AU6894800A - Caspase inhibitors and uses thereof - Google Patents
Caspase inhibitors and uses thereofInfo
- Publication number
- AU6894800A AU6894800A AU68948/00A AU6894800A AU6894800A AU 6894800 A AU6894800 A AU 6894800A AU 68948/00 A AU68948/00 A AU 68948/00A AU 6894800 A AU6894800 A AU 6894800A AU 6894800 A AU6894800 A AU 6894800A
- Authority
- AU
- Australia
- Prior art keywords
- compounds
- caspase
- pdat
- hil
- caspase inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000011727 Caspases Human genes 0.000 title abstract 3
- 108010076667 Caspases Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 101710133727 Phospholipid:diacylglycerol acyltransferase Proteins 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| EP (1) | EP1163208B1 (https=) |
| JP (1) | JP2003506389A (https=) |
| AT (1) | ATE266623T1 (https=) |
| AU (1) | AU6894800A (https=) |
| DE (1) | DE60010675T2 (https=) |
| DK (1) | DK1163208T3 (https=) |
| ES (1) | ES2219381T3 (https=) |
| PT (1) | PT1163208E (https=) |
| TW (1) | TWI281910B (https=) |
| WO (1) | WO2001010383A2 (https=) |
Families Citing this family (30)
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| JP2002539183A (ja) | 1999-03-16 | 2002-11-19 | サイトビア インコーポレイテッド | 置換2−アミノベンズアミドカスパーゼインヒビターおよびその使用 |
| CN1176941C (zh) | 1999-04-09 | 2004-11-24 | 西托维亚公司 | Caspase抑制剂及其应用 |
| CN1235875C (zh) | 1999-08-27 | 2006-01-11 | 西托维亚公司 | 取代的α-羟基酸天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途 |
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| AT413485B (de) * | 2001-04-09 | 2006-03-15 | Hemoteq Gmbh | Mit einem pharmazeutikum beschichteter stent |
| US6878743B2 (en) | 2001-09-18 | 2005-04-12 | Sunesis Pharmaceuticals, Inc. | Small molecule inhibitors of caspases |
| US7410956B2 (en) | 2002-02-11 | 2008-08-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
| US7960398B2 (en) | 2002-04-19 | 2011-06-14 | Vertex Pharmaceuticals Incorporated | Regulation of TNF-alpha |
| GB2389580A (en) * | 2002-06-12 | 2003-12-17 | Bayer Ag | 2-Naphthamide PGI2 antagonists |
| JPWO2004073742A1 (ja) * | 2003-02-24 | 2006-06-01 | 第一製薬株式会社 | B型肝炎ウイルスx相互作用蛋白質の分解阻害剤 |
| CA2524882A1 (en) * | 2003-05-06 | 2004-11-25 | Cytovia, Inc. | Protease inhibitors for coronaviruses and sars-cov and the use thereof |
| AU2003902704A0 (en) * | 2003-05-29 | 2003-06-19 | Crc For Waste Management And Pollution Control Limited Of Unsw | Process for producing a nanoscale zero-valent metal |
| IL158599A0 (en) * | 2003-10-26 | 2004-05-12 | Yeda Res & Dev | Methods of modulating hematopoiesis |
| WO2005080353A1 (en) * | 2004-02-18 | 2005-09-01 | Georgia Tech Research Corporation | Propenoyl hydrazides |
| SG150547A1 (en) * | 2004-03-12 | 2009-03-30 | Vertex Pharma | Processes and intermediates |
| MXPA06013256A (es) * | 2004-05-15 | 2007-02-08 | Vertex Pharma | Tratamiento de crisis convulsivas utilizando inhibidores ice. |
| CA2567080A1 (en) | 2004-05-27 | 2005-12-15 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
| FR2878522B1 (fr) * | 2004-12-01 | 2008-04-18 | Merck Sante Soc Par Actions Si | Nouveaux inhibiteurs specifiques de la caspas-10 |
| KR20080038369A (ko) | 2005-07-28 | 2008-05-06 | 버텍스 파마슈티칼스 인코포레이티드 | 카스파제 억제제 프로드럭 |
| US8828950B2 (en) * | 2007-05-01 | 2014-09-09 | Cedars-Sinai Medical Center | Caspase inhibitors in the treatment of infection-associated preterm delivery |
