JP2003507411A5 - - Google Patents
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- Publication number
- JP2003507411A5 JP2003507411A5 JP2001518030A JP2001518030A JP2003507411A5 JP 2003507411 A5 JP2003507411 A5 JP 2003507411A5 JP 2001518030 A JP2001518030 A JP 2001518030A JP 2001518030 A JP2001518030 A JP 2001518030A JP 2003507411 A5 JP2003507411 A5 JP 2003507411A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- particles
- phospholipid
- particle
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002245 particle Substances 0.000 description 32
- 150000003839 salts Chemical class 0.000 description 26
- 238000000034 method Methods 0.000 description 20
- 150000003904 phospholipids Chemical class 0.000 description 16
- 239000002253 acid Substances 0.000 description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 8
- 229940039227 diagnostic agent Drugs 0.000 description 7
- 239000000032 diagnostic agent Substances 0.000 description 7
- 230000000069 prophylactic effect Effects 0.000 description 7
- 230000001225 therapeutic effect Effects 0.000 description 7
- -1 phosphatidyl glycerols Chemical class 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical group [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical group CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 3
- 239000001110 calcium chloride Substances 0.000 description 3
- 229910001628 calcium chloride Inorganic materials 0.000 description 3
- 150000001805 chlorine compounds Chemical group 0.000 description 3
- 150000008105 phosphatidylcholines Chemical class 0.000 description 3
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 3
- 229940067605 phosphatidylethanolamines Drugs 0.000 description 3
- 229940067626 phosphatidylinositols Drugs 0.000 description 3
- 150000003905 phosphatidylinositols Chemical class 0.000 description 3
- 150000008106 phosphatidylserines Chemical class 0.000 description 3
- 229960002052 salbutamol Drugs 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15066299P | 1999-08-25 | 1999-08-25 | |
| US60/150,662 | 1999-08-25 | ||
| PCT/US2000/023118 WO2001013892A2 (en) | 1999-08-25 | 2000-08-23 | Large porous particles by spray-drying |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003507411A JP2003507411A (ja) | 2003-02-25 |
| JP2003507411A5 true JP2003507411A5 (enExample) | 2007-06-21 |
Family
ID=22535487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001518030A Withdrawn JP2003507411A (ja) | 1999-08-25 | 2000-08-23 | 噴霧乾燥大多孔性粒子製剤 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1210069B1 (enExample) |
| JP (1) | JP2003507411A (enExample) |
| AT (1) | ATE285755T1 (enExample) |
| AU (1) | AU768299B2 (enExample) |
| CA (1) | CA2383491A1 (enExample) |
| DE (1) | DE60017152D1 (enExample) |
| WO (1) | WO2001013892A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| WO2001085136A2 (en) * | 2000-05-10 | 2001-11-15 | Alliance Pharmaceutical Corporation | Phospholipid-based powders for drug delivery |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| US6848197B2 (en) | 2001-04-18 | 2005-02-01 | Advanced Inhalation Research, Inc. | Control of process humidity to produce large, porous particles |
| JP2004528339A (ja) * | 2001-04-26 | 2004-09-16 | ネクター セラピューティクス | 気道に対して又は気道を介して高分子を送達するための新規方法及び組成物 |
| GB0120123D0 (en) * | 2001-08-17 | 2001-10-10 | Upperton Ltd | Preparation of microparticles |
| AU2002364701B8 (en) * | 2001-11-20 | 2006-06-22 | Alkermes, Inc. | Compositions for sustained action product delivery |
| JP2005514393A (ja) | 2001-12-19 | 2005-05-19 | ネクター セラピューティクス | アミノグリコシドの肺への供給 |
| AU2003287132B2 (en) * | 2002-12-13 | 2009-03-12 | Adagit | Pharmaceutical porous particles |
| ES2625260T5 (es) * | 2009-03-26 | 2020-07-29 | Pulmatrix Operating Co Inc | Formulaciones de polvo seco y métodos para el tratamiento de enfermedades pulmonares |
| WO2010111641A2 (en) * | 2009-03-26 | 2010-09-30 | Pulmatrix, Inc. | Methods for treating and preventing pneumonia and ventilator-associated tracheobronchitis |
| EP2611438B1 (en) * | 2010-08-30 | 2020-04-01 | Pulmatrix Operating Company, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| WO2012030647A1 (en) | 2010-08-30 | 2012-03-08 | Pulmatrix, Inc. | Treatment of cystic fibrosis using calcium lactate, leucine and sodium chloride in a respiraple dry powder |
| DK2621488T3 (en) | 2010-09-29 | 2019-03-04 | Pulmatrix Operating Co Inc | CATIONIC DRY POWDER |
| JP5877204B2 (ja) | 2010-09-29 | 2016-03-02 | パルマトリックス，インコーポレイテッド | 吸入用の一価金属カチオン乾燥粉末 |
| CN107596518B (zh) | 2012-02-29 | 2021-04-23 | 普马特里克斯营业公司 | 可吸入干粉剂 |
| WO2014165303A1 (en) | 2013-04-01 | 2014-10-09 | Pulmatrix, Inc. | Tiotropium dry powders |
| EP3725311A1 (en) | 2014-02-10 | 2020-10-21 | Respivant Sciences GmbH | Methods for the treatment of lung diseases with mast cell stabilizers |
| EP3653207A1 (en) | 2014-02-10 | 2020-05-20 | Respivant Sciences GmbH | Mast cell stabilizers treatment for systemic disorders |
| CA2965759C (en) | 2014-10-31 | 2023-12-12 | Glaxosmithkline Intellectual Property Development Limited | Powdered polypeptides with decreased disulfide impurities comprising divalent cationic materials |
| US10265296B2 (en) | 2015-08-07 | 2019-04-23 | Respivant Sciences Gmbh | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
| EP3331522A1 (en) | 2015-08-07 | 2018-06-13 | Patara Pharma LLC | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
| CN110139646A (zh) | 2016-08-31 | 2019-08-16 | 瑞思皮万特科学有限责任公司 | 用于治疗由特发性肺纤维化引起的慢性咳嗽的色甘酸组合物 |
| WO2018067341A1 (en) | 2016-10-07 | 2018-04-12 | Patara Pharma, LLC | Cromolyn compositions for treatment of pulmonary fibrosis |
| JP2022527054A (ja) * | 2019-03-22 | 2022-05-30 | マンカインド コーポレイション | 吸入可能な乾燥粉末 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| CZ292186B6 (cs) * | 1996-01-24 | 2003-08-13 | Altana Pharma Ag | Způsob výroby práškového prostředku s obsahem plicní povrchově aktivní látky, práškový prostředek a jeho použití |
| US5855913A (en) * | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| CA2277801C (en) * | 1997-01-16 | 2002-10-15 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
-
2000
- 2000-08-23 CA CA002383491A patent/CA2383491A1/en not_active Abandoned
- 2000-08-23 EP EP00959327A patent/EP1210069B1/en not_active Expired - Lifetime
- 2000-08-23 WO PCT/US2000/023118 patent/WO2001013892A2/en not_active Ceased
- 2000-08-23 JP JP2001518030A patent/JP2003507411A/ja not_active Withdrawn
- 2000-08-23 DE DE60017152T patent/DE60017152D1/de not_active Expired - Lifetime
- 2000-08-23 AT AT00959327T patent/ATE285755T1/de not_active IP Right Cessation
- 2000-08-23 AU AU70666/00A patent/AU768299B2/en not_active Ceased
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