JP2003506389A - カスパーゼ阻害剤およびその使用 - Google Patents

カスパーゼ阻害剤およびその使用

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Publication number
JP2003506389A
JP2003506389A JP2001514908A JP2001514908A JP2003506389A JP 2003506389 A JP2003506389 A JP 2003506389A JP 2001514908 A JP2001514908 A JP 2001514908A JP 2001514908 A JP2001514908 A JP 2001514908A JP 2003506389 A JP2003506389 A JP 2003506389A
Authority
JP
Japan
Prior art keywords
disease
caspase
dmso
nmr
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001514908A
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English (en)
Japanese (ja)
Other versions
JP2003506389A5 (https=
Inventor
ジュリアン・ゴレック
ポール・チャリフソン
ガイ・ブレンチリー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of JP2003506389A publication Critical patent/JP2003506389A/ja
Publication of JP2003506389A5 publication Critical patent/JP2003506389A5/ja
Pending legal-status Critical Current

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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WO2004073742A1 (ja) * 2003-02-24 2004-09-02 Daiichi Pharmaceutical Co.,Ltd. Ｂ型肝炎ウイルスx相互作用蛋白質の分解阻害剤
JP2007526254A (ja) * 2004-02-18 2007-09-13 ジョージア テック リサーチ コーポレイション プロペノイルヒドラジド
JP2008521841A (ja) * 2004-12-01 2008-06-26 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 新規特異的カスパーゼ−１０阻害剤
JP2015536990A (ja) * 2012-11-09 2015-12-24 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ Ｍａｌｔ１の低分子阻害剤
JP2020505388A (ja) * 2017-01-23 2020-02-20 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドChia Tai Tianqing Pharmaceutical Group Co., Ltd. カスパーゼ阻害薬としての二環式化合物

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CN1176941C (zh) 1999-04-09 2004-11-24 西托维亚公司 Caspase抑制剂及其应用
CN1235875C (zh) 1999-08-27 2006-01-11 西托维亚公司 取代的α－羟基酸天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途
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CA2567080A1 (en) 2004-05-27 2005-12-15 Vertex Pharmaceuticals Incorporated Ice inhibitors for the treatment of autoinflammatory diseases
KR20080038369A (ko) 2005-07-28 2008-05-06 버텍스 파마슈티칼스 인코포레이티드 카스파제 억제제 프로드럭
US8828950B2 (en) * 2007-05-01 2014-09-09 Cedars-Sinai Medical Center Caspase inhibitors in the treatment of infection-associated preterm delivery
US9116157B2 (en) 2010-11-05 2015-08-25 Brandeis University Ice-cleaved alpha-synuclein as a biomarker
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
ES2751652T3 (es) 2014-05-12 2020-04-01 Conatus Pharmaceuticals Inc Tratamiento con inhibidor de caspasa emricasan de las complicaciones por las enfermedades hepáticas crónicas
WO2017079566A1 (en) 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Caspase inhibitors for use in the treatment of liver cancer
JP2019500397A (ja) 2015-12-31 2019-01-10 クオナトウス ファーマシューティカルズ，インコーポレイテッド カスパーゼ阻害剤を肝疾患の治療に使用する方法
RU2019113150A (ru) 2016-10-05 2020-11-06 Новартис Аг Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения
WO2022123062A1 (en) 2020-12-11 2022-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients
WO2022187440A1 (en) 2021-03-03 2022-09-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services La protien as a novel regulator of osteoclastogenesis

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Cited By (8)

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WO2004073742A1 (ja) * 2003-02-24 2004-09-02 Daiichi Pharmaceutical Co.,Ltd. Ｂ型肝炎ウイルスx相互作用蛋白質の分解阻害剤
JP2007526254A (ja) * 2004-02-18 2007-09-13 ジョージア テック リサーチ コーポレイション プロペノイルヒドラジド
JP2008521841A (ja) * 2004-12-01 2008-06-26 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 新規特異的カスパーゼ−１０阻害剤
JP2015536990A (ja) * 2012-11-09 2015-12-24 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ Ｍａｌｔ１の低分子阻害剤
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JP2020505388A (ja) * 2017-01-23 2020-02-20 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドChia Tai Tianqing Pharmaceutical Group Co., Ltd. カスパーゼ阻害薬としての二環式化合物
JP7113831B2 (ja) 2017-01-23 2022-08-05 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド カスパーゼ阻害薬としての二環式化合物
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US6632962B2 (en) 2003-10-14
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