| US9116157B2 (en) | 2010-11-05 | 2015-08-25 | Brandeis University | Ice-cleaved alpha-synuclein as a biomarker |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| BR112015010504A2 (pt) | 2012-11-09 | 2017-12-05 | Univ Cornell | uso de inibidores de molécula pequena de malt1, método de identificação de um modulador de molécula pequena de malt1, e composição farmacêutica |
| ES2751652T3 (es) | 2014-05-12 | 2020-04-01 | Conatus Pharmaceuticals Inc | Tratamiento con inhibidor de caspasa emricasan de las complicaciones por las enfermedades hepáticas crónicas |
| WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
| JP2019500397A (ja) | 2015-12-31 | 2019-01-10 | クオナトウス ファーマシューティカルズ,インコーポレイテッド | カスパーゼ阻害剤を肝疾患の治療に使用する方法 |
| RU2019113150A (ru) | 2016-10-05 | 2020-11-06 | Новартис Аг | Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения |
| WO2018133870A1 (zh) | 2017-01-23 | 2018-07-26 | 正大天晴药业集团股份有限公司 | 作为Caspase抑制剂的联环化合物 |
| WO2022123062A1 (en) | 2020-12-11 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients |
| WO2022187440A1 (en) | 2021-03-03 | 2022-09-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | La protien as a novel regulator of osteoclastogenesis |
Family Cites Families (6)
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|---|---|---|---|---|
| EP0618223A3 (en) * | 1993-03-08 | 1996-06-12 | Sandoz Ltd | Peptides, the release of Interleukin 1-Bêta, useful as anti-inflammatory agents. |
| NZ330451A (https=) * | 1996-09-12 | 2000-01-28 | Idun Pharmaceuticals Inc | |
| US6242422B1 (en) * | 1998-10-22 | 2001-06-05 | Idun Pharmacueticals, Inc. | (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
| JP2002539183A (ja) * | 1999-03-16 | 2002-11-19 | サイトビア インコーポレイテッド | 置換2−アミノベンズアミドカスパーゼインヒビターおよびその使用 |
| TR200200767T1 (tr) * | 2000-05-23 | 2002-09-23 | Vertex Pharmaceuticals Incorporated | Kaspaz engelleyiciler ve kullanımları |
| EP1289993B9 (en) * | 2000-06-07 | 2008-08-20 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
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2000
- 2000-08-04 EP EP00957311A patent/EP1163208B1/en not_active Expired - Lifetime
- 2000-08-04 AU AU68948/00A patent/AU6894800A/en not_active Abandoned
- 2000-08-04 AT AT00957311T patent/ATE266623T1/de not_active IP Right Cessation
- 2000-08-04 DE DE60010675T patent/DE60010675T2/de not_active Expired - Lifetime
- 2000-08-04 WO PCT/US2000/021503 patent/WO2001010383A2/en not_active Ceased
- 2000-08-04 ES ES00957311T patent/ES2219381T3/es not_active Expired - Lifetime
- 2000-08-04 DK DK00957311T patent/DK1163208T3/da active
- 2000-08-04 JP JP2001514908A patent/JP2003506389A/ja active Pending
- 2000-08-04 PT PT00957311T patent/PT1163208E/pt unknown
- 2000-08-05 TW TW089115790A patent/TWI281910B/zh active
-
2001
- 2001-04-03 US US09/834,052 patent/US6632962B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1163208A2 (en) | 2001-12-19 |
| EP1163208B1 (en) | 2004-05-12 |
| DE60010675T2 (de) | 2005-06-16 |
| WO2001010383A3 (en) | 2001-09-07 |
| US6632962B2 (en) | 2003-10-14 |
| EP1163208A4 (en) | 2002-07-03 |
| PT1163208E (pt) | 2004-08-31 |
| US20020132833A1 (en) | 2002-09-19 |
| DK1163208T3 (da) | 2004-08-16 |
| DE60010675D1 (de) | 2004-06-17 |
| TWI281910B (en) | 2007-06-01 |
| ATE266623T1 (de) | 2004-05-15 |
| ES2219381T3 (es) | 2004-12-01 |
| WO2001010383A2 (en) | 2001-02-15 |
| JP2003506389A (ja) | 2003-02-18 |
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