JP2003506389A - カスパーゼ阻害剤およびその使用 - Google Patents

カスパーゼ阻害剤およびその使用

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Publication number
JP2003506389A
JP2003506389A JP2001514908A JP2001514908A JP2003506389A JP 2003506389 A JP2003506389 A JP 2003506389A JP 2001514908 A JP2001514908 A JP 2001514908A JP 2001514908 A JP2001514908 A JP 2001514908A JP 2003506389 A JP2003506389 A JP 2003506389A
Authority
JP
Japan
Prior art keywords
disease
caspase
dmso
nmr
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001514908A
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English (en)
Japanese (ja)
Other versions
JP2003506389A5 (https=
Inventor
ジュリアン・ゴレック
ポール・チャリフソン
ガイ・ブレンチリー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of JP2003506389A publication Critical patent/JP2003506389A/ja
Publication of JP2003506389A5 publication Critical patent/JP2003506389A5/ja
Pending legal-status Critical Current

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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JP2007526254A (ja) * 2004-02-18 2007-09-13 ジョージア テック リサーチ コーポレイション プロペノイルヒドラジド
JP2008521841A (ja) * 2004-12-01 2008-06-26 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 新規特異的カスパーゼ−１０阻害剤
JP2015536990A (ja) * 2012-11-09 2015-12-24 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ Ｍａｌｔ１の低分子阻害剤
JP2020505388A (ja) * 2017-01-23 2020-02-20 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドChia Tai Tianqing Pharmaceutical Group Co., Ltd. カスパーゼ阻害薬としての二環式化合物

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US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
JP2017515854A (ja) 2014-05-12 2017-06-15 クオナトウス ファーマシューティカルズ，インコーポレイテッド カスパーゼ阻害剤による慢性肝疾患の合併症の治療
WO2017079566A1 (en) 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Caspase inhibitors for use in the treatment of liver cancer
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RU2019113150A (ru) 2016-10-05 2020-11-06 Новартис Аг Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения
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WO2004073742A1 (ja) * 2003-02-24 2004-09-02 Daiichi Pharmaceutical Co.,Ltd. Ｂ型肝炎ウイルスx相互作用蛋白質の分解阻害剤
JP2007526254A (ja) * 2004-02-18 2007-09-13 ジョージア テック リサーチ コーポレイション プロペノイルヒドラジド
JP2008521841A (ja) * 2004-12-01 2008-06-26 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 新規特異的カスパーゼ−１０阻害剤
JP2015536990A (ja) * 2012-11-09 2015-12-24 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ Ｍａｌｔ１の低分子阻害剤
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JP2020505388A (ja) * 2017-01-23 2020-02-20 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドChia Tai Tianqing Pharmaceutical Group Co., Ltd. カスパーゼ阻害薬としての二環式化合物
JP7113831B2 (ja) 2017-01-23 2022-08-05 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド カスパーゼ阻害薬としての二環式化合物
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EP1163208A2 (en) 2001-12-19
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EP1163208B1 (en) 2004-05-12
WO2001010383A3 (en) 2001-09-07
WO2001010383A2 (en) 2001-02-15
US20020132833A1 (en) 2002-09-19
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