JP2003504045A5 - - Google Patents
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- Publication number
- JP2003504045A5 JP2003504045A5 JP2001509473A JP2001509473A JP2003504045A5 JP 2003504045 A5 JP2003504045 A5 JP 2003504045A5 JP 2001509473 A JP2001509473 A JP 2001509473A JP 2001509473 A JP2001509473 A JP 2001509473A JP 2003504045 A5 JP2003504045 A5 JP 2003504045A5
- Authority
- JP
- Japan
- Prior art keywords
- monoclonal antibody
- wild
- type protein
- protein
- factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 description 16
- 102000004169 proteins and genes Human genes 0.000 description 16
- 238000000034 method Methods 0.000 description 9
- 102000001690 Factor VIII Human genes 0.000 description 7
- 108010054218 Factor VIII Proteins 0.000 description 7
- 229960000301 factor viii Drugs 0.000 description 7
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 108020001580 protein domains Proteins 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229960000103 thrombolytic agent Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14389199P | 1999-07-14 | 1999-07-14 | |
| US60/143,891 | 1999-07-14 | ||
| GBGB9916450.1A GB9916450D0 (en) | 1999-07-14 | 1999-07-14 | Ligands for use in therapeutic compounds for the treatment of hemostasis disorders |
| GB9916450.1 | 1999-07-14 | ||
| PCT/EP2000/006677 WO2001004269A1 (en) | 1999-07-14 | 2000-07-13 | Ligands for use in therapeutic compositions for the treatment of hemostasis disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008198354A Division JP4297225B2 (ja) | 1999-07-14 | 2008-07-31 | 止血障害処置のための治療組成物に使用するためのリガンド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003504045A JP2003504045A (ja) | 2003-02-04 |
| JP2003504045A5 true JP2003504045A5 (cg-RX-API-DMAC7.html) | 2006-01-05 |
| JP4297207B2 JP4297207B2 (ja) | 2009-07-15 |
Family
ID=26315767
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001509473A Expired - Fee Related JP4297207B2 (ja) | 1999-07-14 | 2000-07-13 | 止血障害処置のための治療組成物に使用するためのリガンド |
| JP2008198354A Expired - Fee Related JP4297225B2 (ja) | 1999-07-14 | 2008-07-31 | 止血障害処置のための治療組成物に使用するためのリガンド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008198354A Expired - Fee Related JP4297225B2 (ja) | 1999-07-14 | 2008-07-31 | 止血障害処置のための治療組成物に使用するためのリガンド |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1194528B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP4297207B2 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE356201T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU781638B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2381125C (cg-RX-API-DMAC7.html) |
| CY (1) | CY1107638T1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE60033814T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1194528T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2283308T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1194528E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2001004269A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7829085B2 (en) | 1999-07-14 | 2010-11-09 | Life Sciences Research Partners Vzw | Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII |
| DK1222929T3 (da) | 2001-01-11 | 2010-09-06 | Life Sciences Res Partners Vzw | Fremgangsmåde og farmaceutisk sammensætning til forebyggelse og/eller behandling af systematisk betændelsesreaktionssyndrom |
| AU2002313194B9 (en) * | 2001-06-12 | 2008-06-05 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Human-type anti-blood coagulation factor VIII antibody |
| EP1388544A1 (en) | 2002-07-31 | 2004-02-11 | D. Collen Research Foundation vzw | Anti-idiotypic antibodies against factor VIII inhibitor and uses thereof |
| JP4422430B2 (ja) | 2003-05-14 | 2010-02-24 | 帝國製薬株式会社 | エストロゲン及び／又はプロゲストゲン含有外用貼付剤 |
| CA2535489C (en) | 2003-08-14 | 2014-09-30 | D. Collen Research Foundation Vzw | Antibodies against factor viii with modified glycosylation in the variable region |
| US7566701B2 (en) | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
| AU2005282380A1 (en) | 2004-09-07 | 2006-03-16 | Archemix Corp. | Aptamer medicinal chemistry |
| ATE509957T1 (de) * | 2005-07-29 | 2011-06-15 | Life Sciences Res Partners Vzw | An die a2-domäne bindende, humane inhibitorische anti-faktor-viii-antikörper |
| FR2892724B1 (fr) | 2005-11-02 | 2008-01-04 | Lab Francais Du Fractionnement | Anticorps cytotoxiques diriges contre des anticorps inhibiteurs du facteur viii. |
| FR2897868B1 (fr) * | 2006-02-24 | 2012-08-31 | Lab Francais Du Fractionnement | Anticorps anti-idiotypiques neutralisant l'activite inhibitrice d'un anticorps inhibiteur dirige contre le domaine c1 du facteur viii. |
| NZ597452A (en) | 2009-07-10 | 2013-10-25 | Thrombogenics Nv | Variants of plasminogen and plasmin |
| WO2011023805A1 (en) | 2009-08-28 | 2011-03-03 | Thrombogenics N.V. | Use of plasmin for the treatment of filtration failure after trabeculectomy |
| CA2823491A1 (en) | 2011-01-05 | 2012-07-12 | Thrombogenics Nv | Plasminogen and plasmin variants |
| CA2844644A1 (en) | 2011-08-12 | 2013-02-21 | Thrombogenics N.V. | Plasminogen and plasmin variants |
| EP2785739B1 (en) | 2011-12-01 | 2017-03-15 | ThromboGenics N.V. | Improving trabeculectomy outcome |
| KR101395736B1 (ko) * | 2012-07-10 | 2014-05-16 | 아주대학교산학협력단 | 인간 혈액응고인자 ⅷ 도메인 특이적 항체 및 이의 제조방법 |
| EP3426685A1 (en) | 2016-03-10 | 2019-01-16 | Oxurion NV | Posterior ocular fibrosis inhibition by antagonizing placental growth factor |
| KR20200005635A (ko) * | 2017-05-11 | 2020-01-15 | 브이아이비 브이지더블유 | 가변 면역글로불린 도메인의 글리코실화 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA24512A1 (fr) * | 1996-01-17 | 1998-12-31 | Univ Vermont And State Agrienl | Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose |
-
2000
- 2000-07-13 JP JP2001509473A patent/JP4297207B2/ja not_active Expired - Fee Related
- 2000-07-13 AT AT00949329T patent/ATE356201T1/de active
- 2000-07-13 WO PCT/EP2000/006677 patent/WO2001004269A1/en not_active Ceased
- 2000-07-13 ES ES00949329T patent/ES2283308T3/es not_active Expired - Lifetime
- 2000-07-13 DE DE60033814T patent/DE60033814T2/de not_active Expired - Lifetime
- 2000-07-13 PT PT00949329T patent/PT1194528E/pt unknown
- 2000-07-13 DK DK00949329T patent/DK1194528T3/da active
- 2000-07-13 EP EP00949329A patent/EP1194528B1/en not_active Expired - Lifetime
- 2000-07-13 CA CA2381125A patent/CA2381125C/en not_active Expired - Fee Related
- 2000-07-13 AU AU62730/00A patent/AU781638B2/en not_active Ceased
-
2007
- 2007-05-24 CY CY20071100703T patent/CY1107638T1/el unknown
-
2008
- 2008-07-31 JP JP2008198354A patent/JP4297225B2/ja not_active Expired - Fee Related
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