofen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000499 gel Substances 0.000 description 17
- 239000002775 capsule Substances 0.000 description 16
- 239000000203 mixture Substances 0.000 description 15
- 239000007788 liquid Substances 0.000 description 14
- 239000002202 Polyethylene glycol Substances 0.000 description 13
- 229920001223 polyethylene glycol Polymers 0.000 description 13
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 12
- 229960001680 ibuprofen Drugs 0.000 description 12
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 9
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 9
- 238000009472 formulation Methods 0.000 description 8
- 239000000945 filler Substances 0.000 description 7
- 239000004094 surface-active agent Substances 0.000 description 7
- 239000002253 acid Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- 239000004359 castor oil Substances 0.000 description 4
- 235000019438 castor oil Nutrition 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 125000005456 glyceride group Chemical group 0.000 description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 4
- -1 polyoxyethylene Polymers 0.000 description 4
- 239000004014 plasticizer Substances 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 2
- 230000001387 anti-histamine Effects 0.000 description 2
- 239000000739 antihistaminic agent Substances 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000000133 nasal decongestant Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/389,003 | 1999-09-02 | ||
| US09/389,003 US6251426B1 (en) | 1999-09-02 | 1999-09-02 | Ibuprofen-containing softgels |
| PCT/US2000/023908 WO2001015688A1 (en) | 1999-09-02 | 2000-09-01 | Ibuprofen-containing softgels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003508434A JP2003508434A (ja) | 2003-03-04 |
| JP2003508434A5 true JP2003508434A5 (enExample) | 2007-10-18 |
Family
ID=23536433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001519902A Pending JP2003508434A (ja) | 1999-09-02 | 2000-09-01 | イブプロフェン含有ソフトゲル |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6251426B1 (enExample) |
| EP (1) | EP1207872B1 (enExample) |
| JP (1) | JP2003508434A (enExample) |
| AT (1) | ATE357229T1 (enExample) |
| AU (1) | AU780212B2 (enExample) |
| CA (1) | CA2382292C (enExample) |
| DE (1) | DE60034044T2 (enExample) |
| PL (1) | PL362850A1 (enExample) |
| WO (1) | WO2001015688A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020177626A1 (en) * | 2001-01-19 | 2002-11-28 | Cook Graham D. | Treatment of sleep disturbances |
| GB0119480D0 (en) | 2001-08-09 | 2001-10-03 | Jagotec Ag | Novel compositions |
| US6551615B1 (en) * | 2001-10-18 | 2003-04-22 | M/S. Strides Arcolab Limited | Dexibuprofen-containing soft gelatin capsules and process for preparing the same |
| ES2302926T5 (es) * | 2002-04-25 | 2012-08-23 | Banner Pharmacaps, Inc. | Cápsula blanda masticable |
| US20030232097A1 (en) * | 2002-06-17 | 2003-12-18 | Strides Inc. | Oily wax matrix suspension formulation comprising ibuprofen free acid and potassium salt of ibuprofen |
| CA2498207C (en) * | 2002-09-11 | 2012-03-13 | Elan Pharma International Ltd. | Gel-stabilized nanoparticulate active agent compositions |
| KR20040106915A (ko) * | 2003-06-05 | 2004-12-20 | 한국유나이티드제약 주식회사 | 가용성 이부프로펜의 연질캅셀제 조성물 및 그의 제조방법 |
| USD530814S1 (en) | 2003-09-16 | 2006-10-24 | Novartis Ag | Combined capsule and tablets |
| USD520635S1 (en) | 2003-09-16 | 2006-05-09 | Novartis Ag | Combine capsule and tablets |
| US20050137262A1 (en) * | 2003-12-22 | 2005-06-23 | Hu Patrick C. | Highly concentrated pourable aqueous solutions of potassium ibuprofen, their preparation and their uses |
| CA2554243A1 (en) * | 2004-01-20 | 2005-08-11 | Stiefel Laboratories, Inc. | Dermatologic soft gel compositions |
| US20050249802A1 (en) * | 2004-05-06 | 2005-11-10 | The Procter & Gamble Company | Softgel encapsulated pharmaceutical compositions comprising concentrated active ingredients |
| CA2570649A1 (en) * | 2004-06-07 | 2005-12-22 | Strides Arcolab Limited | Pharmaceutical composition containing a stable and clear solution of anti-inflammatory drug in soft gelatin capsule and process for producing the same |
| US20070053868A1 (en) | 2005-03-08 | 2007-03-08 | Banner Pharmacaps, Inc. | Solvent system for enhancing the solubility of pharmaceutical agents |
| US20060240051A1 (en) * | 2005-04-26 | 2006-10-26 | Singleton Andy H | Eutectic blends containing a water soluble vitamin derivative |
| JP5406529B2 (ja) * | 2005-10-26 | 2014-02-05 | バナー ファーマキャプス， インコーポレイテッド | カプセル充墳物としての親油性ベヒクルに基づく二重制御された放出マトリクスシステム |
| CN101360485B (zh) * | 2005-10-26 | 2013-04-17 | 班纳制药公司 | 作为胶囊填充物的基于亲水性载体的双重控释基质系统 |
| US20090004231A1 (en) | 2007-06-30 | 2009-01-01 | Popp Shane M | Pharmaceutical dosage forms fabricated with nanomaterials for quality monitoring |
| US8497303B2 (en) * | 2008-01-18 | 2013-07-30 | Dow Global Technologies Llc | Method to enhance aqueous solubility of poorly soluble actives |
| US20090214648A1 (en) * | 2008-02-15 | 2009-08-27 | Malathi Kandakatla | Pharmaceutical formulations comprising ibuprofen and diphenhydramine |
| ES2363964B1 (es) | 2009-11-20 | 2012-08-22 | Gp Pharm, S.A. | Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados. |
| DE102010063609A1 (de) | 2010-12-20 | 2012-06-21 | Awd.Pharma Gmbh & Co. Kg | Neue Multikomponentenkristalle aus ([2-Amino-6-(4-fluoro-benzylamino)-pyridin-3yl)-carbamidsäureethylester und einer Arylpropionsäure |
| MX364440B (es) * | 2013-03-15 | 2019-04-26 | Warner Chilcott Co Llc | Forma de dosis farmacéutica de cápsula de gelatina blanda con goma guar modificada. |
| JP6451310B2 (ja) | 2014-12-24 | 2019-01-16 | ライオン株式会社 | 固形医薬組成物及びその製造方法 |
| EP3053598A1 (en) | 2015-02-06 | 2016-08-10 | Faes Farma, S.A. | Calcifediol soft capsules |
| GB2595301B (en) * | 2020-05-21 | 2025-01-08 | Reckitt Benckiser Health Ltd | Novel Formulation |
| WO2025150072A1 (en) * | 2024-01-13 | 2025-07-17 | Pulse Pharmaceuticals Pvt Ltd | A stable oral pro-dispersion formulation and implementations thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8305693D0 (en) * | 1983-03-02 | 1983-04-07 | Scherer Ltd R P | Pharmaceutical compositions |
| DE3307353C2 (de) * | 1983-03-02 | 1985-01-31 | R.P. Scherer GmbH, 6930 Eberbach | Polyethylenglykolhaltige Weichgelatinekapsel und Verfahren zu ihrer Herstellung |
| DE3437599C2 (de) * | 1984-10-13 | 1987-04-16 | Dolorgiet GmbH & Co KG, 5205 St Augustin | Ibuprofen enthaltende Weichgelatinekapseln |
| US5071643A (en) * | 1986-10-17 | 1991-12-10 | R. P. Scherer Corporation | Solvent system enhancing the solubility of pharmaceuticals for encapsulation |
| US4900775A (en) | 1988-02-29 | 1990-02-13 | Gaf Chemicals Corporation | Solubilization of complexes of water-insoluble organic compounds by aqueous solutions of polyvinylpyrrolidone |
| US5141961A (en) * | 1991-06-27 | 1992-08-25 | Richrdson-Vicks Inc. | Process for solubilizing difficulty soluble pharmaceutical actives |
| US5376688A (en) | 1992-12-18 | 1994-12-27 | R. P. Scherer Corporation | Enhanced solubility pharmaceutical solutions |
| US5431916A (en) | 1993-04-29 | 1995-07-11 | The Procter & Gamble Company | Pharmaceutical compositions and process of manufacture thereof |
| JPH08509725A (ja) | 1993-04-30 | 1996-10-15 | ザ、プロクター、エンド、ギャンブル、カンパニー | コートされた医薬組成物 |
| IT1264855B1 (it) | 1993-06-21 | 1996-10-17 | Zambon Spa | Composizioni farmaceutiche contenenti sali dell'acido s(+)-2-(4-isobutilfenil) propionico con amminoacidi basici |
| CA2181241C (en) | 1994-01-24 | 2000-04-25 | Dadi Jamshed Dhabhar | Process for solubilizing difficultly soluble pharmaceutical actives |
| US5484606A (en) | 1994-01-24 | 1996-01-16 | The Procter & Gamble Company | Process for reducing the precipitation of difficulty soluble pharmaceutical actives |
| US5538737A (en) | 1994-11-30 | 1996-07-23 | Applied Analytical Industries, Inc. | Oral compositions of H2 -antagonists |
| US5468502A (en) | 1994-12-20 | 1995-11-21 | American Home Products Corporation | Ibuprofen enhancing solvent system |
| US5660859A (en) | 1994-12-29 | 1997-08-26 | Mcneil-Ppc, Inc. | Gelling agent for polyethylene glycol |
| US5641512A (en) | 1995-03-29 | 1997-06-24 | The Procter & Gamble Company | Soft gelatin capsule compositions |
| EP0839029A1 (en) * | 1995-07-20 | 1998-05-06 | PHARMACIA & UPJOHN COMPANY | Stable clear solutions of non-steroidal anti-inflammatory drugs for incorporation into gelatin capsules |
| US6221391B1 (en) | 1998-11-23 | 2001-04-24 | Accucaps Industries Limited | Self-emulsifying ibuprofen solution and soft gelatin capsule for use therewith |
-
1999
- 1999-09-02 US US09/389,003 patent/US6251426B1/en not_active Expired - Lifetime
-
2000
- 2000-09-01 EP EP00959667A patent/EP1207872B1/en not_active Expired - Lifetime
- 2000-09-01 AU AU70949/00A patent/AU780212B2/en not_active Ceased
- 2000-09-01 DE DE60034044T patent/DE60034044T2/de not_active Expired - Fee Related
- 2000-09-01 JP JP2001519902A patent/JP2003508434A/ja active Pending
- 2000-09-01 CA CA002382292A patent/CA2382292C/en not_active Expired - Fee Related
- 2000-09-01 PL PL00362850A patent/PL362850A1/xx not_active Application Discontinuation
- 2000-09-01 AT AT00959667T patent/ATE357229T1/de not_active IP Right Cessation
- 2000-09-01 WO PCT/US2000/023908 patent/WO2001015688A1/en not_active Ceased
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